Circulating Transcriptome Reveals Markers of Atherosclerosis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 9; pp. 3423 - 3428
• Main Authors: Patino, Willmar D., Mian, Omar Y., Kang, Ju-Gyeong, Matoba, Satoaki, Bartlett, Linda D., Holbrook, Brenda, Trout, Hugh H., Kozloff, Louis, Hwang, Paul M., Vogelstein, Bert
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 01.03.2005; National Acad Sciences
• Subjects: Arteriosclerosis - blood; Arteriosclerosis - genetics; Atherosclerosis; Biological Sciences; Blotting, Western; Case-Control Studies; Cell adhesion; Cell lines; Comparative analysis; Coronary vessels; Gene expression; Genes; Humans; Immunohistochemistry; Libraries; Macrophages; Medical research; Monocytes; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Proteins - genetics; RNA, Messenger - blood; Small interfering RNA; Surgery

Circulating monocytes mediate inflammation in atherosclerosis and may serve as easily accessible reporters of disease. To search for markers of atherosclerosis, we compared the in vivo transcriptomes of monocytes purified from patients undergoing carotid endarterectomy and normal subjects by using t...