Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation

Here we describe the first detailed catalog of gene expression in the developing lower urinary tract (LUT), including epithelial and mesenchymal portions of the developing bladder, urogenital sinus, urethra, and genital tubercle (GT) at E13 and E14. Top compartment-specific genes implicated by the m...

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Published inDevelopmental biology Vol. 344; no. 2; pp. 1071 - 1087
Main Authors Chiu, Han Sheng, Szucsik, John C., Georgas, Kylie M., Jones, Julia L., Rumballe, Bree A., Tang, Dave, Grimmond, Sean M., Lewis, Alfor G., Aronow, Bruce J., Lessard, James L., Little, Melissa H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.08.2010
Subjects
Androgens - genetics
Animals
Appendage development
Cell Differentiation - genetics
Embryo, Mammalian
Epidermis
Extremities
Gene Expression
Gene Regulatory Networks
Genital tubercle development
Genitalia, Male - embryology
Lower urinary tract development
Male
Mice
Organogenesis - genetics
Urethra - embryology
Urogenital System - embryology
Wnt
Appendage development
Genital tubercle development
Gene expression
Wnt
Lower urinary tract development
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Abstract Here we describe the first detailed catalog of gene expression in the developing lower urinary tract (LUT), including epithelial and mesenchymal portions of the developing bladder, urogenital sinus, urethra, and genital tubercle (GT) at E13 and E14. Top compartment-specific genes implicated by the microarray data were validated using whole-mount in situ hybridization (ISH) over the entire LUT. To demonstrate the potential of this resource to implicate developmentally critical features, we focused on gene expression patterns and pathways in the sexually indeterminate, androgen-independent GT. GT expression patterns reinforced the proposed similarities between development of GT, limb, and craniofacial prominences. Comparison of spatial expression patterns predicted a network of Wnt7a-associated GT-enriched epithelial genes, including Gjb2, Dsc3, Krt5, and Sostdc1. Known from other contexts, these genes are associated with normal epidermal differentiation, with disruptions in Dsc3 and Gjb2 showing palmo-plantar keratoderma in the limb. We propose that this gene network contributes to normal foreskin, scrotum, and labial development. As several of these genes are known to be regulated by, or contain cis elements responsive to retinoic acid, estrogen, or androgen, this implicates this pathway in the later androgen-dependent development of the GT.
AbstractList Here we describe the first detailed catalogue of gene expression in the developing lower urinary tract (LUT), including epithelial and mesenchymal portions of the developing bladder, urogenital sinus, urethra and genital tubercle (GT) at E13 and E14. Top compartment-specific genes implicated by the microarray data were validated using wholemount in situ hybridization (ISH) over the entire LUT. To demonstrate the potential of this resource to implicate developmentally critical features, we focused on gene expression patterns and pathways in the sexually indeterminate, androgen-independent GT. GT expression patterns reinforced the proposed similarities between development of GT, limb and craniofacial prominences. Comparison of spatial expression patterns predicted a network of Wnt7a -associated GT-enriched epithelial genes, including Gjb2, Dsc3, Krt5 and Sostdc1 . Known from other contexts, these genes are associated with normal epidermal differentiation, with disruptions in Dsc3 and Gjb2 showing palmo-plantar keratoderma in the limb. We propose that this gene network contributes to normal foreskin, scrotum and labial development. As several of these are known regulated by, or contain cis elements responsive to retinoic acid, estrogen, or androgen, this implicates this pathway in the later androgen-dependent development of the GT.
Here we describe the first detailed catalog of gene expression in the developing lower urinary tract (LUT), including epithelial and mesenchymal portions of the developing bladder, urogenital sinus, urethra, and genital tubercle (GT) at E13 and E14. Top compartment-specific genes implicated by the microarray data were validated using whole-mount in situ hybridization (ISH) over the entire LUT. To demonstrate the potential of this resource to implicate developmentally critical features, we focused on gene expression patterns and pathways in the sexually indeterminate, androgen-independent GT. GT expression patterns reinforced the proposed similarities between development of GT, limb, and craniofacial prominences. Comparison of spatial expression patterns predicted a network of Wnt7a-associated GT-enriched epithelial genes, including Gjb2, Dsc3, Krt5, and Sostdc1. Known from other contexts, these genes are associated with normal epidermal differentiation, with disruptions in Dsc3 and Gjb2 showing palmo-plantar keratoderma in the limb. We propose that this gene network contributes to normal foreskin, scrotum, and labial development. As several of these genes are known to be regulated by, or contain cis elements responsive to retinoic acid, estrogen, or androgen, this implicates this pathway in the later androgen-dependent development of the GT.
Here we describe the first detailed catalog of gene expression in the developing lower urinary tract (LUT), including epithelial and mesenchymal portions of the developing bladder, urogenital sinus, urethra, and genital tubercle (GT) at E13 and E14. Top compartment-specific genes implicated by the microarray data were validated using whole-mount in situ hybridization (ISH) over the entire LUT. To demonstrate the potential of this resource to implicate developmentally critical features, we focused on gene expression patterns and pathways in the sexually indeterminate, androgen-independent GT. GT expression patterns reinforced the proposed similarities between development of GT, limb, and craniofacial prominences. Comparison of spatial expression patterns predicted a network of Wnt7a-associated GT-enriched epithelial genes, including Gjb2, Dsc3, Krt5, and Sostdc1. Known from other contexts, these genes are associated with normal epidermal differentiation, with disruptions in Dsc3 and Gjb2 showing palmo-plantar keratoderma in the limb. We propose that this gene network contributes to normal foreskin, scrotum, and labial development. As several of these genes are known to be regulated by, or contain cis elements responsive to retinoic acid, estrogen, or androgen, this implicates this pathway in the later androgen-dependent development of the GT.
Author Szucsik, John C.
Rumballe, Bree A.
Grimmond, Sean M.
Tang, Dave
Lessard, James L.
Chiu, Han Sheng
Jones, Julia L.
Little, Melissa H.
Lewis, Alfor G.
Aronow, Bruce J.
Georgas, Kylie M.
AuthorAffiliation 2 Division of Developmental Biology, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
1 Institute for Molecular Bioscience, The University of Queensland, St. Lucia, 4072, Australia
3 Division of Biomedical Informatics, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
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Issue 2
Keywords Appendage development
Genital tubercle development
Gene expression
Wnt
Lower urinary tract development
Language English
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Snippet Here we describe the first detailed catalog of gene expression in the developing lower urinary tract (LUT), including epithelial and mesenchymal portions of...
Here we describe the first detailed catalogue of gene expression in the developing lower urinary tract (LUT), including epithelial and mesenchymal portions of...
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SubjectTerms Androgens - genetics
Animals
Appendage development
Cell Differentiation - genetics
Embryo, Mammalian
Epidermis
Extremities
Gene Expression
Gene Regulatory Networks
Genital tubercle development
Genitalia, Male - embryology
Lower urinary tract development
Male
Mice
Organogenesis - genetics
Urethra - embryology
Urogenital System - embryology
Wnt
Title Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation
URI https://dx.doi.org/10.1016/j.ydbio.2010.05.495
https://www.ncbi.nlm.nih.gov/pubmed/20510229
https://search.proquest.com/docview/748924787
https://pubmed.ncbi.nlm.nih.gov/PMC3154616
Volume 344
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