Functional and Comparative Genomic Analyses of an Operon Involved in Fructooligosaccharide Utilization by Lactobacillus acidophilus

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 100; no. 15; pp. 8957 - 8962
• Main Authors: Barrangou, Rodolphe, Altermann, Eric, Hutkins, Robert, Cano, Raul, Klaenhammer, Todd R.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.07.2003; National Acad Sciences
• Subjects: ATP binding cassette transporters; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Base Sequence; Biological Sciences; Biological Transport, Active; Chromosome Mapping; Comparative analysis; DNA, Bacterial - genetics; Enzymes; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Genes; Genetic loci; Genome, Bacterial; Genomes; Genomics; Lac Repressors; Lactobacillus acidophilus - genetics; Lactobacillus acidophilus - metabolism; Molecular Sequence Data; Multigene Family; Mutation; Oligosaccharides - metabolism; Operon; Operons; Phenotype; Phylogeny; Regulator genes; Repression; Repressor Proteins - genetics; Repressor Proteins - metabolism; RNA; Sequence Homology, Nucleic Acid; Species Specificity; Sugars

Lactobacillus acidophilus is a probiotic organism that displays the ability to use prebiotic compounds such as fructooligosaccharides (FOS), which stimulate the growth of beneficial commensals in the gastrointestinal tract. However, little is known about the mechanisms and genes involved in FOS util...