PAPPA2, an Enzyme That Cleaves an Insulin-Like Growth-Factor-Binding Protein, Is a Candidate Gene for a Quantitative Trait Locus Affecting Body Size in Mice

• Published in: Genetics (Austin) Vol. 173; no. 3; pp. 1547 - 1553
• Main Authors: Christians, Julian K, Hoeflich, Andreas, Keightley, Peter D
• Format: Journal Article
• Language: English
• Published: United States Genetics Soc America 01.07.2006; Genetics Society of America; Copyright © 2006 by the Genetics Society of America
• Subjects: Animals; Body size; Body Size - genetics; Bone density; Enzymes; Female; Gene expression; Gene loci; Gene mapping; Genetics; Genotype & phenotype; Insulin-Like Growth Factor Binding Protein 5 - metabolism; Insulin-Like Growth Factor Binding Proteins - genetics; Insulin-Like Growth Factor Binding Proteins - metabolism; Investigations; Metalloendopeptidases - genetics; Metalloendopeptidases - metabolism; Mice; Mice, Inbred C57BL; Parents & parenting; Polymorphism, Single Nucleotide; Pregnancy-Associated Plasma Protein-A - genetics; Pregnancy-Associated Plasma Protein-A - metabolism; Proteins; Quantitative Trait Loci; Studies

Identifying genes responsible for quantitative variation remains a major challenge. We previously identified a quantitative trait locus (QTL) affecting body size that segregated between two inbred strains of mice. By fine mapping, we have refined the location of this QTL to a genomic region containi...