The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

• Published in: Neurobiology of disease Vol. 123; pp. 110 - 114
• Main Authors: Vespa, Paul M., Shrestha, Vikesh, Abend, Nicholas, Agoston, Denes, Au, Alicia, Bell, Michael J., Bleck, Thomas P., Blanco, Manuel Buitrago, Claassen, Jan, Diaz-Arrastia, Ramon, Duncan, Dominique, Ellingson, Ben, Foreman, Brandon, Gilmore, Emily J., Hirsch, Lawrence, Hunn, Martin, Kamnaksh, Alaa, McArthur, David, Morokoff, Andrew, O'Brien, Terrence, O'Phelan, Kristine, Robertson, Courtney L., Rosenthal, Eric, Staba, Richard, Toga, Arthur, Willyerd, Frederick A., Zimmermann, Lara, Yam, Elisa, Martinez, Susana, Real, Courtney, Engel, Jerome
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2019; Elsevier
• Subjects: Biomarkers - blood; Brain - physiopathology; Brain Injuries, Traumatic - blood; Brain Injuries, Traumatic - complications; Brain Injuries, Traumatic - diagnosis; Brain Injuries, Traumatic - physiopathology; Computational Biology; Epilepsy, Post-Traumatic - blood; Epilepsy, Post-Traumatic - diagnosis; Epilepsy, Post-Traumatic - etiology; Epilepsy, Post-Traumatic - physiopathology; Humans; Longitudinal Studies; Observational Studies as Topic; Prospective Studies; CDE; HFF; HIF-1α; p-tau; LFF; INF-γ; CK-BB; TBI; NSE; UCLA; PROMIS; IL-1β; IL-8; IL-6; eCRFs; ADAPT; Hz; SAE; DTI; BioSEND; GRE; FPI; pHFOs; rHFOSs; PTE; DSMB; MRI; cEEG; rs-BOLD; SD; 2D; T; NF-H; FLAIR; MBP; T1; T2; SWI; NIH; S100B; DAI; GOS-E; GFAP; CT; 3D; EpiBioS4Rx; TNF-α; GCS; LONI IDA; REDCap; ICU; USC LONI

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinar...