Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder - Fuchs, Claudia; Rimondini, Roberto; Viggiano, Rocchina; Trazzi, Stefania; De Franceschi, Marianna; Bartesaghi, Renata; Ciani, Elisabetta (Neurobiology of disease, 2015)
Keywords: Animals; Apoptosis - drug effects; Apoptosis - physiology; CDKL5 disorder; Cell Survival - drug effects; Cell Survival - physiology; Disease Models, Animal; Encephalopathy; Glycogen Synthase Kinase 3 - antagonists & inhibitors; Glycogen Synthase Kinase 3 - metabolism; Glycogen Synthase Kinase 3 beta; GSK3β inhibitor; Hippocampus - drug effects; Hippocampus - enzymology; Hippocampus - growth & development; Hippocampus - pathology; Indoles - pharmacology; Learning Disabilities - drug therapy; Learning Disabilities - enzymology; Learning Disabilities - pathology; Male; Maleimides - pharmacology; Maze Learning - drug effects; Maze Learning - physiology; Mice, Knockout; Neural Stem Cells - drug effects; Neural Stem Cells - enzymology; Neural Stem Cells - pathology; Neurogenesis - drug effects; Neurogenesis - physiology; Neurology; Neurons - drug effects; Neurons - enzymology; Neurons - pathology; Neuroprotective Agents - pharmacology; Nootropic Agents - pharmacology; Pharmacotherapy; Protein Kinase Inhibitors - pharmacology; Protein Serine-Threonine Kinases - deficiency; Protein Serine-Threonine Kinases - genetics; Rescue of hippocampal developmental; Spatial Memory; Rescue of hippocampal developmental; Pharmacotherapy; GSK3β inhibitor; CDKL5 disorder; Encephalopathy