Insulin dysfunction and Tau pathology

• Published in: Frontiers in cellular neuroscience Vol. 8; p. 22
• Main Authors: El Khoury, Noura B, Gratuze, Maud, Papon, Marie-Amélie, Bretteville, Alexis, Planel, Emmanuel
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 11.02.2014; Frontiers; Frontiers Media S.A
• Subjects: Aging; Alzheimer's disease; Amino acids; Amyloid precursor protein; Anesthesia; Brain; Cognitive ability; Dementia; Dementia disorders; Diabetes; Diabetes Mellitus; Diabetes mellitus (insulin dependent); Diabetes mellitus (non-insulin dependent); Epidemiology; Filaments; Gene expression; Genetic diversity; Hypothermia; Insulin; Insulin resistance; Kinases; Life Sciences; Memory; Neurodegeneration; Neurodegenerative diseases; Neurofibrillary tangles; Neuropathology; Neuroscience; Neurosciences; Pathology; Peptides; Phosphatase; Phosphatases; Phosphorylation; Proteins; Senile plaques; Tau phosphorylation; Tau protein; β-Amyloid; Canada; Tau phosphorylation; diabetes mellitus; kinases; Alzheimer's disease; phosphatases

The neuropathological hallmarks of Alzheimer's disease (AD) include senile plaques of β-amyloid (Aβ) peptides (a cleavage product of the Amyloid Precursor Protein, or APP) and neurofibrillary tangles (NFT) of hyperphosphorylated Tau protein assembled in paired helical filaments (PHF). NFT patho...