The interactive effect of improvement of vitamin D status and VDR FokI variants on oxidative stress in type 2 diabetic subjects: a randomized controlled trial

• Published in: European journal of clinical nutrition Vol. 69; no. 2; pp. 216 - 222
• Main Authors: Shab-Bidar, S, Neyestani, T R, Djazayery, A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2015; Nature Publishing Group
• Subjects: 13/21; 25-Hydroxyvitamin D; 38/77; 692/308; 692/308/2056; Adult; Alfacalcidol; Antioxidants; Antioxidants - metabolism; Biomarkers; Biomarkers - blood; Bovine serum albumin; Calcifediol; Calciferol; Calcium; Calcium, Dietary - administration & dosage; Cholecalciferol - pharmacology; Clinical Nutrition; Deoxyribonucleases, Type II Site-Specific - genetics; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Epidemiology; Female; Food, Fortified; Genotype; Genotype & phenotype; Genotypes; Glutathione; Glutathione - blood; Health aspects; Humans; Internal Medicine; Male; Malondialdehyde; Malondialdehyde - blood; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; original-article; Oxidative stress; Oxidative Stress - drug effects; Physiological aspects; Polymorphism, Genetic; Public Health; Receptors, Calcitriol - genetics; Serum albumin; Subgroups; Superoxide dismutase; Superoxide Dismutase - blood; Type 2 diabetes; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D receptors; Vitamin D3; Vitamins - pharmacology; Yogurt

Background/Objectives: The objectives were to evaluate the effects of improvement of vitamin D status on biomarkers of oxidative stress (OS) in type 2 diabetic (T2D) subjects and whether vitamin D receptor (VDR)- Fok I polymorphisms could modulate the response to vitamin D3 intake. Subjects/Methods:...