Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs

• Published in: PLoS medicine Vol. 2; no. 10; p. e295
• Main Authors: Loukas, Alex, Bethony, Jeffrey M, Mendez, Susana, Fujiwara, Ricardo T, Goud, Gaddam Narsa, Ranjit, Najju, Zhan, Bin, Jones, Karen, Bottazzi, Maria Elena, Hotez, Peter J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2005; Public Library of Science (PLoS)
• Subjects: Allergy/Immunology; Amino Acid Sequence; Ancylostoma - pathogenicity; Anemia; Anemia - etiology; Anemia - prevention & control; Animals; Antibodies; Antibody Formation; Antigens; Aspartic Acid Endopeptidases - pharmacology; Aspartic Acid Endopeptidases - therapeutic use; Developing countries; Dogs; Enzymes; Glycerol; Hemoglobin; Hemorrhage - etiology; Hemorrhage - prevention & control; Hookworm Infections - drug therapy; Hookworm Infections - pathology; Hookworm Infections - veterinary; Immunization; Immunoglobulin G - analysis; Immunology and allergy; Infections; Infectious Diseases; LDCs; Male; Microbiology; Molecular Sequence Data; Nematodes; Parasites; Parasitology; Recombinant Proteins; Vaccination - veterinary; Vaccines; United States > US; Amino Acid Sequence; Anemia; Immunoglobulin G; Vaccination; Ancylostoma; Molecular Sequence Data; Male; Recombinant Proteins; Hemorrhage; Animals; Aspartic Acid Endopeptidases; Dogs; Antibody Formation; Hookworm Infections

Hookworms infect 730 million people in developing countries where they are a leading cause of intestinal blood loss and iron-deficiency anemia. At the site of attachment to the host, adult hookworms ingest blood and lyse the erythrocytes to release hemoglobin. The parasites subsequently digest hemog...