Programmed death-ligand 1 (PD-L1) characterization of circulating tumor cells (CTCs) in muscle invasive and metastatic bladder cancer patients

• Published in: BMC cancer Vol. 16; no. 1; p. 744
• Main Authors: Anantharaman, Archana, Friedlander, Terence, Lu, David, Krupa, Rachel, Premasekharan, Gayatri, Hough, Jeffrey, Edwards, Matthew, Paz, Rosa, Lindquist, Karla, Graf, Ryon, Jendrisak, Adam, Louw, Jessica, Dugan, Lyndsey, Baird, Sarah, Wang, Yipeng, Dittamore, Ryan, Paris, Pamela L
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.09.2016; BioMed Central
• Subjects: Bladder cancer; Care and treatment; Gene expression; Metastasis; Physiological aspects; Prognosis; United States; Biomarkers; PD-L1; Liquid biopsy; Circulating tumor cells; Bladder cancer

While programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) checkpoint inhibitors have activity in a proportion of patients with advanced bladder cancer, strongly predictive and prognostic biomarkers are still lacking. In this study, we evaluated PD-L1 protein expression on circulating tum...