Modeling Variation in Tumors in vivo

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 7; pp. 2408 - 2413
• Main Authors: Stringer, James R., Larson, Jon S., Fischer, Jared M., Medvedovic, Mario, Hersh, Megan N., Boivin, Gregory P., Stringer, Saundra L., Vogt, Peter K.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 15.02.2005; National Acad Sciences
• Subjects: 3T3 cells; Alkaline Phosphatase - genetics; Animals; Biological Sciences; Cell growth; Cell Proliferation; Cells; Cellular biology; Computer Simulation; Female; Frameshift Mutation; Genes, Reporter; Genetic mutation; Genetic Variation; Genetics; GPI-Linked Proteins; Human genetics; Isoenzymes - genetics; Male; Mammary Neoplasms, Experimental - enzymology; Mammary Neoplasms, Experimental - genetics; Mammary Neoplasms, Experimental - pathology; Mice; Mice, Transgenic; Models, Genetic; Mutation; Phenotypes; Placenta - enzymology; Pregnancy; Rodents; Somatic cells; Transgenes; Tumors

Transgenic mice that allow mutant cells to be visualized in situ were used to study variation in tumors. These mice carry the G11 placental alkaline phosphatase (PLAP) transgene, a mutant allele rendered incapable of producing its enzyme product by a frameshift caused by insertion of a tract of G:C...