Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

The funny current, If, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that If plays an important role in pacemaking in the sinus node, the innate pacemaker of the heart, and more recently evidence has accumulated to show that If may p...

Full description

Saved in:
Bibliographic Details
Published inProgress in biophysics and molecular biology Vol. 166; pp. 61 - 85
Main Authors Boyett, Mark R., Yanni, Joseph, Tellez, James, Bucchi, Annalisa, Mesirca, Pietro, Cai, Xue, Logantha, Sunil Jit R.J., Wilson, Claire, Anderson, Cali, Ariyaratnam, Jonathan, Stuart, Luke, Nakao, Shu, Abd Allah, Eman, Jones, Sandra, Lancaster, Matthew, Stephenson, Robert, Chandler, Natalie, Smith, Matthew, Bussey, Carol, Monfredi, Oliver, Morris, Gwilym, Billeter, Rudi, Mangoni, Matteo E., Zhang, Henggui, Hart, George, D'Souza, Alicia
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.2021
Elsevier
Subjects
Action Potentials
Ageing
Athletic training
Atrial Fibrillation
Atrioventricular Node
Cardiac arrhythmias
Cardiac conduction system
Cardiology and cardiovascular system
Circadian rhythm
Heart failure
Heart Rate
Human health and pathology
Humans
Life Sciences
Sinoatrial Node
Heart failure
Cardiac conduction system
Cardiac arrhythmias
Athletic training
Circadian rhythm
Ageing
Online AccessGet full text
ISSN0079-6107
1873-1732
1873-1732
DOI10.1016/j.pbiomolbio.2021.06.008

Cover

Abstract The funny current, If, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that If plays an important role in pacemaking in the sinus node, the innate pacemaker of the heart, and more recently evidence has accumulated to show that If may play an important role in action potential conduction through the atrioventricular (AV) node. Evidence has also accumulated to show that regulation of the transcription and translation of the underlying Hcn genes plays an important role in the regulation of sinus node pacemaking and AV node conduction under normal physiological conditions - in athletes, during the circadian rhythm, in pregnancy, and during postnatal development - as well as pathological states - ageing, heart failure, pulmonary hypertension, diabetes and atrial fibrillation. There may be yet more pathological conditions involving changes in the expression of the Hcn genes. Here, we review the role of If and the underlying HCN channels in physiological and pathological changes of the sinus and AV nodes and we begin to explore the signalling pathways (microRNAs, transcription factors, GIRK4, the autonomic nervous system and inflammation) involved in this regulation. This review is dedicated to Dario DiFrancesco on his retirement.
AbstractList The funny current, If, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that If plays an important role in pacemaking in the sinus node, the innate pacemaker of the heart, and more recently evidence has accumulated to show that If may play an important role in action potential conduction through the atrioventricular (AV) node. Evidence has also accumulated to show that regulation of the transcription and translation of the underlying Hcn genes plays an important role in the regulation of sinus node pacemaking and AV node conduction under normal physiological conditions - in athletes, during the circadian rhythm, in pregnancy, and during postnatal development - as well as pathological states - ageing, heart failure, pulmonary hypertension, diabetes and atrial fibrillation. There may be yet more pathological conditions involving changes in the expression of the Hcn genes. Here, we review the role of If and the underlying HCN channels in physiological and pathological changes of the sinus and AV nodes and we begin to explore the signalling pathways (microRNAs, transcription factors, GIRK4, the autonomic nervous system and inflammation) involved in this regulation. This review is dedicated to Dario DiFrancesco on his retirement.
The funny current, If, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that If plays an important role in pacemaking in the sinus node, the innate pacemaker of the heart, and more recently evidence has accumulated to show that If may play an important role in action potential conduction through the atrioventricular (AV) node. Evidence has also accumulated to show that regulation of the transcription and translation of the underlying Hcn genes plays an important role in the regulation of sinus node pacemaking and AV node conduction under normal physiological conditions - in athletes, during the circadian rhythm, in pregnancy, and during postnatal development - as well as pathological states - ageing, heart failure, pulmonary hypertension, diabetes and atrial fibrillation. There may be yet more pathological conditions involving changes in the expression of the Hcn genes. Here, we review the role of If and the underlying HCN channels in physiological and pathological changes of the sinus and AV nodes and we begin to explore the signalling pathways (microRNAs, transcription factors, GIRK4, the autonomic nervous system and inflammation) involved in this regulation. This review is dedicated to Dario DiFrancesco on his retirement.The funny current, If, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that If plays an important role in pacemaking in the sinus node, the innate pacemaker of the heart, and more recently evidence has accumulated to show that If may play an important role in action potential conduction through the atrioventricular (AV) node. Evidence has also accumulated to show that regulation of the transcription and translation of the underlying Hcn genes plays an important role in the regulation of sinus node pacemaking and AV node conduction under normal physiological conditions - in athletes, during the circadian rhythm, in pregnancy, and during postnatal development - as well as pathological states - ageing, heart failure, pulmonary hypertension, diabetes and atrial fibrillation. There may be yet more pathological conditions involving changes in the expression of the Hcn genes. Here, we review the role of If and the underlying HCN channels in physiological and pathological changes of the sinus and AV nodes and we begin to explore the signalling pathways (microRNAs, transcription factors, GIRK4, the autonomic nervous system and inflammation) involved in this regulation. This review is dedicated to Dario DiFrancesco on his retirement.
The funny current, I , was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that I plays an important role in pacemaking in the sinus node, the innate pacemaker of the heart, and more recently evidence has accumulated to show that I may play an important role in action potential conduction through the atrioventricular (AV) node. Evidence has also accumulated to show that regulation of the transcription and translation of the underlying Hcn genes plays an important role in the regulation of sinus node pacemaking and AV node conduction under normal physiological conditions - in athletes, during the circadian rhythm, in pregnancy, and during postnatal development - as well as pathological states - ageing, heart failure, pulmonary hypertension, diabetes and atrial fibrillation. There may be yet more pathological conditions involving changes in the expression of the Hcn genes. Here, we review the role of I and the underlying HCN channels in physiological and pathological changes of the sinus and AV nodes and we begin to explore the signalling pathways (microRNAs, transcription factors, GIRK4, the autonomic nervous system and inflammation) involved in this regulation. This review is dedicated to Dario DiFrancesco on his retirement.
Author Bucchi, Annalisa
Nakao, Shu
Wilson, Claire
Ariyaratnam, Jonathan
Stuart, Luke
Abd Allah, Eman
Morris, Gwilym
Jones, Sandra
Chandler, Natalie
Logantha, Sunil Jit R.J.
Bussey, Carol
D'Souza, Alicia
Mesirca, Pietro
Tellez, James
Smith, Matthew
Lancaster, Matthew
Mangoni, Matteo E.
Anderson, Cali
Boyett, Mark R.
Billeter, Rudi
Zhang, Henggui
Yanni, Joseph
Monfredi, Oliver
Hart, George
Cai, Xue
Stephenson, Robert
Author_xml – sequence: 1
  givenname: Mark R.
  orcidid: 0000-0003-3931-2020
  surname: Boyett
  fullname: Boyett, Mark R.
  email: mark.richard.boyett@gmail.com
  organization: Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK
– sequence: 2
  givenname: Joseph
  surname: Yanni
  fullname: Yanni, Joseph
  organization: Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK
– sequence: 3
  givenname: James
  surname: Tellez
  fullname: Tellez, James
  organization: Northern Molecular Genetics Service, Institute of Genetic Medicine, Biomedicine East Wing, Central Parkway, Newcastle Upon Tyne, NE1 3BZ, UK
– sequence: 4
  givenname: Annalisa
  orcidid: 0000-0002-5303-4242
  surname: Bucchi
  fullname: Bucchi, Annalisa
  organization: Department of Biosciences, Università Degli Studi di Milano, Via G. Celoria, 26 20133, Milan, Italy
– sequence: 5
  givenname: Pietro
  orcidid: 0000-0002-9538-3096
  surname: Mesirca
  fullname: Mesirca, Pietro
  organization: Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France
– sequence: 6
  givenname: Xue
  surname: Cai
  fullname: Cai, Xue
  organization: Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK
– sequence: 7
  givenname: Sunil Jit R.J.
  surname: Logantha
  fullname: Logantha, Sunil Jit R.J.
  organization: Liverpool Centre for Cardiovascular Science and Department of Cardiovascular and Metabolic Medicine, University of Liverpool, UK
– sequence: 8
  givenname: Claire
  orcidid: 0000-0003-0456-1350
  surname: Wilson
  fullname: Wilson, Claire
  organization: Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK
– sequence: 9
  givenname: Cali
  orcidid: 0000-0003-4952-8044
  surname: Anderson
  fullname: Anderson, Cali
  organization: Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK
– sequence: 10
  givenname: Jonathan
  surname: Ariyaratnam
  fullname: Ariyaratnam, Jonathan
  organization: Centre for Heart Rhythm Disorders, Royal Adelaide Hospital, Cardiology 4G751-769, University of Adelaide, Port Rd, SA, 5000, Australia
– sequence: 11
  givenname: Luke
  surname: Stuart
  fullname: Stuart, Luke
  organization: Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK
– sequence: 12
  givenname: Shu
  orcidid: 0000-0001-8990-1179
  surname: Nakao
  fullname: Nakao, Shu
  organization: Department of Biomedical Sciences, College of Life Sciences and Ritsumeikan Global Innovation Research Organization, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga, 525-8577, Japan
– sequence: 13
  givenname: Eman
  orcidid: 0000-0002-3370-4827
  surname: Abd Allah
  fullname: Abd Allah, Eman
  organization: Medical Physiology Department, Faculty of Medicine, Assuit University, Assuit, Egypt
– sequence: 14
  givenname: Sandra
  orcidid: 0000-0003-4917-7264
  surname: Jones
  fullname: Jones, Sandra
  organization: Department of Biomedical Sciences, Faculty of Health Sciences, University of Hull, Hull, HU6 7RX, UK
– sequence: 15
  givenname: Matthew
  orcidid: 0000-0002-3976-736X
  surname: Lancaster
  fullname: Lancaster, Matthew
  organization: School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK
– sequence: 16
  givenname: Robert
  orcidid: 0000-0002-4153-6026
  surname: Stephenson
  fullname: Stephenson, Robert
  organization: Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
– sequence: 17
  givenname: Natalie
  surname: Chandler
  fullname: Chandler, Natalie
  organization: Rare & Inherited Disease Laboratory, NHS North Thames Genomic Laboratory Hub, Levels 4-6, Barclay House, Great Ormond Street Hospital for Children NHS Foundation Trust, 37 Queen Square, London, WC1N 3BH, UK
– sequence: 18
  givenname: Matthew
  surname: Smith
  fullname: Smith, Matthew
  organization: Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK
– sequence: 19
  givenname: Carol
  orcidid: 0000-0002-5975-7513
  surname: Bussey
  fullname: Bussey, Carol
  organization: Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand
– sequence: 20
  givenname: Oliver
  surname: Monfredi
  fullname: Monfredi, Oliver
  organization: University of Virginia Health System University Hospital, 1215 Lee St, Charlottesville VA 22903, USA and Laboratory of Cardiovascular Medicine, National Institute on Aging, NIH Biomedical Research Center, Baltimore MD, 21224, USA
– sequence: 21
  givenname: Gwilym
  orcidid: 0000-0001-9893-6648
  surname: Morris
  fullname: Morris, Gwilym
  organization: Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK
– sequence: 22
  givenname: Rudi
  surname: Billeter
  fullname: Billeter, Rudi
  organization: University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK
– sequence: 23
  givenname: Matteo E.
  orcidid: 0000-0002-8892-3373
  surname: Mangoni
  fullname: Mangoni, Matteo E.
  organization: Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France
– sequence: 24
  givenname: Henggui
  surname: Zhang
  fullname: Zhang, Henggui
  organization: Biological Physics Group, Department of Physics & Astronomy, University of Manchester, M13 9PL, UK
– sequence: 25
  givenname: George
  surname: Hart
  fullname: Hart, George
  organization: Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK
– sequence: 26
  givenname: Alicia
  surname: D'Souza
  fullname: D'Souza, Alicia
  organization: Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34197836$$D View this record in MEDLINE/PubMed
https://hal.science/hal-03437472$$DView record in HAL
BookMark eNqNkV2LEzEUhoOsuN3VvyC51IuZzddM0hthLWoXioLodcgkp9vUmaQmM4X996addQVv9CYHwvM-cM57hS5CDIAQpqSmhLY3-_rQ-TjEvrw1I4zWpK0JUc_QgirJKyo5u0ALQuSyaimRl-gq5z0hhZTtC3TJBV1KxdsFCl_hfurN6GPAcYuzD1PGITrAB2NhMD98uMcmOGzG5OMRQhm2BNIM2RjcZM_p7gGvV5-x3ZkQoM_YB7wD04-7c9z5DCbDS_R8a_oMrx7nNfr-8cO31brafPl0t7rdVLZhYqwoNGUPwQ3vuHRcEUMkb5eMtspIkFI5I2THJJWGMmFpx5dKqaUgHXPSdoJfo7ezd2d6fUh-MOlBR-P1-najT3-ECy6FZEda2Dcze0jx5wR51IPPFvreBIhT1qwRSlDaNLygrx_RqRvAPZl_37MAagZsijkn2D4hlOhTdXqv_1SnT9Vp0upSXYm--ytq_XguZkzG9_8jeD8LyvXh6CHpbD0EC84nsKN20f9b8gs1ObrW
CitedBy_id crossref_primary_10_1016_j_hrthm_2024_05_018
crossref_primary_10_1016_j_hrthm_2024_02_050
crossref_primary_10_3390_ijms252212212
crossref_primary_10_1152_advan_00029_2023
crossref_primary_10_3390_jcm12237472
crossref_primary_10_1016_j_jelectrocard_2024_04_003
crossref_primary_10_3390_ijms24087264
crossref_primary_10_1152_physrev_00053_2021
crossref_primary_10_3389_fcvm_2024_1488207
crossref_primary_10_1111_joa_13640
crossref_primary_10_14202_vetworld_2024_2880_2888
crossref_primary_10_1007_s10565_023_09797_7
crossref_primary_10_3390_jcm13010203
crossref_primary_10_1371_journal_pcbi_1010098
crossref_primary_10_3390_ijms23084299
crossref_primary_10_1371_journal_pcbi_1011708
crossref_primary_10_1016_j_pbiomolbio_2021_10_001
crossref_primary_10_3390_cells10113203
Cites_doi 10.1113/expphysiol.2009.046920
10.1097/00004872-199715040-00011
10.1161/CIRCRESAHA.119.313349
10.1016/S0735-1097(02)01722-9
10.1161/01.CIR.13.6.801
10.1113/jphysiol.1883.sp000121
10.1046/j.1365-2281.2001.00328.x
10.1074/jbc.274.18.12835
10.1016/S0008-6363(01)00240-1
10.1016/j.hrthm.2014.03.002
10.1161/01.CIR.96.1.260
10.1161/01.CIR.76.3.493
10.1016/j.mad.2015.10.003
10.1152/ajpheart.01000.2007
10.1113/expphysiol.2005.031252
10.1016/j.ijcard.2015.08.207
10.1016/j.hrthm.2014.08.007
10.1073/pnas.1010122108
10.2170/jjphysiol.30.841
10.4161/chan.5.3.15266
10.1183/09031936.98.11020434
10.1113/JP276508
10.1016/j.ijcard.2016.07.203
10.1054/jelc.2001.25134
10.1161/CIRCULATIONAHA.108.789677
10.1016/j.jccase.2019.12.003
10.1016/j.jacc.2014.05.045
10.3920/CEP12020
10.1093/cvr/cvt164
10.1161/CIRCULATIONAHA.110.940577
10.1016/j.hrthm.2020.11.026
10.1056/NEJMoa052475
10.1161/01.CIR.80.6.1675
10.1016/j.yjmcc.2009.03.022
10.1161/CIRCULATIONAHA.113.007101
10.1113/JP272979
10.1161/HYPERTENSIONAHA.114.03782
10.1073/pnas.1308477110
10.1016/0002-9149(94)90158-9
10.1085/jgp.200509389
10.1016/j.ijcard.2017.04.058
10.1007/BF00582385
10.1093/eurheartj/eht176
10.1016/j.jacep.2020.09.012
10.1113/jphysiol.1991.sp018457
10.1152/japplphysiol.01126.2012
10.1016/j.hrthm.2018.08.026
10.2337/dc20-0084
10.1016/j.pbiomolbio.2007.07.009
10.1152/ajpheart.01291.2007
10.1016/j.tcm.2020.08.002
10.1111/j.1540-8159.1990.tb06947.x
10.1038/ncomms5664
10.1093/cvr/4.2.160
10.1007/s13105-016-0481-9
10.1136/bjsm.33.4.239
10.1113/expphysiol.2010.055780
10.1016/j.yjmcc.2009.07.028
10.1152/jappl.1982.52.6.1652
10.1161/CIRCULATIONAHA.106.663070
10.1016/j.pharmthera.2005.01.005
10.1002/ejhf.566
10.1515/BC.2003.078
10.1002/clc.20452
10.1038/s41746-019-0134-9
10.1007/BF00569430
10.1253/jcj.57.760
10.1371/journal.pgen.1005882
10.1536/ihj.20.765
10.1073/pnas.1311865110
10.1055/s-0033-1334138
10.1016/j.jaccas.2020.05.067
10.1038/188495b0
10.1146/annurev-neuro-060909-153128
10.1097/01.crd.0000181622.22277.b7
10.1002/ctm2.200
10.1161/01.CIR.0000139336.69955.AB
10.1007/s12574-014-0235-z
10.1074/jbc.M111.297606
10.1093/oxfordjournals.eurheartj.a060636
10.1146/annurev-physiol-021119-034453
10.1016/j.hrthm.2020.06.016
10.1161/01.RES.0000251717.98379.69
10.1177/1753944709345792
10.1073/pnas.1517181113
10.1111/j.1542-474X.2001.tb00092.x
10.1161/CIRCRESAHA.110.219949
10.1161/01.CIR.94.11.2953
10.1161/01.CIR.73.4.615
10.1007/BF00583909
10.1139/cjpp-2016-0418
10.1371/journal.pone.0141452
10.1080/21548331.1994.11442964
10.1016/j.jacep.2016.02.012
10.1113/expphysiol.2011.057752
10.1161/CIRCULATIONAHA.113.001689
10.1371/annotation/1baecd19-92b6-4683-b7d7-39c13a3f2e15
10.1161/01.CIR.101.25.2975
10.1016/j.pcad.2012.06.002
10.1007/s12576-012-0248-1
10.1038/31255
10.1038/s41598-020-66673-8
10.1093/eurheartj/ehs449
10.1113/JP275303
10.1093/cvr/cvz112
10.1172/JCI106167
10.1113/jphysiol.1992.sp019029
10.1016/j.atherosclerosis.2010.02.017
10.1161/CIRCRESAHA.117.311607
10.1152/ajpcell.00383.2012
10.3109/07420520903237984
10.1186/s13054-020-02933-3
10.1161/CIRCULATIONAHA.119.041694
10.3201/eid2610.202648
10.1152/jn.1993.69.6.2129
10.1186/s12882-016-0375-7
10.1152/physiol.00054.2012
10.1016/j.yjmcc.2009.08.023
10.1016/S0167-4781(99)00092-5
10.1371/journal.pone.0159618
10.1136/hrt.61.2.155
10.1161/01.CIR.25.6.947
10.1183/09031936.95.08040537
10.1007/978-3-540-72110-9_5
10.1093/emboj/18.9.2323
10.1113/jphysiol.1980.sp013474
10.1093/eurheartj/14.9.1278
10.1113/jphysiol.1880.sp000083
10.1111/jce.14277
10.1152/physiol.00009.2019
10.1113/expphysiol.2004.029439
10.1113/jphysiol.1997.sp021889
10.1161/01.CIR.0000083719.51661.B9
10.1085/jgp.201812293
10.1113/jphysiol.1981.sp013713
10.1093/ehjcr/ytaa132
10.1038/15973
10.1085/jgp.201611674
10.1161/CIRCULATIONAHA.106.613562
10.1093/oxfordjournals.eurheartj.a060792
10.1161/01.CIR.0000152100.04087.DB
10.1016/j.recesp.2017.03.005
10.1101/gad.322198.118
10.1172/JCI200316387
10.1161/01.CIR.88.6.2953
10.1111/j.0954-6820.1975.tb19555.x
10.1016/j.hrthm.2015.06.033
10.1053/euhj.1998.1347
10.1038/s41598-020-67790-0
10.1016/j.transproceed.2005.03.087
10.1097/00005344-199810000-00002
10.1016/j.hrthm.2009.09.017
10.1023/A:1021376002896
10.1111/j.1365-2869.2007.00581.x
10.1038/ncomms4775
10.1113/jphysiol.2004.072108
10.1152/ajpheart.00028.2019
10.1038/s41467-019-10709-9
10.1016/j.cub.2009.12.034
10.1136/hrt.47.3.213
10.2165/00007256-200333120-00003
10.1038/s41598-021-82202-7
10.1016/j.cardiores.2005.02.011
10.3389/fphys.2020.547577
10.1093/eurheartj/ehm555
10.1093/eurheartj/ehv582
10.1161/CIRCRESAHA.109.206078
10.1080/09291016.2012.704801
10.1080/09291016.2016.1174404
10.1016/j.yjmcc.2015.02.003
10.3389/fphys.2019.00826
10.1038/s41580-019-0179-2
10.1161/CIRCRESAHA.109.209957
10.1007/s00395-007-0660-5
10.1378/chest.121.2.513
10.1113/jphysiol.2014.284356
10.1111/j.1749-6632.1999.tb11353.x
10.1016/j.pharmthera.2013.04.010
10.1016/j.hrthm.2017.12.027
10.1016/0165-1838(94)00117-3
10.1016/j.jccase.2020.07.015
10.1007/s00018-008-8525-0
10.1253/circj.CJ-13-0996
10.1016/0031-9384(94)90392-1
10.1093/eurheartj/ehn123
10.3389/fphys.2020.546508
10.1113/jphysiol.1996.sp021285
10.1378/chest.82.1.19
10.1002/ar.21379
10.1093/eurheartj/ehs041
10.3389/fphys.2015.00037
10.1007/BF00584356
10.1016/j.ijcard.2016.09.044
10.1038/s41598-017-07694-8
10.1136/hrt.55.3.253
10.1161/CIRCULATIONAHA.109.902148
10.1161/01.RES.0000101913.95604.B9
10.1111/j.1540-8167.2009.01704.x
10.1016/j.yjmcc.2020.08.005
10.1016/0002-9149(93)91017-C
10.1016/j.jacc.2014.12.049
10.1038/s41467-017-01342-5
10.1371/journal.pone.0153934
10.1292/jvms.59.149
10.1016/j.recesp.2011.07.009
10.1113/jphysiol.1968.sp008454
10.1161/01.CIR.96.5.1667
10.1093/eurheartj/ehs391
10.1016/S0002-9149(00)01450-8
ContentType Journal Article
Copyright 2021 Elsevier Ltd
Copyright © 2021 Elsevier Ltd. All rights reserved.
Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml – notice: 2021 Elsevier Ltd
– notice: Copyright © 2021 Elsevier Ltd. All rights reserved.
– notice: Distributed under a Creative Commons Attribution 4.0 International License
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
1XC
VOOES
DOI 10.1016/j.pbiomolbio.2021.06.008
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1873-1732
EndPage 85
ExternalDocumentID oai_HAL_hal_03437472v1
34197836
10_1016_j_pbiomolbio_2021_06_008
S0079610721000687
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GrantInformation_xml – fundername: British Heart Foundation
  grantid: FS/18/47/33669
– fundername: British Heart Foundation
  grantid: PG/13/99/30233
– fundername: British Heart Foundation
  grantid: PG/15/16/31330
– fundername: British Heart Foundation
  grantid: FS/19/1/34035
GroupedDBID ---
--K
--M
-~X
.GJ
.~1
0R~
123
1B1
1RT
1~.
1~5
29P
3O-
4.4
457
4G.
53G
5RE
5VS
7-5
71M
8P~
9JM
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AAXUO
ABEFU
ABFNM
ABFRF
ABGSF
ABJNI
ABLJU
ABMAC
ABTAH
ABUDA
ABXDB
ABYKQ
ACDAQ
ACGFO
ACGFS
ACIUM
ACRLP
ADBBV
ADEZE
ADMUD
ADUVX
AEBSH
AEFWE
AEHWI
AEKER
AENEX
AFFNX
AFKWA
AFTJW
AFXIZ
AGHFR
AGRDE
AGUBO
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
CS3
DOVZS
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F20
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
G8K
GBLVA
HLW
HVGLF
HX~
HZ~
IHE
J1W
KOM
LX3
M41
MO0
MVM
N9A
O-L
O9-
OAUVE
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SBG
SDF
SDG
SDP
SES
SEW
SPCBC
SPD
SSU
SSZ
T5K
UNMZH
UQL
VQP
WUQ
XFK
ZGI
ZY4
~G-
AATTM
AAXKI
AAYWO
AAYXX
ABDPE
ABWVN
ACRPL
ACVFH
ADCNI
ADNMO
ADVLN
AEIPS
AEUPX
AFJKZ
AFPUW
AGCQF
AGQPQ
AGRNS
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
APXCP
BNPGV
CITATION
SSH
CGR
CUY
CVF
ECM
EFKBS
EIF
NPM
7X8
1XC
VOOES
ID FETCH-LOGICAL-c524t-1e518743a3b37d380a073692168a7e778da47b2717a124c1b39888940b2d7cb43
IEDL.DBID .~1
ISSN 0079-6107
1873-1732
IngestDate Fri Jul 04 06:52:21 EDT 2025
Thu Jul 10 18:04:50 EDT 2025
Mon Jul 21 06:00:24 EDT 2025
Tue Jul 01 00:42:41 EDT 2025
Thu Apr 24 22:54:48 EDT 2025
Fri Feb 23 02:46:37 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Heart failure
Cardiac conduction system
Cardiac arrhythmias
Athletic training
Circadian rhythm
Ageing
Language English
License Copyright © 2021 Elsevier Ltd. All rights reserved.
Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c524t-1e518743a3b37d380a073692168a7e778da47b2717a124c1b39888940b2d7cb43
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ORCID 0000-0002-3976-736X
0000-0002-9538-3096
0000-0003-4917-7264
0000-0001-9893-6648
0000-0002-5303-4242
0000-0002-8892-3373
0000-0003-3931-2020
0000-0001-8990-1179
0000-0003-4952-8044
0000-0003-0456-1350
0000-0002-4153-6026
0000-0002-5975-7513
0000-0002-3370-4827
0000-0002-0863-5807
0000-0002-9700-5523
0000-0002-3532-6970
OpenAccessLink https://hal.science/hal-03437472
PMID 34197836
PQID 2548411553
PQPubID 23479
PageCount 25
ParticipantIDs hal_primary_oai_HAL_hal_03437472v1
proquest_miscellaneous_2548411553
pubmed_primary_34197836
crossref_primary_10_1016_j_pbiomolbio_2021_06_008
crossref_citationtrail_10_1016_j_pbiomolbio_2021_06_008
elsevier_sciencedirect_doi_10_1016_j_pbiomolbio_2021_06_008
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate November 2021
2021-11-00
20211101
2021-11
PublicationDateYYYYMMDD 2021-11-01
PublicationDate_xml – month: 11
  year: 2021
  text: November 2021
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Progress in biophysics and molecular biology
PublicationTitleAlternate Prog Biophys Mol Biol
PublicationYear 2021
Publisher Elsevier Ltd
Elsevier
Publisher_xml – name: Elsevier Ltd
– name: Elsevier
References Senga, Dohi, Kumagai, Takamura, Fujimoto, Kurita, Fujii, Ota, Tanigawa, Kitamura, Onishi, Yamada, Nakamura, Okubo, Isaka, Ito (bib204) 2007; 28
Peigh, Leya, Baman, Cantey, Knight, Flaherty (bib178) 2020; 4
Shi, Hida, McGuinness, Wasserman, Yamazaki, Johnson (bib206) 2010; 20
Anderson, Forte, Wilson, Oceandy, Boyett, D’Souza (bib13) 2019; 45
D'Souza, Trussell, Morris, Dobrzynski, Boyett (bib66) 2019; 34
DiFrancesco (bib69) 1981; 314
Muir-Nisbet (bib163) 2008
Portilla (bib182) 2011; 107
Rana, Prabhu, Young (bib187) 2020; 126
Hao, Zhang, Zhang, Nirmalan, Davies, Dobrzynski, Wang, Grace, Zhang, Boyett, Huang, Lei (bib90) 2011; 4
Vanderdonckt, Lambert, Montero, Boland, Brohet (bib224) 2001; 34
Rautio, Gadler, Gudbjornsdottir, Franzen, Ryden, Svensson, Mellbin (bib189) 2018; 39
Elvan, Wylie, Zipes (bib79) 1996; 94
Lolicato, Nardini, Gazzarrini, Möller, Bertinetti, Herberg, Bolognesi, Martin, Fasolini, Bertrand, Arrigoni, Thiel, Moroni (bib136) 2011; 286
Moghtadaei, Jansen, Mackasey, Rafferty, Bogachev, Sapp, Howlett, Rose (bib155) 2016; 594
Yanni, Tellez, Sutyagin, Boyett, Dobrzynski (bib243) 2010; 48
Milano, Vermeer Alexa, Lodder Elisabeth, Barc, Verkerk Arie, Postma, van der Bilt Ivo, Baars Marieke, van Haelst Paul, Caliskan, Hoedemaekers Yvonne, Le Scouarnec, Redon, Pinto Yigal, Christiaans, Wilde Arthur, Bezzina Connie (bib154) 2014; 64
Berczeller (bib29) 1994; 29
Amaratunga, Corwin, Moran, Snyder (bib11) 2020; 12
Hoogsteen, Bennekers, Ban de Wall, van Hemel, Wilde, Crijns, Gorgels, Smeets, Hauer, Jordaens, Schalij (bib97) 2004; 12
Ferdous, Qureshi, Jayaprakash, Parekh, John, Oz, Raza, Dobrzynski, Adrian, Howarth (bib81) 2016; 11
Alings, Bouman (bib10) 1993; 14
Koehler, Fus, Grimm, Pankow, Schafer, Stammnitz, Peter (bib116) 1998; 11
Logantha, Cai, Yanni, Jones, Stephenson, Quigley, Monfredi, Vohra, Hutcheon, Corno, Jarvis, Dobrzynski, Boyett, Hart (bib135) 2021
Kozasa, Nakashima, Ito, Ishikawa, Kimoto, Ushijima, Makita, Takano (bib121) 2018; 596
Sah, Mesirca, Van den Boogert, Rosen, Mably, Mangoni, Clapham (bib195) 2013; 110
Lear, Lawrence, Burden (bib129) 1996; 33
Tong, Wang, Pang, Zhou, Cui, Ruan, Su, Chen (bib221) 2016; 47
Monfredi, Boyett (bib157) 2015; 83
Cimino, Pascariello, Bernardi, Calvi, Arabia, Salghetti, Bontempi, Vizzardi, Metra, Curnis (bib59) 2020; 2
Yanagihara, Irisawa (bib239) 1980; 385
Hood, Northcote (bib96) 1999; 33
Stevenson, Stevenson, Middlekauff, Saxon (bib210) 1993; 88
D'Souza, Sharma, Boyett (bib65) 2015; 593
Peters, Sharpe, Proenza (bib180) 2020; 82
Zicha, Fernandez-Velasco, Lonardo, L'Heureux, Nattel (bib251) 2005; 66
Luthi, Zuber, Ritter, Oechslin, Jenni, Seifert, Baldesberger, Jost (bib140) 2008; 9
Baruscotti, Bucchi, Milanesi, Paina, Barbuti, Gnecchi-Ruscone, Bianco, Vitali-Serdoz, Cappato, DiFrancesco (bib23) 2015; 38
Aro, Anttonen, Kerola, Junttila, Tikkanen, Rissanen, Reunanen, Huikuri (bib16) 2014; 35
Saeed, Temple, Borbas, Atkinson, Yanni, Maczewski, Mackiewicz, Aly, Logantha, Garratt, Dobrzynski (bib194) 2018; 15
Capoferri, Osthoff, Egli, Stoeckle, Bassetti (bib55) 2020
Warren, Champney, Cassone (bib232) 1994; 55
Yamaya, Kubo, Amada, Sato (bib238) 1997; 59
Mesirca, Alig, Torrente, Muller, Marger, Rollin, Marquilly, Vincent, Dubel, Bidaud, Fernandez, Seniuk, Engeland, Singh, Miquerol, Ehmke, Eschenhagen, Nargeot, Wickman, Isbrandt, Mangoni (bib150) 2014; 5
Wong, Kalman, Pedagogos, Toussaint, Vohra, Sparks, Sanders, Kistler, Halloran, Lee, Joseph, Morton (bib233) 2015; 65
Baruscotti, DiFrancesco, Robinson (bib25) 1996; 492
Monfredi, Lakatta (bib158) 2019; 115
Oosting, Struijker-Boudier, Janssen (bib172) 1997; 15
Accili, Robinson, DiFrancesco (bib2) 1997; 272
Makino, Hayashi, Takezawa, Hirai, Saito, Ebihara (bib144) 1997; 96
Lakatta, Maltsev, Vinogradova (bib124) 2010; 106
Morris, D'Souza, Dobrzynski, Lei, Choudhury, Billeter, Kryukova, Robinson, Kingston, Boyett (bib162) 2013; 100
Ludwig, Zong, Jeglitsch, Hofmann, Biel (bib138) 1998; 393
Chiamvimonvat, Newman, Tang, Green, Mitchell, Wulffhart, Dorian (bib57) 1998; 32
Landgraf, Wang, Diemer, Welsh (bib126) 2016; 12
Manolis, Manolis, Manolis, Apostolopoulos, Papatheou, Melita (bib145) 2020; 30
Adachi, Shibata, Okamoto, Sato, Fujisawa, Ohba, Ono (bib3) 2013; 63
Jose, Collison (bib111) 1970; 4
Scheer, Kalsbeek, Buijs (bib199) 2003; 384
Alboni, Brignole, Menozzi, Scarfo (bib4) 1999; 20
Durgan, Young (bib77) 2010; 106
Tellez, Dobrzynski, Greener, Graham, Laing, Honjo, Hubbard, Boyett, Billeter (bib217) 2006; 99
Chandler, Aslanidi, Buckley, Inada, Birchall, Atkinson, Kirk, Monfredi, Molenaar, Anderson, Sharma, Sigg, Zhang, Boyett, Dobrzynski (bib56) 2011; 294
Beesley, Noguchi, Welsh (bib27) 2016; 11
Stephenson, Atkinson, Kottas, Perde, Jafarzadeh, Bateman, Iaizzo, Zhao, Zhang, Anderson, Jarvis, Dobrzynski (bib208) 2017; 7
Verrier, Josephson (bib228) 2009; 2
Rautio, Gadler, Gudbjörnsdottir, Franzén, Rydén, Svensson, Mellbin (bib188) 2020
Romero-Leon, Galvez-Contreras, Diez-Garcia (bib191) 2016; 69
Bahrainy, Levy, Busey, Caldwell, Stratton (bib20) 2016; 222
Bhatla, Mayer, Adusumalli, Hyman, Oh, Tierney, Moss, Chahal, Anesi, Denduluri, Domenico, Arkles, Abella, Bullinga, Callans, Dixit, Epstein, Frankel, Garcia, Kumareswaram, Nazarian, Riley, Santangeli, Schaller, Supple, Lin, Marchlinski, Deo (bib34) 2020; 17
Ishii, Takano, Xie, Noma, Ohmori (bib106) 1999; 274
Martini, Kunderfranco, Peano, Carullo, Cremonesi, Schorn, Carriero, Termanini, Colombo, Jachetti, Panico, Faggian, Fumero, Torracca, Molgora, Cibella, Pagiatakis, Brummelman, Alvisi, Mazza, Colombo, Lugli, Condorelli, Kallikourdis (bib148) 2019; 140
Protas, Oren, Clancy, Robinson (bib185) 2010; 48
Huang, Du, Yang, Lin, Xi, Yang, Ma (bib101) 2015; 152
Ntalianis, Nanas (bib171) 2006; 14
Yeh, Burstein, Qi, Sakabe, Chartier, Comtois, Wang, Kuo, Nattel (bib245) 2009; 119
Laks, Lehrhaft, Grunstein, Sullivan (bib125) 1995; 8
Dobrzynski, Nikolski, Sambelashvili, Greener, Boyett, Efimov (bib74) 2003; 93
Hagiwara, Irisawa, Kasanuki, Hosada (bib88) 1992; 448
Faggiano, d’Aloia, Gualeni, Gardini, Giordano (bib80) 2001; 87
Kolloch, Legler, Champion, Cooper-Dehoff, Handberg, Zhou, Pepine (bib119) 2008; 29
de Melo, de Souza, Mandarim-de-Lacerda (bib68) 2002; 3
Wongcharoen, Ruttanaphol, Gunaparn, Phrommintikul (bib235) 2016; 224
Bexton, Vallin, Camm (bib31) 1986; 55
Jones, Boyett, Lancaster (bib109) 2007; 115
Nikolaidou, Ghosh, Clark (bib166) 2016; 2
Mohawk, Green, Takahashi (bib156) 2012; 35
Brennan, Chen, Gams, Dyavanapalli, Mendelowitz, Peng, Efimov (bib48) 2020; 6
Caliskan, Balk, Jordaens, Szili-Torok (bib53) 2010; 21
Verkerk, Wilders, Coronel, Ravesloot, Verheijck (bib226) 2003; 108
Gaskell (bib86) 1883; 4
Luu, Stevenson, Stevenson, Baron, Walden (bib141) 1989; 80
Gaskell (bib85) 1880; 3
Protas, DiFrancesco, Robinson (bib184) 2001; 281
El Khoury, Mathieu, Marger, Ross, El Gebeily, Ethier, Fiset (bib78) 2013; 127
Härtel, Talvensaari (bib91) 1975; 198
Hiss, Lamb (bib95) 1962; 25
Strassheim, Dempsey, Gerasimovskaya, Stenmark, Karoor (bib211) 2019; 2019
Talan, Bauernfeind, Ashley, Kanakis, Rosen (bib215) 1982; 82
Zaza, Lombardi (bib246) 2001; 50
Howarth, Jacobson, Naseer, Adeghate (bib98) 2005; 90
Huang, Yang, Du, Zhang, Ma (bib102) 2007; 102
Viitasalo, Kala, Eisalo (bib229) 1982; 47
Semelka, Gera, Usman (bib203) 2013; 87
Alboni, Scarfo, Fuca (bib6) 2001; 2
Finley, Nugent (bib82) 1995; 51
Alghamdi, Testrow, Whittaker, Boyett, Hancox, Zhang (bib8) 2020; 11
Parati, Esler (bib175) 2012; 33
Monfredi, Lyashkov, Johnsen, Inada, Schneider, Wang, Nirmalan, Wisloff, Maltsev, Lakatta, Zhang, Boyett (bib159) 2014; 64
Zhang, Wang, Yanni, Qureshi, Logantha, Kassab, Boyett, Gardiner, Sun, Howarth, Dobrzynski (bib248) 2019; 10
Santoro, Tibbs (bib197) 1999; 868
Nagatomo, Kotooka, Yoshioka, Node (bib164) 2020; 21
Rosen, Brink, Cohen, Robinson (bib192) 2007
Katona, McLean, Dighton, Guz (bib114) 1982; 52
Morris, Boyett (bib161) 2009; 3
Hu, Gong, Jiang, Wang, Zou, Zhu (bib100) 2020; 24
Baldesberger, Bauersfeld, Candinas, Seifert, Zuber, Ritter, Jenni, Oechslin, Luthi, Scharf, Marti, Attenhofer Jost (bib21) 2008; 29
Brown, DiFrancesco (bib49) 1980; 308
Lemmer (bib130) 2009; 26
Sharpe, Larson, Proenza (bib205) 2017; 149
Kanemoto, Sasamoto (bib113) 1979; 20
Crespo-Leiro, Anker, Maggioni, Coats, Filippatos, Ruschitzka, Ferrari, Piepoli, Delgado Jimenez, Metra, Fonseca, Hradec, Amir, Logeart, Dahlstrom, Merkely, Drozdz, Goncalvesova, Hassanein, Chioncel, Lainscak, Seferovic, Tousoulis, Kavoliuniene, Fruhwald, Fazlibegovic, Temizhan, Gatzov, Erglis, Laroche, Mebazaa (bib60) 2016; 18
Jose, Taylor (bib112) 1969; 48
Kokubun, Nishimura, Noma, Irisawa (bib117) 1982; 393
Monfredi, Maltsev, Lakatta (bib160) 2013; 28
Boyden, Hirose, Dun (bib43) 2010; 7
Marger, Mesirca, Alig, Torrente, Dubel, Engeland, Kanani, Fontanaud, Striessnig, Shin, Isbrandt, Ehmke, Nargeot, Mangoni (bib146) 2011; 5
Zhang, Boyett, Holden, Honjo, Kodama (bib247) 1998; 511
Zhou, Ding, Makiyama, Miyamoto, Matsumoto, Kimura, Tarutani, Zhao, Wu, Zang, Matsuura, Horie (bib249) 2014; 78
Dilaveris, Farbom, Batchvarov, Ghuran, Malik (bib71) 2001; 6
Stein, Medeiros, Rosito, Zimerman, Ribeiro (bib207) 2002; 39
Tang, Gao, Li, Miao, Huang, Liu, Xie, Li, Wen, Zheng, Su (bib216) 2020; 10
Ueyama, Krout, Nguyen, Karpitskiy, Kollert, Mettenleiter, Loewy (bib222) 1999; 2
Proenza, Yellen (bib183) 2006; 127
Liu, Noble, Xiao, Abdelrahman, Dobrzynski, Boyett, Lei, Noble (bib134) 2008; 96
Stephenson, Boyett, Hart, Nikolaidou, Cai, Corno, Alphonso, Jeffery, Jarvis (bib209) 2012; 7
Yahalom, Spitz, Sandler, Heno, Roguin, Turgeman (bib236) 2013; 22
Parodi, Bellandi, Valenti, Memisha, Giuliani, Velluzzi, Migliorini, Carrabba, Antoniucci (bib176) 2010; 211
Boas, Weiss (bib41) 1929; 92
Yanagihara, Noma, Irisawa (bib240) 1980; 30
Yanni, Tellez, Maczewski, Mackiewicz, Beresewicz, Billeter, Dobrzynski, Boyett (bib242) 2011; 4
Avram, Tison, Aschbacher, Kuhar, Vittinghoff, Butzner, Runge, Wu, Pletcher, Marcus, Olgin (bib18) 2019; 2
Ostchega, Porter, Hughes, Dillon, Nwankwo (bib174) 2011; vol. 41
Alghamdi, Boyett, Hancox, Zhang (bib7) 2020; 11
Schulze-Bahr, Neu, Friederich, Kaupp, Breithardt, Pongs, Isbrandt (bib202) 2003; 111
Alboni,
Berczeller (10.1016/j.pbiomolbio.2021.06.008_bib29) 1994; 29
Zicha (10.1016/j.pbiomolbio.2021.06.008_bib251) 2005; 66
Amaratunga (10.1016/j.pbiomolbio.2021.06.008_bib11) 2020; 12
Wahl-Schott (10.1016/j.pbiomolbio.2021.06.008_bib230) 2009; 66
Aquilina (10.1016/j.pbiomolbio.2021.06.008_bib15) 2006; 8
Bhatla (10.1016/j.pbiomolbio.2021.06.008_bib34) 2020; 17
Mesirca (10.1016/j.pbiomolbio.2021.06.008_bib150) 2014; 5
Rajdev (10.1016/j.pbiomolbio.2021.06.008_bib186) 2012; 55
Yanni (10.1016/j.pbiomolbio.2021.06.008_bib243) 2010; 48
Muir-Nisbet (10.1016/j.pbiomolbio.2021.06.008_bib163) 2008
Bahrainy (10.1016/j.pbiomolbio.2021.06.008_bib20) 2016; 222
Warren (10.1016/j.pbiomolbio.2021.06.008_bib232) 1994; 55
Lakatta (10.1016/j.pbiomolbio.2021.06.008_bib124) 2010; 106
Strassheim (10.1016/j.pbiomolbio.2021.06.008_bib211) 2019; 2019
Yeh (10.1016/j.pbiomolbio.2021.06.008_bib245) 2009; 119
Jones (10.1016/j.pbiomolbio.2021.06.008_bib110) 2004; 560
Aubert (10.1016/j.pbiomolbio.2021.06.008_bib17) 2003; 33
Nikolaidou (10.1016/j.pbiomolbio.2021.06.008_bib165) 2015; 10
Marger (10.1016/j.pbiomolbio.2021.06.008_bib146) 2011; 5
Li (10.1016/j.pbiomolbio.2021.06.008_bib131) 2014; 41
Adachi (10.1016/j.pbiomolbio.2021.06.008_bib3) 2013; 63
Hao (10.1016/j.pbiomolbio.2021.06.008_bib90) 2011; 4
Noble (10.1016/j.pbiomolbio.2021.06.008_bib167) 1960; 188
Sutherland (10.1016/j.pbiomolbio.2021.06.008_bib213) 1929; 22
Rubler (10.1016/j.pbiomolbio.2021.06.008_bib193) 1975; 75
Viitasalo (10.1016/j.pbiomolbio.2021.06.008_bib229) 1982; 47
Aro (10.1016/j.pbiomolbio.2021.06.008_bib16) 2014; 35
Lakatta (10.1016/j.pbiomolbio.2021.06.008_bib123) 2009; 47
Beytebiere (10.1016/j.pbiomolbio.2021.06.008_bib33) 2019; 33
Chandler (10.1016/j.pbiomolbio.2021.06.008_bib56) 2011; 294
Duhme (10.1016/j.pbiomolbio.2021.06.008_bib76) 2013; 34
Rana (10.1016/j.pbiomolbio.2021.06.008_bib187) 2020; 126
Anderson (10.1016/j.pbiomolbio.2021.06.008_bib13) 2019; 45
Stuart (10.1016/j.pbiomolbio.2021.06.008_bib212) 2021
Dobrzynski (10.1016/j.pbiomolbio.2021.06.008_bib73) 2005; 111
Ishii (10.1016/j.pbiomolbio.2021.06.008_bib106) 1999; 274
Laks (10.1016/j.pbiomolbio.2021.06.008_bib125) 1995; 8
Mesirca (10.1016/j.pbiomolbio.2021.06.008_bib152) 2021
Brubaker (10.1016/j.pbiomolbio.2021.06.008_bib50) 2011; 123
Swoap (10.1016/j.pbiomolbio.2021.06.008_bib214) 2008; 294
Wong (10.1016/j.pbiomolbio.2021.06.008_bib233) 2015; 65
Bexton (10.1016/j.pbiomolbio.2021.06.008_bib31) 1986; 55
Landgraf (10.1016/j.pbiomolbio.2021.06.008_bib126) 2016; 12
Alings (10.1016/j.pbiomolbio.2021.06.008_bib10) 1993; 14
Tong (10.1016/j.pbiomolbio.2021.06.008_bib220) 2013; 44
El Khoury (10.1016/j.pbiomolbio.2021.06.008_bib78) 2013; 127
Oosting (10.1016/j.pbiomolbio.2021.06.008_bib172) 1997; 15
Durgan (10.1016/j.pbiomolbio.2021.06.008_bib77) 2010; 106
Zhou (10.1016/j.pbiomolbio.2021.06.008_bib249) 2014; 78
Alings (10.1016/j.pbiomolbio.2021.06.008_bib9) 1995; 16
Jose (10.1016/j.pbiomolbio.2021.06.008_bib111) 1970; 4
Cimino (10.1016/j.pbiomolbio.2021.06.008_bib59) 2020; 2
Hiraiwa (10.1016/j.pbiomolbio.2021.06.008_bib94) 2020; 22
Wang (10.1016/j.pbiomolbio.2021.06.008_bib231) 2021; 11
Kotsis (10.1016/j.pbiomolbio.2021.06.008_bib120) 2005; 37
Schoeller (10.1016/j.pbiomolbio.2021.06.008_bib200) 1993; 71
Monfredi (10.1016/j.pbiomolbio.2021.06.008_bib158) 2019; 115
Ostchega (10.1016/j.pbiomolbio.2021.06.008_bib174) 2011; vol. 41
Bussey (10.1016/j.pbiomolbio.2021.06.008_bib51) 2019; 43
Verrier (10.1016/j.pbiomolbio.2021.06.008_bib227) 2014; 11
Gaskell (10.1016/j.pbiomolbio.2021.06.008_bib86) 1883; 4
Hoogsteen (10.1016/j.pbiomolbio.2021.06.008_bib97) 2004; 12
DiFrancesco (10.1016/j.pbiomolbio.2021.06.008_bib69) 1981; 314
Maccaferri (10.1016/j.pbiomolbio.2021.06.008_bib142) 1993; 69
Tellez (10.1016/j.pbiomolbio.2021.06.008_bib218) 2011; 96
Hall (10.1016/j.pbiomolbio.2021.06.008_bib89) 2011; 64
Santoro (10.1016/j.pbiomolbio.2021.06.008_bib197) 1999; 868
Baruscotti (10.1016/j.pbiomolbio.2021.06.008_bib26) 1997; 498
Bossone (10.1016/j.pbiomolbio.2021.06.008_bib42) 2002; 121
Monfredi (10.1016/j.pbiomolbio.2021.06.008_bib160) 2013; 28
Rautio (10.1016/j.pbiomolbio.2021.06.008_bib188) 2020
Fye (10.1016/j.pbiomolbio.2021.06.008_bib84) 1987; 76
Morris (10.1016/j.pbiomolbio.2021.06.008_bib162) 2013; 100
Caliskan (10.1016/j.pbiomolbio.2021.06.008_bib53) 2010; 21
Monfredi (10.1016/j.pbiomolbio.2021.06.008_bib159) 2014; 64
Abd Allah (10.1016/j.pbiomolbio.2021.06.008_bib1) 2011; 96
Wong (10.1016/j.pbiomolbio.2021.06.008_bib234) 2015; 12
Scheer (10.1016/j.pbiomolbio.2021.06.008_bib199) 2003; 384
Tong (10.1016/j.pbiomolbio.2021.06.008_bib221) 2016; 47
Morris (10.1016/j.pbiomolbio.2021.06.008_bib161) 2009; 3
Portilla (10.1016/j.pbiomolbio.2021.06.008_bib182) 2011; 107
Yamanushi (10.1016/j.pbiomolbio.2021.06.008_bib237) 2010; 48
Yanagihara (10.1016/j.pbiomolbio.2021.06.008_bib239) 1980; 385
Koehler (10.1016/j.pbiomolbio.2021.06.008_bib116) 1998; 11
Dobrzynski (10.1016/j.pbiomolbio.2021.06.008_bib72) 2013; 139
Vanderdonckt (10.1016/j.pbiomolbio.2021.06.008_bib224) 2001; 34
Kokubun (10.1016/j.pbiomolbio.2021.06.008_bib117) 1982; 393
Iwataki (10.1016/j.pbiomolbio.2021.06.008_bib107) 2015; 13
Faggiano (10.1016/j.pbiomolbio.2021.06.008_bib80) 2001; 87
Dilaveris (10.1016/j.pbiomolbio.2021.06.008_bib71) 2001; 6
Patke (10.1016/j.pbiomolbio.2021.06.008_bib177) 2020; 21
Kuga (10.1016/j.pbiomolbio.2021.06.008_bib122) 1993; 57
Rautio (10.1016/j.pbiomolbio.2021.06.008_bib189) 2018; 39
Schulze-Bahr (10.1016/j.pbiomolbio.2021.06.008_bib202) 2003; 111
Manolis (10.1016/j.pbiomolbio.2021.06.008_bib145) 2020; 30
Saeed (10.1016/j.pbiomolbio.2021.06.008_bib194) 2018; 15
D'Souza (10.1016/j.pbiomolbio.2021.06.008_bib66) 2019; 34
Lemmer (10.1016/j.pbiomolbio.2021.06.008_bib130) 2009; 26
Sharpe (10.1016/j.pbiomolbio.2021.06.008_bib205) 2017; 149
Baruscotti (10.1016/j.pbiomolbio.2021.06.008_bib23) 2015; 38
Ludwig (10.1016/j.pbiomolbio.2021.06.008_bib139) 1999; 18
Crouse (10.1016/j.pbiomolbio.2021.06.008_bib61) 2009; 32
Jones (10.1016/j.pbiomolbio.2021.06.008_bib109) 2007; 115
Choudhury (10.1016/j.pbiomolbio.2021.06.008_bib58) 2018; 596
Härtel (10.1016/j.pbiomolbio.2021.06.008_bib91) 1975; 198
Wongcharoen (10.1016/j.pbiomolbio.2021.06.008_bib235) 2016; 224
Lin (10.1016/j.pbiomolbio.2021.06.008_bib132) 2019; 151
Beesley (10.1016/j.pbiomolbio.2021.06.008_bib27) 2016; 11
Finley (10.1016/j.pbiomolbio.2021.06.008_bib82) 1995; 51
Lear (10.1016/j.pbiomolbio.2021.06.008_bib129) 1996; 33
Huang (10.1016/j.pbiomolbio.2021.06.008_bib102) 2007; 102
Alboni (10.1016/j.pbiomolbio.2021.06.008_bib4) 1999; 20
Hood (10.1016/j.pbiomolbio.2021.06.008_bib96) 1999; 33
Noble (10.1016/j.pbiomolbio.2021.06.008_bib168) 1968; 195
Du (10.1016/j.pbiomolbio.2021.06.008_bib75) 2016; 72
Nikolaidou (10.1016/j.pbiomolbio.2021.06.008_bib166) 2016; 2
Betros (10.1016/j.pbiomolbio.2021.06.008_bib30) 2013; 9
Romero-Leon (10.1016/j.pbiomolbio.2021.06.008_bib191) 2016; 69
Black (10.1016/j.pbiomolbio.2021.06.008_bib37) 2019; 16
Alghamdi (10.1016/j.pbiomolbio.2021.06.008_bib7) 2020; 11
Rosen (10.1016/j.pbiomolbio.2021.06.008_bib192) 2007
Semelka (10.1016/j.pbiomolbio.2021.06.008_bib203) 2013; 87
Proenza (10.1016/j.pbiomolbio.2021.06.008_bib183) 2006; 127
Tellez (10.1016/j.pbiomolbio.2021.06.008_bib217) 2006; 99
Alboni (10.1016/j.pbiomolbio.2021.06.008_bib6) 2001; 2
Protas (10.1016/j.pbiomolbio.2021.06.008_bib184) 2001; 281
Chiamvimonvat (10.1016/j.pbiomolbio.2021.06.008_bib57) 1998; 32
Beyls (10.1016/j.pbiomolbio.2021.06.008_bib32) 2020; 13
Huang (10.1016/j.pbiomolbio.2021.06.008_bib103) 2016; 95
Boyden (10.1016/j.pbiomolbio.2021.06.008_bib43) 2010; 7
Hagiwara (10.1016/j.pbiomolbio.2021.06.008_bib88) 1992; 448
D'Souza (10.1016/j.pbiomolbio.2021.06.008_bib64) 2017; 121
Howarth (10.1016/j.pbiomolbio.2021.06.008_bib99) 2005; 90
Luthi (10.1016/j.pbiomolbio.2021.06.008_bib140) 2008; 9
Larson (10.1016/j.pbiomolbio.2021.06.008_bib128) 2013; 110
Idema (10.1016/j.pbiomolbio.2021.06.008_bib104) 1994; 73
Macri (10.1016/j.pbiomolbio.2021.06.008_bib143) 2014; 11
Scharhag (10.1016/j.pbiomolbio.2021.06.008_bib198) 2013; 110
Vaccari (10.1016/j.pbiomolbio.2021.06.008_bib223) 1999; 1446
Baruscotti (10.1016/j.pbiomolbio.2021.06.008_bib25) 1996; 492
Fontenla (10.1016/j.pbiomolbio.2021.06.008_bib83) 2017; 70
Verrier (10.1016/j.pbiomolbio.2021.06.008_bib228) 2009; 2
Yanagihara (10.1016/j.pbiomolbio.2021.06.008_bib240) 1980; 30
Roche (10.1016/j.pbiomolbio.2021.06.008_bib190) 2001; 21
Peigh (10.1016/j.pbiomolbio.2021.06.008_bib178) 2020; 4
Hiss (10.1016/j.pbiomolbio.2021.06.008_bib95) 1962; 25
Ludwig (10.1016/j.pbiomolbio.2021.06.008_bib138) 1998; 393
Long (10.1016/j.pbiomolbio.2021.06.008_bib137) 2020; 147
Kolloch (10.1016/j.pbiomolbio.2021.06.008_bib119) 2008; 29
Babapoor-Farrokhran (10.1016/j.pbiomolbio.2021.06.008_bib19) 2020
Hasking (10.1016/j.pbiomolbio.2021.06.008_bib92) 1986; 73
Luu (10.1016/j.pbiomolbio.2021.06.008_bib141) 1989; 80
Baruscotti (10.1016/j.pbiomolbio.2021.06.008_bib24) 2011; 108
Brennan (10.1016/j.pbiomolbio.2021.06.008_bib48) 2020; 6
Jose (10.1016/j.pbiomolbio.2021.06.008_bib112) 1969; 48
Howarth (10.1016/j.pbiomolbio.2021.06.008_bib98) 2005; 90
Crespo-Leiro (10.1016/j.pbiomolbio.2021.06.008_bib60) 2016; 18
Zhang (10.1016/j.pbiomolbio.2021.06.008_bib248) 2019; 10
Baruscotti (10.1016/j.pbiomolbio.2021.06.008_bib22) 2005; 107
Laroumanie (10.1016/j.pbiomolbio.2021.06.008_bib127) 2014; 129
D'Souza (10.1016/j.pbiomolbio.2021.06.008_bib67) 2021; 18
Kanemoto (10.1016/j.pbiomolbio.2021.06.008_bib113) 1979; 20
Ntalianis (10.1016/j.pbiomolbio.2021.06.008_bib171) 2006; 14
Blanton (10.1016/j.pbiomolbio.2021.06.008_bib39) 2019; 317
D'Souza (10.1016/j.pbiomolbio.2021.06.008_bib65) 2015; 593
Zhang (10.1016/j.pbiomolbio.2021.06.008_bib247) 1998; 511
Bloch Thomsen (10.1016/j.pbiomolbio.2021.06.008_bib40) 2010; 122
Aminu (10.1016/j.pbiomolbio.2021.06.008_bib12) 2021
de Melo (10.1016/j.pbiomolbio.2021.06.008_bib68) 2002; 3
Kollai (10.1016/j.pbiomolbio.2021.06.008_bib118) 1994; 15
Yamaya (10.1016/j.pbiomolbio.2021.06.008_bib238) 1997; 59
Sanders (10.1016/j.pbiomolbio.2021.06.008_bib196) 2004; 110
Stephenson (10.1016/j.pbiomolbio.2021.06.008_bib208) 2017; 7
Johansen (10.1016/j.pbiomolbio.2021.06.008_bib1
References_xml – volume: 59
  start-page: 149
  year: 1997
  end-page: 151
  ident: bib238
  article-title: Intrinsic atrioventricular conductive function in horses with a second degree atrioventricular block
  publication-title: J. Vet. Med. Sci.
– volume: 64
  start-page: 1334
  year: 2014
  end-page: 1343
  ident: bib159
  article-title: Biophysical characterisation of the under-appreciated and important relationship between heart rate variability and heart rate
  publication-title: Hypertension
– volume: 22
  start-page: 519
  year: 1929
  end-page: 529
  ident: bib213
  article-title: The pulse rate and range in health and disease during childhood
  publication-title: Q. J. Med.
– volume: 286
  start-page: 44811
  year: 2011
  end-page: 44820
  ident: bib136
  article-title: Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels
  publication-title: J. Biol. Chem.
– volume: 13
  start-page: 801
  year: 1956
  end-page: 824
  ident: bib179
  article-title: Some clinical features of complete heart block
  publication-title: Circulation
– volume: 34
  start-page: 2768
  year: 2013
  end-page: 2775
  ident: bib76
  article-title: Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation
  publication-title: Eur. Heart J.
– volume: 110
  start-page: 14
  year: 2013
  end-page: 23
  ident: bib198
  article-title: Competitive sports and the heart: benefit or risk?
  publication-title: Dtsch. Ärztebl. Int.
– volume: 51
  start-page: 103
  year: 1995
  end-page: 108
  ident: bib82
  article-title: Heart rate variability in infants, children and young adults
  publication-title: J. Auton. Nerv. Syst.
– volume: 26
  start-page: 2504
  year: 2020
  end-page: 2506
  ident: bib105
  article-title: Relative bradycardia in patients with mild-to-moderate coronavirus disease, Japan
  publication-title: Emerg. Infect. Dis.
– volume: 50
  start-page: 434
  year: 2001
  end-page: 442
  ident: bib246
  article-title: Autonomic indexes based on the analysis of heart rate variability: a view from the sinus node
  publication-title: Cardiovasc. Res.
– volume: 11
  year: 2016
  ident: bib81
  article-title: Different profile of mRNA expression in sinoatrial node from streptozotocin-induced diabetic rat
  publication-title: PloS One
– volume: 448
  start-page: 53
  year: 1992
  end-page: 72
  ident: bib88
  article-title: Background current in sino-atrial node cells of the rabbit heart
  publication-title: J. Physiol.
– volume: 12
  start-page: 157
  year: 2004
  end-page: 164
  ident: bib97
  article-title: Recommendations and cardiological evaluation of athletes with arrythmias
  publication-title: Neth. Heart J.
– volume: 241
  start-page: 364
  year: 2017
  end-page: 372
  ident: bib93
  article-title: A novel 'splice site' HCN4 Gene mutation, c.1737+1 G>T, causes familial bradycardia, reduced heart rate response, impaired chronotropic competence and increased short-term heart rate variability
  publication-title: Int. J. Cardiol.
– volume: 10
  year: 2020
  ident: bib216
  article-title: The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID-19
  publication-title: Clin. Transl. Med.
– volume: 34
  start-page: 1732
  year: 2013
  end-page: 1739
  ident: bib108
  article-title: Resting, night-time, and 24 h heart rate as markers of cardiovascular risk in middle-aged and elderly men and women with no apparent heart disease
  publication-title: Eur. Heart J.
– volume: 88
  start-page: 2953
  year: 1993
  end-page: 2961
  ident: bib210
  article-title: Sudden death prevention in patients with advanced ventricular dysfunction
  publication-title: Circulation
– volume: 4
  start-page: 1
  year: 2020
  end-page: 6
  ident: bib178
  article-title: Novel coronavirus 19 (COVID-19) associated sinus node dysfunction: a case series
  publication-title: Eur. Heart J. - Case Rep.
– volume: 24
  start-page: 257
  year: 2020
  ident: bib100
  article-title: Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia
  publication-title: Crit. Care
– volume: 73
  start-page: 1006
  year: 1994
  end-page: 1009
  ident: bib104
  article-title: Decreased circadian blood pressure variation up to three years after heart transplantation
  publication-title: Am. J. Cardiol.
– volume: 9
  start-page: 43
  year: 2013
  end-page: 50
  ident: bib30
  article-title: Effect of training on intrinsic and resting heart rate and plasma volume in young and old horses
  publication-title: Comp. Exerc. Physiol.
– volume: 99
  start-page: 1384
  year: 2006
  end-page: 1393
  ident: bib217
  article-title: Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit
  publication-title: Circ. Res.
– volume: 195
  start-page: 185
  year: 1968
  end-page: 214
  ident: bib168
  article-title: The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres
  publication-title: J. Physiol.
– volume: 48
  year: 2010
  ident: bib237
  article-title: Changes in ion channel expression in right-sided congestive heart failure
  publication-title: J. Mol. Cell. Cardiol.
– volume: 1446
  start-page: 419
  year: 1999
  end-page: 425
  ident: bib223
  article-title: The human gene coding for HCN2, a pacemaker channel of the heart
  publication-title: Biochim. Biophys. Acta
– volume: 33
  start-page: 169
  year: 1996
  end-page: 170
  ident: bib129
  article-title: Prevalence of diabetes in elderly patients requiring permanent cardiac pacemaker insertion
  publication-title: Acta Diabetol.
– volume: 107
  start-page: 206
  year: 2011
  end-page: 208
  ident: bib182
  article-title: Bradycardia: an important physical finding in anorexia nervosa
  publication-title: J. Ark. Med. Soc.
– volume: 11
  start-page: 1055
  year: 2014
  end-page: 1062
  ident: bib143
  article-title: A novel trafficking-defective HCN4 mutation is associated with early-onset atrial fibrillation
  publication-title: Heart Rhythm
– volume: 33
  start-page: 889
  year: 2003
  end-page: 919
  ident: bib17
  article-title: Heart rate variability in athletes
  publication-title: Sports Med.
– year: 2021
  ident: bib212
  article-title: Development of Constructs for Cardiac Conduction System Specific Gene Therapy
– volume: 294
  start-page: H1581
  year: 2008
  end-page: H1588
  ident: bib214
  article-title: Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
– volume: 29
  start-page: 71
  year: 2008
  end-page: 78
  ident: bib21
  article-title: Sinus node disease and arrhythmias in the long-term follow-up of former professional cyclists
  publication-title: Eur. Heart J.
– volume: 55
  start-page: 180
  year: 2012
  end-page: 186
  ident: bib186
  article-title: Arrhythmias in pulmonary arterial hypertension
  publication-title: Prog. Cardiovasc. Dis.
– volume: 13
  year: 2020
  ident: bib32
  article-title: Lopinavir-ritonavir treatment for COVID-19 infection in intensive care unit: risk of bradycardia
  publication-title: Circ.: Arrhythm. Electrophysiol.
– volume: 115
  start-page: 1183
  year: 2007
  end-page: 1190
  ident: bib109
  article-title: Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node
  publication-title: Circulation
– volume: 82
  start-page: 19
  year: 1982
  end-page: 24
  ident: bib215
  article-title: Twenty-four hour continuous ECG recordings in long-distance runners
  publication-title: Chest
– volume: 26
  start-page: 1019
  year: 2009
  end-page: 1068
  ident: bib130
  article-title: Discoveries of rhythms in human biological functions: a historical review
  publication-title: Chronobiol. Int.
– volume: 140
  start-page: 2089
  year: 2019
  end-page: 2107
  ident: bib148
  article-title: Single-cell sequencing of mouse heart immune infiltrate in pressure overload-driven heart failure reveals extent of immune activation
  publication-title: Circulation
– volume: 115
  start-page: 1576
  year: 2019
  end-page: 1595
  ident: bib158
  article-title: Complexities in cardiovascular rhythmicity: perspectives on circadian normality, ageing and disease
  publication-title: Cardiovasc. Res.
– volume: 152
  start-page: 80
  year: 2015
  end-page: 90
  ident: bib101
  article-title: Age-dependent alterations of voltage-gated Na
  publication-title: Mech. Ageing Dev.
– volume: 11
  start-page: 546508
  year: 2020
  ident: bib7
  article-title: Cardiac pacemaker dysfunction arising from different studies of ion channel remodeling in the aging rat heart
  publication-title: Front. Physiol.
– volume: 22
  start-page: 260
  year: 2020
  end-page: 264
  ident: bib94
  article-title: Relative bradycardia as a clinical feature in patients with coronavirus disease 2019 (COVID-19): a report of two cases
  publication-title: J. Cardiol. Cases
– volume: 596
  start-page: 6141
  year: 2018
  end-page: 6155
  ident: bib58
  article-title: TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome
  publication-title: J. Physiol.
– volume: 102
  start-page: 429
  year: 2007
  end-page: 435
  ident: bib102
  article-title: Age-related down-regulation of HCN channels in rat sinoatrial node
  publication-title: Basic Res. Cardiol.
– volume: 48
  start-page: 2019
  year: 1969
  end-page: 2031
  ident: bib112
  article-title: Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man
  publication-title: J. Clin. Invest.
– volume: 41
  start-page: 172
  year: 1907
  end-page: 189
  ident: bib115
  article-title: The form and nature of the muscular connections between the primary divisions of the vertebrate heart
  publication-title: J. Anat Physiol.
– volume: 71
  start-page: 720
  year: 1993
  end-page: 726
  ident: bib200
  article-title: First- or second-degree atrioventricular block as a risk factor in idiopathic dilated cardiomyopathy
  publication-title: Am. J. Cardiol.
– volume: 55
  start-page: 1091
  year: 1994
  end-page: 1099
  ident: bib232
  article-title: The suprachiasmatic nucleus controls the circadian rhythm of heart rate via the sympathetic nervous system
  publication-title: Physiol. Behav.
– volume: 314
  start-page: 359
  year: 1981
  end-page: 376
  ident: bib69
  article-title: A new interpretation of the pace-maker current in calf Purkinje fibres
  publication-title: J. Physiol.
– volume: 93
  start-page: 1102
  year: 2003
  end-page: 1110
  ident: bib74
  article-title: Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart
  publication-title: Circ. Res.
– volume: 96
  start-page: 260
  year: 1997
  end-page: 266
  ident: bib5
  article-title: Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial
  publication-title: Circulation
– volume: 28
  start-page: 586
  year: 2007
  end-page: 589
  ident: bib204
  article-title: A case of bradycardia-induced severe right-sided heart failure with cardiogenic shock rescued by right ventricular pacing
  publication-title: Ther. Res.
– volume: 272
  start-page: H1549
  year: 1997
  end-page: H1552
  ident: bib2
  article-title: Properties and modulation of i
  publication-title: Am. J. Physiol.
– volume: 90
  start-page: 827
  year: 2005
  end-page: 835
  ident: bib99
  article-title: Long-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats
  publication-title: Exp. Physiol.
– volume: 35
  start-page: 123
  year: 2014
  end-page: 129
  ident: bib16
  article-title: Prognostic significance of prolonged PR interval in the general population
  publication-title: Eur. Heart J.
– volume: 15
  start-page: 401
  year: 1997
  end-page: 410
  ident: bib172
  article-title: Autonomic control of ultradian and circadian rhythms of blood pressure, heart rate, and baroreflex sensitivity in spontaneously hypertensive rats
  publication-title: J. Hypertens.
– volume: 94
  start-page: 2953
  year: 1996
  end-page: 2960
  ident: bib79
  article-title: Pacing-induced chronic atrial fibrillation impairs sinus node function in dogs. Electrophysiological remodeling
  publication-title: Circulation
– volume: 69
  start-page: 529
  year: 2016
  end-page: 530
  ident: bib191
  article-title: Symptomatic bradycardia and heart failure triggered by ivabradine in a patient receiving antiretroviral therapy
  publication-title: Rev. Española Cardiol.
– volume: 16
  start-page: 298
  year: 2018
  end-page: 307
  ident: bib38
  article-title: Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms
  publication-title: Heart Rhythm
– volume: 80
  start-page: 1675
  year: 1989
  end-page: 1680
  ident: bib141
  article-title: Diverse mechanisms of unexpected cardiac arrest in advanced heart failure
  publication-title: Circulation
– volume: 2
  start-page: 9
  year: 2001
  end-page: 12
  ident: bib6
  article-title: Development of heart failure in bradycardic sick sinus syndrome
  publication-title: Ital. Heart J.
– volume: 106
  start-page: 647
  year: 2010
  end-page: 658
  ident: bib77
  article-title: The cardiomyocyte circadian clock: emerging roles in health and disease
  publication-title: Circ. Res.
– volume: 2
  start-page: 181
  year: 2016
  end-page: 192
  ident: bib166
  article-title: Outcomes related to first-degree atrioventricular block and therapeutic implications in patients with heart failure
  publication-title: JACC Clin. Electrophysiol.
– volume: 11
  start-page: 2288
  year: 2014
  end-page: 2296
  ident: bib227
  article-title: I
  publication-title: Heart Rhythm
– volume: 45
  start-page: C06
  year: 2019
  ident: bib13
  article-title: MicroRNA control of the circadian rhythm in heart rate
  publication-title: Proc. Physiol. Soc.
– volume: 30
  start-page: 841
  year: 1980
  end-page: 857
  ident: bib240
  article-title: Reconstruction of sino-atrial node pacemaker potential based on the voltage clamp experiments
  publication-title: Jpn. J. Physiol.
– volume: 96
  start-page: 294
  year: 2008
  end-page: 304
  ident: bib134
  article-title: Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node
  publication-title: Prog. Biophys. Mol. Biol.
– volume: 202
  start-page: 73
  year: 2016
  end-page: 74
  ident: bib54
  article-title: Addition of ivabradine to betablockers in patients with atrial fibrillation: effects on heart rate and exercise tolerance
  publication-title: Int. J. Cardiol.
– volume: 17
  start-page: 1439
  year: 2020
  end-page: 1444
  ident: bib34
  article-title: COVID-19 and cardiac arrhythmias
  publication-title: Heart Rhythm
– volume: 123
  start-page: 1010
  year: 2011
  end-page: 1020
  ident: bib50
  article-title: Chronotropic incompetence: causes, consequences, and management
  publication-title: Circulation
– volume: 114
  start-page: 1633
  year: 2006
  end-page: 1644
  ident: bib147
  article-title: The heart of trained athletes: cardiac remodeling and the risks of sports, including sudden death
  publication-title: Circulation
– volume: 11
  start-page: 1798
  year: 2020
  ident: bib36
  article-title: Genetic ablation of G protein-gated inwardly rectifying K
  publication-title: Front. Physiol.
– volume: 7
  start-page: 7188
  year: 2017
  ident: bib208
  article-title: High resolution 3-dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling
  publication-title: Sci. Rep.
– year: 2008
  ident: bib163
  article-title: The Electrophysiology of the Atrioventricular Node in Normal and Failing Rabbit Hearts
– volume: 21
  start-page: 67
  year: 2020
  end-page: 84
  ident: bib177
  article-title: Molecular mechanisms and physiological importance of circadian rhythms
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 122
  start-page: 1258
  year: 2010
  end-page: 1264
  ident: bib40
  article-title: Long-term recording of cardiac arrhythmias with an implantable cardiac monitor in patients with reduced ejection fraction after acute myocardial infarction: the Cardiac Arrhythmias and Risk Stratification after Acute Myocardial Infarction (CARISMA) study
  publication-title: Circulation
– volume: 32
  start-page: 37
  year: 2009
  end-page: 42
  ident: bib61
  article-title: Electrocardiograms of collegiate football athletes
  publication-title: Clin. Cardiol.
– volume: 107
  start-page: 126
  year: 2010
  end-page: 137
  ident: bib52
  article-title: Mechanistic links between Na
  publication-title: Circ. Res.
– volume: 5
  start-page: 4664
  year: 2014
  ident: bib150
  article-title: Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation
  publication-title: Nat. Commun.
– volume: 47
  start-page: 213
  year: 1982
  end-page: 220
  ident: bib229
  article-title: Ambulatory electrocardiographic recording in endurance athletes
  publication-title: Br. Heart J.
– volume: 55
  start-page: 253
  year: 1986
  end-page: 258
  ident: bib31
  article-title: Diurnal variation of the QT interval - influence of the autonomic nervous system
  publication-title: Br. Heart J.
– volume: 127
  start-page: 183
  year: 2006
  end-page: 190
  ident: bib183
  article-title: Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents
  publication-title: J. Gen. Physiol.
– year: 2020
  ident: bib55
  article-title: Relative bradycardia in patients with COVID-19
  publication-title: Clin. Microbiol. Infect.
– volume: 72
  start-page: 293
  year: 2016
  end-page: 302
  ident: bib75
  article-title: β1-adrenergic blocker bisoprolol reverses down-regulated ion channels in sinoatrial node of heart failure rats
  publication-title: J. Physiol. Biochem.
– volume: 96
  start-page: 1163
  year: 2011
  end-page: 1178
  ident: bib218
  article-title: Ageing-dependent remodelling of ion channel and Ca
  publication-title: Exp. Physiol.
– volume: 511
  start-page: 76P
  year: 1998
  end-page: 77P
  ident: bib247
  article-title: A hypothesis to explain the decline of sinoatrial node function with age
  publication-title: J. Physiol.
– volume: 14
  start-page: 1278
  year: 1993
  end-page: 1288
  ident: bib10
  article-title: Electrophysiology of the ageing rabbit and cat sinoatrial node - a comparative study
  publication-title: Eur. Heart J.
– volume: 393
  start-page: 15
  year: 1982
  end-page: 22
  ident: bib117
  article-title: Membrane currents in the rabbit atrioventricular node cell
  publication-title: Pflügers Archiv
– volume: 2
  start-page: 58
  year: 2019
  ident: bib18
  article-title: Real-world heart rate norms in the Health eHeart study
  publication-title: npj Digital Medicine
– volume: 498
  start-page: 641
  year: 1997
  end-page: 648
  ident: bib26
  article-title: The newborn rabbit sino-atrial node expresses a neuronal type I-like Na
  publication-title: J. Physiol.
– volume: 110
  start-page: 897
  year: 2004
  end-page: 903
  ident: bib196
  article-title: Remodeling of sinus node function in patients with congestive heart failure: reduction in sinus node reserve
  publication-title: Circulation
– volume: 6
  start-page: 92
  year: 2001
  end-page: 97
  ident: bib71
  article-title: Circadian behavior of P-wave duration, P-wave area, and PR interval in healthy subjects
  publication-title: Ann. Noninvasive Electrocardiol.
– volume: 4
  start-page: 160
  year: 1970
  end-page: 167
  ident: bib111
  article-title: The normal range and determinants of the intrinsic heart rate in man
  publication-title: Cardiovasc. Res.
– volume: 52
  start-page: 1652
  year: 1982
  end-page: 1657
  ident: bib114
  article-title: Sympathetic and parasympathetic cardiac control in athletes and nonathletes at rest
  publication-title: J. Appl. Physiol.
– volume: 111
  start-page: 1537
  year: 2003
  end-page: 1545
  ident: bib202
  article-title: Pacemaker channel dysfunction in a patient with sinus node disease
  publication-title: J. Clin. Invest.
– volume: 294
  start-page: 970
  year: 2011
  end-page: 979
  ident: bib56
  article-title: Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area
  publication-title: Anat. Rec.
– volume: 65
  start-page: 1263
  year: 2015
  end-page: 1265
  ident: bib233
  article-title: Bradycardia and asystole is the predominant mechanism of sudden cardiac death in patients with chronic kidney disease
  publication-title: J. Am. Coll. Cardiol.
– volume: 87
  start-page: 691
  year: 2013
  end-page: 696
  ident: bib203
  article-title: Sick sinus syndrome: a review
  publication-title: Am. Fam. Physician
– volume: 29
  start-page: 111
  year: 1994
  end-page: 114
  ident: bib29
  article-title: ‘Congestive heart failure’ and bradycardia
  publication-title: Hosp. Pract.
– volume: 48
  start-page: 653
  year: 2010
  end-page: 662
  ident: bib243
  article-title: Structural remodelling of the sinoatrial node in obese old rats
  publication-title: J. Mol. Cell. Cardiol.
– volume: 75
  start-page: 2517
  year: 1975
  end-page: 2521
  ident: bib193
  article-title: Diabetes mellitus and impaired atrioventricular conduction
  publication-title: N. Y. State J. Med.
– volume: 63
  start-page: 133
  year: 2013
  end-page: 146
  ident: bib3
  article-title: The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice
  publication-title: J. Physiol. Sci.
– volume: 7
  year: 2012
  ident: bib209
  article-title: Contrast enhanced micro-computed tomography resolves the 3-dimensional morphology of the cardiac conduction system in mammalian hearts
  publication-title: PloS One
– volume: 222
  start-page: 213
  year: 2016
  end-page: 216
  ident: bib20
  article-title: Exercise training bradycardia is largely explained by reduced intrinsic heart rate
  publication-title: Int. J. Cardiol.
– volume: 139
  start-page: 260
  year: 2013
  end-page: 288
  ident: bib72
  article-title: Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues
  publication-title: Pharmacol. Ther.
– year: 2020
  ident: bib188
  article-title: Patients with type 2 diabetes have an increased demand for pacemaker treatment: a comparison with age- and sex-matched control subjects from the general population
  publication-title: Diabetes Care
– volume: 4
  start-page: 397
  year: 2011
  end-page: 406
  ident: bib90
  article-title: TGF-β1 mediated fibrosis and ion channel remodeling are key mechanisms producing sinus node dysfunction associated with SCN5A deficiency and aging
  publication-title: Circ.: Arrhythm. Electrophysiol.
– volume: 33
  start-page: 1058
  year: 2012
  end-page: 1066
  ident: bib175
  article-title: The human sympathetic nervous system: its relevance in hypertension and heart failure
  publication-title: Eur. Heart J.
– volume: 34
  start-page: 314
  year: 2019
  end-page: 326
  ident: bib66
  article-title: Supraventricular arrhythmias in athletes: basic mechanisms and new directions
  publication-title: Physiology
– volume: 12
  year: 2016
  ident: bib126
  article-title: NPAS2 compensates for loss of CLOCK in peripheral circadian oscillators
  publication-title: PLoS Genet.
– volume: 3
  start-page: 48
  year: 1880
  end-page: 92
  ident: bib85
  article-title: On the tonicity of the heart and blood vessels
  publication-title: J. Physiol.
– volume: 47
  start-page: 631
  year: 2016
  end-page: 639
  ident: bib221
  article-title: Circadian expression of connexins in the mouse heart
  publication-title: Biol. Rhythm. Res.
– volume: 7
  start-page: 127
  year: 2010
  end-page: 135
  ident: bib43
  article-title: Cardiac Purkinje cells
  publication-title: Heart Rhythm
– volume: 9
  year: 2020
  ident: bib181
  article-title: Identification of key small non-coding microRNAs controlling pacemaker mechanisms in the human sinus node
  publication-title: J. Am. Heart Assoc.
– volume: 11
  year: 2016
  ident: bib27
  article-title: Cardiomyocyte circadian oscillations are cell-autonomous, amplified by β-adrenergic signaling, and synchronized in cardiac ventricle tissue
  publication-title: PloS One
– volume: 121
  start-page: 513
  year: 2002
  end-page: 518
  ident: bib42
  article-title: The prognostic role of the ECG in primary pulmonary hypertension
  publication-title: Chest
– volume: 149
  start-page: 237
  year: 2017
  end-page: 247
  ident: bib205
  article-title: Cyclic AMP reverses the effects of aging on pacemaker activity and i
  publication-title: J. Gen. Physiol.
– volume: 83
  start-page: 88
  year: 2015
  end-page: 100
  ident: bib157
  article-title: Sick sinus syndrome and atrial fibrillation in older persons - a view from the sinoatrial nodal myocyte
  publication-title: J. Mol. Cell. Cardiol.
– volume: 16
  start-page: 148
  year: 2007
  end-page: 155
  ident: bib225
  article-title: Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiod
  publication-title: J. Sleep Res.
– volume: 108
  start-page: 760
  year: 2003
  end-page: 766
  ident: bib226
  article-title: Ionic remodeling of sinoatrial node cells by heart failure
  publication-title: Circulation
– volume: 29
  start-page: 1327
  year: 2008
  end-page: 1334
  ident: bib119
  article-title: Impact of resting heart rate on outcomes in hypertensive patients with coronary artery disease: findings from the INternational VErapamil-SR/trandolapril STudy (INVEST)
  publication-title: Eur. Heart J.
– volume: 8
  start-page: 1258
  year: 2017
  ident: bib244
  article-title: Mammalian gamma2 AMPK regulates intrinsic heart rate
  publication-title: Nat. Commun.
– volume: 492
  start-page: 21
  year: 1996
  end-page: 30
  ident: bib25
  article-title: A TTX-sensitive inward sodium current contributes to spontaneous activity in newborn rabbit sino-atrial node cells
  publication-title: J. Physiol.
– volume: 10
  year: 2015
  ident: bib165
  article-title: Congestive heart failure leads to prolongation of the PR Interval and atrioventricular junction enlargement and ion channel remodelling in the rabbit
  publication-title: PloS One
– volume: 126
  start-page: 258
  year: 2020
  end-page: 279
  ident: bib187
  article-title: Chronobiological influence over cardiovascular function: the good, the bad, and the ugly
  publication-title: Circ. Res.
– volume: 100
  start-page: 160
  year: 2013
  end-page: 169
  ident: bib162
  article-title: Characterization of a right atrial subsidiary pacemaker and acceleration of the pacing rate by HCN over-expression
  publication-title: Cardiovasc. Res.
– volume: 110
  start-page: E3037
  year: 2013
  end-page: E3046
  ident: bib195
  article-title: Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– volume: 147
  start-page: 27
  year: 2020
  end-page: 34
  ident: bib137
  article-title: Contribution of estrogen to the pregnancy-induced increase in cardiac automaticity
  publication-title: J. Mol. Cell. Cardiol.
– volume: 28
  start-page: 74
  year: 2013
  end-page: 92
  ident: bib160
  article-title: Modern concepts concerning the origin of the heartbeat
  publication-title: Physiology
– volume: 64
  start-page: 745
  year: 2014
  end-page: 756
  ident: bib154
  article-title: HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy
  publication-title: J. Am. Coll. Cardiol.
– volume: 38
  start-page: 280
  year: 2015
  end-page: 288
  ident: bib23
  article-title: A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial inappropriate sinus tachycardia
  publication-title: Eur. Heart J.
– volume: 20
  start-page: 252
  year: 1999
  end-page: 255
  ident: bib4
  article-title: Is sinus bradycardia a factor facilitating overt heart failure?
  publication-title: Eur. J. Heart Fail.
– volume: 3
  start-page: 479
  year: 2009
  end-page: 483
  ident: bib161
  article-title: Perspectives - biological pacing, a clinical reality?
  publication-title: Ther. Adv. Cardiovasc. Dis.
– volume: 66
  start-page: 470
  year: 2009
  end-page: 494
  ident: bib230
  article-title: HCN channels: structure, cellular regulation and physiological function
  publication-title: Cell. Mol. Life Sci.
– volume: 66
  start-page: 472
  year: 2005
  end-page: 481
  ident: bib251
  article-title: Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model
  publication-title: Cardiovasc. Res.
– volume: 95
  start-page: 586
  year: 2016
  end-page: 594
  ident: bib103
  article-title: Reduced expression of HCN channels in the sinoatrial node of streptozotocin-induced diabetic rats
  publication-title: Can. J. Physiol. Pharmacol.
– volume: 31
  start-page: 286
  year: 2020
  end-page: 292
  ident: bib149
  article-title: Pacing induced cardiomyopathy
  publication-title: J. Cardiovasc. Electrophysiol.
– volume: 120
  start-page: 18
  year: 2020
  end-page: 21
  ident: bib45
  article-title: Are you ruled by your head or your heart? Neurogenic versus myogenic debate on origin of the heart beat
  publication-title: Physiol. News
– start-page: 1215
  year: 1995
  end-page: 1247
  ident: bib28
  article-title: Sinus node dysfunction: pathophysiology, clinical features, evaluation, and treatment
  publication-title: Cardiac Electrophysiology: from Cell to Bedside
– volume: 78
  start-page: 938
  year: 2014
  end-page: 942
  ident: bib249
  article-title: A novel HCN4 mutation, G1097W, is associated with atrioventricular block
  publication-title: Circ. J.
– volume: 10
  start-page: 826
  year: 2019
  ident: bib248
  article-title: Electrical conduction system remodeling in streptozotocin-induced diabetes mellitus rat heart
  publication-title: Front. Physiol.
– volume: 107
  start-page: 59
  year: 2005
  end-page: 79
  ident: bib22
  article-title: Physiology and pharmacology of the cardiac pacemaker ("funny") current
  publication-title: Pharmacol. Ther.
– volume: 108
  start-page: 1705
  year: 2011
  end-page: 1710
  ident: bib24
  article-title: Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– year: 2007
  ident: bib192
  article-title: Biological pacemakers based on i
  publication-title: Biopacemaking Series in Biomedical Engineering
– volume: 20
  start-page: 765
  year: 1979
  end-page: 775
  ident: bib113
  article-title: Arrhythmias in primary pulmonary hypertension
  publication-title: Jpn. Heart J.
– volume: 18
  start-page: 613
  year: 2016
  end-page: 625
  ident: bib60
  article-title: European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions
  publication-title: Eur. J. Heart Fail.
– volume: 57
  start-page: 760
  year: 1993
  end-page: 768
  ident: bib122
  article-title: Age-related changes of sinus node function and autonomic regulation in subjects without sinus node disease: assessment by pharmacologic autonomic blockade
  publication-title: Jpn. Circ. J.
– volume: 16
  start-page: 1655
  year: 1995
  end-page: 1667
  ident: bib9
  article-title: Age-related changes in structure and relative collagen content of the human and feline sinoatrial node. A comparative study
  publication-title: Eur. Heart J.
– volume: 47
  start-page: 157
  year: 2009
  end-page: 170
  ident: bib123
  article-title: What keeps us ticking: a funny current, a calcium clock, or both?
  publication-title: J. Mol. Cell. Cardiol.
– volume: 96
  start-page: 426
  year: 2011
  end-page: 438
  ident: bib1
  article-title: Changes in the expression of ion channels, connexins and Ca
  publication-title: Exp. Physiol.
– volume: 119
  start-page: 1576
  year: 2009
  end-page: 1585
  ident: bib245
  article-title: Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome
  publication-title: Circulation
– volume: 13
  start-page: 27
  year: 2015
  end-page: 34
  ident: bib107
  article-title: Different characteristics of heart failure due to pump failure and bradyarrhythmia
  publication-title: J. Echocardiogr.
– volume: 5
  start-page: 251
  year: 2011
  end-page: 261
  ident: bib146
  article-title: Functional roles of Ca
  publication-title: Channels
– volume: 129
  start-page: 2111
  year: 2014
  end-page: 2124
  ident: bib127
  article-title: CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload
  publication-title: Circulation
– volume: 385
  start-page: 11
  year: 1980
  end-page: 19
  ident: bib239
  article-title: Inward current activated during hyperpolarization in the rabbit sinoatrial node cell
  publication-title: Pflügers Archiv
– volume: 48
  start-page: 172
  year: 2010
  end-page: 180
  ident: bib185
  article-title: Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node
  publication-title: J. Mol. Cell. Cardiol.
– volume: 5
  start-page: 3775
  year: 2014
  ident: bib63
  article-title: Exercise training reduces resting heart rate via downregulation of the funny channel HCN4
  publication-title: Nat. Commun.
– volume: 37
  start-page: 2244
  year: 2005
  end-page: 2246
  ident: bib120
  article-title: Impact of cardiac transplantation in 24 hours circadian blood pressure and heart rate profile
  publication-title: Transplant. Proc.
– volume: 111
  start-page: 846
  year: 2005
  end-page: 854
  ident: bib73
  article-title: Computer three-dimensional reconstruction of the sinoatrial node
  publication-title: Circulation
– volume: 8
  start-page: 17
  year: 2006
  end-page: 81
  ident: bib15
  article-title: A brief history of cardiac pacing
  publication-title: Images Paediatr. Cardiol.
– volume: 22
  start-page: 83
  year: 2013
  end-page: 94
  ident: bib236
  article-title: The significance of bradycardia in anorexia nervosa
  publication-title: Int. J. Angiol.
– volume: 15
  start-page: 1113
  year: 1994
  end-page: 1118
  ident: bib118
  article-title: Cardiac vagal hyperactivity in adolescent anorexia nervosa
  publication-title: Eur. Heart J.
– volume: 32
  start-page: 516
  year: 1998
  end-page: 520
  ident: bib57
  article-title: A double-blind placebo-controlled evaluation of the human electrophysiologic effects of zatebradine, a sinus node inhibitor
  publication-title: J. Cardiovasc. Pharmacol.
– volume: 33
  year: 2019
  ident: bib33
  article-title: Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmic enhancer–enhancer interactions
  publication-title: Genes Dev.
– volume: 17
  start-page: 162
  year: 2016
  ident: bib14
  article-title: Case report: severe bradycardia, a reversible cause of “Cardio-Renal-Cerebral Syndrome”
  publication-title: BMC Nephrol.
– volume: 304
  start-page: C954
  year: 2013
  end-page: C965
  ident: bib201
  article-title: The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility
  publication-title: Am. J. Physiol. Cell Physiol.
– volume: 69
  start-page: 2129
  year: 1993
  end-page: 2136
  ident: bib142
  article-title: Properties of the hyperpolarization-activated current in rat hippocampal CA1 pyramidal cells
  publication-title: J. Neurophysiol.
– volume: 397
  start-page: 190
  year: 1983
  end-page: 194
  ident: bib169
  article-title: Does the "pacemaker current" generate the diastolic depolarization in the rabbit SA node cells?
  publication-title: Pflügers Archiv
– volume: 11
  start-page: 3565
  year: 2021
  ident: bib231
  article-title: RNAseq shows an all-pervasive circadian rhythm in the transcriptome of the pacemaker of the heart, the sinus node
  publication-title: Sci. Rep.
– volume: 61
  start-page: 155
  year: 1989
  end-page: 160
  ident: bib170
  article-title: Electrocardiographic findings in male veteran endurance athletes
  publication-title: Br. Heart J.
– volume: 12
  year: 2020
  ident: bib11
  article-title: Bradycardia in patients with COVID-19: a calm before the storm?
  publication-title: Cureus
– volume: 198
  start-page: 341
  year: 1975
  end-page: 347
  ident: bib91
  article-title: Treatment of sinoatrial syndrome with permanent cardiac pacing in 90 patients
  publication-title: Acta Med. Scand.
– volume: 274
  start-page: 12835
  year: 1999
  end-page: 12839
  ident: bib106
  article-title: Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node
  publication-title: J. Biol. Chem.
– volume: 354
  start-page: 151
  year: 2006
  end-page: 157
  ident: bib153
  article-title: Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel
  publication-title: N. Engl. J. Med.
– volume: 76
  start-page: 493
  year: 1987
  end-page: 500
  ident: bib84
  article-title: The origin of the heart beat: a tale of frogs, jellyfish, and turtles
  publication-title: Circulation
– volume: 101
  start-page: 2975
  year: 2000
  end-page: 2980
  ident: bib173
  article-title: Changes in sinus node function in a rabbit model of heart failure with ventricular arrhythmias and sudden death
  publication-title: Circulation
– volume: 308
  start-page: 331
  year: 1980
  end-page: 351
  ident: bib49
  article-title: Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sino-atrial node
  publication-title: J. Physiol.
– volume: 2
  start-page: 450
  year: 2009
  end-page: 459
  ident: bib228
  article-title: Impact of sleep on arrhythmogenesis
  publication-title: Circ.: Arrhythm. Electrophysiol.
– volume: 39
  start-page: 1033
  year: 2002
  end-page: 1038
  ident: bib207
  article-title: Intrinsic sinus and atrioventricular node electrophysiologic adaptations in endurance athletes
  publication-title: J. Am. Coll. Cardiol.
– volume: 9
  year: 2016
  ident: bib219
  article-title: Atrioventricular node dysfunction and ion channel transcriptome in pulmonary hypertension
  publication-title: Circ.: Arrhythm. Electrophysiol.
– volume: vol. 41
  year: 2011
  ident: bib174
  publication-title: Resting Pulse Rate Reference Data for Children, Adolescents, and Adults: United States, 1999–2008
– volume: 12
  start-page: 2047
  year: 2015
  end-page: 2055
  ident: bib234
  article-title: Temporal distribution of arrhythmic events in chronic kidney disease: highest incidence in the long interdialytic period
  publication-title: Heart Rhythm
– volume: 594
  start-page: 7105
  year: 2016
  end-page: 7126
  ident: bib155
  article-title: The impacts of age and frailty on heart rate and sinoatrial node function
  publication-title: J. Physiol.
– volume: 281
  start-page: H1252
  year: 2001
  end-page: H1259
  ident: bib184
  article-title: L-type but not T-type calcium current changes during postnatal development in rabbit sinoatrial node
  publication-title: Am. J. Physiol.
– volume: 35
  start-page: 445
  year: 2012
  end-page: 462
  ident: bib156
  article-title: Central and peripheral circadian clocks in mammals
  publication-title: Annu. Rev. Neurosci.
– volume: 18
  start-page: 2323
  year: 1999
  end-page: 2329
  ident: bib139
  article-title: Two pacemaker channels from human heart with profoundly different activation kinetics
  publication-title: EMBO J.
– year: 2021
  ident: bib152
  article-title: Why do athletes have AV block? A new role for electrical remodelling of the atrioventricular node in equine and murine models of endurance exercise
  publication-title: Circ. Res.
– volume: 18
  start-page: 801
  year: 2021
  end-page: 810
  ident: bib67
  article-title: A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate
  publication-title: Heart Rhythm
– volume: 10
  start-page: 11279
  year: 2020
  ident: bib241
  article-title: Silencing miR-370-3p rescues funny current and sinus node function in heart failure
  publication-title: Sci. Rep.
– volume: 114
  start-page: 1351
  year: 2013
  end-page: 1355
  ident: bib46
  article-title: Viewpoint: is the resting bradycardia in athletes the result of remodelling of the sinoatrial node rather than high vagal tone?
  publication-title: J. Appl. Physiol.
– volume: 294
  start-page: H1036
  year: 2008
  end-page: H1047
  ident: bib47
  article-title: Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
– volume: 30
  start-page: 451
  year: 2020
  end-page: 460
  ident: bib145
  article-title: COVID-19 infection and cardiac arrhythmias
  publication-title: Trends Cardiovasc. Med.
– volume: 9
  start-page: 261
  year: 2008
  end-page: 267
  ident: bib140
  article-title: Echocardiographic findings in former professional cyclists after long-term deconditioning of more than 30 years
  publication-title: Eur. J. Echocardiogr.
– volume: 868
  start-page: 741
  year: 1999
  end-page: 764
  ident: bib197
  article-title: The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels
  publication-title: Ann. N. Y. Acad. Sci.
– volume: 6
  start-page: 1827
  year: 2020
  end-page: 1840
  ident: bib48
  article-title: Evidence of superior and inferior sinoatrial nodes in the mammalian heart
  publication-title: JACC Clin. Electrophysiol.
– volume: 21
  start-page: 335
  year: 2001
  end-page: 342
  ident: bib190
  article-title: Chronotropic incompetence response to exercise in congestive heart failure, relationship with the cardiac autonomic status
  publication-title: Clin. Physiol. Funct. Imag.
– volume: 10
  start-page: 9835
  year: 2020
  ident: bib35
  article-title: Inhibition of G protein-gated K
  publication-title: Sci. Rep.
– volume: 393
  start-page: 587
  year: 1998
  end-page: 591
  ident: bib138
  article-title: A family of hyperpolarization-activated mammalian cation channels
  publication-title: Nature
– volume: 14
  start-page: e14
  year: 2006
  end-page: 15
  ident: bib171
  article-title: Immediate relief of congestive heart failure by ventricular pacing in chronic bradycardia
  publication-title: Cardiol. Rev.
– start-page: 1
  year: 2020
  end-page: 6
  ident: bib19
  article-title: Arrhythmia in COVID-19
  publication-title: SN Compr. Clin. Med.
– volume: 34
  start-page: 233
  year: 2001
  end-page: 242
  ident: bib224
  article-title: The 12-lead electrocardiogram in anorexia nervosa: a report of 2 cases followed by a retrospective study
  publication-title: J. Electrocardiol.
– volume: 94
  start-page: 1035
  year: 2009
  end-page: 1049
  ident: bib44
  article-title: And the beat goes on'. The cardiac conduction system: the wiring system of the heart
  publication-title: Exp. Physiol.
– volume: 121
  start-page: 1058
  year: 2017
  end-page: 1068
  ident: bib64
  article-title: Targeting miR-423-5p reverses exercise training-induced HCN4 channel remodeling and sinus bradycardia
  publication-title: Circ. Res.
– year: 2021
  ident: bib135
  article-title: Remodelling of the Purkinje network in congestive heart failure in the rabbit
  publication-title: Circ.: Heart Fail
– volume: 73
  start-page: 615
  year: 1986
  end-page: 621
  ident: bib92
  article-title: Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity
  publication-title: Circulation
– volume: 593
  start-page: 1749
  year: 2015
  end-page: 1751
  ident: bib65
  article-title: CrossTalk opposing view: bradycardia in the trained athlete is attributable to a downregulation of a pacemaker channel in the sinus node
  publication-title: J. Physiol.
– year: 2021
  ident: bib12
  article-title: Further insights into the molecular complexity of the human sinus node – the role of‘novel’ transcription factors and microRNAs
  publication-title: Prog. Biophys. Mol. Biol.
– volume: 39
  year: 2018
  ident: bib189
  article-title: Type 2 diabetes increases the need for pacemaker and implantable cardioverter defibrillator treatment - a Swedish registry report
  publication-title: Eur. Heart J.
– volume: 92
  start-page: 2162
  year: 1929
  end-page: 2168
  ident: bib41
  article-title: The heart rate during sleep as determined by the cardiotachometer: its clinical significance
  publication-title: J. Am. Med. Assoc.
– volume: 41
  start-page: 865
  year: 2014
  end-page: 868
  ident: bib131
  article-title: Theoretical study of the role of the funny current (I
  publication-title: Comput. Cardiol.
– volume: 20
  start-page: 316
  year: 2010
  end-page: 321
  ident: bib206
  article-title: Circadian clock gene Bmal1 is not essential; functional replacement with its paralog
  publication-title: Bmal2.
– volume: 434
  start-page: 23
  year: 1991
  end-page: 40
  ident: bib70
  article-title: The contribution of the 'pacemaker' current (i
  publication-title: J. Physiol.
– volume: 11
  start-page: 434
  year: 1998
  end-page: 439
  ident: bib116
  article-title: Heart block in patients with obstructive sleep apnoea: pathogenetic factors and effects of treatment
  publication-title: Eur. Respir. J.
– volume: 10
  start-page: 2889
  year: 2019
  ident: bib133
  article-title: Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
  publication-title: Nat. Commun.
– volume: 90
  start-page: 237
  year: 2005
  end-page: 245
  ident: bib98
  article-title: Short-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats
  publication-title: Exp. Physiol.
– volume: 13
  start-page: 2086
  year: 1990
  end-page: 2090
  ident: bib87
  article-title: Symptoms, cardiovascular risk profile and spontaneous ECG in paced patients: a five-year follow-up study
  publication-title: Pacing Clin. Electrophysiol.
– volume: 110
  start-page: 18011
  year: 2013
  end-page: 18016
  ident: bib128
  article-title: Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate
  publication-title: Proc. Natl. Acad. Sci. U. S. A
– volume: 2
  start-page: 1240
  year: 2020
  end-page: 1244
  ident: bib59
  article-title: Sinus node dysfunction in a young patient with COVID-19
  publication-title: JACC Case Rep.
– volume: 106
  start-page: 659
  year: 2010
  end-page: 673
  ident: bib124
  article-title: A coupled SYSTEM of intracellular Ca
  publication-title: Circ. Res.
– volume: 82
  start-page: 21
  year: 2020
  end-page: 43
  ident: bib180
  article-title: Cardiac pacemaker activity and aging
  publication-title: Annu. Rev. Physiol.
– volume: 3
  start-page: 383
  year: 2002
  end-page: 390
  ident: bib68
  article-title: Stereologic study of the sinoatrial node of rats - age related changes
  publication-title: Biogerontology
– volume: 6
  start-page: 37
  year: 2015
  ident: bib62
  article-title: Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction
  publication-title: Front. Physiol.
– volume: 87
  year: 2001
  ident: bib80
  article-title: Mechanisms and immediate outcome of in-hospital cardiac arrest in patients with advanced heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
  publication-title: Am. J. Cardiol.
– volume: 151
  start-page: 1051
  year: 2019
  end-page: 1058
  ident: bib132
  article-title: Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling
  publication-title: J. Gen. Physiol.
– volume: 64
  start-page: 1045
  year: 2011
  end-page: 1050
  ident: bib89
  article-title: The heart during pregnancy
  publication-title: Rev. Española Cardiol.
– volume: 21
  start-page: 822
  year: 2010
  end-page: 824
  ident: bib53
  article-title: Bradycardiomyopathy: the case for a causative relationship between severe sinus bradycardia and heart failure
  publication-title: J. Cardiovasc. Electrophysiol.
– volume: 15
  start-page: 752
  year: 2018
  end-page: 760
  ident: bib194
  article-title: Structural and functional remodeling of the atrioventricular node with aging in rats: the role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels
  publication-title: Heart Rhythm
– volume: 43
  start-page: SA034
  year: 2019
  ident: bib51
  article-title: Direct recordings of cardiac sympathetic and vagal parasympathetic nerve activity to clarify the underlying mechanisms of circadian heart rhythm
  publication-title: Proc. Physiol. Soc.
– volume: 44
  start-page: 519
  year: 2013
  end-page: 530
  ident: bib220
  article-title: Circadian expressions of cardiac ion channel genes in mouse might be associated with the central clock in the SCN but not the peripheral clock in the heart
  publication-title: Biol. Rhythm. Res.
– volume: 8
  start-page: 537
  year: 1995
  end-page: 541
  ident: bib125
  article-title: Pulmonary hypertension in obstructive sleep apnoea
  publication-title: Eur. Respir. J.
– volume: 11
  start-page: 1516
  year: 2020
  ident: bib8
  article-title: Mechanistic insights into the reduced pacemaking rate of the rabbit sinoatrial node during postnatal development: a simulation study
  publication-title: Front. Physiol.
– volume: 2
  start-page: 1051
  year: 1999
  end-page: 1053
  ident: bib222
  article-title: Suprachiasmatic nucleus: a central autonomic clock
  publication-title: Nat. Neurosci.
– volume: 317
  start-page: H124
  year: 2019
  end-page: H140
  ident: bib39
  article-title: T-cell recruitment to the heart: friendly guests or unwelcome visitors?
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
– volume: 188
  start-page: 495
  year: 1960
  end-page: 497
  ident: bib167
  article-title: Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations
  publication-title: Nature
– volume: 560
  start-page: 429
  year: 2004
  end-page: 437
  ident: bib110
  article-title: Ageing-related changes of connexins and conduction within the sinoatrial node
  publication-title: J. Physiol.
– volume: 70
  start-page: 1019
  year: 2017
  end-page: 1020
  ident: bib83
  article-title: Ivabradine as an alternative to AV node ablation in a patient with permanent atrial fibrillation
  publication-title: Rev. Española Cardiol.
– volume: 4
  start-page: 43
  year: 1883
  end-page: 230
  ident: bib86
  article-title: On the innervation of the heart, with especial reference to the heart of the tortoise
  publication-title: J. Physiol.
– volume: 21
  start-page: 153
  year: 2020
  end-page: 156
  ident: bib164
  article-title: Strategy for estimating optimal heart rate in refractory heart failure with relative sinus bradycardia: a case report
  publication-title: J. Cardiol. Cases
– volume: 16
  start-page: 298
  year: 2019
  end-page: 307
  ident: bib37
  article-title: Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms
  publication-title: Heart Rhythm
– volume: 25
  start-page: 947
  year: 1962
  end-page: 961
  ident: bib95
  article-title: Electrocardiographic findings in 122,043 individuals
  publication-title: Circulation
– volume: 113
  start-page: E932
  year: 2016
  end-page: E941
  ident: bib151
  article-title: G protein-gated I
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
– volume: 596
  start-page: 809
  year: 2018
  end-page: 825
  ident: bib121
  article-title: HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node
  publication-title: J. Physiol.
– volume: 211
  start-page: 255
  year: 2010
  end-page: 259
  ident: bib176
  article-title: Heart rate as an independent prognostic risk factor in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention
  publication-title: Atherosclerosis
– volume: 2019
  start-page: 2164017
  year: 2019
  ident: bib211
  article-title: Role of inflammatory cell subtypes in heart failure
  publication-title: J. Immunol. Res.
– volume: 127
  start-page: 2009
  year: 2013
  end-page: 2020
  ident: bib78
  article-title: Upregulation of the hyperpolarization-activated current increases pacemaker activity of the sinoatrial node and heart rate during pregnancy in mice
  publication-title: Circulation
– volume: 384
  start-page: 697
  year: 2003
  end-page: 709
  ident: bib199
  article-title: Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat
  publication-title: Biol. Chem.
– volume: 33
  start-page: 239
  year: 1999
  end-page: 243
  ident: bib96
  article-title: Cardiac assessment of veteran endurance athletes: a 12 year follow up study
  publication-title: Br. J. Sports Med.
– volume: 96
  start-page: 1667
  year: 1997
  end-page: 1674
  ident: bib144
  article-title: Circadian rhythms of cardiovascular functions are modulated by the baroreflex and the autonomic nervous system in the rat
  publication-title: Circulation
– volume: 224
  start-page: 252
  year: 2016
  end-page: 255
  ident: bib235
  article-title: Ivabradine reduced ventricular rate in patients with non-paroxysmal atrial fibrillation
  publication-title: Int. J. Cardiol.
– volume: 4
  start-page: 496
  year: 2011
  end-page: 508
  ident: bib242
  article-title: Changes in ion channel gene expression underlying heart failure-induced sinoatrial node dysfunction
  publication-title: Circulation: Heart Fail.
– volume: 92
  start-page: 2162
  year: 1929
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib41
  article-title: The heart rate during sleep as determined by the cardiotachometer: its clinical significance
  publication-title: J. Am. Med. Assoc.
– volume: 94
  start-page: 1035
  year: 2009
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib44
  article-title: And the beat goes on'. The cardiac conduction system: the wiring system of the heart
  publication-title: Exp. Physiol.
  doi: 10.1113/expphysiol.2009.046920
– volume: 15
  start-page: 401
  year: 1997
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib172
  article-title: Autonomic control of ultradian and circadian rhythms of blood pressure, heart rate, and baroreflex sensitivity in spontaneously hypertensive rats
  publication-title: J. Hypertens.
  doi: 10.1097/00004872-199715040-00011
– volume: 126
  start-page: 258
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib187
  article-title: Chronobiological influence over cardiovascular function: the good, the bad, and the ugly
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.119.313349
– volume: 39
  start-page: 1033
  year: 2002
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib207
  article-title: Intrinsic sinus and atrioventricular node electrophysiologic adaptations in endurance athletes
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/S0735-1097(02)01722-9
– volume: 13
  start-page: 801
  year: 1956
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib179
  article-title: Some clinical features of complete heart block
  publication-title: Circulation
  doi: 10.1161/01.CIR.13.6.801
– volume: 4
  start-page: 43
  year: 1883
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib86
  article-title: On the innervation of the heart, with especial reference to the heart of the tortoise
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1883.sp000121
– volume: 21
  start-page: 335
  year: 2001
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib190
  article-title: Chronotropic incompetence response to exercise in congestive heart failure, relationship with the cardiac autonomic status
  publication-title: Clin. Physiol. Funct. Imag.
  doi: 10.1046/j.1365-2281.2001.00328.x
– volume: 274
  start-page: 12835
  year: 1999
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib106
  article-title: Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.274.18.12835
– volume: 50
  start-page: 434
  year: 2001
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib246
  article-title: Autonomic indexes based on the analysis of heart rate variability: a view from the sinus node
  publication-title: Cardiovasc. Res.
  doi: 10.1016/S0008-6363(01)00240-1
– volume: 8
  start-page: 17
  year: 2006
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib15
  article-title: A brief history of cardiac pacing
  publication-title: Images Paediatr. Cardiol.
– volume: 4
  start-page: 397
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib90
  article-title: TGF-β1 mediated fibrosis and ion channel remodeling are key mechanisms producing sinus node dysfunction associated with SCN5A deficiency and aging
  publication-title: Circ.: Arrhythm. Electrophysiol.
– volume: 11
  start-page: 1055
  year: 2014
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib143
  article-title: A novel trafficking-defective HCN4 mutation is associated with early-onset atrial fibrillation
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2014.03.002
– volume: 96
  start-page: 260
  year: 1997
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib5
  article-title: Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial
  publication-title: Circulation
  doi: 10.1161/01.CIR.96.1.260
– volume: 76
  start-page: 493
  year: 1987
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib84
  article-title: The origin of the heart beat: a tale of frogs, jellyfish, and turtles
  publication-title: Circulation
  doi: 10.1161/01.CIR.76.3.493
– volume: 152
  start-page: 80
  year: 2015
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib101
  article-title: Age-dependent alterations of voltage-gated Na+ channel isoforms in rat sinoatrial node
  publication-title: Mech. Ageing Dev.
  doi: 10.1016/j.mad.2015.10.003
– volume: 294
  start-page: H1581
  year: 2008
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib214
  article-title: Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.01000.2007
– volume: 9
  start-page: 261
  year: 2008
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib140
  article-title: Echocardiographic findings in former professional cyclists after long-term deconditioning of more than 30 years
  publication-title: Eur. J. Echocardiogr.
– volume: 90
  start-page: 827
  year: 2005
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib99
  article-title: Long-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats
  publication-title: Exp. Physiol.
  doi: 10.1113/expphysiol.2005.031252
– volume: 202
  start-page: 73
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib54
  article-title: Addition of ivabradine to betablockers in patients with atrial fibrillation: effects on heart rate and exercise tolerance
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2015.08.207
– volume: 11
  start-page: 2288
  year: 2014
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib227
  article-title: If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2014.08.007
– start-page: 1
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib19
  article-title: Arrhythmia in COVID-19
  publication-title: SN Compr. Clin. Med.
– volume: 75
  start-page: 2517
  year: 1975
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib193
  article-title: Diabetes mellitus and impaired atrioventricular conduction
  publication-title: N. Y. State J. Med.
– year: 2008
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib163
– volume: 108
  start-page: 1705
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib24
  article-title: Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4
  publication-title: Proc. Natl. Acad. Sci. U. S. A
  doi: 10.1073/pnas.1010122108
– volume: 30
  start-page: 841
  year: 1980
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib240
  article-title: Reconstruction of sino-atrial node pacemaker potential based on the voltage clamp experiments
  publication-title: Jpn. J. Physiol.
  doi: 10.2170/jjphysiol.30.841
– volume: 5
  start-page: 251
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib146
  article-title: Functional roles of Cav1.3, Cav3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism
  publication-title: Channels
  doi: 10.4161/chan.5.3.15266
– volume: 11
  start-page: 434
  year: 1998
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib116
  article-title: Heart block in patients with obstructive sleep apnoea: pathogenetic factors and effects of treatment
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.98.11020434
– volume: 596
  start-page: 6141
  year: 2018
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib58
  article-title: TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome
  publication-title: J. Physiol.
  doi: 10.1113/JP276508
– volume: 222
  start-page: 213
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib20
  article-title: Exercise training bradycardia is largely explained by reduced intrinsic heart rate
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2016.07.203
– volume: 41
  start-page: 172
  year: 1907
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib115
  article-title: The form and nature of the muscular connections between the primary divisions of the vertebrate heart
  publication-title: J. Anat Physiol.
– volume: 34
  start-page: 233
  year: 2001
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib224
  article-title: The 12-lead electrocardiogram in anorexia nervosa: a report of 2 cases followed by a retrospective study
  publication-title: J. Electrocardiol.
  doi: 10.1054/jelc.2001.25134
– volume: 119
  start-page: 1576
  year: 2009
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib245
  article-title: Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.108.789677
– volume: 21
  start-page: 153
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib164
  article-title: Strategy for estimating optimal heart rate in refractory heart failure with relative sinus bradycardia: a case report
  publication-title: J. Cardiol. Cases
  doi: 10.1016/j.jccase.2019.12.003
– volume: 64
  start-page: 745
  year: 2014
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib154
  article-title: HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2014.05.045
– volume: 9
  start-page: 43
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib30
  article-title: Effect of training on intrinsic and resting heart rate and plasma volume in young and old horses
  publication-title: Comp. Exerc. Physiol.
  doi: 10.3920/CEP12020
– volume: 100
  start-page: 160
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib162
  article-title: Characterization of a right atrial subsidiary pacemaker and acceleration of the pacing rate by HCN over-expression
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvt164
– volume: 123
  start-page: 1010
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib50
  article-title: Chronotropic incompetence: causes, consequences, and management
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.110.940577
– volume: 18
  start-page: 801
  year: 2021
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib67
  article-title: A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2020.11.026
– volume: 354
  start-page: 151
  year: 2006
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib153
  article-title: Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa052475
– volume: 80
  start-page: 1675
  year: 1989
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib141
  article-title: Diverse mechanisms of unexpected cardiac arrest in advanced heart failure
  publication-title: Circulation
  doi: 10.1161/01.CIR.80.6.1675
– volume: 47
  start-page: 157
  year: 2009
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib123
  article-title: What keeps us ticking: a funny current, a calcium clock, or both?
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2009.03.022
– volume: 129
  start-page: 2111
  year: 2014
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib127
  article-title: CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.113.007101
– volume: 12
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib11
  article-title: Bradycardia in patients with COVID-19: a calm before the storm?
  publication-title: Cureus
– volume: 594
  start-page: 7105
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib155
  article-title: The impacts of age and frailty on heart rate and sinoatrial node function
  publication-title: J. Physiol.
  doi: 10.1113/JP272979
– volume: 64
  start-page: 1334
  year: 2014
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib159
  article-title: Biophysical characterisation of the under-appreciated and important relationship between heart rate variability and heart rate
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.114.03782
– volume: 110
  start-page: 18011
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib128
  article-title: Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate
  publication-title: Proc. Natl. Acad. Sci. U. S. A
  doi: 10.1073/pnas.1308477110
– volume: 73
  start-page: 1006
  year: 1994
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib104
  article-title: Decreased circadian blood pressure variation up to three years after heart transplantation
  publication-title: Am. J. Cardiol.
  doi: 10.1016/0002-9149(94)90158-9
– volume: 127
  start-page: 183
  year: 2006
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib183
  article-title: Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents
  publication-title: J. Gen. Physiol.
  doi: 10.1085/jgp.200509389
– volume: 241
  start-page: 364
  year: 2017
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib93
  article-title: A novel 'splice site' HCN4 Gene mutation, c.1737+1 G>T, causes familial bradycardia, reduced heart rate response, impaired chronotropic competence and increased short-term heart rate variability
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2017.04.058
– volume: 393
  start-page: 15
  year: 1982
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib117
  article-title: Membrane currents in the rabbit atrioventricular node cell
  publication-title: Pflügers Archiv
  doi: 10.1007/BF00582385
– volume: 35
  start-page: 123
  year: 2014
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib16
  article-title: Prognostic significance of prolonged PR interval in the general population
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/eht176
– volume: 6
  start-page: 1827
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib48
  article-title: Evidence of superior and inferior sinoatrial nodes in the mammalian heart
  publication-title: JACC Clin. Electrophysiol.
  doi: 10.1016/j.jacep.2020.09.012
– volume: 434
  start-page: 23
  year: 1991
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib70
  article-title: The contribution of the 'pacemaker' current (if) to generation of spontaneous activity in rabbit sino-atrial node myocytes
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1991.sp018457
– volume: 114
  start-page: 1351
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib46
  article-title: Viewpoint: is the resting bradycardia in athletes the result of remodelling of the sinoatrial node rather than high vagal tone?
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.01126.2012
– volume: 9
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib181
  article-title: Identification of key small non-coding microRNAs controlling pacemaker mechanisms in the human sinus node
  publication-title: J. Am. Heart Assoc.
– volume: 16
  start-page: 298
  year: 2018
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib38
  article-title: Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2018.08.026
– year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib188
  article-title: Patients with type 2 diabetes have an increased demand for pacemaker treatment: a comparison with age- and sex-matched control subjects from the general population
  publication-title: Diabetes Care
  doi: 10.2337/dc20-0084
– volume: 96
  start-page: 294
  year: 2008
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib134
  article-title: Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node
  publication-title: Prog. Biophys. Mol. Biol.
  doi: 10.1016/j.pbiomolbio.2007.07.009
– volume: 294
  start-page: H1036
  year: 2008
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib47
  article-title: Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.01291.2007
– volume: 30
  start-page: 451
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib145
  article-title: COVID-19 infection and cardiac arrhythmias
  publication-title: Trends Cardiovasc. Med.
  doi: 10.1016/j.tcm.2020.08.002
– volume: 13
  start-page: 2086
  year: 1990
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib87
  article-title: Symptoms, cardiovascular risk profile and spontaneous ECG in paced patients: a five-year follow-up study
  publication-title: Pacing Clin. Electrophysiol.
  doi: 10.1111/j.1540-8159.1990.tb06947.x
– volume: 5
  start-page: 4664
  year: 2014
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib150
  article-title: Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms5664
– volume: 4
  start-page: 160
  year: 1970
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib111
  article-title: The normal range and determinants of the intrinsic heart rate in man
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/4.2.160
– volume: 72
  start-page: 293
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib75
  article-title: β1-adrenergic blocker bisoprolol reverses down-regulated ion channels in sinoatrial node of heart failure rats
  publication-title: J. Physiol. Biochem.
  doi: 10.1007/s13105-016-0481-9
– volume: 33
  start-page: 239
  year: 1999
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib96
  article-title: Cardiac assessment of veteran endurance athletes: a 12 year follow up study
  publication-title: Br. J. Sports Med.
  doi: 10.1136/bjsm.33.4.239
– volume: 96
  start-page: 426
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib1
  article-title: Changes in the expression of ion channels, connexins and Ca2+-handling proteins in the sinoatrial node during postnatal development
  publication-title: Exp. Physiol.
  doi: 10.1113/expphysiol.2010.055780
– volume: 48
  start-page: 172
  year: 2010
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib185
  article-title: Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2009.07.028
– volume: 52
  start-page: 1652
  year: 1982
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib114
  article-title: Sympathetic and parasympathetic cardiac control in athletes and nonathletes at rest
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1982.52.6.1652
– volume: 115
  start-page: 1183
  year: 2007
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib109
  article-title: Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.663070
– volume: 107
  start-page: 59
  year: 2005
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib22
  article-title: Physiology and pharmacology of the cardiac pacemaker ("funny") current
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2005.01.005
– volume: 18
  start-page: 613
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib60
  article-title: European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions
  publication-title: Eur. J. Heart Fail.
  doi: 10.1002/ejhf.566
– volume: 384
  start-page: 697
  year: 2003
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib199
  article-title: Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat
  publication-title: Biol. Chem.
  doi: 10.1515/BC.2003.078
– volume: 32
  start-page: 37
  year: 2009
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib61
  article-title: Electrocardiograms of collegiate football athletes
  publication-title: Clin. Cardiol.
  doi: 10.1002/clc.20452
– volume: 2
  start-page: 58
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib18
  article-title: Real-world heart rate norms in the Health eHeart study
  publication-title: npj Digital Medicine
  doi: 10.1038/s41746-019-0134-9
– volume: 33
  start-page: 169
  year: 1996
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib129
  article-title: Prevalence of diabetes in elderly patients requiring permanent cardiac pacemaker insertion
  publication-title: Acta Diabetol.
  doi: 10.1007/BF00569430
– volume: 57
  start-page: 760
  year: 1993
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib122
  article-title: Age-related changes of sinus node function and autonomic regulation in subjects without sinus node disease: assessment by pharmacologic autonomic blockade
  publication-title: Jpn. Circ. J.
  doi: 10.1253/jcj.57.760
– volume: 12
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib126
  article-title: NPAS2 compensates for loss of CLOCK in peripheral circadian oscillators
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1005882
– volume: 69
  start-page: 529
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib191
  article-title: Symptomatic bradycardia and heart failure triggered by ivabradine in a patient receiving antiretroviral therapy
  publication-title: Rev. Española Cardiol.
– volume: 20
  start-page: 765
  year: 1979
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib113
  article-title: Arrhythmias in primary pulmonary hypertension
  publication-title: Jpn. Heart J.
  doi: 10.1536/ihj.20.765
– volume: 16
  start-page: 298
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib37
  article-title: Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2018.08.026
– volume: 110
  start-page: E3037
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib195
  article-title: Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity
  publication-title: Proc. Natl. Acad. Sci. U. S. A
  doi: 10.1073/pnas.1311865110
– volume: 22
  start-page: 83
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib236
  article-title: The significance of bradycardia in anorexia nervosa
  publication-title: Int. J. Angiol.
  doi: 10.1055/s-0033-1334138
– volume: 2
  start-page: 1240
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib59
  article-title: Sinus node dysfunction in a young patient with COVID-19
  publication-title: JACC Case Rep.
  doi: 10.1016/j.jaccas.2020.05.067
– volume: 188
  start-page: 495
  year: 1960
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib167
  article-title: Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations
  publication-title: Nature
  doi: 10.1038/188495b0
– volume: 35
  start-page: 445
  year: 2012
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib156
  article-title: Central and peripheral circadian clocks in mammals
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev-neuro-060909-153128
– volume: 511
  start-page: 76P
  year: 1998
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib247
  article-title: A hypothesis to explain the decline of sinoatrial node function with age
  publication-title: J. Physiol.
– volume: 14
  start-page: e14
  year: 2006
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib171
  article-title: Immediate relief of congestive heart failure by ventricular pacing in chronic bradycardia
  publication-title: Cardiol. Rev.
  doi: 10.1097/01.crd.0000181622.22277.b7
– volume: 10
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib216
  article-title: The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID-19
  publication-title: Clin. Transl. Med.
  doi: 10.1002/ctm2.200
– volume: 110
  start-page: 897
  year: 2004
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib196
  article-title: Remodeling of sinus node function in patients with congestive heart failure: reduction in sinus node reserve
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000139336.69955.AB
– volume: 13
  start-page: 27
  year: 2015
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib107
  article-title: Different characteristics of heart failure due to pump failure and bradyarrhythmia
  publication-title: J. Echocardiogr.
  doi: 10.1007/s12574-014-0235-z
– volume: 286
  start-page: 44811
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib136
  article-title: Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.297606
– volume: 41
  start-page: 865
  year: 2014
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib131
  article-title: Theoretical study of the role of the funny current (If) and the background inward current (Ib) in atrioventricular nodal conduction
  publication-title: Comput. Cardiol.
– volume: 15
  start-page: 1113
  year: 1994
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib118
  article-title: Cardiac vagal hyperactivity in adolescent anorexia nervosa
  publication-title: Eur. Heart J.
  doi: 10.1093/oxfordjournals.eurheartj.a060636
– volume: 82
  start-page: 21
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib180
  article-title: Cardiac pacemaker activity and aging
  publication-title: Annu. Rev. Physiol.
  doi: 10.1146/annurev-physiol-021119-034453
– volume: 45
  start-page: C06
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib13
  article-title: MicroRNA control of the circadian rhythm in heart rate
  publication-title: Proc. Physiol. Soc.
– volume: 17
  start-page: 1439
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib34
  article-title: COVID-19 and cardiac arrhythmias
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2020.06.016
– volume: 99
  start-page: 1384
  year: 2006
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib217
  article-title: Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000251717.98379.69
– volume: 3
  start-page: 479
  year: 2009
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib161
  article-title: Perspectives - biological pacing, a clinical reality?
  publication-title: Ther. Adv. Cardiovasc. Dis.
  doi: 10.1177/1753944709345792
– volume: 113
  start-page: E932
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib151
  article-title: G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.1517181113
– volume: 6
  start-page: 92
  year: 2001
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib71
  article-title: Circadian behavior of P-wave duration, P-wave area, and PR interval in healthy subjects
  publication-title: Ann. Noninvasive Electrocardiol.
  doi: 10.1111/j.1542-474X.2001.tb00092.x
– volume: 107
  start-page: 126
  year: 2010
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib52
  article-title: Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.110.219949
– volume: 94
  start-page: 2953
  year: 1996
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib79
  article-title: Pacing-induced chronic atrial fibrillation impairs sinus node function in dogs. Electrophysiological remodeling
  publication-title: Circulation
  doi: 10.1161/01.CIR.94.11.2953
– volume: 73
  start-page: 615
  year: 1986
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib92
  article-title: Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity
  publication-title: Circulation
  doi: 10.1161/01.CIR.73.4.615
– volume: 385
  start-page: 11
  year: 1980
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib239
  article-title: Inward current activated during hyperpolarization in the rabbit sinoatrial node cell
  publication-title: Pflügers Archiv
  doi: 10.1007/BF00583909
– volume: 95
  start-page: 586
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib103
  article-title: Reduced expression of HCN channels in the sinoatrial node of streptozotocin-induced diabetic rats
  publication-title: Can. J. Physiol. Pharmacol.
  doi: 10.1139/cjpp-2016-0418
– volume: 10
  year: 2015
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib165
  article-title: Congestive heart failure leads to prolongation of the PR Interval and atrioventricular junction enlargement and ion channel remodelling in the rabbit
  publication-title: PloS One
  doi: 10.1371/journal.pone.0141452
– volume: 29
  start-page: 111
  year: 1994
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib29
  article-title: ‘Congestive heart failure’ and bradycardia
  publication-title: Hosp. Pract.
  doi: 10.1080/21548331.1994.11442964
– volume: 2
  start-page: 181
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib166
  article-title: Outcomes related to first-degree atrioventricular block and therapeutic implications in patients with heart failure
  publication-title: JACC Clin. Electrophysiol.
  doi: 10.1016/j.jacep.2016.02.012
– volume: 96
  start-page: 1163
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib218
  article-title: Ageing-dependent remodelling of ion channel and Ca2+ clock genes underlying sinoatrial node pacemaking
  publication-title: Exp. Physiol.
  doi: 10.1113/expphysiol.2011.057752
– volume: 127
  start-page: 2009
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib78
  article-title: Upregulation of the hyperpolarization-activated current increases pacemaker activity of the sinoatrial node and heart rate during pregnancy in mice
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.113.001689
– volume: 7
  year: 2012
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib209
  article-title: Contrast enhanced micro-computed tomography resolves the 3-dimensional morphology of the cardiac conduction system in mammalian hearts
  publication-title: PloS One
  doi: 10.1371/annotation/1baecd19-92b6-4683-b7d7-39c13a3f2e15
– year: 2021
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib12
  article-title: Further insights into the molecular complexity of the human sinus node – the role of‘novel’ transcription factors and microRNAs
– volume: 2
  start-page: 450
  year: 2009
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib228
  article-title: Impact of sleep on arrhythmogenesis
  publication-title: Circ.: Arrhythm. Electrophysiol.
– volume: 101
  start-page: 2975
  year: 2000
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib173
  article-title: Changes in sinus node function in a rabbit model of heart failure with ventricular arrhythmias and sudden death
  publication-title: Circulation
  doi: 10.1161/01.CIR.101.25.2975
– volume: 55
  start-page: 180
  year: 2012
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib186
  article-title: Arrhythmias in pulmonary arterial hypertension
  publication-title: Prog. Cardiovasc. Dis.
  doi: 10.1016/j.pcad.2012.06.002
– volume: 63
  start-page: 133
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib3
  article-title: The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice
  publication-title: J. Physiol. Sci.
  doi: 10.1007/s12576-012-0248-1
– volume: 393
  start-page: 587
  year: 1998
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib138
  article-title: A family of hyperpolarization-activated mammalian cation channels
  publication-title: Nature
  doi: 10.1038/31255
– volume: 10
  start-page: 9835
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib35
  article-title: Inhibition of G protein-gated K+ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-66673-8
– volume: 34
  start-page: 1732
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib108
  article-title: Resting, night-time, and 24 h heart rate as markers of cardiovascular risk in middle-aged and elderly men and women with no apparent heart disease
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehs449
– year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib55
  article-title: Relative bradycardia in patients with COVID-19
  publication-title: Clin. Microbiol. Infect.
– volume: 596
  start-page: 809
  year: 2018
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib121
  article-title: HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node
  publication-title: J. Physiol.
  doi: 10.1113/JP275303
– volume: 115
  start-page: 1576
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib158
  article-title: Complexities in cardiovascular rhythmicity: perspectives on circadian normality, ageing and disease
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvz112
– volume: 48
  start-page: 2019
  year: 1969
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib112
  article-title: Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI106167
– volume: 448
  start-page: 53
  year: 1992
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib88
  article-title: Background current in sino-atrial node cells of the rabbit heart
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1992.sp019029
– volume: 211
  start-page: 255
  year: 2010
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib176
  article-title: Heart rate as an independent prognostic risk factor in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2010.02.017
– volume: 121
  start-page: 1058
  year: 2017
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib64
  article-title: Targeting miR-423-5p reverses exercise training-induced HCN4 channel remodeling and sinus bradycardia
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.117.311607
– volume: 304
  start-page: C954
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib201
  article-title: The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00383.2012
– volume: 26
  start-page: 1019
  year: 2009
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib130
  article-title: Discoveries of rhythms in human biological functions: a historical review
  publication-title: Chronobiol. Int.
  doi: 10.3109/07420520903237984
– volume: 24
  start-page: 257
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib100
  article-title: Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia
  publication-title: Crit. Care
  doi: 10.1186/s13054-020-02933-3
– year: 2021
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib135
  article-title: Remodelling of the Purkinje network in congestive heart failure in the rabbit
  publication-title: Circ.: Heart Fail
– volume: 140
  start-page: 2089
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib148
  article-title: Single-cell sequencing of mouse heart immune infiltrate in pressure overload-driven heart failure reveals extent of immune activation
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.119.041694
– volume: 26
  start-page: 2504
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib105
  article-title: Relative bradycardia in patients with mild-to-moderate coronavirus disease, Japan
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2610.202648
– volume: 69
  start-page: 2129
  year: 1993
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib142
  article-title: Properties of the hyperpolarization-activated current in rat hippocampal CA1 pyramidal cells
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.1993.69.6.2129
– volume: 272
  start-page: H1549
  year: 1997
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib2
  article-title: Properties and modulation of if in newborn versus adult cardiac SA node
  publication-title: Am. J. Physiol.
– volume: 17
  start-page: 162
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib14
  article-title: Case report: severe bradycardia, a reversible cause of “Cardio-Renal-Cerebral Syndrome”
  publication-title: BMC Nephrol.
  doi: 10.1186/s12882-016-0375-7
– volume: 281
  start-page: H1252
  year: 2001
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib184
  article-title: L-type but not T-type calcium current changes during postnatal development in rabbit sinoatrial node
  publication-title: Am. J. Physiol.
– volume: 28
  start-page: 74
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib160
  article-title: Modern concepts concerning the origin of the heartbeat
  publication-title: Physiology
  doi: 10.1152/physiol.00054.2012
– volume: 48
  start-page: 653
  year: 2010
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib243
  article-title: Structural remodelling of the sinoatrial node in obese old rats
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2009.08.023
– volume: 1446
  start-page: 419
  year: 1999
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib223
  article-title: The human gene coding for HCN2, a pacemaker channel of the heart
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/S0167-4781(99)00092-5
– volume: 11
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib27
  article-title: Cardiomyocyte circadian oscillations are cell-autonomous, amplified by β-adrenergic signaling, and synchronized in cardiac ventricle tissue
  publication-title: PloS One
  doi: 10.1371/journal.pone.0159618
– volume: 61
  start-page: 155
  year: 1989
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib170
  article-title: Electrocardiographic findings in male veteran endurance athletes
  publication-title: Br. Heart J.
  doi: 10.1136/hrt.61.2.155
– volume: 25
  start-page: 947
  year: 1962
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib95
  article-title: Electrocardiographic findings in 122,043 individuals
  publication-title: Circulation
  doi: 10.1161/01.CIR.25.6.947
– volume: 8
  start-page: 537
  year: 1995
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib125
  article-title: Pulmonary hypertension in obstructive sleep apnoea
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.95.08040537
– year: 2007
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib192
  article-title: Biological pacemakers based on if
  doi: 10.1007/978-3-540-72110-9_5
– volume: 18
  start-page: 2323
  year: 1999
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib139
  article-title: Two pacemaker channels from human heart with profoundly different activation kinetics
  publication-title: EMBO J.
  doi: 10.1093/emboj/18.9.2323
– volume: 22
  start-page: 519
  year: 1929
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib213
  article-title: The pulse rate and range in health and disease during childhood
  publication-title: Q. J. Med.
– volume: 308
  start-page: 331
  year: 1980
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib49
  article-title: Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sino-atrial node
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1980.sp013474
– volume: 43
  start-page: SA034
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib51
  article-title: Direct recordings of cardiac sympathetic and vagal parasympathetic nerve activity to clarify the underlying mechanisms of circadian heart rhythm
  publication-title: Proc. Physiol. Soc.
– volume: 14
  start-page: 1278
  year: 1993
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib10
  article-title: Electrophysiology of the ageing rabbit and cat sinoatrial node - a comparative study
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/14.9.1278
– volume: 3
  start-page: 48
  year: 1880
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib85
  article-title: On the tonicity of the heart and blood vessels
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1880.sp000083
– volume: 31
  start-page: 286
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib149
  article-title: Pacing induced cardiomyopathy
  publication-title: J. Cardiovasc. Electrophysiol.
  doi: 10.1111/jce.14277
– volume: 34
  start-page: 314
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib66
  article-title: Supraventricular arrhythmias in athletes: basic mechanisms and new directions
  publication-title: Physiology
  doi: 10.1152/physiol.00009.2019
– volume: 28
  start-page: 586
  year: 2007
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib204
  article-title: A case of bradycardia-induced severe right-sided heart failure with cardiogenic shock rescued by right ventricular pacing
  publication-title: Ther. Res.
– volume: 90
  start-page: 237
  year: 2005
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib98
  article-title: Short-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats
  publication-title: Exp. Physiol.
  doi: 10.1113/expphysiol.2004.029439
– volume: 498
  start-page: 641
  year: 1997
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib26
  article-title: The newborn rabbit sino-atrial node expresses a neuronal type I-like Na+ channel
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1997.sp021889
– volume: 87
  start-page: 691
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib203
  article-title: Sick sinus syndrome: a review
  publication-title: Am. Fam. Physician
– volume: 108
  start-page: 760
  year: 2003
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib226
  article-title: Ionic remodeling of sinoatrial node cells by heart failure
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000083719.51661.B9
– volume: 151
  start-page: 1051
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib132
  article-title: Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling
  publication-title: J. Gen. Physiol.
  doi: 10.1085/jgp.201812293
– volume: 314
  start-page: 359
  year: 1981
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib69
  article-title: A new interpretation of the pace-maker current in calf Purkinje fibres
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1981.sp013713
– volume: 4
  start-page: 1
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib178
  article-title: Novel coronavirus 19 (COVID-19) associated sinus node dysfunction: a case series
  publication-title: Eur. Heart J. - Case Rep.
  doi: 10.1093/ehjcr/ytaa132
– volume: 2
  start-page: 1051
  year: 1999
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib222
  article-title: Suprachiasmatic nucleus: a central autonomic clock
  publication-title: Nat. Neurosci.
  doi: 10.1038/15973
– volume: 149
  start-page: 237
  year: 2017
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib205
  article-title: Cyclic AMP reverses the effects of aging on pacemaker activity and if in sinoatrial node myocytes
  publication-title: J. Gen. Physiol.
  doi: 10.1085/jgp.201611674
– volume: 114
  start-page: 1633
  year: 2006
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib147
  article-title: The heart of trained athletes: cardiac remodeling and the risks of sports, including sudden death
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.613562
– volume: 16
  start-page: 1655
  year: 1995
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib9
  article-title: Age-related changes in structure and relative collagen content of the human and feline sinoatrial node. A comparative study
  publication-title: Eur. Heart J.
  doi: 10.1093/oxfordjournals.eurheartj.a060792
– volume: 111
  start-page: 846
  year: 2005
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib73
  article-title: Computer three-dimensional reconstruction of the sinoatrial node
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000152100.04087.DB
– volume: 70
  start-page: 1019
  year: 2017
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib83
  article-title: Ivabradine as an alternative to AV node ablation in a patient with permanent atrial fibrillation
  publication-title: Rev. Española Cardiol.
  doi: 10.1016/j.recesp.2017.03.005
– volume: 33
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib33
  article-title: Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmic enhancer–enhancer interactions
  publication-title: Genes Dev.
  doi: 10.1101/gad.322198.118
– volume: 111
  start-page: 1537
  year: 2003
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib202
  article-title: Pacemaker channel dysfunction in a patient with sinus node disease
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI200316387
– volume: 88
  start-page: 2953
  year: 1993
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib210
  article-title: Sudden death prevention in patients with advanced ventricular dysfunction
  publication-title: Circulation
  doi: 10.1161/01.CIR.88.6.2953
– volume: 39
  year: 2018
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib189
  article-title: Type 2 diabetes increases the need for pacemaker and implantable cardioverter defibrillator treatment - a Swedish registry report
  publication-title: Eur. Heart J.
– volume: 12
  start-page: 157
  year: 2004
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib97
  article-title: Recommendations and cardiological evaluation of athletes with arrythmias
  publication-title: Neth. Heart J.
– volume: 107
  start-page: 206
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib182
  article-title: Bradycardia: an important physical finding in anorexia nervosa
  publication-title: J. Ark. Med. Soc.
– volume: 198
  start-page: 341
  year: 1975
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib91
  article-title: Treatment of sinoatrial syndrome with permanent cardiac pacing in 90 patients
  publication-title: Acta Med. Scand.
  doi: 10.1111/j.0954-6820.1975.tb19555.x
– volume: 12
  start-page: 2047
  year: 2015
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib234
  article-title: Temporal distribution of arrhythmic events in chronic kidney disease: highest incidence in the long interdialytic period
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2015.06.033
– volume: 20
  start-page: 252
  year: 1999
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib4
  article-title: Is sinus bradycardia a factor facilitating overt heart failure?
  publication-title: Eur. J. Heart Fail.
  doi: 10.1053/euhj.1998.1347
– volume: 48
  year: 2010
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib237
  article-title: Changes in ion channel expression in right-sided congestive heart failure
  publication-title: J. Mol. Cell. Cardiol.
– volume: 2
  start-page: 9
  year: 2001
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib6
  article-title: Development of heart failure in bradycardic sick sinus syndrome
  publication-title: Ital. Heart J.
– volume: 10
  start-page: 11279
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib241
  article-title: Silencing miR-370-3p rescues funny current and sinus node function in heart failure
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-67790-0
– volume: 37
  start-page: 2244
  year: 2005
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib120
  article-title: Impact of cardiac transplantation in 24 hours circadian blood pressure and heart rate profile
  publication-title: Transplant. Proc.
  doi: 10.1016/j.transproceed.2005.03.087
– volume: 32
  start-page: 516
  year: 1998
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib57
  article-title: A double-blind placebo-controlled evaluation of the human electrophysiologic effects of zatebradine, a sinus node inhibitor
  publication-title: J. Cardiovasc. Pharmacol.
  doi: 10.1097/00005344-199810000-00002
– volume: 7
  start-page: 127
  year: 2010
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib43
  article-title: Cardiac Purkinje cells
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2009.09.017
– volume: 3
  start-page: 383
  year: 2002
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib68
  article-title: Stereologic study of the sinoatrial node of rats - age related changes
  publication-title: Biogerontology
  doi: 10.1023/A:1021376002896
– volume: 16
  start-page: 148
  year: 2007
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib225
  article-title: Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiod
  publication-title: J. Sleep Res.
  doi: 10.1111/j.1365-2869.2007.00581.x
– volume: 5
  start-page: 3775
  year: 2014
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib63
  article-title: Exercise training reduces resting heart rate via downregulation of the funny channel HCN4
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms4775
– volume: 560
  start-page: 429
  year: 2004
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib110
  article-title: Ageing-related changes of connexins and conduction within the sinoatrial node
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2004.072108
– volume: 317
  start-page: H124
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib39
  article-title: T-cell recruitment to the heart: friendly guests or unwelcome visitors?
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00028.2019
– volume: 10
  start-page: 2889
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib133
  article-title: Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-10709-9
– volume: 20
  start-page: 316
  year: 2010
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib206
  article-title: Circadian clock gene Bmal1 is not essential; functional replacement with its paralog
  publication-title: Bmal2. Current Biology
  doi: 10.1016/j.cub.2009.12.034
– volume: 4
  start-page: 496
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib242
  article-title: Changes in ion channel gene expression underlying heart failure-induced sinoatrial node dysfunction
  publication-title: Circulation: Heart Fail.
– volume: 47
  start-page: 213
  year: 1982
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib229
  article-title: Ambulatory electrocardiographic recording in endurance athletes
  publication-title: Br. Heart J.
  doi: 10.1136/hrt.47.3.213
– volume: 33
  start-page: 889
  year: 2003
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib17
  article-title: Heart rate variability in athletes
  publication-title: Sports Med.
  doi: 10.2165/00007256-200333120-00003
– volume: 11
  start-page: 3565
  year: 2021
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib231
  article-title: RNAseq shows an all-pervasive circadian rhythm in the transcriptome of the pacemaker of the heart, the sinus node
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-82202-7
– volume: 66
  start-page: 472
  year: 2005
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib251
  article-title: Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model
  publication-title: Cardiovasc. Res.
  doi: 10.1016/j.cardiores.2005.02.011
– volume: 11
  start-page: 1516
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib8
  article-title: Mechanistic insights into the reduced pacemaking rate of the rabbit sinoatrial node during postnatal development: a simulation study
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2020.547577
– volume: 29
  start-page: 71
  year: 2008
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib21
  article-title: Sinus node disease and arrhythmias in the long-term follow-up of former professional cyclists
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehm555
– year: 2021
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib152
  article-title: Why do athletes have AV block? A new role for electrical remodelling of the atrioventricular node in equine and murine models of endurance exercise
  publication-title: Circ. Res.
– volume: 2019
  start-page: 2164017
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib211
  article-title: Role of inflammatory cell subtypes in heart failure
  publication-title: J. Immunol. Res.
– start-page: 1215
  year: 1995
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib28
  article-title: Sinus node dysfunction: pathophysiology, clinical features, evaluation, and treatment
– volume: 38
  start-page: 280
  year: 2015
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib23
  article-title: A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial inappropriate sinus tachycardia
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehv582
– volume: 106
  start-page: 659
  year: 2010
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib124
  article-title: A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.109.206078
– volume: 120
  start-page: 18
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib45
  article-title: Are you ruled by your head or your heart? Neurogenic versus myogenic debate on origin of the heart beat
  publication-title: Physiol. News
– volume: 44
  start-page: 519
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib220
  article-title: Circadian expressions of cardiac ion channel genes in mouse might be associated with the central clock in the SCN but not the peripheral clock in the heart
  publication-title: Biol. Rhythm. Res.
  doi: 10.1080/09291016.2012.704801
– volume: 47
  start-page: 631
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib221
  article-title: Circadian expression of connexins in the mouse heart
  publication-title: Biol. Rhythm. Res.
  doi: 10.1080/09291016.2016.1174404
– volume: 83
  start-page: 88
  year: 2015
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib157
  article-title: Sick sinus syndrome and atrial fibrillation in older persons - a view from the sinoatrial nodal myocyte
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2015.02.003
– volume: vol. 41
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib174
– volume: 10
  start-page: 826
  year: 2019
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib248
  article-title: Electrical conduction system remodeling in streptozotocin-induced diabetes mellitus rat heart
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2019.00826
– volume: 21
  start-page: 67
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib177
  article-title: Molecular mechanisms and physiological importance of circadian rhythms
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-019-0179-2
– volume: 106
  start-page: 647
  year: 2010
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib77
  article-title: The cardiomyocyte circadian clock: emerging roles in health and disease
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.109.209957
– volume: 102
  start-page: 429
  year: 2007
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib102
  article-title: Age-related down-regulation of HCN channels in rat sinoatrial node
  publication-title: Basic Res. Cardiol.
  doi: 10.1007/s00395-007-0660-5
– volume: 121
  start-page: 513
  year: 2002
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib42
  article-title: The prognostic role of the ECG in primary pulmonary hypertension
  publication-title: Chest
  doi: 10.1378/chest.121.2.513
– volume: 593
  start-page: 1749
  year: 2015
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib65
  article-title: CrossTalk opposing view: bradycardia in the trained athlete is attributable to a downregulation of a pacemaker channel in the sinus node
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2014.284356
– volume: 868
  start-page: 741
  year: 1999
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib197
  article-title: The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.1999.tb11353.x
– volume: 139
  start-page: 260
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib72
  article-title: Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2013.04.010
– year: 2021
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib212
– volume: 15
  start-page: 752
  year: 2018
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib194
  article-title: Structural and functional remodeling of the atrioventricular node with aging in rats: the role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2017.12.027
– volume: 13
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib32
  article-title: Lopinavir-ritonavir treatment for COVID-19 infection in intensive care unit: risk of bradycardia
  publication-title: Circ.: Arrhythm. Electrophysiol.
– volume: 51
  start-page: 103
  year: 1995
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib82
  article-title: Heart rate variability in infants, children and young adults
  publication-title: J. Auton. Nerv. Syst.
  doi: 10.1016/0165-1838(94)00117-3
– volume: 22
  start-page: 260
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib94
  article-title: Relative bradycardia as a clinical feature in patients with coronavirus disease 2019 (COVID-19): a report of two cases
  publication-title: J. Cardiol. Cases
  doi: 10.1016/j.jccase.2020.07.015
– volume: 66
  start-page: 470
  year: 2009
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib230
  article-title: HCN channels: structure, cellular regulation and physiological function
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-008-8525-0
– volume: 78
  start-page: 938
  year: 2014
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib249
  article-title: A novel HCN4 mutation, G1097W, is associated with atrioventricular block
  publication-title: Circ. J.
  doi: 10.1253/circj.CJ-13-0996
– volume: 55
  start-page: 1091
  year: 1994
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib232
  article-title: The suprachiasmatic nucleus controls the circadian rhythm of heart rate via the sympathetic nervous system
  publication-title: Physiol. Behav.
  doi: 10.1016/0031-9384(94)90392-1
– volume: 11
  start-page: 1798
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib36
  article-title: Genetic ablation of G protein-gated inwardly rectifying K+ (GIRK4) channels prevents training-induced sinus bradycardia
  publication-title: Front. Physiol.
– volume: 29
  start-page: 1327
  year: 2008
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib119
  article-title: Impact of resting heart rate on outcomes in hypertensive patients with coronary artery disease: findings from the INternational VErapamil-SR/trandolapril STudy (INVEST)
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehn123
– volume: 11
  start-page: 546508
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib7
  article-title: Cardiac pacemaker dysfunction arising from different studies of ion channel remodeling in the aging rat heart
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2020.546508
– volume: 492
  start-page: 21
  year: 1996
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib25
  article-title: A TTX-sensitive inward sodium current contributes to spontaneous activity in newborn rabbit sino-atrial node cells
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1996.sp021285
– volume: 82
  start-page: 19
  year: 1982
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib215
  article-title: Twenty-four hour continuous ECG recordings in long-distance runners
  publication-title: Chest
  doi: 10.1378/chest.82.1.19
– volume: 294
  start-page: 970
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib56
  article-title: Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area
  publication-title: Anat. Rec.
  doi: 10.1002/ar.21379
– volume: 9
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib219
  article-title: Atrioventricular node dysfunction and ion channel transcriptome in pulmonary hypertension
  publication-title: Circ.: Arrhythm. Electrophysiol.
– volume: 33
  start-page: 1058
  year: 2012
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib175
  article-title: The human sympathetic nervous system: its relevance in hypertension and heart failure
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehs041
– volume: 6
  start-page: 37
  year: 2015
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib62
  article-title: Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2015.00037
– volume: 397
  start-page: 190
  year: 1983
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib169
  article-title: Does the "pacemaker current" generate the diastolic depolarization in the rabbit SA node cells?
  publication-title: Pflügers Archiv
  doi: 10.1007/BF00584356
– volume: 224
  start-page: 252
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib235
  article-title: Ivabradine reduced ventricular rate in patients with non-paroxysmal atrial fibrillation
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2016.09.044
– volume: 7
  start-page: 7188
  year: 2017
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib208
  article-title: High resolution 3-dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-07694-8
– volume: 55
  start-page: 253
  year: 1986
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib31
  article-title: Diurnal variation of the QT interval - influence of the autonomic nervous system
  publication-title: Br. Heart J.
  doi: 10.1136/hrt.55.3.253
– volume: 122
  start-page: 1258
  year: 2010
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib40
  article-title: Long-term recording of cardiac arrhythmias with an implantable cardiac monitor in patients with reduced ejection fraction after acute myocardial infarction: the Cardiac Arrhythmias and Risk Stratification after Acute Myocardial Infarction (CARISMA) study
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.109.902148
– volume: 93
  start-page: 1102
  year: 2003
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib74
  article-title: Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000101913.95604.B9
– volume: 21
  start-page: 822
  year: 2010
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib53
  article-title: Bradycardiomyopathy: the case for a causative relationship between severe sinus bradycardia and heart failure
  publication-title: J. Cardiovasc. Electrophysiol.
  doi: 10.1111/j.1540-8167.2009.01704.x
– volume: 147
  start-page: 27
  year: 2020
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib137
  article-title: Contribution of estrogen to the pregnancy-induced increase in cardiac automaticity
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2020.08.005
– volume: 71
  start-page: 720
  year: 1993
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib200
  article-title: First- or second-degree atrioventricular block as a risk factor in idiopathic dilated cardiomyopathy
  publication-title: Am. J. Cardiol.
  doi: 10.1016/0002-9149(93)91017-C
– volume: 65
  start-page: 1263
  year: 2015
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib233
  article-title: Bradycardia and asystole is the predominant mechanism of sudden cardiac death in patients with chronic kidney disease
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2014.12.049
– volume: 8
  start-page: 1258
  year: 2017
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib244
  article-title: Mammalian gamma2 AMPK regulates intrinsic heart rate
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01342-5
– volume: 11
  year: 2016
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib81
  article-title: Different profile of mRNA expression in sinoatrial node from streptozotocin-induced diabetic rat
  publication-title: PloS One
  doi: 10.1371/journal.pone.0153934
– volume: 59
  start-page: 149
  year: 1997
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib238
  article-title: Intrinsic atrioventricular conductive function in horses with a second degree atrioventricular block
  publication-title: J. Vet. Med. Sci.
  doi: 10.1292/jvms.59.149
– volume: 110
  start-page: 14
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib198
  article-title: Competitive sports and the heart: benefit or risk?
  publication-title: Dtsch. Ärztebl. Int.
– volume: 64
  start-page: 1045
  year: 2011
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib89
  article-title: The heart during pregnancy
  publication-title: Rev. Española Cardiol.
  doi: 10.1016/j.recesp.2011.07.009
– volume: 195
  start-page: 185
  year: 1968
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib168
  article-title: The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1968.sp008454
– volume: 96
  start-page: 1667
  year: 1997
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib144
  article-title: Circadian rhythms of cardiovascular functions are modulated by the baroreflex and the autonomic nervous system in the rat
  publication-title: Circulation
  doi: 10.1161/01.CIR.96.5.1667
– volume: 34
  start-page: 2768
  year: 2013
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib76
  article-title: Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehs391
– volume: 87
  year: 2001
  ident: 10.1016/j.pbiomolbio.2021.06.008_bib80
  article-title: Mechanisms and immediate outcome of in-hospital cardiac arrest in patients with advanced heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
  publication-title: Am. J. Cardiol.
  doi: 10.1016/S0002-9149(00)01450-8
SSID ssj0002176
Score 2.4245708
SecondaryResourceType review_article
Snippet The funny current, If, was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that If plays an...
The funny current, I , was first recorded in the heart 40 or more years ago by Dario DiFrancesco and others. Since then, we have learnt that I plays an...
SourceID hal
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 61
SubjectTerms Action Potentials
Ageing
Athletic training
Atrial Fibrillation
Atrioventricular Node
Cardiac arrhythmias
Cardiac conduction system
Cardiology and cardiovascular system
Circadian rhythm
Heart failure
Heart Rate
Human health and pathology
Humans
Life Sciences
Sinoatrial Node
Title Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease
URI https://dx.doi.org/10.1016/j.pbiomolbio.2021.06.008
https://www.ncbi.nlm.nih.gov/pubmed/34197836
https://www.proquest.com/docview/2548411553
https://hal.science/hal-03437472
Volume 166
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Na9swFBdpR6GXsm79SLcFtezqJrJly2anEFa8rc1hLJCbkGyZprRyaJJCL_3b-55kpxRaCOxisK1ny9KT3vv5fRHyXSVVWqlKB3C7CAB_6UCDFhIIrpIyTjEjGlp0r8ZJPuG_p_G0Q0ZtLAy6VTZ7v9_T3W7dXOk3o9mfz2YY4ysyEP4AYXDPTTGinHOBXH7-9OLmASq3s1dC4wBbN9483sdrjjHu9S0cASmGzGXyxEKTb4uorWv0lXxPEXUC6eIj2Ws0STr0nd0nHWM_kR1fW_LxM7F_fZV5GHdaV3Qxs6sFtXVpKKBkc-eKUFFlS4o5-mv0enS_AtW9bwQwufSJZal-pPloTDFE2EI36cxSHz3pyBsLzwGZXPz8N8qDprhCUMQhXwbMxFiOL1KRjkQZpQMFiz3JQpakShgh0lJxoUNAewpUgILpKAOwnPGBDktRaB4dkm1bW3MM48mMrlBx0wOQiSVTRWXCTIkCoF-i4rRLRDuesmgyj2MBjFvZupjdyJeZkDgT0nnbASVbU8599o0NaH60UyZfcZIEIbEB9RnM8vplmHw7H15KvAYfFwH4Ch9Yl5y2TCBhNaKJRVlTrxYS4HbKGdZi6pIjzx3rZ2HmPIyZOfmvDn4hu3jmwyG_ku3l_cp8A71oqXuO8Xvkw_DXn3z8DAenDMc
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dT9swED9BERovaBts6xjMm3iNqPPlRDxVFSiM0gcEEm-WnTiiE3Mq2iLx3-8udoqQQELiJQ9JLnH8cXe_-O53AIcqrbNa1TrAy2WA-EsHGr2QQMQqrZKMGNFoR_dikhbX8Z-b5GYNRl0uDIVVet3vdHqrrf2ZI9-bR7PplHJ8RY7GHyEM6dxMrMMGsVMlPdgYnp0Xk5VCRq-73bLE-wMS8AE9LsxrRmnuzR0eESyGvCXzpFqTL1up9VsKl3zNF21t0ulH2PbOJBu69n6CNWM_w6YrL_m4A_bSFZrHrmdNzeZTu5wz21SGIVA2_9o6VEzZihFNf0OBj-3fQHXvbkKkXDluWaYfWTGaMMoStthMNrXMJVC24n6TZxeuT0-uRkXg6ysEZRLGi4CbhCryRSrSkaiibKBwvad5yNNMCSNEVqlY6BABn0IvoOQ6yhEv5_FAh5UodRx9gZ5trPmG_cmNrsl30wM0ixVXZW3CXIkS0V-qkqwPoutPWXrycaqBcSe7KLO_8mkkJI2EbAPuUJKvJGeOgOMNMsfdkMlnk0minXiD9G8c5dXLiH-7GI4lncOPixB_hQ-8D7-6SSBxQdIui7KmWc4lIu4s5lSOqQ9f3exYPYvI8yht5vu7GvgTPhRXF2M5Ppuc78EWXXHZkT-gt7hfmn10kxb6wC-D_zPYD3g
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Regulation+of+sinus+node+pacemaking+and+atrioventricular+node+conduction+by+HCN+channels+in+health+and+disease&rft.jtitle=Progress+in+biophysics+and+molecular+biology&rft.au=Boyett%2C+Mark&rft.au=Yanni%2C+Joseph&rft.au=Tellez%2C+James&rft.au=Bucchi%2C+Annalisa&rft.date=2021-11-01&rft.pub=Elsevier&rft.issn=0079-6107&rft.volume=166&rft.spage=61&rft.epage=85&rft_id=info:doi/10.1016%2Fj.pbiomolbio.2021.06.008&rft_id=info%3Apmid%2F34197836&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=oai_HAL_hal_03437472v1
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0079-6107&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0079-6107&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0079-6107&client=summon