Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 308; no. 10; pp. G840 - G851
• Main Authors: Hamilton, M. Kristina, Boudry, Gaëlle, Lemay, Danielle G., Raybould, Helen E.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.05.2015
• Subjects: Animals; Cells; Diet; Diet, High-Fat; Dietary Fats - metabolism; Intestinal Absorption; Intestinal Mucosa - microbiology; Intestinal Mucosa - physiopathology; Life Sciences; Male; Microbiology; Microbiota - physiology; Mucosal Biology; Obesity; Obesity - microbiology; Obesity - physiopathology; Rats; Rats, Wistar; Rodents; intestinal permeability; HF diet; gut barrier; gut microbiota; obesity

A causal relationship between the pathophysiological changes in the gut epithelium and altered gut microbiota with the onset of obesity have been suggested but not defined. The aim of this study was to determine the temporal relationship between impaired intestinal barrier function and microbial dys...