Determination of APTT factor sensitivity - the misguiding guideline

• Published in: International journal of laboratory hematology Vol. 35; no. 6; pp. 652 - 657
• Main Authors: Lawrie, A. S., Kitchen, S., Efthymiou, M., Mackie, I. J., Machin, S. J.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.12.2013; BlackWell Publishing Ltd
• Subjects: APTT; Blood Coagulation Factors - metabolism; Blood Coagulation Tests - methods; Blood Coagulation Tests - standards; Humans; Original; Partial Thromboplastin Time - methods; Partial Thromboplastin Time - standards; plasma clotting factors; Practice Guidelines as Topic; Reagent Kits, Diagnostic; Reference Values; Sensitivity and Specificity; APTT; plasma clotting factors

Summary Introduction The Clinical and Laboratory Standards Institute (CLSI) has produced a guideline detailing how to determine the activated partial thromboplastin time's (APTT) sensitivity to clotting factor deficiencies, by mixing normal and deficient plasmas. Using the guideline, we determi...