LZTR1 is a regulator of RAS ubiquitination and signaling - Bigenzahn, Johannes W.; Collu, Giovanna M.; Kartnig, Felix; Pieraks, Melanie; Vladimer, Gregory I.; Heinz, Leonhard X.; Sedlyarov, Vitaly; Schischlik, Fiorella; Fauster, Astrid; Rebsamen, Manuele; Parapatics, Katja; Blomen, Vincent A.; et al. (Science (American Association for the Advancement of Science), 2018)
Keywords: Adapter proteins; Adapters; Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; BCR-ABL protein; Cell Line, Tumor; Chronic myeloid leukemia; Cullin; Deactivation; Developmental disabilities; Drosophila melanogaster; Drug resistance; Drug Resistance, Neoplasm - genetics; Fruit flies; Fusion protein; Fusion Proteins, bcr-abl - antagonists & inhibitors; Gain of Function Mutation; Gene Knockdown Techniques; Genetic screening; Guanosine; Homology; Humans; Imidazoles - pharmacology; Imidazoles - therapeutic use; Inactivation; Inhibitors; Isoforms; Kinases; Leucine; Leucine zipper proteins; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - epidemiology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics; Localization; Loss of Function Mutation; MAP kinase; MAP Kinase Signaling System - genetics; Mutation; Myeloid leukemia; Noonan's syndrome; Phenotypes; Protein Kinase Inhibitors - pharmacology; Protein Kinase Inhibitors - therapeutic use; Protein-tyrosine kinase; Proteins; Proto-Oncogene Proteins p21(ras) - metabolism; Pyridazines - pharmacology; Pyridazines - therapeutic use; Sarcoma; Signal Transduction; Signaling; Transcription; Transcription Factors - genetics; Transcription Factors - physiology; Triphosphatase; Tyrosine; Ubiquitination; Ubiquitination - genetics