Evaluation of the Immunomodulatory Properties of Streptococcus suis and Group B Streptococcus Capsular Polysaccharides on the Humoral Response

and group B (GBS) are encapsulated streptococci causing septicemia and meningitis. Antibodies (Abs) against capsular polysaccharides (CPSs) have a crucial protective role, but the structure/composition of the CPS, including the presence of sialic acid, may interfere with the generation of anti-CPS A...

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Published inPathogens (Basel) Vol. 6; no. 2; p. 16
Main Authors Calzas, Cynthia, Taillardet, Morgan, Fourati, Insaf Salem, Roy, David, Gottschalk, Marcelo, Soudeyns, Hugo, Defrance, Thierry, Segura, Mariela
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.04.2017
MDPI
Subjects
Acids
Antibodies
Antibody response
Bacteriology
Capsular polysaccharides
Immune response (humoral)
Immune system
Immunization
Immunogenicity
Immunoglobulin M
Immunology
Immunomodulation
Life Sciences
Meningitis
Mice
Microbiology and Parasitology
Polysaccharides
Protective structures
Rodents
Saccharides
Septicemia
Serotypes
Streptococcus
Streptococcus infections
Sugar
Switching
Virology
group B Streptococcus
capsular polysaccharide
sialic acid
Streptococcus suis
humoral response
murine B cells
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Abstract and group B (GBS) are encapsulated streptococci causing septicemia and meningitis. Antibodies (Abs) against capsular polysaccharides (CPSs) have a crucial protective role, but the structure/composition of the CPS, including the presence of sialic acid, may interfere with the generation of anti-CPS Ab responses. We investigated the features of the CPS-specific Ab response directed against serotypes 2 and 14 and GBS serotypes III and V after infection or immunization with purified native or desialylated CPSs in mice. Whereas -infected mice developed a very low/undetectable CPS-specific IgM response, significant anti-CPS IgM titers were measured in GBS-infected animals (especially for type III GBS). No isotype switching was detected in - or GBS-infected mice. While the expression of sialic acid was essential for the immunogenicity of purified GBS type III CPS, this sugar was not responsible for the inability of purified types 2, 14 and GBS type V CPSs to induce a specific Ab response. Thus, other biochemical criteria unrelated to the presence of sialic acid may be responsible for the inaptitude of the host immune system to mount an effective response against certain and GBS CPS types.
AbstractList Streptococcus suis and group B Streptococcus (GBS) are encapsulated streptococci causing septicemia and meningitis. Antibodies (Abs) against capsular polysaccharides (CPSs) have a crucial protective role, but the structure/composition of the CPS, including the presence of sialic acid, may interfere with the generation of anti-CPS Ab responses. We investigated the features of the CPS-specific Ab response directed against S. suis serotypes 2 and 14 and GBS serotypes III and V after infection or immunization with purified native or desialylated CPSs in mice. Whereas S. suis -infected mice developed a very low/undetectable CPS-specific IgM response, significant anti-CPS IgM titers were measured in GBS-infected animals (especially for type III GBS). No isotype switching was detected in S. suis - or GBS-infected mice. While the expression of sialic acid was essential for the immunogenicity of purified GBS type III CPS, this sugar was not responsible for the inability of purified S. suis types 2, 14 and GBS type V CPSs to induce a specific Ab response. Thus, other biochemical criteria unrelated to the presence of sialic acid may be responsible for the inaptitude of the host immune system to mount an effective response against certain S. suis and GBS CPS types.
Streptococcus suis and group B Streptococcus (GBS) are encapsulated streptococci causing septicemia and meningitis. Antibodies (Abs) against capsular polysaccharides (CPSs) have a crucial protective role, but the structure/composition of the CPS, including the presence of sialic acid, may interfere with the generation of anti-CPS Ab responses. We investigated the features of the CPS-specific Ab response directed against S. suis serotypes 2 and 14 and GBS serotypes III and V after infection or immunization with purified native or desialylated CPSs in mice. Whereas S. suis-infected mice developed a very low/undetectable CPS-specific IgM response, significant anti-CPS IgM titers were measured in GBS-infected animals (especially for type III GBS). No isotype switching was detected in S. suis- or GBS-infected mice. While the expression of sialic acid was essential for the immunogenicity of purified GBS type III CPS, this sugar was not responsible for the inability of purified S. suis types 2, 14 and GBS type V CPSs to induce a specific Ab response. Thus, other biochemical criteria unrelated to the presence of sialic acid may be responsible for the inaptitude of the host immune system to mount an effective response against certain S. suis and GBS CPS types.
and group B (GBS) are encapsulated streptococci causing septicemia and meningitis. Antibodies (Abs) against capsular polysaccharides (CPSs) have a crucial protective role, but the structure/composition of the CPS, including the presence of sialic acid, may interfere with the generation of anti-CPS Ab responses. We investigated the features of the CPS-specific Ab response directed against serotypes 2 and 14 and GBS serotypes III and V after infection or immunization with purified native or desialylated CPSs in mice. Whereas -infected mice developed a very low/undetectable CPS-specific IgM response, significant anti-CPS IgM titers were measured in GBS-infected animals (especially for type III GBS). No isotype switching was detected in - or GBS-infected mice. While the expression of sialic acid was essential for the immunogenicity of purified GBS type III CPS, this sugar was not responsible for the inability of purified types 2, 14 and GBS type V CPSs to induce a specific Ab response. Thus, other biochemical criteria unrelated to the presence of sialic acid may be responsible for the inaptitude of the host immune system to mount an effective response against certain and GBS CPS types.
Author Segura, Mariela
Soudeyns, Hugo
Fourati, Insaf Salem
Calzas, Cynthia
Taillardet, Morgan
Gottschalk, Marcelo
Roy, David
Defrance, Thierry
AuthorAffiliation 1 Swine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte St., Saint-Hyacinthe, QC J2S 2M2, Canada; cynthia.calzas@umontreal.ca (C.C.); dav.roy@gmail.com (D.R.); marcelo.gottschalk@umontreal.ca (M.G.)
3 Department of Microbiology, Infectiology and Immunology, Faculty of Medicine, University of Montreal, C.P. 6128, Succ. Centre-ville, Montreal, QC H3C 3J7, Canada; insaf.salem@umontreal.ca (I.S.-F.); hugo.soudeyns@umontreal.ca (H.S.)
2 CIRI, INSERM, U1111, CNRS UMR5308, University of Lyon 1, 21 Avenue Tony Garnier, 69007 Lyon, France; morgan.taillardet@inserm.fr (M.T.); thierry.defrance@inserm.fr (T.D.)
AuthorAffiliation_xml – name: 3 Department of Microbiology, Infectiology and Immunology, Faculty of Medicine, University of Montreal, C.P. 6128, Succ. Centre-ville, Montreal, QC H3C 3J7, Canada; insaf.salem@umontreal.ca (I.S.-F.); hugo.soudeyns@umontreal.ca (H.S.)
– name: 2 CIRI, INSERM, U1111, CNRS UMR5308, University of Lyon 1, 21 Avenue Tony Garnier, 69007 Lyon, France; morgan.taillardet@inserm.fr (M.T.); thierry.defrance@inserm.fr (T.D.)
– name: 1 Swine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte St., Saint-Hyacinthe, QC J2S 2M2, Canada; cynthia.calzas@umontreal.ca (C.C.); dav.roy@gmail.com (D.R.); marcelo.gottschalk@umontreal.ca (M.G.)
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  givenname: Insaf Salem
  surname: Fourati
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  organization: Swine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte St., Saint-Hyacinthe, QC J2S 2M2, Canada. marcelo.gottschalk@umontreal.ca
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  givenname: Hugo
  surname: Soudeyns
  fullname: Soudeyns, Hugo
  email: hugo.soudeyns@umontreal.ca
  organization: Department of Microbiology, Infectiology and Immunology, Faculty of Medicine, University of Montreal, C.P. 6128, Succ. Centre-ville, Montreal, QC H3C 3J7, Canada. hugo.soudeyns@umontreal.ca
– sequence: 7
  givenname: Thierry
  surname: Defrance
  fullname: Defrance, Thierry
  email: thierry.defrance@inserm.fr
  organization: CIRI, INSERM, U1111, CNRS UMR5308, University of Lyon 1, 21 Avenue Tony Garnier, 69007 Lyon, France. thierry.defrance@inserm.fr
– sequence: 8
  givenname: Mariela
  surname: Segura
  fullname: Segura, Mariela
  email: mariela.segura@umontreal.ca
  organization: Swine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte St., Saint-Hyacinthe, QC J2S 2M2, Canada. mariela.segura@umontreal.ca
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Issue 2
Keywords group B Streptococcus
capsular polysaccharide
sialic acid
Streptococcus suis
humoral response
murine B cells
Language English
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Snippet and group B (GBS) are encapsulated streptococci causing septicemia and meningitis. Antibodies (Abs) against capsular polysaccharides (CPSs) have a crucial...
Streptococcus suis and group B Streptococcus (GBS) are encapsulated streptococci causing septicemia and meningitis. Antibodies (Abs) against capsular...
Streptococcus suis and group B Streptococcus (GBS) are encapsulated streptococci causing septicemia and meningitis. Antibodies (Abs) against capsular...
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StartPage 16
SubjectTerms Acids
Antibodies
Antibody response
Bacteriology
Capsular polysaccharides
Immune response (humoral)
Immune system
Immunization
Immunogenicity
Immunoglobulin M
Immunology
Immunomodulation
Life Sciences
Meningitis
Mice
Microbiology and Parasitology
Polysaccharides
Protective structures
Rodents
Saccharides
Septicemia
Serotypes
Streptococcus
Streptococcus infections
Sugar
Switching
Virology
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Title Evaluation of the Immunomodulatory Properties of Streptococcus suis and Group B Streptococcus Capsular Polysaccharides on the Humoral Response
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