Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling

• Published in: International journal of oncology Vol. 50; no. 3; pp. 873 - 882
• Main Authors: Chang, Chao-Hsiang, Lee, Chao-Ying, Lu, Chi-Cheng, Tsai, Fuu-Jen, Hsu, Yuan-Man, Tsao, Je-Wei, Juan, Yu-Ning, Chiu, Hong-Yi, Yang, Jai-Sing, Wang, Ching-Chiung
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.03.2017; Spandidos Publications UK Ltd
• Subjects: Amino Acid Chloromethyl Ketones - pharmacology; AMP-Activated Protein Kinases - metabolism; Antineoplastic Agents - pharmacology; Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; Autophagy-Related Protein 12 - genetics; Autophagy-Related Protein 5 - genetics; Beclin-1 - genetics; Cancer therapies; Care and treatment; Caspase 3 - metabolism; Caspase 9 - metabolism; Cell Line, Tumor; Cellular signal transduction; Chemotherapy; Cisplatin - pharmacology; Cytochrome; Cytoplasm; Deoxyribonucleic acid; Development and progression; DNA; DNA Fragmentation - drug effects; Drug Resistance, Neoplasm; Health aspects; Humans; Immunoglobulins; Kinases; Microtubule-Associated Proteins - genetics; Mitochondria; Morphology; Mouth cancer; Mouth Neoplasms - pathology; Oral cancer; Penicillin; Phosphorylation - drug effects; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Resveratrol; RNA, Messenger - genetics; Rodents; Signal Transduction - drug effects; Stilbenes - pharmacology; TOR Serine-Threonine Kinases - metabolism; United States > US

Resveratrol is known to be an effective chemo-preventive phytochemical against multiple tumor cells. However, the increasing drug resistance avoids the cancer treatment in oral cavity cancer. In this study, we investigated the oral antitumor activity of resveratrol and its mechanism in cisplatin-res...