Alternative splicing of the androgen receptor in polycystic ovary syndrome

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 15; pp. 4743 - 4748
• Main Authors: Wang, Fangfang, Pan, Jiexue, Liu, Ye, Meng, Qing, Lv, Pingping, Qu, Fan, Ding, Guo-Lian, Klausen, Christian, Leung, Peter C. K., Chan, Hsiao Chang, Yao, Weimiao, Zhou, Cai-Yun, Shi, Biwei, Zhang, Junyu, Sheng, Jianzhong, Huang, Hefeng
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 14.04.2015; National Acad Sciences
• Subjects: Adult; Alternative Splicing; androgen receptors; Androgens; animal ovaries; Base Sequence; Biological Sciences; Cells; Cells, Cultured; Dehydroepiandrosterone - blood; Endocrine system; etiology; Female; Gene Expression Profiling; Genes; Genome-Wide Association Study; Granulosa Cells - metabolism; HEK293 Cells; Humans; Hyperandrogenism - blood; Hyperandrogenism - genetics; INDEL Mutation; metabolism; Oogenesis - genetics; Ovarian Follicle - physiopathology; Polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - physiopathology; Protein Isoforms - genetics; Receptors, Androgen - genetics; Reverse Transcriptase Polymerase Chain Reaction; Testosterone - blood; women; Womens health; AR; folliculogenesis; PCOS; splicing; hyperandrogenism

Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders and a leading cause of female subfertility. The mechanism underlying the pathophysiology of PCOS remains to be illustrated. Here, we identify two alternative splice variants (ASVs) of the androgen receptor (AR), in...