Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

• Published in: Journal of neuropathology and experimental neurology Vol. 70; no. 11; pp. 960 - 969
• Main Authors: Braak, Heiko, Thal, Dietmar R., Ghebremedhin, Estifanos, Del Tredici, Kelly
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Association of Neuropathologists, Inc 01.11.2011; Lippincott Williams & Wilkins; Oxford University Press
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Biological and medical sciences; Brain; Brain - metabolism; Brain - pathology; Child; Child, Preschool; Cloning; Cohort Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Progression; Female; Humans; Infant; Male; Medical research; Medical sciences; Middle Aged; Neurofibrillary Tangles - pathology; Neurology; Neurons - metabolism; Neurons - pathology; Silver Staining - methods; Statistics, Nonparametric; tau Proteins - metabolism; Young Adult; Nervous system diseases; Phosphorylation; Alzheimer disease; Brain stem; Central nervous system; Brainstem; Neurofibrillary tangle; Encephalon; Cerebral disorder; Thread; Pretangles/neurofibrillary tangles; Neuropil threads; Tau protein; β Amyloid protein; Central nervous system disease; Hyper-phosphorylated tau protein; Degenerative disease; Microtubule associated protein; Age; Locus coeruleus; β-amyloid
• ISSN: 0022-3069; 1554-6578; 1554-6578
• DOI: 10.1097/NEN.0b013e318232a379

Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for abnormal tau; immunocytochemistry (4G8) and Campbell-Switzer staining were used for the detection ofβ-amyloid. A total of 342...