Molecular Mechanism of NLRP3 Inflammasome Activation

• Published in: Journal of clinical immunology Vol. 30; no. 5; pp. 628 - 631
• Main Authors: Jin, Chengcheng, Flavell, Richard A
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.09.2010; Springer US; Springer Nature B.V
• Subjects: agonists; Animals; Biomedical and Life Sciences; Biomedicine; Carrier Proteins; Carrier Proteins - agonists; Carrier Proteins - immunology; Caspase 1; Caspase 1 - metabolism; cathepsin B; Cathepsin B - metabolism; Humans; Immunology; Infection - immunology; Infections; Infectious Diseases; Inflammasomes; Inflammasomes - immunology; Interleukin-1beta; Interleukin-1beta - immunology; Internal Medicine; Medical Microbiology; metabolism; NLR Family, Pyrin Domain-Containing 3 Protein; NLRP3 inflammasome; Oxidative Stress; Oxidative Stress - immunology; Potassium; Potassium - metabolism; potassium efflux; reactive oxygen species; Reactive Oxygen Species - metabolism; Receptors, Pattern Recognition; Receptors, Pattern Recognition - agonists; Receptors, Pattern Recognition - immunology; Signal Transduction; Signal Transduction - immunology; Stress, Physiological; Stress, Physiological - immunology; potassium efflux; agonist; NLRP3 inflammasome; cathepsin B; reactive oxygen species

The inflammasome is an intracellular multimolecular complex that controls caspase-1 activity in the innate immune system. NLRP3, a member of the NLR family of cytosolic pattern recognition receptors, along with the adaptor protein ASC, mediates caspase-1 activation via assembly of the inflammasome i...