Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles

• Published in: Journal of extracellular vesicles Vol. 9; no. 1; pp. 1766822 - n/a
• Main Authors: Cheng, Lesley, Vella, Laura J., Barnham, Kevin J., McLean, Catriona, Masters, Colin L., Hill, Andrew F.
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis 01.01.2020; John Wiley & Sons, Inc; Wiley
• Subjects: Alzheimer's disease; Biomarkers; Biopsy; brain derived exosomes and extracellular vesicles; Cortex (frontal); exosomes; Extracellular vesicles; Horizontal transfer; MicroRNAs; miRNA; Neurodegenerative diseases; Pathology; Peptide mapping; Transcriptomics

Alzheimer's disease is a progressive neurodegenerative disorder, with the strongest disease-associated changes observed at clinical or end-stage disease. Transcriptomic deregulation of miRNA expression can spread via "horizontal" RNA transfer through extracellular vesicles (EVs) to ac...