Assessing the Associations of Blood Metabolites With Osteoporosis: A Mendelian Randomization Study

• Published in: The journal of clinical endocrinology and metabolism Vol. 103; no. 5; pp. 1850 - 1855
• Main Authors: Liu, Li, Wen, Yan, Zhang, Lei, Xu, Peng, Liang, Xiao, Du, Yanan, Li, Ping, He, Awen, Fan, QianRui, Hao, Jingcan, Wang, Wenyu, Guo, Xiong, Shen, Hui, Tian, Qing, Zhang, Feng, Deng, Hong-Wen
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.05.2018; Copyright Oxford University Press; Oxford University Press
• Subjects: Absorptiometry, Photon; Adult; Aged; Biomarkers - analysis; Biomarkers - blood; Biomarkers - metabolism; Blood; Bone Density - genetics; Bone diseases; Bone mineral density; Clinical s; Correlation analysis; Dual energy X-ray absorptiometry; Editor's Choice; Female; Gene polymorphism; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomes; Genotype; Genotyping; Hip; Humans; Male; Mendelian Randomization Analysis; Metabolites; Methionine; Middle Aged; Osteoporosis; Osteoporosis - blood; Osteoporosis - epidemiology; Osteoporosis - genetics; Osteoporosis - metabolism; Phenotype; Phenotypes; Phenotypic variations; Polymorphism, Single Nucleotide; Random Allocation; Replication; Single-nucleotide polymorphism; Theophylline; Whole genome sequencing

Abstract Context Osteoporosis is a metabolic bone disease. The effect of blood metabolites on the development of osteoporosis remains elusive. Objective To explore the relationship between blood metabolites and osteoporosis. Design and Methods We used 2286 unrelated white subjects for the discovery...