Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study
ABSTRACT Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk...
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| Published in | The journal of clinical hypertension (Greenwich, Conn.) Vol. 27; no. 1; pp. e14939 - n/a |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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United States
John Wiley & Sons, Inc
01.01.2025
John Wiley and Sons Inc Wiley |
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| Abstract | ABSTRACT
Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O‐18:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn‐2 position, were associated with a reduced risk of preeclampsia/eclampsia (all p < 0.05). The results of the stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease. |
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| AbstractList | ABSTRACT Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O‐18:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn‐2 position, were associated with a reduced risk of preeclampsia/eclampsia (all p < 0.05). The results of the stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease. Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O‐18:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn‐2 position, were associated with a reduced risk of preeclampsia/eclampsia (all p < 0.05). The results of the stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease. Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O‐18:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn‐2 position, were associated with a reduced risk of preeclampsia/eclampsia (all p < 0.05). The results of the stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease. Circulating lipids play a crucial role during pregnancy and may impact various pregnancy-related diseases. This study employed a two-sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O-18:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn-2 position, were associated with a reduced risk of preeclampsia/eclampsia (all p < 0.05). The results of the stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease.Circulating lipids play a crucial role during pregnancy and may impact various pregnancy-related diseases. This study employed a two-sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O-18:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn-2 position, were associated with a reduced risk of preeclampsia/eclampsia (all p < 0.05). The results of the stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease. ABSTRACT Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O‐18:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn‐2 position, were associated with a reduced risk of preeclampsia/eclampsia (all p < 0.05). The results of the stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease. ABSTRACT Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O‐18:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn‐2 position, were associated with a reduced risk of preeclampsia/eclampsia (all p < 0.05). The results of the stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease. |
| Author | Zhao, Shanshan Wu, Fangyuan Shi, Shaole Wang, Zilian Fan, Yongqiang |
| AuthorAffiliation | 3 Division of Hypertension and Vascular Diseases Department of Cardiology Heart Center The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China 2 Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases Guangzhou China 1 Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China 4 Department of Cardiology Donguan Songshan Lake Tungwah Hospital Dongguan China |
| AuthorAffiliation_xml | – name: 3 Division of Hypertension and Vascular Diseases Department of Cardiology Heart Center The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China – name: 2 Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases Guangzhou China – name: 4 Department of Cardiology Donguan Songshan Lake Tungwah Hospital Dongguan China – name: 1 Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China |
| Author_xml | – sequence: 1 givenname: Shaole orcidid: 0009-0002-0431-7323 surname: Shi fullname: Shi, Shaole organization: Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases – sequence: 2 givenname: Fangyuan surname: Wu fullname: Wu, Fangyuan organization: The First Affiliated Hospital of Sun Yat‐sen University – sequence: 3 givenname: Shanshan surname: Zhao fullname: Zhao, Shanshan organization: Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases – sequence: 4 givenname: Zilian surname: Wang fullname: Wang, Zilian email: wangzil@mail.sysu.edu.cn organization: Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases – sequence: 5 givenname: Yongqiang surname: Fan fullname: Fan, Yongqiang email: fanyoqia@163.com organization: Donguan Songshan Lake Tungwah Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39550220$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1161/HYPERTENSIONAHA.123.21144 10.1101/cshperspect.a038984 10.3390/nu16172927 10.1093/eurheartj/ehad736 10.1002/jmv.28784 10.1001/jamanetworkopen.2023.0034 10.1038/s41467-023-42532-8 10.1097/AOG.0000000000003891 10.1002/dmrr.2803 10.1111/1471-0528.12375 10.1016/j.bcp.2022.115296 10.3390/antiox11050869 10.1038/s41598-017-12491-4 10.1016/S0002-9378(84)80023-X 10.1038/s41598-024-56790-z 10.1016/j.pharmthera.2024.108681 10.1161/01.RES.0000130527.92537.06 10.3390/ijms21031019 10.1016/j.ajog.2019.03.025 10.1016/j.advnut.2023.100164 10.1038/s41572-023-00417-6 10.1016/j.jacl.2020.10.001 10.1016/j.atherosclerosis.2018.05.051 10.1016/j.diabres.2020.108548 10.1007/s11745-015-4098-5 10.1016/j.plefa.2003.04.010 10.1159/000252971 10.1016/j.cbpa.2023.102370 10.1093/eurheartj/ehad472 10.3390/metabo12070590 10.1097/MOL.0000000000000927 10.1016/j.placenta.2018.05.011 10.3390/biom14060691 10.1038/s41419-022-04641-y 10.1016/j.jare.2018.01.002 10.1097/EDE.0000000000000559 10.1111/aogs.14505 10.1016/j.jlr.2024.100610 10.1038/s41598-021-83674-3 10.1136/bmj.n2233 10.1177/1933719114557896 10.3390/nu13103398 10.1080/10641950500281118 10.1186/s12876-024-03246-3 10.1016/j.ebiom.2023.104704 10.1136/bmj-2022-072148 10.1007/s00404-006-0140-4 10.1016/j.cellsig.2021.110041 10.1111/joim.13823 10.3109/01443610903391005 10.1016/j.trsl.2017.06.006 10.1161/CIRCULATIONAHA.117.029468 10.1385/ENDO:19:1:43 |
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| Copyright | 2024 The Author(s). published by Wiley Periodicals LLC. 2024 The Author(s). The Journal of Clinical Hypertension published by Wiley Periodicals LLC. 2025. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | eclampsia Mendelian randomization preeclampsia plasma lipids |
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| Notes | This work was supported by the Ministry of Science and Technology of the People's Republic of China (2021YFC2700700), Guangzhou Clinical Major Technology Project (2024P‐ZD12), Sun Yat‐Sen University Clinical Research 5010 Program (2022003). Funding Shaole Shi, Fangyuan Wu, and Shanshan Zhao contributed to the work equally and should be regarded as co‐first authors. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Funding: This work was supported by the Ministry of Science and Technology of the People's Republic of China (2021YFC2700700), Guangzhou Clinical Major Technology Project (2024P‐ZD12), Sun Yat‐Sen University Clinical Research 5010 Program (2022003). |
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| References | 2023; 76 2017; 7 2010; 97 2002; 19 2023; 6 2023; 381 2023; 102 2023; 9 2016; 32 2024; 35 2013; 120 2023; 80 2005; 24 2020; 18 2024; 260 2004; 70 2018; 137 2024; 65 2020; 135 2024; 24 2021; 85 2022; 206 2010; 30 2023; 95 2023; 14 2017; 28 1984; 148 2016; 51 2006; 274 2024; 14 2024; 15 2024; 16 2019; 221 2018; 69 2021; 13 2018; 276 2021; 15 2004; 94 2023; 44 2021; 11 2015; 22 2022; 12 2021; 171 2022; 13 2024; 296 2021; 375 2022; 11 2020; 21 2018; 11 2017; 189 2023; 94 e_1_2_11_32_1 e_1_2_11_55_1 e_1_2_11_30_1 e_1_2_11_36_1 e_1_2_11_51_1 e_1_2_11_13_1 Hong X. (e_1_2_11_31_1) 2020; 18 e_1_2_11_34_1 e_1_2_11_53_1 e_1_2_11_11_1 e_1_2_11_29_1 e_1_2_11_6_1 e_1_2_11_27_1 e_1_2_11_4_1 e_1_2_11_48_1 e_1_2_11_2_1 e_1_2_11_20_1 e_1_2_11_45_1 e_1_2_11_47_1 e_1_2_11_24_1 e_1_2_11_41_1 e_1_2_11_8_1 e_1_2_11_22_1 e_1_2_11_43_1 e_1_2_11_17_1 e_1_2_11_15_1 e_1_2_11_38_1 e_1_2_11_19_1 e_1_2_11_50_1 e_1_2_11_10_1 e_1_2_11_14_1 e_1_2_11_35_1 e_1_2_11_52_1 e_1_2_11_33_1 e_1_2_11_54_1 e_1_2_11_7_1 e_1_2_11_28_1 e_1_2_11_5_1 e_1_2_11_26_1 e_1_2_11_3_1 e_1_2_11_49_1 e_1_2_11_21_1 e_1_2_11_44_1 e_1_2_11_46_1 e_1_2_11_25_1 e_1_2_11_40_1 e_1_2_11_9_1 e_1_2_11_23_1 e_1_2_11_42_1 e_1_2_11_18_1 e_1_2_11_16_1 e_1_2_11_37_1 Clayton G. L. (e_1_2_11_12_1) 2023; 381 e_1_2_11_39_1 |
| References_xml | – volume: 80 start-page: 1771 year: 2023 end-page: 1783 article-title: Longitudinal Lipidomic Profile of Hypertension in American Indians: Findings From the Strong Heart Family Study publication-title: Hypertension – volume: 102 start-page: 334 year: 2023 end-page: 343 article-title: Metabolic Profiling of Pregnancies Complicated by Preeclampsia: A Longitudinal Study publication-title: Acta Obstetricia Et Gynecologica Scandinavica – volume: 375 year: 2021 article-title: Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomisation (STROBE‐MR): Explanation and Elaboration publication-title: British Medical Journal – volume: 11 start-page: 869 year: 2022 article-title: Increased Circulating Levels of PCSK9 and Pro‐Atherogenic Lipoprotein Profile in Pregnant Women With Maternal Supraphysiological Hypercholesterolemia publication-title: Antioxidants (Basel) – volume: 260 year: 2024 article-title: Bioactive Lipids in the Skin Barrier Mediate Its Functionality in Health and Disease publication-title: Pharmacology & Therapeutics – volume: 19 start-page: 43 year: 2002 end-page: 55 article-title: Lipid Metabolism in Pregnancy and Its Consequences in the Fetus and Newborn publication-title: Endocrine – volume: 51 start-page: 85 year: 2016 end-page: 94 article-title: Reduced Maternal Erythrocyte Long Chain Polyunsaturated Fatty Acids Exist in Early Pregnancy in Preeclampsia publication-title: Lipids – volume: 94 year: 2023 article-title: Plasma Lipids Are Dysregulated Preceding Diagnosis of Preeclampsia or Delivery of a Growth Restricted Infant publication-title: EBioMedicine – volume: 24 start-page: 158 year: 2024 article-title: Genetically Predicted Gut Microbiota Mediate the Association Between Plasma Lipidomics and Primary Sclerosing Cholangitis publication-title: BMC Gastroenterology [Electronic Resource] – volume: 12 start-page: 590 year: 2022 article-title: Dissecting the Roles of Lipids in Preeclampsia publication-title: Metabolites – volume: 18 start-page: 277 year: 2020 article-title: Postpartum Plasma Metabolomic Profile Among Women With Preeclampsia and Preterm Delivery: Implications for Long‐Term Health publication-title: BMC Medicine [Electronic Resource] – volume: 28 start-page: 30 year: 2017 end-page: 42 article-title: Sensitivity Analyses for Robust Causal Inference From Mendelian Randomization Analyses With Multiple Genetic Variants publication-title: Epidemiology (Cambridge, Mass) – volume: 137 start-page: 841 year: 2018 end-page: 853 article-title: Metabolic Predictors of Incident Coronary Heart Disease in Women publication-title: Circulation – volume: 135 start-page: e237 year: 2020 end-page: e260 article-title: Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222 publication-title: Obstetrics and Gynecology – volume: 14 start-page: 691 year: 2024 article-title: Paradoxes: Cholesterol and Hypoxia in Preeclampsia publication-title: Biomolecules – volume: 381 year: 2023 article-title: A Framework for Assessing Selection and Misclassification Bias in Mendelian Randomisation Studies: An Illustrative Example Between Body Mass Index and Covid‐19 publication-title: British Medical Journal – volume: 32 start-page: 835 year: 2016 end-page: 842 article-title: Clustering of Metabolic Risk Factors and Adverse Pregnancy Outcomes: A Prospective Cohort Study publication-title: Diabetes Metabolism Research and Reviews – volume: 30 start-page: 151 year: 2010 end-page: 154 article-title: Erythrocyte Omega‐3 and Omega‐6 Fatty Acids Profile in Sudanese Women With Pre‐Eclampsia publication-title: Journal of Obstetrics and Gynaecology – volume: 65 year: 2024 article-title: Dyslipidemia‐Induced Renal Fibrosis Related to Ferroptosis and Endoplasmic Reticulum Stress publication-title: Journal of Lipid Research – volume: 11 start-page: 43 year: 2018 end-page: 55 article-title: Arachidonic Acid in Health and Disease With Focus on Hypertension and Diabetes Mellitus: A Review publication-title: Journal of Advanced Research – volume: 274 start-page: 97 year: 2006 end-page: 103 article-title: Erythrocyte Omega‐3 and Omega‐6 Polyunsaturated Fatty Acids and Preeclampsia Risk in Peruvian Women publication-title: Archives of Gynecology and Obstetrics – volume: 94 start-page: 1515 year: 2004 end-page: 1522 article-title: PPARgamma Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol‐Protein Kinase C Signaling Pathway: Role of Diacylglycerol Kinase publication-title: Circulation Research – volume: 35 start-page: 133 year: 2024 end-page: 140 article-title: Lipid Metabolism During Pregnancy: Consequences for Mother and Child publication-title: Current Opinion in Lipidology – volume: 14 start-page: 6934 year: 2023 article-title: Genome‐Wide Association Analysis of Plasma Lipidome Identifies 495 Genetic Associations publication-title: Nature Communications – volume: 97 start-page: 190 year: 2010 end-page: 194 article-title: Long‐Chain Polyunsaturated Fatty Acid Composition of Breast Milk in Pre‐Eclamptic Mothers publication-title: Neonatology – volume: 44 start-page: 4157 year: 2023 end-page: 4173 article-title: Women, Lipids, and Atherosclerotic Cardiovascular Disease: A Call to Action From the European Atherosclerosis Society publication-title: European Heart Journal – volume: 24 start-page: 235 year: 2005 end-page: 245 article-title: Placental Tissue Levels of Nonesterified Polyunsaturated Fatty Acids in Normal and Preeclamptic Pregnancies publication-title: Hypertension in Pregnancy – volume: 15 start-page: 162 year: 2021 end-page: 172 article-title: Association of High Maternal Triglyceride Levels Early and Late in Pregnancy With Adverse Outcomes: A Retrospective Cohort Study publication-title: Journal of Clinical Lipidology – volume: 6 year: 2023 article-title: Association of Hypertensive Disorders of Pregnancy With Future Cardiovascular Disease publication-title: JAMA Network Open – volume: 11 year: 2021 article-title: Multivariable Mendelian Randomization and Mediation publication-title: Cold Spring Harbor Perspectives in Medicine – volume: 69 start-page: 118 year: 2018 end-page: 124 article-title: Altered Maternal and Placental Lipid Metabolism and Fetal Fat Development in Obesity: Current Knowledge and Advances in Non‐Invasive Assessment publication-title: Placenta – volume: 44 start-page: 4913 year: 2023 end-page: 4924 article-title: Mendelian Randomization for Cardiovascular Diseases: Principles and Applications publication-title: European Heart Journal – volume: 120 start-page: 1321 year: 2013 end-page: 1332 article-title: Pre‐Eclampsia Is Associated With, and Preceded by Hypertriglyceridaemia: A Meta‐Analysis publication-title: British Journal of Obstetrics and Gynaecology – volume: 76 year: 2023 article-title: Recent Advances Towards Mass Spectrometry‐Based Clinical Lipidomics publication-title: Current Opinion in Chemical Biology – volume: 11 start-page: 4048 year: 2021 article-title: The Association Between Dietary Fatty Acid Intake and the Risk of Developing Preeclampsia: A Matched Case‐Control Study publication-title: Scientific Reports – volume: 296 start-page: 216 issue: 3 year: 2024 end-page: 233 article-title: Can Short‐ and Long‐Term Maternal and Infant Risks Linked to Hypertension and Diabetes During Pregnancy be Reduced by Therapy? publication-title: Journal of Internal Medicine – volume: 85 year: 2021 article-title: Hemmings DG. Physiological and Pathological Functions of Sphingolipids in Pregnancy publication-title: Cellular Signalling – volume: 9 start-page: 8 year: 2023 article-title: Pre‐Eclampsia publication-title: Nature Reviews Disease Primers – volume: 15 year: 2024 article-title: The Relationship of Circulating Choline and Choline‐Related Metabolite Levels With Health Outcomes: A Scoping Review of Genome‐Wide Association Studies and Mendelian Randomization Studies publication-title: Advances in Nutrition – volume: 95 year: 2023 article-title: The Causal Links Between Gut Microbiota and COVID‐19: A Mendelian Randomization Study publication-title: Journal of Medical Virology – volume: 13 start-page: 3398 year: 2021 article-title: Influence of Dietary Behaviors on Dyslipidemia in Pregnant Women and Its Effects on Physical Development of Fetuses and Infants: A Bidirectional Cohort Study publication-title: Nutrients – volume: 13 start-page: 191 year: 2022 article-title: Dichotomy in Hypoxia‐Induced Mitochondrial Fission in Placental Mesenchymal Cells During Development and Preeclampsia: Consequences for Trophoblast Mitochondrial Homeostasis publication-title: Cell Death & Disease – volume: 171 year: 2021 article-title: Nuclear Magnetic Resonance‐Based Metabolomic Analysis in the Assessment of Preclinical Atherosclerosis in Type 1 Diabetes and Preeclampsia publication-title: Diabetes Research and Clinical Practice – volume: 276 start-page: 189 year: 2018 end-page: 194 article-title: Lipid Profile, Plasma Apolipoproteins, and Pre‐Eclampsia Risk in the GenPE Case‐Control Study publication-title: Atherosclerosis – volume: 206 year: 2022 article-title: Regulation of Membrane Phospholipid Biosynthesis in Mammalian Cells publication-title: Biochemical Pharmacology – volume: 21 start-page: 1019 year: 2020 article-title: Sphingolipid Signature of Human Feto‐Placental Vasculature in Preeclampsia publication-title: International Journal of Molecular Sciences – volume: 148 start-page: 5 year: 1984 end-page: 9 article-title: Serum Arachidonic Acid Levels in Normal and Preeclamptic Pregnancies publication-title: American Journal of Obstetrics and Gynecology – volume: 189 start-page: 13 year: 2017 end-page: 29 article-title: Lipidomics in Translational Research and the Clinical Significance of Lipid‐Based Biomarkers publication-title: Translational Research – volume: 22 start-page: 712 year: 2015 end-page: 717 article-title: Early Pregnancy Maternal Lipid Profiles and the Risk of Gestational Diabetes Mellitus Stratified for Body Mass Index publication-title: Reproductive Sciences – volume: 16 start-page: 2927 year: 2024 article-title: Characteristics, Physiopathology and Management of Dyslipidemias in Pregnancy: A Narrative Review publication-title: Nutrients – volume: 7 year: 2017 article-title: A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin Into the Maternal Circulation in Preeclampsia publication-title: Scientific Reports – volume: 221 start-page: 150 year: 2019 article-title: Is Maternal Lipid Profile in Early Pregnancy Associated With Pregnancy Complications and Blood Pressure in Pregnancy and Long Term Postpartum? publication-title: American Journal of Obstetrics and Gynecology – volume: 70 start-page: 223 year: 2004 end-page: 232 article-title: Eicosanoids in Preeclampsia publication-title: Prostaglandins Leukotrienes and Essential Fatty Acids – volume: 14 start-page: 6182 year: 2024 article-title: Gestational Diabetes Mellitus, Hypertension, and Dyslipidemia as the Risk Factors of Preeclampsia publication-title: Scientific Reports – ident: e_1_2_11_26_1 doi: 10.1161/HYPERTENSIONAHA.123.21144 – ident: e_1_2_11_16_1 doi: 10.1101/cshperspect.a038984 – ident: e_1_2_11_21_1 doi: 10.3390/nu16172927 – ident: e_1_2_11_10_1 doi: 10.1093/eurheartj/ehad736 – ident: e_1_2_11_50_1 doi: 10.1002/jmv.28784 – ident: e_1_2_11_14_1 doi: 10.1001/jamanetworkopen.2023.0034 – ident: e_1_2_11_9_1 doi: 10.1038/s41467-023-42532-8 – ident: e_1_2_11_3_1 doi: 10.1097/AOG.0000000000003891 – ident: e_1_2_11_29_1 doi: 10.1002/dmrr.2803 – ident: e_1_2_11_20_1 doi: 10.1111/1471-0528.12375 – ident: e_1_2_11_38_1 doi: 10.1016/j.bcp.2022.115296 – ident: e_1_2_11_27_1 doi: 10.3390/antiox11050869 – ident: e_1_2_11_35_1 doi: 10.1038/s41598-017-12491-4 – ident: e_1_2_11_49_1 doi: 10.1016/S0002-9378(84)80023-X – ident: e_1_2_11_52_1 doi: 10.1038/s41598-024-56790-z – ident: e_1_2_11_55_1 doi: 10.1016/j.pharmthera.2024.108681 – ident: e_1_2_11_33_1 doi: 10.1161/01.RES.0000130527.92537.06 – ident: e_1_2_11_36_1 doi: 10.3390/ijms21031019 – ident: e_1_2_11_24_1 doi: 10.1016/j.ajog.2019.03.025 – ident: e_1_2_11_40_1 doi: 10.1016/j.advnut.2023.100164 – ident: e_1_2_11_2_1 doi: 10.1038/s41572-023-00417-6 – ident: e_1_2_11_23_1 doi: 10.1016/j.jacl.2020.10.001 – ident: e_1_2_11_7_1 doi: 10.1016/j.atherosclerosis.2018.05.051 – ident: e_1_2_11_39_1 doi: 10.1016/j.diabres.2020.108548 – ident: e_1_2_11_44_1 doi: 10.1007/s11745-015-4098-5 – ident: e_1_2_11_41_1 doi: 10.1016/j.plefa.2003.04.010 – ident: e_1_2_11_46_1 doi: 10.1159/000252971 – ident: e_1_2_11_8_1 doi: 10.1016/j.cbpa.2023.102370 – ident: e_1_2_11_19_1 doi: 10.1093/eurheartj/ehad472 – ident: e_1_2_11_17_1 doi: 10.3390/metabo12070590 – ident: e_1_2_11_6_1 doi: 10.1097/MOL.0000000000000927 – ident: e_1_2_11_54_1 doi: 10.1016/j.placenta.2018.05.011 – ident: e_1_2_11_5_1 doi: 10.3390/biom14060691 – ident: e_1_2_11_34_1 doi: 10.1038/s41419-022-04641-y – ident: e_1_2_11_43_1 doi: 10.1016/j.jare.2018.01.002 – volume: 18 start-page: 277 year: 2020 ident: e_1_2_11_31_1 article-title: Postpartum Plasma Metabolomic Profile Among Women With Preeclampsia and Preterm Delivery: Implications for Long‐Term Health publication-title: BMC Medicine [Electronic Resource] – ident: e_1_2_11_15_1 doi: 10.1097/EDE.0000000000000559 – ident: e_1_2_11_22_1 doi: 10.1111/aogs.14505 – ident: e_1_2_11_28_1 doi: 10.1016/j.jlr.2024.100610 – ident: e_1_2_11_42_1 doi: 10.1038/s41598-021-83674-3 – ident: e_1_2_11_11_1 doi: 10.1136/bmj.n2233 – ident: e_1_2_11_51_1 doi: 10.1177/1933719114557896 – ident: e_1_2_11_30_1 doi: 10.3390/nu13103398 – ident: e_1_2_11_45_1 doi: 10.1080/10641950500281118 – ident: e_1_2_11_13_1 doi: 10.1186/s12876-024-03246-3 – ident: e_1_2_11_32_1 doi: 10.1016/j.ebiom.2023.104704 – volume: 381 year: 2023 ident: e_1_2_11_12_1 article-title: A Framework for Assessing Selection and Misclassification Bias in Mendelian Randomisation Studies: An Illustrative Example Between Body Mass Index and Covid‐19 publication-title: British Medical Journal doi: 10.1136/bmj-2022-072148 – ident: e_1_2_11_47_1 doi: 10.1007/s00404-006-0140-4 – ident: e_1_2_11_37_1 doi: 10.1016/j.cellsig.2021.110041 – ident: e_1_2_11_4_1 doi: 10.1111/joim.13823 – ident: e_1_2_11_48_1 doi: 10.3109/01443610903391005 – ident: e_1_2_11_53_1 doi: 10.1016/j.trsl.2017.06.006 – ident: e_1_2_11_25_1 doi: 10.1161/CIRCULATIONAHA.117.029468 – ident: e_1_2_11_18_1 doi: 10.1385/ENDO:19:1:43 |
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| Snippet | ABSTRACT
Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian... Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian... Circulating lipids play a crucial role during pregnancy and may impact various pregnancy-related diseases. This study employed a two-sample Mendelian... ABSTRACT Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian... |
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| SubjectTerms | Adult Eclampsia Eclampsia - blood Eclampsia - epidemiology Eclampsia - genetics Female Finland - epidemiology Humans Lipidomics - methods Lipids Lipids - blood Mendelian randomization Mendelian Randomization Analysis - methods Original Plasma plasma lipids Pre-Eclampsia - blood Pre-Eclampsia - epidemiology Pre-Eclampsia - genetics Preeclampsia Pregnancy Risk Factors Triglycerides - blood |
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| Title | Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study |
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