Effects of spaceflight on human calf hemodynamics
Departments of Physiology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 Chronic microgravity may modify adaptations of the leg circulation to gravitational pressures. We measured resting calf compliance and blood flow with venous occlusion plethysmograph...
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| Published in | Journal of applied physiology (1985) Vol. 90; no. 4; pp. 1552 - 1558 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Legacy CDMS
Am Physiological Soc
01.04.2001
American Physiological Society |
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| Abstract | Departments of Physiology and Internal Medicine, University of
Texas Southwestern Medical Center, Dallas, Texas 75235
Chronic
microgravity may modify adaptations of the leg circulation to
gravitational pressures. We measured resting calf compliance and blood flow with venous occlusion plethysmography, and arterial blood pressure with sphygmomanometry, in seven subjects before, during,
and after spaceflight. Calf vascular resistance equaled mean arterial
pressure divided by calf flow. Compliance equaled the slope of the calf
volume change and venous occlusion pressure relationship for thigh cuff
pressures of 20, 40, 60, and 80 mmHg held for 1, 2, 3, and 4 min,
respectively, with 1-min breaks between occlusions. Calf blood flow
decreased 41% in microgravity (to 1.15 ± 0.16 ml · 100 ml 1 · min 1 ) relative to 1-G supine
conditions (1.94 ± 0.19 ml · 100 ml 1 · min 1 , P = 0.01), and arterial pressure tended to increase ( P = 0.05), such that calf vascular resistance doubled in microgravity
(preflight: 43 ± 4 units; in-flight: 83 ± 13 units;
P < 0.001) yet returned to preflight levels after
flight. Calf compliance remained unchanged in microgravity but tended
to increase during the first week postflight ( P > 0.2). Calf vasoconstriction in microgravity qualitatively agrees with
the "upright set-point" hypothesis: the circulation seeks
conditions approximating upright posture on Earth. No calf hemodynamic
result exhibited obvious mechanistic implications for postflight
orthostatic intolerance.
weightlessness; gravity; leg; vascular resistance; blood flow; venous compliance |
|---|---|
| AbstractList | Chronic microgravity may modify adaptations of the leg circulation to gravitational pressures. We measured resting calf compliance and blood flow with venous occlusion plethysmography, and arterial blood pressure with sphygmomanometry, in seven subjects before, during, and after spaceflight. Calf vascular resistance equaled mean arterial pressure divided by calf flow. Compliance equaled the slope of the calf volume change and venous occlusion pressure relationship for thigh cuff pressures of 20, 40, 60, and 80 mmHg held for 1, 2, 3, and 4 min, respectively, with 1-min breaks between occlusions. Calf blood flow decreased 41% in microgravity (to 1.15 +/- 0.16 ml x 100 ml(-1) x min(-1)) relative to 1-G supine conditions (1.94 +/- 0.19 ml x 100 ml(-1) x min(-1), P = 0.01), and arterial pressure tended to increase (P = 0.05), such that calf vascular resistance doubled in microgravity (preflight: 43 +/- 4 units; in-flight: 83 +/- 13 units; P < 0.001) yet returned to preflight levels after flight. Calf compliance remained unchanged in microgravity but tended to increase during the first week postflight (P > 0.2). Calf vasoconstriction in microgravity qualitatively agrees with the "upright set-point" hypothesis: the circulation seeks conditions approximating upright posture on Earth. No calf hemodynamic result exhibited obvious mechanistic implications for postflight orthostatic intolerance. Departments of Physiology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 Chronic microgravity may modify adaptations of the leg circulation to gravitational pressures. We measured resting calf compliance and blood flow with venous occlusion plethysmography, and arterial blood pressure with sphygmomanometry, in seven subjects before, during, and after spaceflight. Calf vascular resistance equaled mean arterial pressure divided by calf flow. Compliance equaled the slope of the calf volume change and venous occlusion pressure relationship for thigh cuff pressures of 20, 40, 60, and 80 mmHg held for 1, 2, 3, and 4 min, respectively, with 1-min breaks between occlusions. Calf blood flow decreased 41% in microgravity (to 1.15 ± 0.16 ml · 100 ml 1 · min 1 ) relative to 1-G supine conditions (1.94 ± 0.19 ml · 100 ml 1 · min 1 , P = 0.01), and arterial pressure tended to increase ( P = 0.05), such that calf vascular resistance doubled in microgravity (preflight: 43 ± 4 units; in-flight: 83 ± 13 units; P < 0.001) yet returned to preflight levels after flight. Calf compliance remained unchanged in microgravity but tended to increase during the first week postflight ( P > 0.2). Calf vasoconstriction in microgravity qualitatively agrees with the "upright set-point" hypothesis: the circulation seeks conditions approximating upright posture on Earth. No calf hemodynamic result exhibited obvious mechanistic implications for postflight orthostatic intolerance. weightlessness; gravity; leg; vascular resistance; blood flow; venous compliance Chronic microgravity may modify adaptations of the leg circulation to gravitational pressures. We measured resting calf compliance and blood flow with venous occlusion plethysmography, and arterial blood pressure with sphygmomanometry, in sevel subjects before, during, and after spaceflight. Chronic microgravity may modify adaptations of the leg circulation to gravitational pressures. We measured resting calf compliance and blood flow with venous occlusion plethysmography, and arterial blood pressure with sphygmomanometry, in seven subjects before, during, and after spaceflight. Calf vascular resistance equaled mean arterial pressure divided by calf flow. Compliance equaled the slope of the calf volume change and venous occlusion pressure relationship for thigh cuff pressures of 20, 40, 60, and 80 mmHg held for 1, 2, 3, and 4 min, respectively, with 1-min breaks between occlusions. Calf blood flow decreased 41% in microgravity (to 1.15 ± 0.16 ml · 100 ml −1 · min −1 ) relative to 1-G supine conditions (1.94 ± 0.19 ml · 100 ml −1 · min −1 , P = 0.01), and arterial pressure tended to increase ( P = 0.05), such that calf vascular resistance doubled in microgravity (preflight: 43 ± 4 units; in-flight: 83 ± 13 units; P < 0.001) yet returned to preflight levels after flight. Calf compliance remained unchanged in microgravity but tended to increase during the first week postflight ( P > 0.2). Calf vasoconstriction in microgravity qualitatively agrees with the “upright set-point” hypothesis: the circulation seeks conditions approximating upright posture on Earth. No calf hemodynamic result exhibited obvious mechanistic implications for postflight orthostatic intolerance. Chronic microgravity may modify adaptations of the leg circulation to gravitational pressures. We measured resting calf compliance and blood flow with venous occlusion plethysmography, and arterial blood pressure with sphygmomanometry, in seven subjects before, during, and after spaceflight. Calf vascular resistance equaled mean arterial pressure divided by calf flow. Compliance equaled the slope of the calf volume change and venous occlusion pressure relationship for thigh cuff pressures of 20, 40, 60, and 80 mmHg held for 1, 2, 3, and 4 min, respectively, with 1-min breaks between occlusions. Calf blood flow decreased 41% in microgravity (to 1.15 +/- 0.16 ml x 100 ml(-1) x min(-1)) relative to 1-G supine conditions (1.94 +/- 0.19 ml x 100 ml(-1) x min(-1), P = 0.01), and arterial pressure tended to increase (P = 0.05), such that calf vascular resistance doubled in microgravity (preflight: 43 +/- 4 units; in-flight: 83 +/- 13 units; P < 0.001) yet returned to preflight levels after flight. Calf compliance remained unchanged in microgravity but tended to increase during the first week postflight (P > 0.2). Calf vasoconstriction in microgravity qualitatively agrees with the "upright set-point" hypothesis: the circulation seeks conditions approximating upright posture on Earth. No calf hemodynamic result exhibited obvious mechanistic implications for postflight orthostatic intolerance. |
| Audience | PUBLIC |
| Author | Gaffney, F. Andrew Blomqvist, C. Gunnar Buckey, Jay C Watenpaugh, Donald E Moore, Willie E Wright, Sheryl J Levine, Benjamin D Lane, Lynda D |
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| Keywords | Sts-58 Shuttle Project Nasa Discipline Cardiopulmonary Nasa Experiment Number 178294 2/2 Nasa Experiment Number 178294 1/2 Sts-40 Shuttle Project Non-Nasa Center Manned Short Duration Flight Experiment Human Lower limb Environmental factor Weightlessness Space flight Compliance(volume pressure) Resistance Vascular resistance Blood vessel Calf(anatomy) Circulatory system Hemodynamics Orthostatic tolerance Microgravity Adaptation NASA Discipline Cardiopulmonary NASA Experiment Number 178294 1/2 NASA Experiment Number 178294 2/2 Non-NASA Center |
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| Snippet | Departments of Physiology and Internal Medicine, University of
Texas Southwestern Medical Center, Dallas, Texas 75235
Chronic
microgravity may modify... Chronic microgravity may modify adaptations of the leg circulation to gravitational pressures. We measured resting calf compliance and blood flow with venous... |
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| SubjectTerms | Adult Biological and medical sciences Blood Pressure - physiology Blood vessels Effects Female Gravity Heart Rate - physiology Hemodynamics - physiology Humans Leg - blood supply Legs Life Sciences (General) Male Medical sciences Metabolic diseases Middle Aged Obesity Regional Blood Flow - physiology Space Flight Space life sciences Supine Position - physiology Vascular Resistance - physiology Weightlessness |
| Title | Effects of spaceflight on human calf hemodynamics |
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