G-Protein coupled receptors: structure and function in drug discovery
The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged into families or classes thus making it one of the largest in the mammalian genome. GPCRs take part in many vital physiological functions making them targets for numerous novel drugs. GPCRs share some distinctive...
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| Published in | RSC advances Vol. 1; no. 6; pp. 36337 - 36348 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
01.10.2020
The Royal Society of Chemistry |
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| Abstract | The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged into families or classes thus making it one of the largest in the mammalian genome. GPCRs take part in many vital physiological functions making them targets for numerous novel drugs. GPCRs share some distinctive features, such as the seven transmembrane domains, they also differ in the number of conserved residues in their transmembrane domain. Here we provide an introductory and accessible review detailing the computational advances in GPCR pharmacology and drug discovery. An overview is provided on family A-C GPCRs; their structural differences, GPCR signalling, allosteric binding and cooperativity. The dielectric constant (relative permittivity) of proteins is also discussed in the context of site-specific environmental effects.
The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged into families or classes thus making it one of the largest in the mammalian genome. |
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| AbstractList | The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged into families or classes thus making it one of the largest in the mammalian genome. GPCRs take part in many vital physiological functions making them targets for numerous novel drugs. GPCRs share some distinctive features, such as the seven transmembrane domains, they also differ in the number of conserved residues in their transmembrane domain. Here we provide an introductory and accessible review detailing the computational advances in GPCR pharmacology and drug discovery. An overview is provided on family A-C GPCRs; their structural differences, GPCR signalling, allosteric binding and cooperativity. The dielectric constant (relative permittivity) of proteins is also discussed in the context of site-specific environmental effects.
The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged into families or classes thus making it one of the largest in the mammalian genome. The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged into families or classes thus making it one of the largest in the mammalian genome. GPCRs take part in many vital physiological functions making them targets for numerous novel drugs. GPCRs share some distinctive features, such as the seven transmembrane domains, they also differ in the number of conserved residues in their transmembrane domain. Here we provide an introductory and accessible review detailing the computational advances in GPCR pharmacology and drug discovery. An overview is provided on family A-C GPCRs; their structural differences, GPCR signalling, allosteric binding and cooperativity. The dielectric constant (relative permittivity) of proteins is also discussed in the context of site-specific environmental effects.The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged into families or classes thus making it one of the largest in the mammalian genome. GPCRs take part in many vital physiological functions making them targets for numerous novel drugs. GPCRs share some distinctive features, such as the seven transmembrane domains, they also differ in the number of conserved residues in their transmembrane domain. Here we provide an introductory and accessible review detailing the computational advances in GPCR pharmacology and drug discovery. An overview is provided on family A-C GPCRs; their structural differences, GPCR signalling, allosteric binding and cooperativity. The dielectric constant (relative permittivity) of proteins is also discussed in the context of site-specific environmental effects. The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged into families or classes thus making it one of the largest in the mammalian genome. GPCRs take part in many vital physiological functions making them targets for numerous novel drugs. GPCRs share some distinctive features, such as the seven transmembrane domains, they also differ in the number of conserved residues in their transmembrane domain. Here we provide an introductory and accessible review detailing the computational advances in GPCR pharmacology and drug discovery. An overview is provided on family A-C GPCRs; their structural differences, GPCR signalling, allosteric binding and cooperativity. The dielectric constant (relative permittivity) of proteins is also discussed in the context of site-specific environmental effects. |
| Author | Percival, Benita Ahmad, Zeeshan Williams, Ian H Burton, Emily Wallis, Helen Chang, Ming-Wei Wilson, Philippe B Kamerlin, Caroline Lynn Odoemelam, Chiemela S Scholey, Dawn |
| AuthorAffiliation | Department of Chemistry De Montfort University Uppsala University University of Ulster Nanotechnology and Integrated Bioengineering Centre University of Bath Department of Chemistry - BMC Nottingham Trent University |
| AuthorAffiliation_xml | – name: Uppsala University – name: De Montfort University – name: Department of Chemistry – name: Nanotechnology and Integrated Bioengineering Centre – name: University of Bath – name: Nottingham Trent University – name: Department of Chemistry - BMC – name: University of Ulster |
| Author_xml | – sequence: 1 givenname: Chiemela S surname: Odoemelam fullname: Odoemelam, Chiemela S – sequence: 2 givenname: Benita surname: Percival fullname: Percival, Benita – sequence: 3 givenname: Helen surname: Wallis fullname: Wallis, Helen – sequence: 4 givenname: Ming-Wei surname: Chang fullname: Chang, Ming-Wei – sequence: 5 givenname: Zeeshan surname: Ahmad fullname: Ahmad, Zeeshan – sequence: 6 givenname: Dawn surname: Scholey fullname: Scholey, Dawn – sequence: 7 givenname: Emily surname: Burton fullname: Burton, Emily – sequence: 8 givenname: Ian H surname: Williams fullname: Williams, Ian H – sequence: 9 givenname: Caroline Lynn surname: Kamerlin fullname: Kamerlin, Caroline Lynn – sequence: 10 givenname: Philippe B surname: Wilson fullname: Wilson, Philippe B |
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| Cites_doi | 10.3934/biophy.2017.3.491 10.1038/nrd2518 10.1038/nrd2760 10.4062/biomolther.2017.073 10.1007/s13238-014-0062-z 10.1038/257751a0 10.1016/j.tips.2014.10.009 10.1038/aps.2011.186 10.2174/138161212799436377 10.1093/emboj/18.7.1723 10.1038/nchembio.102 10.1002/prot.1106 10.1038/nature13001 10.1016/j.tibs.2009.02.004 10.1124/mol.117.111062 10.1093/nar/gkw403 10.1021/jp505344a 10.1074/jbc.R115.662759 10.1007/s11947-017-1920-5 10.1016/S0006-8993(97)00759-2 10.2174/092986712799320619 10.1016/j.tips.2013.11.001 10.1371/journal.pcbi.1002193 10.1016/j.abb.2011.12.017 10.1016/j.ygcen.2004.12.018 10.1111/j.1476-5381.2011.01629.x 10.2174/138945007779315614 10.1124/mol.63.6.1256 10.3389/fphar.2018.00128 10.3390/ijms19072105 10.1016/j.cell.2020.03.003 10.1093/nar/26.1.275 10.1242/jcs.00902 10.1016/j.tips.2019.04.001 10.1016/j.cell.2017.07.009 10.1038/s41467-018-03727-6 10.1186/1752-0509-3-9 10.1016/j.bmcl.2014.07.009 10.1038/nature08144 10.1016/j.biochi.2014.01.016 10.1111/bph.14023 10.1016/j.bbamem.2006.10.021 10.1016/j.tibs.2017.10.003 10.1242/jcs.175158 10.1038/nrm3933 10.1093/bioinformatics/btm506 10.1111/bph.12293 10.3389/fphar.2015.00264 10.1111/j.1742-4658.2012.08614.x 10.1111/bph.12689 10.1038/s41598-017-15707-9 10.1016/j.neuropharm.2010.08.009 10.1146/annurev.bb.20.060191.001411 10.1146/annurev.biochem.75.103004.142743 10.1021/bi0155091 10.1073/pnas.0404702101 10.1007/s42000-018-0009-5 10.1111/j.1527-3458.2005.tb00034.x 10.1021/ct400065j 10.1351/pac200779030293 10.1093/nar/gkg103 10.4161/psb.4.10.9530 10.1007/s00210-015-1111-8 10.1007/s41048-017-0036-9 10.1146/annurev-biochem-060614-033910 10.1371/journal.pcbi.1007680 10.14348/molcells.2015.0037 10.1002/cmdc.201100317 10.1038/s41467-020-14934-5 10.1038/aps.2011.210 10.1074/jbc.M106692200 10.1038/nrd.2017.178 10.1016/j.bios.2019.04.041 10.3390/biom10040631 10.1002/open.202000108 10.1093/nar/gkx1109 10.1016/S0959-440X(98)80041-9 10.1016/S0021-9258(18)53442-6 10.1124/mol.117.111518 10.1038/s41594-019-0252-8 10.1038/s41594-017-0011-7 10.3390/ijms18122519 10.3389/fphar.2015.00040 10.2174/092986712799320556 |
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| References | Karageorgos (D0RA08003A-(cit37)/*[position()=1]) 2018; 17 Møller (D0RA08003A-(cit48)/*[position()=1]) 2017; 3 Augustine (D0RA08003A-(cit74)/*[position()=1]) 2004 Hauser (D0RA08003A-(cit6)/*[position()=1]) 2017; 16 Dong (D0RA08003A-(cit50)/*[position()=1]) 2014; 171 Tibaduiza (D0RA08003A-(cit64)/*[position()=1]) 2001; 276 Kroeze (D0RA08003A-(cit2)/*[position()=1]) 2003; 116 Wu (D0RA08003A-(cit39)/*[position()=1]) 2020; 11 Nussinov (D0RA08003A-(cit60)/*[position()=1]) 2012; 18 Baram (D0RA08003A-(cit66)/*[position()=1]) 1997; 770 Wilson (D0RA08003A-(cit83)/*[position()=1]) 2015; 119 Lenaerts (D0RA08003A-(cit68)/*[position()=1]) 2009; 3 Orel (D0RA08003A-(cit51)/*[position()=1]) 2012; 279 Ghosh (D0RA08003A-(cit5)/*[position()=1]) 2015; 16 Hollenstein (D0RA08003A-(cit40)/*[position()=1]) 2014; 35 Schiöth (D0RA08003A-(cit4)/*[position()=1]) 2005; 142 Rondard (D0RA08003A-(cit42)/*[position()=1]) 2011; 60 Sasaki (D0RA08003A-(cit33)/*[position()=1]) 1975; 257 Braslavsky (D0RA08003A-(cit76)/*[position()=1]) 2007; 79 Tang (D0RA08003A-(cit7)/*[position()=1]) 2012; 33 Esguerra (D0RA08003A-(cit15)/*[position()=1]) 2016; 44 Roth (D0RA08003A-(cit46)/*[position()=1]) 2019; 26 Lagerström (D0RA08003A-(cit31)/*[position()=1]) 2008; 7 Li (D0RA08003A-(cit82)/*[position()=1]) 2013; 9 Zhang (D0RA08003A-(cit47)/*[position()=1]) 2014; 5 Warshel (D0RA08003A-(cit81)/*[position()=1]) 1991; 20 Jacobson (D0RA08003A-(cit11)/*[position()=1]) 2014; 35 Gurevich (D0RA08003A-(cit16)/*[position()=1]) 2017; 18 Heifetz (D0RA08003A-(cit13)/*[position()=1]) 2015; 388 Bortolato (D0RA08003A-(cit52)/*[position()=1]) 2014; 171 Hu (D0RA08003A-(cit26)/*[position()=1]) 2017; 7 Kobilka (D0RA08003A-(cit21)/*[position()=1]) 2007; 1768 Park (D0RA08003A-(cit17)/*[position()=1]) 2012; 19 Provasi (D0RA08003A-(cit18)/*[position()=1]) 2011; 7 Grace (D0RA08003A-(cit36)/*[position()=1]) 2004; 101 Hans (D0RA08003A-(cit44)/*[position()=1]) 2007; 8 Doijen (D0RA08003A-(cit73)/*[position()=1]) 2019; 137 Ciancetta (D0RA08003A-(cit89)/*[position()=1]) 2018 Bockaert (D0RA08003A-(cit22)/*[position()=1]) 1999; 18 Tuteja (D0RA08003A-(cit61)/*[position()=1]) 2009; 4 Dijkman (D0RA08003A-(cit1)/*[position()=1]) 2018; 9 Sriram (D0RA08003A-(cit9)/*[position()=1]) 2018; 93 Jaiteh (D0RA08003A-(cit84)/*[position()=1]) 2020; 16 Trzaskowski (D0RA08003A-(cit55)/*[position()=1]) 2012; 19 Amin (D0RA08003A-(cit77)/*[position()=1]) 2020; 9 Nakliang (D0RA08003A-(cit86)/*[position()=1]) 2020; 10 Gacasan (D0RA08003A-(cit29)/*[position()=1]) 2017; 4 Schulman (D0RA08003A-(cit72)/*[position()=1]) 2014 Wacker (D0RA08003A-(cit57)/*[position()=1]) 2017; 170 Basith (D0RA08003A-(cit12)/*[position()=1]) 2018; 9 Culhane (D0RA08003A-(cit53)/*[position()=1]) 2015; 6 Insel (D0RA08003A-(cit10)/*[position()=1]) 2019; 40 Pándy-Szekeres (D0RA08003A-(cit27)/*[position()=1]) 2018; 46 Hilger (D0RA08003A-(cit85)/*[position()=1]) 2018; 25 Davies (D0RA08003A-(cit23)/*[position()=1]) 2007; 23 Chun (D0RA08003A-(cit41)/*[position()=1]) 2012; 33 Yuan (D0RA08003A-(cit14)/*[position()=1]) 2018; 19 Alshami (D0RA08003A-(cit80)/*[position()=1]) 2017; 10 Fredriksson (D0RA08003A-(cit3)/*[position()=1]) 2003; 63 Warshel (D0RA08003A-(cit75)/*[position()=1]) 1998; 8 Hellyer (D0RA08003A-(cit43)/*[position()=1]) 2018; 93 Motlagh (D0RA08003A-(cit59)/*[position()=1]) 2014; 508 Rosenbaum (D0RA08003A-(cit28)/*[position()=1]) 2009; 459 Kim (D0RA08003A-(cit8)/*[position()=1]) 2018; 26 Weis (D0RA08003A-(cit56)/*[position()=1]) 2018; 87 Teller (D0RA08003A-(cit32)/*[position()=1]) 2001; 40 Jong (D0RA08003A-(cit70)/*[position()=1]) 2018; 175 Conn (D0RA08003A-(cit63)/*[position()=1]) 2009; 8 Zachariou (D0RA08003A-(cit71)/*[position()=1]) 2012 Hanlon (D0RA08003A-(cit62)/*[position()=1]) 2015; 128 de Munnik (D0RA08003A-(cit20)/*[position()=1]) 2015; 6 Tautermann (D0RA08003A-(cit45)/*[position()=1]) 2014; 24 Tewatia (D0RA08003A-(cit54)/*[position()=1]) 2014; 101 Amin (D0RA08003A-(cit78)/*[position()=1]) 2020 de Graaf (D0RA08003A-(cit88)/*[position()=1]) 2011; 6 Schutz (D0RA08003A-(cit79)/*[position()=1]) 2001; 44 Zhang (D0RA08003A-(cit49)/*[position()=1]) 2015; 38 Denisov (D0RA08003A-(cit69)/*[position()=1]) 2012; 519 Horn (D0RA08003A-(cit25)/*[position()=1]) 1998; 26 de Graaf (D0RA08003A-(cit38)/*[position()=1]) 2017; 42 Congreve (D0RA08003A-(cit87)/*[position()=1]) 2020; 181 Horn (D0RA08003A-(cit24)/*[position()=1]) 2003; 31 Samama (D0RA08003A-(cit19)/*[position()=1]) 1993; 268 Palczewski (D0RA08003A-(cit30)/*[position()=1]) 2006; 75 Williamson (D0RA08003A-(cit67)/*[position()=1]) 2008; 4 Li (D0RA08003A-(cit65)/*[position()=1]) 2005; 11 Parthier (D0RA08003A-(cit34)/*[position()=1]) 2009; 34 Wheatley (D0RA08003A-(cit35)/*[position()=1]) 2012; 165 Gentry (D0RA08003A-(cit58)/*[position()=1]) 2015; 290 |
| References_xml | – issn: 2004 publication-title: Neuroscience doi: Augustine – issn: 2018 end-page: p 45-72 publication-title: Computational Methods for GPCR Drug Discovery doi: Ciancetta Jacobson – issn: 2014 end-page: p 119-148 publication-title: From Molecules to Networks doi: Schulman – issn: 2020 doi: Amin Küpper – issn: 2012 end-page: p 411-422 publication-title: Basic Neurochemistry doi: Zachariou Duman Nestler – volume: 4 start-page: 491 year: 2017 ident: D0RA08003A-(cit29)/*[position()=1] publication-title: AIMS Biophys. doi: 10.3934/biophy.2017.3.491 – volume: 7 start-page: 339 year: 2008 ident: D0RA08003A-(cit31)/*[position()=1] publication-title: Nat. Rev. Drug Discovery doi: 10.1038/nrd2518 – volume: 8 start-page: 41 year: 2009 ident: D0RA08003A-(cit63)/*[position()=1] publication-title: Nat. Rev. Drug Discovery doi: 10.1038/nrd2760 – volume: 26 start-page: 101 year: 2018 ident: D0RA08003A-(cit8)/*[position()=1] publication-title: Biomol. Ther. doi: 10.4062/biomolther.2017.073 – volume: 5 start-page: 492 year: 2014 ident: D0RA08003A-(cit47)/*[position()=1] publication-title: Protein Cell doi: 10.1007/s13238-014-0062-z – volume: 257 start-page: 751 year: 1975 ident: D0RA08003A-(cit33)/*[position()=1] publication-title: Nature doi: 10.1038/257751a0 – volume: 35 start-page: 658 year: 2014 ident: D0RA08003A-(cit11)/*[position()=1] publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2014.10.009 – volume-title: Neuroscience year: 2004 ident: D0RA08003A-(cit74)/*[position()=1] – volume: 33 start-page: 312 year: 2012 ident: D0RA08003A-(cit41)/*[position()=1] publication-title: Acta Pharmacol. Sin. doi: 10.1038/aps.2011.186 – volume: 18 start-page: 1311 year: 2012 ident: D0RA08003A-(cit60)/*[position()=1] publication-title: Curr. Pharm. Des. doi: 10.2174/138161212799436377 – volume: 18 start-page: 1723 year: 1999 ident: D0RA08003A-(cit22)/*[position()=1] publication-title: EMBO J. doi: 10.1093/emboj/18.7.1723 – volume: 4 start-page: 458 year: 2008 ident: D0RA08003A-(cit67)/*[position()=1] publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.102 – volume: 44 start-page: 400 year: 2001 ident: D0RA08003A-(cit79)/*[position()=1] publication-title: Proteins: Struct., Funct., Bioinf. doi: 10.1002/prot.1106 – volume: 508 start-page: 331 year: 2014 ident: D0RA08003A-(cit59)/*[position()=1] publication-title: Nature doi: 10.1038/nature13001 – volume: 34 start-page: 303 year: 2009 ident: D0RA08003A-(cit34)/*[position()=1] publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2009.02.004 – volume: 93 start-page: 251 year: 2018 ident: D0RA08003A-(cit9)/*[position()=1] publication-title: Mol. Pharmacol. doi: 10.1124/mol.117.111062 – volume-title: Basic Neurochemistry year: 2012 ident: D0RA08003A-(cit71)/*[position()=1] – volume-title: Computational Methods for GPCR Drug Discovery year: 2018 ident: D0RA08003A-(cit89)/*[position()=1] – volume: 44 start-page: W455 year: 2016 ident: D0RA08003A-(cit15)/*[position()=1] publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw403 – volume: 119 start-page: 802 year: 2015 ident: D0RA08003A-(cit83)/*[position()=1] publication-title: J. Phys. Chem. B doi: 10.1021/jp505344a – volume: 290 start-page: 19478 year: 2015 ident: D0RA08003A-(cit58)/*[position()=1] publication-title: J. Biol. Chem. doi: 10.1074/jbc.R115.662759 – volume: 10 start-page: 1548 year: 2017 ident: D0RA08003A-(cit80)/*[position()=1] publication-title: Food Bioprocess Technol. doi: 10.1007/s11947-017-1920-5 – volume: 770 start-page: 89 year: 1997 ident: D0RA08003A-(cit66)/*[position()=1] publication-title: Brain Res. doi: 10.1016/S0006-8993(97)00759-2 – volume: 19 start-page: 1146 year: 2012 ident: D0RA08003A-(cit17)/*[position()=1] publication-title: Curr. Med. Chem. doi: 10.2174/092986712799320619 – volume: 35 start-page: 12 year: 2014 ident: D0RA08003A-(cit40)/*[position()=1] publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2013.11.001 – volume: 7 start-page: e1002193 year: 2011 ident: D0RA08003A-(cit18)/*[position()=1] publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1002193 – volume: 519 start-page: 91 year: 2012 ident: D0RA08003A-(cit69)/*[position()=1] publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2011.12.017 – volume: 142 start-page: 94 year: 2005 ident: D0RA08003A-(cit4)/*[position()=1] publication-title: Gen. Comp. Endocrinol. doi: 10.1016/j.ygcen.2004.12.018 – volume: 165 start-page: 1688 year: 2012 ident: D0RA08003A-(cit35)/*[position()=1] publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2011.01629.x – volume: 8 start-page: 169 year: 2007 ident: D0RA08003A-(cit44)/*[position()=1] publication-title: Curr. Drug Targets doi: 10.2174/138945007779315614 – volume: 63 start-page: 1256 year: 2003 ident: D0RA08003A-(cit3)/*[position()=1] publication-title: Mol. Pharmacol. doi: 10.1124/mol.63.6.1256 – volume: 9 start-page: 128 year: 2018 ident: D0RA08003A-(cit12)/*[position()=1] publication-title: Front. Pharmacol. doi: 10.3389/fphar.2018.00128 – volume-title: From Molecules to Networks year: 2014 ident: D0RA08003A-(cit72)/*[position()=1] – volume: 19 start-page: 2105 year: 2018 ident: D0RA08003A-(cit14)/*[position()=1] publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms19072105 – volume: 181 start-page: 81 year: 2020 ident: D0RA08003A-(cit87)/*[position()=1] publication-title: Cell doi: 10.1016/j.cell.2020.03.003 – volume: 26 start-page: 275 year: 1998 ident: D0RA08003A-(cit25)/*[position()=1] publication-title: Nucleic Acids Res. doi: 10.1093/nar/26.1.275 – volume: 116 start-page: 4867 year: 2003 ident: D0RA08003A-(cit2)/*[position()=1] publication-title: J. Cell Sci. doi: 10.1242/jcs.00902 – volume: 40 start-page: 378 year: 2019 ident: D0RA08003A-(cit10)/*[position()=1] publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2019.04.001 – volume: 170 start-page: 414 year: 2017 ident: D0RA08003A-(cit57)/*[position()=1] publication-title: Cell doi: 10.1016/j.cell.2017.07.009 – volume: 9 start-page: 1710 year: 2018 ident: D0RA08003A-(cit1)/*[position()=1] publication-title: Nat. Commun. doi: 10.1038/s41467-018-03727-6 – volume: 3 start-page: 9 year: 2009 ident: D0RA08003A-(cit68)/*[position()=1] publication-title: BMC Syst. Biol. doi: 10.1186/1752-0509-3-9 – volume: 24 start-page: 4073 year: 2014 ident: D0RA08003A-(cit45)/*[position()=1] publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2014.07.009 – volume: 459 start-page: 356 year: 2009 ident: D0RA08003A-(cit28)/*[position()=1] publication-title: Nature doi: 10.1038/nature08144 – volume: 101 start-page: 168 year: 2014 ident: D0RA08003A-(cit54)/*[position()=1] publication-title: Biochimie doi: 10.1016/j.biochi.2014.01.016 – volume: 175 start-page: 4026 year: 2018 ident: D0RA08003A-(cit70)/*[position()=1] publication-title: Br. J. Pharmacol. doi: 10.1111/bph.14023 – volume: 1768 start-page: 794 year: 2007 ident: D0RA08003A-(cit21)/*[position()=1] publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamem.2006.10.021 – volume: 42 start-page: 946 year: 2017 ident: D0RA08003A-(cit38)/*[position()=1] publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2017.10.003 – volume: 128 start-page: 3533 year: 2015 ident: D0RA08003A-(cit62)/*[position()=1] publication-title: J. Cell Sci. doi: 10.1242/jcs.175158 – volume: 16 start-page: 69 year: 2015 ident: D0RA08003A-(cit5)/*[position()=1] publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3933 – volume: 23 start-page: 3113 year: 2007 ident: D0RA08003A-(cit23)/*[position()=1] publication-title: Bioinformatics doi: 10.1093/bioinformatics/btm506 – volume: 171 start-page: 1085 year: 2014 ident: D0RA08003A-(cit50)/*[position()=1] publication-title: Br. J. Pharmacol. doi: 10.1111/bph.12293 – volume: 6 start-page: 264 year: 2015 ident: D0RA08003A-(cit53)/*[position()=1] publication-title: Front. Pharmacol. doi: 10.3389/fphar.2015.00264 – year: 2020 ident: D0RA08003A-(cit78)/*[position()=1] – volume: 279 start-page: 2357 year: 2012 ident: D0RA08003A-(cit51)/*[position()=1] publication-title: FEBS Journal doi: 10.1111/j.1742-4658.2012.08614.x – volume: 171 start-page: 3132 year: 2014 ident: D0RA08003A-(cit52)/*[position()=1] publication-title: Br. J. Pharmacol. doi: 10.1111/bph.12689 – volume: 7 start-page: 15495 year: 2017 ident: D0RA08003A-(cit26)/*[position()=1] publication-title: Sci. Rep. doi: 10.1038/s41598-017-15707-9 – volume: 60 start-page: 82 year: 2011 ident: D0RA08003A-(cit42)/*[position()=1] publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2010.08.009 – volume: 20 start-page: 267 year: 1991 ident: D0RA08003A-(cit81)/*[position()=1] publication-title: Annu. Rev. Biophys. Biophys. Chem. doi: 10.1146/annurev.bb.20.060191.001411 – volume: 75 start-page: 743 year: 2006 ident: D0RA08003A-(cit30)/*[position()=1] publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.75.103004.142743 – volume: 40 start-page: 7761 year: 2001 ident: D0RA08003A-(cit32)/*[position()=1] publication-title: Biochemistry doi: 10.1021/bi0155091 – volume: 101 start-page: 12836 year: 2004 ident: D0RA08003A-(cit36)/*[position()=1] publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0404702101 – volume: 17 start-page: 45 year: 2018 ident: D0RA08003A-(cit37)/*[position()=1] publication-title: Hormones doi: 10.1007/s42000-018-0009-5 – volume: 11 start-page: 21 year: 2005 ident: D0RA08003A-(cit65)/*[position()=1] publication-title: CNS Drug Rev. doi: 10.1111/j.1527-3458.2005.tb00034.x – volume: 9 start-page: 2126 year: 2013 ident: D0RA08003A-(cit82)/*[position()=1] publication-title: J. Chem. Theory Comput. doi: 10.1021/ct400065j – volume: 79 start-page: 293 year: 2007 ident: D0RA08003A-(cit76)/*[position()=1] publication-title: Pure Appl. Chem. doi: 10.1351/pac200779030293 – volume: 31 start-page: 294 year: 2003 ident: D0RA08003A-(cit24)/*[position()=1] publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkg103 – volume: 4 start-page: 942 year: 2009 ident: D0RA08003A-(cit61)/*[position()=1] publication-title: Plant Signaling Behav. doi: 10.4161/psb.4.10.9530 – volume: 388 start-page: 883 year: 2015 ident: D0RA08003A-(cit13)/*[position()=1] publication-title: Naunyn-Schmiedeberg's Arch. Pharmacol. doi: 10.1007/s00210-015-1111-8 – volume: 3 start-page: 57 year: 2017 ident: D0RA08003A-(cit48)/*[position()=1] publication-title: Biophys. Rep. doi: 10.1007/s41048-017-0036-9 – volume: 87 start-page: 897 year: 2018 ident: D0RA08003A-(cit56)/*[position()=1] publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev-biochem-060614-033910 – volume: 16 start-page: e1007680 year: 2020 ident: D0RA08003A-(cit84)/*[position()=1] publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1007680 – volume: 38 start-page: 836 year: 2015 ident: D0RA08003A-(cit49)/*[position()=1] publication-title: Mol. Cells doi: 10.14348/molcells.2015.0037 – volume: 6 start-page: 2159 year: 2011 ident: D0RA08003A-(cit88)/*[position()=1] publication-title: ChemMedChem doi: 10.1002/cmdc.201100317 – volume: 11 start-page: 1272 year: 2020 ident: D0RA08003A-(cit39)/*[position()=1] publication-title: Nat. Commun. doi: 10.1038/s41467-020-14934-5 – volume: 33 start-page: 363 year: 2012 ident: D0RA08003A-(cit7)/*[position()=1] publication-title: Acta Pharmacol. Sin. doi: 10.1038/aps.2011.210 – volume: 276 start-page: 37787 year: 2001 ident: D0RA08003A-(cit64)/*[position()=1] publication-title: J. Biol. Chem. doi: 10.1074/jbc.M106692200 – volume: 16 start-page: 829 year: 2017 ident: D0RA08003A-(cit6)/*[position()=1] publication-title: Nat. Rev. Drug Discovery doi: 10.1038/nrd.2017.178 – volume: 137 start-page: 33 year: 2019 ident: D0RA08003A-(cit73)/*[position()=1] publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2019.04.041 – volume: 10 start-page: 631 year: 2020 ident: D0RA08003A-(cit86)/*[position()=1] publication-title: Biomolecules doi: 10.3390/biom10040631 – volume: 9 start-page: 691 year: 2020 ident: D0RA08003A-(cit77)/*[position()=1] publication-title: ChemistryOpen doi: 10.1002/open.202000108 – volume: 46 start-page: D440 year: 2018 ident: D0RA08003A-(cit27)/*[position()=1] publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx1109 – volume: 8 start-page: 211 year: 1998 ident: D0RA08003A-(cit75)/*[position()=1] publication-title: Curr. Opin. Struct. Biol. doi: 10.1016/S0959-440X(98)80041-9 – volume: 268 start-page: 4625 year: 1993 ident: D0RA08003A-(cit19)/*[position()=1] publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)53442-6 – volume: 93 start-page: 504 year: 2018 ident: D0RA08003A-(cit43)/*[position()=1] publication-title: Mol. Pharmacol. doi: 10.1124/mol.117.111518 – volume: 26 start-page: 535 year: 2019 ident: D0RA08003A-(cit46)/*[position()=1] publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/s41594-019-0252-8 – volume: 25 start-page: 4 year: 2018 ident: D0RA08003A-(cit85)/*[position()=1] publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/s41594-017-0011-7 – volume: 18 start-page: 2519 year: 2017 ident: D0RA08003A-(cit16)/*[position()=1] publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms18122519 – volume: 6 start-page: 40 year: 2015 ident: D0RA08003A-(cit20)/*[position()=1] publication-title: Front. Pharmacol. doi: 10.3389/fphar.2015.00040 – volume: 19 start-page: 1090 year: 2012 ident: D0RA08003A-(cit55)/*[position()=1] publication-title: Curr. Med. Chem. doi: 10.2174/092986712799320556 |
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