Weight-Independent Changes in Blood Glucose Homeostasis After Gastric Bypass or Vertical Sleeve Gastrectomy in Rats

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 141; no. 3; pp. 950 - 958
• Main Authors: Chambers, Adam P., Jessen, Lene, Ryan, Karen K., Sisley, Stephanie, Wilson–Pérez, Hilary E., Stefater, Margaret A., Gaitonde, Shrawan G., Sorrell, Joyce E., Toure, Mouhamadoul, Berger, Jose, D'Alessio, David A., Woods, Stephen C., Seeley, Randy J., Sandoval, Darleen A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2011
• Subjects: Animals; Blood Glucose - metabolism; Body Weight - physiology; Diabetes; Dietary Fats - adverse effects; Disease Models, Animal; Eating - physiology; Gastrectomy - methods; Gastric Bypass - methods; Gastroenterology and Hepatology; Glucagon-Like Peptide 1 - blood; Homeostasis - physiology; Insulin - blood; Insulin Resistance - physiology; Male; Obesity; Obesity - chemically induced; Obesity - metabolism; Obesity - surgery; Postprandial Period - physiology; Rats; Rats, Long-Evans; Stomach - surgery; Surgery; Weight Reduction; Obesity; GLP-1; RYGB; Weight Reduction; Surgery; IP; Diabetes; VSG; intraperitoneal; Roux-en-Y gastric bypass; glucagon-like peptide 1; vertical sleeve gastrectomy

Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) reduce weight and improve glucose metabolism in obese patients, although it is not clear if metabolic changes are independent of weight loss. We investigated alterations in glucose metabolism in rats following RYGB or VSG. Rats un...