Dose-Limiting Toxicity After Hypofractionated Dose-Escalated Radiotherapy in Non–Small-Cell Lung Cancer

• Published in: Journal of clinical oncology Vol. 31; no. 34; pp. 4343 - 4348
• Main Authors: CANNON, Donald M, MEHTA, Minesh P, CANNON, George M, ADKISON, Jarrod B, KHUNTIA, Deepak, TRAYNOR, Anne M, TOME, Wolfgang A, CHAPPELL, Richard J, TOLAKANAHALLI, Ranjini, MOHINDRA, Pranshu, BENTZEN, Søren M
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Society of Clinical Oncology 01.12.2013
• Subjects: Aged; Biological and medical sciences; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - radiotherapy; Chi-Square Distribution; Dose Fractionation; Dose-Response Relationship, Radiation; Female; Humans; Kaplan-Meier Estimate; Linear Models; Logistic Models; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; Male; Medical sciences; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); ORIGINAL REPORTS; Pneumology; Proportional Hazards Models; Prospective Studies; Radiation Pneumonitis - etiology; Radiation Pneumonitis - mortality; Radiotherapy, Intensity-Modulated - adverse effects; Radiotherapy, Intensity-Modulated - mortality; Radn; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Tumors; Tumors of the respiratory system and mediastinum; Lung disease; Cancerology; Treatment; Respiratory disease; Toxicity; Lung cancer; Bronchus disease; Malignant tumor; non-small cell lung carcinoma; Radiotherapy; Dose; Cancer

Local failure rates after radiation therapy (RT) for locally advanced non-small-cell lung cancer (NSCLC) remain high. Consequently, RT dose intensification strategies continue to be explored, including hypofractionation, which allows for RT acceleration that could potentially improve outcomes. The m...