Modulation of Cytokine Secretion and Oxidative Metabolism of Innate Immune Effectors by Rhodococcus Biosurfactant

• Published in: Bulletin of experimental biology and medicine Vol. 149; no. 6; pp. 734 - 738
• Main Authors: Chereshnev, V. A, Gein, S. V, Baeva, T. A, Galkina, T. V, Kuyukina, M. S, Ivshina, I. B
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.11.2010; Springer US; Springer; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; biosurfactants; Cell Biology; Cell culture; chemiluminescence; Cytokines; Cytokines - metabolism; glycolipid biosurfactant; Glycolipids; Immunity; Immunity, Innate; Interleukin 10; Interleukin 12; Interleukin 18; interleukin-10, interleukin-18, and interleukin-12; Internal Medicine; Laboratory Medicine; Leukocytes (mononuclear); Lipopolysaccharides; Membrane lipids; Monocytes; Oxidation-Reduction; Oxidative metabolism; Pathology; Pharmaceutical industry; Physiological aspects; Plant lipids; Reactive oxygen species; Rhodococcus; Rhodococcus - physiology; Rhodococcus rubber; Rhodococcus ruber; Sugars; Surface-Active Agents - pharmacology; Rhodococcus rubber; interleukin-10, interleukin-18, and interleukin-12; glycolipid biosurfactant; chemiluminescence
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-010-1039-4

The glycolipid biosurfactant complex from Rhodococcus ruber IEGM 231 had a stimulatory effect on the production of IL-12, IL-18, and reactive oxygen species by cells of the innate immunity. This effect depended on the composition of cell cultures and presence of LPS. It was primarily observed in non-stimulated cultures. The glycolipid biosurfactant complex had little effect on IL-10 secretion by monocytes and mononuclear cells.