Allium sativum L. Improves Visual Memory and Attention in Healthy Human Volunteers
Studies have shown that Allium sativum L. (AS) protects amyloid-beta peptide-induced apoptosis, prevents oxidative insults to neurons and synapses, and thus prevent Alzheimer’s disease progression in experimental animals. However, there is no experimental evidence in human regarding its putative rol...
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| Published in | Evidence-based complementary and alternative medicine Vol. 2015; no. 2015; pp. 1 - 8 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cairo, Egypt
Hindawi Publishing Corporation
01.01.2015
John Wiley & Sons, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1741-427X 1741-4288 |
| DOI | 10.1155/2015/103416 |
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| Abstract | Studies have shown that Allium sativum L. (AS) protects amyloid-beta peptide-induced apoptosis, prevents oxidative insults to neurons and synapses, and thus prevent Alzheimer’s disease progression in experimental animals. However, there is no experimental evidence in human regarding its putative role in memory and cognition. We have studied the effect of AS consumption by healthy human volunteers on visual memory, verbal memory, attention, and executive function in comparison to control subjects taking placebo. The study was conducted over five weeks and twenty volunteers of both genders were recruited and divided randomly into two groups: A (AS) and B (placebo). Both groups participated in the 6 computerized neuropsychological tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) twice: at the beginning and after five weeks of the study. We found statistically significant difference ( p < 0.05 ) in several parameters of visual memory and attention due to AS ingestion. We also found statistically nonsignificant ( p > 0.05 ) beneficial effects on verbal memory and executive function within a short period of time among the volunteers. Study for a longer period of time with patients suffering from neurodegenerative diseases might yield more relevant results regarding the potential therapeutic role of AS. |
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| AbstractList | Studies have shown that Allium sativum L. (AS) protects amyloid-beta peptide-induced apoptosis, prevents oxidative insults to neurons and synapses, and thus prevent Alzheimer’s disease progression in experimental animals. However, there is no experimental evidence in human regarding its putative role in memory and cognition. We have studied the effect of AS consumption by healthy human volunteers on visual memory, verbal memory, attention, and executive function in comparison to control subjects taking placebo. The study was conducted over five weeks and twenty volunteers of both genders were recruited and divided randomly into two groups: A (AS) and B (placebo). Both groups participated in the 6 computerized neuropsychological tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) twice: at the beginning and after five weeks of the study. We found statistically significant difference ( p < 0.05 ) in several parameters of visual memory and attention due to AS ingestion. We also found statistically nonsignificant ( p > 0.05 ) beneficial effects on verbal memory and executive function within a short period of time among the volunteers. Study for a longer period of time with patients suffering from neurodegenerative diseases might yield more relevant results regarding the potential therapeutic role of AS. Studies have shown that Allium sativum L. (AS) protects amyloid-beta peptide-induced apoptosis, prevents oxidative insults to neurons and synapses, and thus prevent Alzheimer’s disease progression in experimental animals. However, there is no experimental evidence in human regarding its putative role in memory and cognition. We have studied the effect of AS consumption by healthy human volunteers on visual memory, verbal memory, attention, and executive function in comparison to control subjects taking placebo. The study was conducted over five weeks and twenty volunteers of both genders were recruited and divided randomly into two groups: A (AS) and B (placebo). Both groups participated in the 6 computerized neuropsychological tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) twice: at the beginning and after five weeks of the study. We found statistically significant difference ( p < 0.05 ) in several parameters of visual memory and attention due to AS ingestion. We also found statistically nonsignificant ( p > 0.05 ) beneficial effects on verbal memory and executive function within a short period of time among the volunteers. Study for a longer period of time with patients suffering from neurodegenerative diseases might yield more relevant results regarding the potential therapeutic role of AS. Studies have shown that Allium sativum L. (AS) protects amyloid-beta peptide-induced apoptosis, prevents oxidative insults to neurons and synapses, and thus prevent Alzheimer's disease progression in experimental animals. However, there is no experimental evidence in human regarding its putative role in memory and cognition. We have studied the effect of AS consumption by healthy human volunteers on visual memory, verbal memory, attention, and executive function in comparison to control subjects taking placebo. The study was conducted over five weeks and twenty volunteers of both genders were recruited and divided randomly into two groups: A (AS) and B (placebo). Both groups participated in the 6 computerized neuropsychological tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) twice: at the beginning and after five weeks of the study. We found statistically significant difference ( p < 0.05) in several parameters of visual memory and attention due to AS ingestion. We also found statistically nonsignificant ( p > 0.05) beneficial effects on verbal memory and executive function within a short period of time among the volunteers. Study for a longer period of time with patients suffering from neurodegenerative diseases might yield more relevant results regarding the potential therapeutic role of AS. |
| Audience | Academic |
| Author | Haque, Parsa Sanjana Bhuiyan, Mohiuddin Ahmed Tasnim, Sara Bari, Md. Sazzadul Bin Sayeed, Muhammad Shahdaat Shahriar, Mohammad Hossain, Md. Monir Islam, Sardar Mohd. Ashraful |
| AuthorAffiliation | 2 Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814, Bangladesh 1 Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh 3 Department of Pharmacy, University of Asia Pacific, Dhaka 1209, Bangladesh 4 Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka 1000, Bangladesh |
| AuthorAffiliation_xml | – name: 2 Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814, Bangladesh – name: 4 Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka 1000, Bangladesh – name: 3 Department of Pharmacy, University of Asia Pacific, Dhaka 1209, Bangladesh – name: 1 Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh |
| Author_xml | – sequence: 1 fullname: Bin Sayeed, Muhammad Shahdaat – sequence: 2 fullname: Shahriar, Mohammad – sequence: 3 fullname: Islam, Sardar Mohd. Ashraful – sequence: 4 fullname: Hossain, Md. Monir – sequence: 5 fullname: Bari, Md. Sazzadul – sequence: 6 fullname: Haque, Parsa Sanjana – sequence: 7 fullname: Tasnim, Sara – sequence: 8 fullname: Bhuiyan, Mohiuddin Ahmed |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26351508$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1111_psyg_70007 crossref_primary_10_4236_jbbs_2017_72004 crossref_primary_10_1007_s11064_024_04184_y crossref_primary_10_1155_2016_3730940 crossref_primary_10_1111_jfbc_13165 |
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| ContentType | Journal Article |
| Copyright | Copyright © 2015 Sara Tasnim et al. COPYRIGHT 2015 John Wiley & Sons, Inc. Copyright © 2015 Sara Tasnim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2015 Sara Tasnim et al. 2015 |
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| Snippet | Studies have shown that Allium sativum L. (AS) protects amyloid-beta peptide-induced apoptosis, prevents oxidative insults to neurons and synapses, and thus... Studies have shown that Allium sativum L. (AS) protects amyloid-beta peptide-induced apoptosis, prevents oxidative insults to neurons and synapses, and thus... |
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| SubjectTerms | Allium sativum Animal bites Antioxidants Free radicals Garlic Health aspects Laboratories Memory, Disorders of Neural transmission Neurodegeneration Oxidative stress Pharmacy Prevention Rodents Studies |
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| Title | Allium sativum L. Improves Visual Memory and Attention in Healthy Human Volunteers |
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