Association between uremic toxins and depression in patients with chronic kidney disease undergoing maintenance hemodialysis

• Published in: General hospital psychiatry Vol. 35; no. 1; pp. 23 - 27
• Main Authors: Hsu, Heng-Jung, Yen, Chiung-Hui, Chen, Chih-Ken, Wu, I-Wen, Lee, Chin-Chan, Sun, Chiao-Yin, Chang, Shu-Ju, Chou, Chia-Chi, Hsieh, Ming-Fang, Chen, Chun-Yu, Hsu, Chiao-Ying, Tsai, Chi-Jen, Wu, Mai-Szu
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.2013; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Aged; beta 2-Microglobulin - blood; Biological and medical sciences; Body Mass Index; Chronic kidney disease; Cohort Studies; Creatinine - blood; Cresols - blood; Cross-Sectional Studies; Depression; Depressive Disorder - blood; Depressive Disorder - epidemiology; Female; Hemodialysis; Humans; Indican - blood; Indoxyl sulfate; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - psychology; Kidneys; Logistic Models; Male; Medical sciences; Middle Aged; Mood disorders; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; P-Cresol sulfate; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Renal Dialysis - psychology; Renal failure; Serum Albumin - analysis; Sulfuric Acid Esters - blood; Urea - blood; Uremia - blood; Uremia - etiology; Uremia - psychology; Urinary system involvement in other diseases. Miscellaneous; β2 Microglobulin; Depression; β2 Microglobulin; Chronic kidney disease; Hemodialysis; P-Cresol sulfate; Indoxyl sulfate; Kidney disease; Mood disorder; Human; Urinary system disease; Maintenance hemodialysis; Sulfates; Concomitant disease; Cross sectional study; Renal failure

Patients with chronic kidney disease (CKD) who are undergoing maintenance hemodialysis have a higher prevalence of depression than the general population. The underlying cause of this association is unknown, but may be related to accumulation of uremic toxins. Little is known about the association o...