Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 32; pp. 14158 - 14163
• Main Authors: Wu, Xinle, Ge, Hongfei, Lemon, Bryan, Vonderfecht, Steven, Baribault, Helene, Weiszmann, Jennifer, Gupte, Jamila, Gardner, Jonitha, Lindberg, Richard, Wang, Zhulun, Li, Yang, Kornberg, Roger D.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 10.08.2010; National Acad Sciences
• Subjects: Adipocytes; Amino Acid Sequence; Animals; Biological Sciences; Blood Glucose; Cell cycle; Cell division; Cell growth; Cell Proliferation; Diabetes; Diabetes Mellitus - drug therapy; disease models; disease outbreaks; Endocrine system; energy; engineering; Fibroblast growth factors; Fibroblast Growth Factors - physiology; Genetic Variation; glucose; Heparin; Hepatocytes; Hepatocytes - cytology; homeostasis; Hormones; Insulin Resistance; lipids; Liver; Metabolism; Mice; Molecules; Obesity; Obesity - drug therapy; Peptide Fragments - pharmacology; Proteins; Receptors; Recombinant Fusion Proteins - pharmacology; Recombinant Proteins - pharmacology; structure-activity relationships

FGF19 and FGF21 are distinctive members of the FGF family that function as endocrine hormones. Their potent effects on normalizing glucose, lipid, and energy homeostasis in disease models have made them an interesting focus of research for combating the growing epidemics of diabetes and obesity. Des...