Chaperone-Mediated Autophagy in Neurodegenerative Diseases: Molecular Mechanisms and Pharmacological Opportunities

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 14; p. 2250
• Main Authors: Wang, Yi-Ting, Lu, Jia-Hong
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 20.07.2022; MDPI
• Subjects: Aging; Alzheimer's disease; Autophagy; Cell cycle; chaperone-mediated autophagy; Degradation; Enzymes; Heat shock proteins; Homeostasis; HSC70; Hypoxia; Insects; Kinases; LAMP2A; Lipids; Lysosomes; Metabolism; Molecular modelling; Neurodegeneration; neurodegenerative disease; Neurodegenerative diseases; Oxidative stress; Parkinson's disease; Phenotypes; Physiology; Protein synthesis; Quality control; Review; Synuclein; Tau protein; α-synuclein

Chaperone-mediated autophagy (CMA) is a protein degradation mechanism through lysosomes. By targeting the KFERQ motif of the substrate, CMA is responsible for the degradation of about 30% of cytosolic proteins, including a series of proteins associated with neurodegenerative diseases (NDs). The fact...