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Keywords: Biochemical markers; Biomarkers - metabolism; Bone metabolic marker; Bone turnover; Drug development; Drugs; Female; Guideline; Humans; Japan; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Orthopedics; Osteogenesis; Osteoporosis; Osteoporosis - diagnosis; Osteoporosis - metabolism; Osteoporosis - therapy; Practice Guidelines as Topic; Societies, Medical; Special Report; Therapeutic applications; Japan; Osteoporosis; Guideline; Bone metabolic marker