ATP-binding Cassette Transporter G1 Deficiency Dysregulates Host Defense in the Lung

• Published in: American journal of respiratory and critical care medicine Vol. 182; no. 3; pp. 404 - 412
• Main Authors: DRAPER, David W, MADENSPACHER, Jennifer H, DIXON, Darlene, KING, Debra H, REMALEY, Alan T, FESSLER, Michael B
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 01.08.2010
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; ATP Binding Cassette Transporter, Sub-Family G, Member 1; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - physiology; Bacteria; Biological and medical sciences; Blood coagulation. Blood cells; Bronchoalveolar Lavage Fluid - cytology; Chemokines; Cholesterol; Coagulation factors; Cytokines; Cytokines - metabolism; Defense; Fundamental and applied biological sciences. Psychology; G. Pulmonary Infections; Gene Deletion; Genotype & phenotype; Gram-negative bacteria; Immunity, Innate; Infections; Intensive care medicine; Klebsiella pneumoniae; Laboratory animals; Lavage; Leukocyte Count; Leukocytes - metabolism; Lipopolysaccharides - administration & dosage; Lipoproteins - genetics; Lipoproteins - physiology; Lung - immunology; Lung - metabolism; Macrophages - metabolism; Macrophages - pathology; Medical sciences; Mice; Mice, Inbred C57BL; Molecular and cellular biology; Neutrophil Activation; Neutrophils; Neutrophils - metabolism; Proteins; Public health; Tumor necrosis factor-TNF; United States > US; Lung disease; Pneumonia; Intensive care; Respiratory disease; Deficiency; Lipids; Organism defense; ATP binding cassette G1; Immunity; Cholesterol; lung; innate immunity; ATP; Resuscitation

Mice with genetic deletion of the cholesterol efflux transporter, ATP-binding cassette (ABC) G1, have pulmonary lipidosis and chronic pulmonary inflammation. Whether ABCG1 regulates host defense is unknown. To determine whether ABCG1 regulates pulmonary innate immunity and host defense, and to inves...