Ly6G+ neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury

• Published in: Cell death & disease Vol. 8; no. 11; p. e3170
• Main Authors: Feng, Zunyong, Qi, Shimei, Zhang, Yue, Qi, Zhilin, Yan, Liang, Zhou, Jing, He, Fang, Li, Qianqian, Yang, Yanyan, Chen, Qun, Xiao, Shi, Li, Qiang, Chen, Yang, Zhang, Yao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2017; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/1; 13/21; 13/31; 14/105; 38/109; 38/90; 631/250/256/2177; 631/337/384/331; 631/80/86; 64/60; 692/699/1785; 82/29; 82/80; Acute Lung Injury - genetics; Acute Lung Injury - immunology; Acute Lung Injury - pathology; Adult; Animals; Antibodies; Antigens, Ly - genetics; Antigens, Ly - immunology; Biochemistry; Biomedical and Life Sciences; Bone marrow; Case-Control Studies; Cell activation; Cell Biology; Cell Culture; Cytokines; Female; Humans; IL-1β; Immunology; Inflammasomes; Inflammasomes - immunology; Inflammation; Interleukin-1beta - immunology; Leukocytes (neutrophilic); Life Sciences; Male; Mice; Mice, Inbred C57BL; MicroRNAs - immunology; Middle Aged; miRNA; Mitochondria; Mitochondria, Muscle - genetics; Mitochondria, Muscle - immunology; Neutrophils; Neutrophils - immunology; NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - immunology; Original; original-article; Remission; Respiratory distress syndrome; Respiratory therapy; RNA-mediated interference; Signal transduction; Transfection; Trauma

MicroRNA (miRNA) mediates RNA interference to regulate a variety of innate immune processes, but how miRNAs coordinate the mechanisms underlying acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in patients with pulmonary inflammatory injury is still unknown. In this study, we demonst...