Three-Dimensional Hemodynamics in the Human Pulmonary Arteries Under Resting and Exercise Conditions

The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification of human pulmonary artery hemodynamic conditions under resting and exercise states can be useful in investigating the physiology of disease...

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Published inAnnals of biomedical engineering Vol. 39; no. 1; pp. 347 - 358
Main Authors Tang, Beverly T, Fonte, Tim A, Chan, Frandics P, Tsao, Philip S, Feinstein, Jeffrey A, Taylor, Charles A
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 01.01.2011
Springer US
Springer Nature B.V
Subjects
Adult
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Biophysics
blood flow
Blood Flow Velocity - physiology
Blood Pressure - physiology
Classical Mechanics
Computer Simulation
Energy dissipation
Energy efficiency
Finite-element analysis
Fluid dynamics
Humans
Hydrodynamics
Imaging, Three-Dimensional
magnetic resonance imaging
Middle Aged
Models, Anatomic
Models, Cardiovascular
Physical Exertion - physiology
Pulmonary Artery - anatomy & histology
Pulmonary Artery - physiology
Pulmonary vasculature
Rest - physiology
Shear stress
Young Adult
Shear stress
Pulmonary vasculature
Magnetic resonance imaging
Finite-element analysis
Blood flow
Online AccessGet full text

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Abstract The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification of human pulmonary artery hemodynamic conditions under resting and exercise states can be useful in investigating the physiology of disease development and treatment outcomes. In this study, a combined magnetic resonance imaging and computational fluid dynamics approach was used to quantify pulsatile flow fields, wall shear stress (WSS), oscillations in WSS (OSI), and energy efficiency in six subject-specific models of the human pulmonary vasculature with high spatial and temporal resolution. Averaging over all subjects, WSS was found to increase from 19.8 ± 4.0 to 51.8 ± 6.7 dynes/cm², and OSI was found to decrease from 0.094 ± 0.016 to 0.081 ± 0.015 in the proximal pulmonary arteries between rest and exercise conditions (p < 0.05). These findings demonstrate the localized, biomechanical effects of exercise. Furthermore, an average decrease of 10% in energy efficiency was noted between rest and exercise. These data indicate the amount of energy dissipation that typically occurs with exercise and may be useful in future surgical planning applications.
AbstractList The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification of human pulmonary artery hemodynamic conditions under resting and exercise states can be useful in investigating the physiology of disease development and treatment outcomes. In this study, a combined magnetic resonance imaging and computational fluid dynamics approach was used to quantify pulsatile flow fields, wall shear stress (WSS), oscillations in WSS (OSI), and energy efficiency in six subject-specific models of the human pulmonary vasculature with high spatial and temporal resolution. Averaging over all subjects, WSS was found to increase from 19.8±4.0 to 51.8±6.7 dynes/cm2, and OSI was found to decrease from 0.094±0.016 to 0.081±0.015 in the proximal pulmonary arteries between rest and exercise conditions (p<0.05). These findings demonstrate the localized, biomechanical effects of exercise. Furthermore, an average decrease of 10% in energy efficiency was noted between rest and exercise. These data indicate the amount of energy dissipation that typically occurs with exercise and may be useful in future surgical planning applications.
The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification of human pulmonary artery hemodynamic conditions under resting and exercise states can be useful in investigating the physiology of disease development and treatment outcomes. In this study, a combined magnetic resonance imaging and computational fluid dynamics approach was used to quantify pulsatile flow fields, wall shear stress (WSS), oscillations in WSS (OSI), and energy efficiency in six subject-specific models of the human pulmonary vasculature with high spatial and temporal resolution. Averaging over all subjects, WSS was found to increase from 19.8 plus or minus 4.0 to 51.8 plus or minus 6.7dynes/cm super(2), and OSI was found to decrease from 0.094 plus or minus 0.016 to 0.081 plus or minus 0.015 in the proximal pulmonary arteries between rest and exercise conditions (p<0.05). These findings demonstrate the localized, biomechanical effects of exercise. Furthermore, an average decrease of 10% in energy efficiency was noted between rest and exercise. These data indicate the amount of energy dissipation that typically occurs with exercise and may be useful in future surgical planning applications.
The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification of human pulmonary artery hemodynamic conditions under resting and exercise states can be useful in investigating the physiology of disease development and treatment outcomes. In this study, a combined magnetic resonance imaging and computational fluid dynamics approach was used to quantify pulsatile flow fields, wall shear stress (WSS), oscillations in WSS (OSI), and energy efficiency in six subject-specific models of the human pulmonary vasculature with high spatial and temporal resolution. Averaging over all subjects, WSS was found to increase from 19.8 ± 4.0 to 51.8 ± 6.7 dynes/cm^sup 2^, and OSI was found to decrease from 0.094 ± 0.016 to 0.081 ± 0.015 in the proximal pulmonary arteries between rest and exercise conditions (p < 0.05). These findings demonstrate the localized, biomechanical effects of exercise. Furthermore, an average decrease of 10% in energy efficiency was noted between rest and exercise. These data indicate the amount of energy dissipation that typically occurs with exercise and may be useful in future surgical planning applications.[PUBLICATION ABSTRACT]
The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification of human pulmonary artery hemodynamic conditions under resting and exercise states can be useful in investigating the physiology of disease development and treatment outcomes. In this study, a combined magnetic resonance imaging and computational fluid dynamics approach was used to quantify pulsatile flow fields, wall shear stress (WSS), oscillations in WSS (OSI), and energy efficiency in six subject-specific models of the human pulmonary vasculature with high spatial and temporal resolution. Averaging over all subjects, WSS was found to increase from 19.8±4.0 to 51.8±6.7 dynes/cm2, and OSI was found to decrease from 0.094±0.016 to 0.081±0.015 in the proximal pulmonary arteries between rest and exercise conditions (p<0.05). These findings demonstrate the localized, biomechanical effects of exercise. Furthermore, an average decrease of 10% in energy efficiency was noted between rest and exercise. These data indicate the amount of energy dissipation that typically occurs with exercise and may be useful in future surgical planning applications.The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification of human pulmonary artery hemodynamic conditions under resting and exercise states can be useful in investigating the physiology of disease development and treatment outcomes. In this study, a combined magnetic resonance imaging and computational fluid dynamics approach was used to quantify pulsatile flow fields, wall shear stress (WSS), oscillations in WSS (OSI), and energy efficiency in six subject-specific models of the human pulmonary vasculature with high spatial and temporal resolution. Averaging over all subjects, WSS was found to increase from 19.8±4.0 to 51.8±6.7 dynes/cm2, and OSI was found to decrease from 0.094±0.016 to 0.081±0.015 in the proximal pulmonary arteries between rest and exercise conditions (p<0.05). These findings demonstrate the localized, biomechanical effects of exercise. Furthermore, an average decrease of 10% in energy efficiency was noted between rest and exercise. These data indicate the amount of energy dissipation that typically occurs with exercise and may be useful in future surgical planning applications.
The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification of human pulmonary artery hemodynamic conditions under resting and exercise states can be useful in investigating the physiology of disease development and treatment outcomes. In this study, a combined magnetic resonance imaging and computational fluid dynamics approach was used to quantify pulsatile flow fields, wall shear stress (WSS), oscillations in WSS (OSI), and energy efficiency in six subject-specific models of the human pulmonary vasculature with high spatial and temporal resolution. Averaging over all subjects, WSS was found to increase from 19.8 ± 4.0 to 51.8 ± 6.7 dynes/cm², and OSI was found to decrease from 0.094 ± 0.016 to 0.081 ± 0.015 in the proximal pulmonary arteries between rest and exercise conditions (p < 0.05). These findings demonstrate the localized, biomechanical effects of exercise. Furthermore, an average decrease of 10% in energy efficiency was noted between rest and exercise. These data indicate the amount of energy dissipation that typically occurs with exercise and may be useful in future surgical planning applications.
The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification of human pulmonary artery hemodynamic conditions under resting and exercise states can be useful in investigating the physiology of disease development and treatment outcomes. In this study, a combined magnetic resonance imaging and computational fluid dynamics approach was used to quantify pulsatile flow fields, wall shear stress (WSS), oscillations in WSS (OSI), and energy efficiency in six subject-specific models of the human pulmonary vasculature with high spatial and temporal resolution. Averaging over all subjects, WSS was found to increase from 19.8 ± 4.0 to 51.8 ± 6.7 dynes/cm 2 , and OSI was found to decrease from 0.094 ± 0.016 to 0.081 ± 0.015 in the proximal pulmonary arteries between rest and exercise conditions ( p  < 0.05). These findings demonstrate the localized, biomechanical effects of exercise. Furthermore, an average decrease of 10% in energy efficiency was noted between rest and exercise. These data indicate the amount of energy dissipation that typically occurs with exercise and may be useful in future surgical planning applications.
Author Tsao, Philip S
Chan, Frandics P
Taylor, Charles A
Fonte, Tim A
Feinstein, Jeffrey A
Tang, Beverly T
Author_xml – sequence: 1
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  fullname: Tsao, Philip S
– sequence: 5
  fullname: Feinstein, Jeffrey A
– sequence: 6
  fullname: Taylor, Charles A
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20640512$$D View this record in MEDLINE/PubMed
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Biomedical Engineering Society 2011
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IngestDate Fri Jul 11 07:53:37 EDT 2025
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IsPeerReviewed true
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Issue 1
Keywords Shear stress
Pulmonary vasculature
Magnetic resonance imaging
Finite-element analysis
Blood flow
Language English
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Snippet The biomechanical forces associated with blood flow have been shown to play a role in pulmonary vascular cell health and disease. Therefore, the quantification...
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SubjectTerms Adult
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Biophysics
blood flow
Blood Flow Velocity - physiology
Blood Pressure - physiology
Classical Mechanics
Computer Simulation
Energy dissipation
Energy efficiency
Finite-element analysis
Fluid dynamics
Humans
Hydrodynamics
Imaging, Three-Dimensional
magnetic resonance imaging
Middle Aged
Models, Anatomic
Models, Cardiovascular
Physical Exertion - physiology
Pulmonary Artery - anatomy & histology
Pulmonary Artery - physiology
Pulmonary vasculature
Rest - physiology
Shear stress
Young Adult
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Title Three-Dimensional Hemodynamics in the Human Pulmonary Arteries Under Resting and Exercise Conditions
URI https://link.springer.com/article/10.1007/s10439-010-0124-1
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Volume 39
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