Adropin deficiency worsens HFD-induced metabolic defects

• Published in: Cell death & disease Vol. 8; no. 8; p. e3008
• Main Authors: Chen, Shi, Zeng, Kai, Liu, Qi-cai, Guo, Zheng, Zhang, Sheng, Chen, Xiao-rong, Lin, Jian-hua, Wen, Jun-ping, Zhao, Cheng-fei, Lin, Xin-hua, Gao, Feng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2017; Springer Nature B.V; Nature Publishing Group
• Subjects: 38/23; 631/208/2489/144; 631/208/737; 692/699/1503/1712; 692/699/2743/137/773; Adipocytes; Animals; Antibodies; Biochemistry; Biomedical and Life Sciences; Blood Proteins - deficiency; Cell Biology; Cell Culture; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - pathology; Diabetes Mellitus, Type 2 - therapy; Diet, High-Fat - adverse effects; Fat metabolism; Female; Genetic diversity; Homeostasis; Humans; Immunology; Intercellular Signaling Peptides and Proteins; Life Sciences; Lymphocytes T; Metabolic disorders; Mice; Mice, Inbred C57BL; Middle Aged; Nitric oxide; Nitric-oxide synthase; Obesity - complications; Obesity - pathology; Original; original-article; Pancreas; Pancreas - pathology; Peptides - deficiency; Phosphorylation; Proteins

The limited efficacy of current treatment methods and increased type 2 diabetes mellitus (T2DM) incidence constitute an incentive for investigating how metabolic homeostasis is maintained, to improve treatment efficacy and identify novel treatment methods. We analyzed a three-generation family of Ch...