Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for abnormal tau; immunocytochemistry (4G8) and Campbell-Switzer staining were used for the detection ofβ-amyloid. A total of 342...
Saved in:
| Published in | Journal of neuropathology and experimental neurology Vol. 70; no. 11; pp. 960 - 969 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hagerstown, MD
American Association of Neuropathologists, Inc
01.11.2011
Lippincott Williams & Wilkins Oxford University Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-3069 1554-6578 1554-6578 |
| DOI | 10.1097/NEN.0b013e318232a379 |
Cover
Loading…
| Abstract | Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for abnormal tau; immunocytochemistry (4G8) and Campbell-Switzer staining were used for the detection ofβ-amyloid. A total of 342 cases was negative in the Gallyas stain but when restaged for AT8 only 10 were immunonegative. Fifty-eight cases had subcortical tau predominantly in the locus coeruleus, but there was no abnormal cortical tau (subcortical Stages a-c). Cortical involvement (abnormal tau in neurites) was identified first in the transentorhinal region (Stage 1a, 38 cases). Transentorhinal pyramidal cells displayed pretangle material (Stage 1b, 236 cases). Pretangles gradually became argyrophilic neurofibrillary tangles (NFTs) that progressed in parallel with NFT Stages I to VI. Pretangles restricted to subcortical sites were seen chiefly at younger ages. Of the total cases, 1,031 (44.2%) had β-amyloid plaques. The first plaques occurred in the neocortex after the onset of tauopathy in the brainstem. Plaques generally developed in the 40s in 4% of all cases, culminating in their tenth decade (75%). β-amyloid plaques and NFTs were significantly correlated (p < 0.0001). These data suggest that tauopathy associated with sporadic Alzheimer disease may begin earlier than previously thought and possibly in the lower brainstem rather than in the transentorhinal region. |
|---|---|
| AbstractList | Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for abnormal tau; immunocytochemistry (4G8) and Campbell-Switzer staining were used for the detection ofβ-amyloid. A total of 342 cases was negative in the Gallyas stain but when restaged for AT8 only 10 were immunonegative. Fifty-eight cases had subcortical tau predominantly in the locus coeruleus, but there was no abnormal cortical tau (subcortical Stages a-c). Cortical involvement (abnormal tau in neurites) was identified first in the transentorhinal region (Stage 1a, 38 cases). Transentorhinal pyramidal cells displayed pretangle material (Stage 1b, 236 cases). Pretangles gradually became argyrophilic neurofibrillary tangles (NFTs) that progressed in parallel with NFT Stages I to VI. Pretangles restricted to subcortical sites were seen chiefly at younger ages. Of the total cases, 1,031 (44.2%) had β-amyloid plaques. The first plaques occurred in the neocortex after the onset of tauopathy in the brainstem. Plaques generally developed in the 40s in 4% of all cases, culminating in their tenth decade (75%). β-amyloid plaques and NFTs were significantly correlated (p < 0.0001). These data suggest that tauopathy associated with sporadic Alzheimer disease may begin earlier than previously thought and possibly in the lower brainstem rather than in the transentorhinal region. Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for abnormal tau; immunocytochemistry (4G8) and Campbell-Switzer staining were used for the detection ofβ-amyloid. A total of 342 cases was negative in the Gallyas stain but when restaged for AT8 only 10 were immunonegative. Fifty-eight cases had subcortical tau predominantly in the locus coeruleus, but there was no abnormal cortical tau (subcortical Stages a-c). Cortical involvement (abnormal tau in neurites) was identified first in the transentorhinal region (Stage 1a, 38 cases). Transentorhinal pyramidal cells displayed pretangle material (Stage 1b, 236 cases). Pretangles gradually became argyrophilic neurofibrillary tangles (NFTs) that progressed in parallel with NFT Stages I to VI. Pretangles restricted to subcortical sites were seen chiefly at younger ages. Of the total cases, 1,031 (44.2%) had β-amyloid plaques. The first plaques occurred in the neocortex after the onset of tauopathy in the brainstem. Plaques generally developed in the 40s in 4% of all cases, culminating in their tenth decade (75%). β-amyloid plaques and NFTs were significantly correlated (p < 0.0001). These data suggest that tauopathy associated with sporadic Alzheimer disease may begin earlier than previously thought and possibly in the lower brainstem rather than in the transentorhinal region.Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for abnormal tau; immunocytochemistry (4G8) and Campbell-Switzer staining were used for the detection ofβ-amyloid. A total of 342 cases was negative in the Gallyas stain but when restaged for AT8 only 10 were immunonegative. Fifty-eight cases had subcortical tau predominantly in the locus coeruleus, but there was no abnormal cortical tau (subcortical Stages a-c). Cortical involvement (abnormal tau in neurites) was identified first in the transentorhinal region (Stage 1a, 38 cases). Transentorhinal pyramidal cells displayed pretangle material (Stage 1b, 236 cases). Pretangles gradually became argyrophilic neurofibrillary tangles (NFTs) that progressed in parallel with NFT Stages I to VI. Pretangles restricted to subcortical sites were seen chiefly at younger ages. Of the total cases, 1,031 (44.2%) had β-amyloid plaques. The first plaques occurred in the neocortex after the onset of tauopathy in the brainstem. Plaques generally developed in the 40s in 4% of all cases, culminating in their tenth decade (75%). β-amyloid plaques and NFTs were significantly correlated (p < 0.0001). These data suggest that tauopathy associated with sporadic Alzheimer disease may begin earlier than previously thought and possibly in the lower brainstem rather than in the transentorhinal region. Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for abnormal tau; immunocytochemistry (4G8) and Campbell-Switzer staining were used for the detection of β-amyloid. A total of 342 cases was negative in the Gallyas stain but when restaged for AT8 only 10 were immunonegative. Fifty-eight cases had subcortical tau predominantly in the locus coeruleus, but there was no abnormal cortical tau (subcortical Stages a-c). Cortical involvement (abnormal tau in neurites) was identified first in the transentorhinal region (Stage 1a, 38 cases). Transentorhinal pyramidal cells displayed pretangle material (Stage 1b, 236 cases). Pretangles gradually became argyrophilic neurofibrillary tangles (NFTs) that progressed in parallel with NFT Stages I to VI. Pretangles restricted to subcortical sites were seen chiefly at younger ages. Of the total cases, 1,031 (44.2%) had β-amyloid plaques. The first plaques occurred in the neocortex after the onset of tauopathy in the brainstem. Plaques generally developed in the 40s in 4% of all cases, culminating in their tenth decade (75%). β-amyloid plaques and NFTs were significantly correlated (p < 0.0001). These data suggest that tauopathy associated with sporadic Alzheimer disease may begin earlier than previously thought and possibly in the lower brainstem rather than in the transentorhinal region. [PUBLICATION ABSTRACT] |
| Author | Del Tredici, Kelly Thal, Dietmar R. Ghebremedhin, Estifanos Braak, Heiko |
| AuthorAffiliation | From Clinical Neuroanatomy, Department of Neurology (HB, KDT) and Laboratory for Neuropathology - Institute of Pathology (DT, EG), Center for Clinical Research, University of Ulm, Ulm, Germany; and Department of Anatomy and Developmental Biology (EG), School of Biomedical Sciences, University of Queensland, Brisbane, Australia |
| AuthorAffiliation_xml | – name: From Clinical Neuroanatomy, Department of Neurology (HB, KDT) and Laboratory for Neuropathology - Institute of Pathology (DT, EG), Center for Clinical Research, University of Ulm, Ulm, Germany; and Department of Anatomy and Developmental Biology (EG), School of Biomedical Sciences, University of Queensland, Brisbane, Australia |
| Author_xml | – sequence: 1 givenname: Heiko surname: Braak fullname: Braak, Heiko organization: From Clinical Neuroanatomy, Department of Neurology (HB, KDT) and Laboratory for Neuropathology - Institute of Pathology (DT, EG), Center for Clinical Research, University of Ulm, Ulm, Germany; and Department of Anatomy and Developmental Biology (EG), School of Biomedical Sciences, University of Queensland, Brisbane, Australia – sequence: 2 givenname: Dietmar surname: Thal middlename: R. fullname: Thal, Dietmar R. – sequence: 3 givenname: Estifanos surname: Ghebremedhin fullname: Ghebremedhin, Estifanos – sequence: 4 givenname: Kelly surname: Del Tredici fullname: Del Tredici, Kelly |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24734607$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22002422$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkU1rFEEQhhuJmE30H4g0gniaWP01PZ3bsiYqhBhQDzkNvb01Ox1npmN3D0F_vS27QdiDnupQz_NS1HtCjqYwISEvGZwxMPrd9cX1GayBCRSs4YJboc0TsmBKyapWujkiCwDOKwG1OSYnKd0BgAEjn5FjzstKcr4gt1-y3WKioaO5R3pjcx-GsPWO3sTgMCXqJ7ocfvXoR4z0vU9oE57T5RbpymbchuiLfhnDSBnNgTIAeos2pufkaWeHhC_285R8u7z4uvpYXX3-8Gm1vKqc4tJUjnHVyY0BtVFKu8Y4WVtjlZNOC3DWAJMGOKs7jcAsV5qZugOuBHd6bRpxSt7ucu9j-DFjyu3ok8NhsBOGObUGoBasFqqQrw_IuzDHqRxXoFqVpxhRoFd7aF6PuGnvox9t_Nk-vqwAb_aATc4OXbST8-kvJ7WQNejCne84F0NKEbvW-WyzD1OO1g8tg_ZPj23psT3sscjyQH7M_4_W7LSHMGSM6fswP2Bse7RD7v-t_gbRra3_ |
| CODEN | JNENAD |
| CitedBy_id | crossref_primary_10_3389_fncel_2022_801179 crossref_primary_10_1002_glia_22589 crossref_primary_10_3389_fnhum_2024_1379923 crossref_primary_10_1111_nyas_15138 crossref_primary_10_1111_bpa_12996 crossref_primary_10_1002_alz_12966 crossref_primary_10_1016_j_arr_2021_101449 crossref_primary_10_1016_j_arr_2022_101724 crossref_primary_10_1186_s13195_024_01609_2 crossref_primary_10_1093_jnen_nlw033 crossref_primary_10_3390_biology10111127 crossref_primary_10_1038_s41598_020_58038_y crossref_primary_10_1016_j_bbr_2022_113806 crossref_primary_10_3389_fnins_2023_1184080 crossref_primary_10_1093_brain_awv050 crossref_primary_10_3389_fnsyn_2022_826601 crossref_primary_10_1002_alz_12970 crossref_primary_10_3389_fnins_2019_00659 crossref_primary_10_3390_brainsci12030381 crossref_primary_10_1016_j_neuron_2012_03_004 crossref_primary_10_1093_brain_awx232 crossref_primary_10_3390_life11050388 crossref_primary_10_1016_j_ccr_2022_214726 crossref_primary_10_1093_sleep_zsab110 crossref_primary_10_1186_s13244_022_01358_6 crossref_primary_10_3390_brainsci7050051 crossref_primary_10_1007_s00702_021_02325_z crossref_primary_10_1371_journal_pone_0303338 crossref_primary_10_1016_j_neurobiolaging_2015_10_025 crossref_primary_10_3233_JAD_221048 crossref_primary_10_1038_s41398_023_02328_2 crossref_primary_10_1016_j_brainres_2017_12_027 crossref_primary_10_1093_brain_awu190 crossref_primary_10_1186_s13195_021_00918_0 crossref_primary_10_1007_s12603_023_2005_y crossref_primary_10_1002_slct_202401473 crossref_primary_10_1016_j_biopsych_2014_12_019 crossref_primary_10_1016_j_ecoenv_2023_115565 crossref_primary_10_1093_sleep_zsz017 crossref_primary_10_1002_alz_12943 crossref_primary_10_1146_annurev_devpsych_042320_044338 crossref_primary_10_3233_JAD_201469 crossref_primary_10_1001_jamaneurol_2018_1836 crossref_primary_10_1097_NEN_0000000000000094 crossref_primary_10_1016_j_mri_2014_07_003 crossref_primary_10_1016_j_nbd_2019_104587 crossref_primary_10_1186_s12974_021_02371_0 crossref_primary_10_1523_JNEUROSCI_1387_13_2013 crossref_primary_10_1111_nan_12965 crossref_primary_10_1038_s41598_022_20963_5 crossref_primary_10_2174_1871524923666230726102846 crossref_primary_10_1073_pnas_2113641119 crossref_primary_10_1016_j_jalz_2012_12_009 crossref_primary_10_1038_s41582_021_00595_5 crossref_primary_10_1016_j_jpsychires_2021_08_033 crossref_primary_10_1038_s42003_019_0693_y crossref_primary_10_3390_ijms25074065 crossref_primary_10_1186_s40478_021_01229_z crossref_primary_10_3389_fncel_2018_00131 crossref_primary_10_3233_JAD_210185 crossref_primary_10_3390_molecules28020865 crossref_primary_10_1016_j_cortex_2017_10_015 crossref_primary_10_1016_j_neubiorev_2017_10_023 crossref_primary_10_2139_ssrn_4182791 crossref_primary_10_1007_s00401_014_1373_0 crossref_primary_10_1093_ajcn_nqy225 crossref_primary_10_1016_j_neurobiolaging_2015_10_009 crossref_primary_10_1002_alz_13809 crossref_primary_10_1186_s13195_020_00601_w crossref_primary_10_1177_1533317514537547 crossref_primary_10_3390_v15061319 crossref_primary_10_3233_JAD_221061 crossref_primary_10_1002_alz_12713 crossref_primary_10_1007_s00401_014_1375_y crossref_primary_10_1038_s41398_022_01901_5 crossref_primary_10_3233_JAD_201474 crossref_primary_10_1001_jamaneurol_2019_1667 crossref_primary_10_1186_s13024_022_00578_0 crossref_primary_10_1002_jnr_24718 crossref_primary_10_1162_jocn_a_02245 crossref_primary_10_1002_alz_12722 crossref_primary_10_3389_fncel_2021_789903 crossref_primary_10_1002_hbm_25438 crossref_primary_10_1016_j_neuroimage_2019_06_049 crossref_primary_10_1016_j_neurol_2015_10_008 crossref_primary_10_1212_WNL_0000000000008838 crossref_primary_10_3233_JAD_180404 crossref_primary_10_1017_S0954422415000141 crossref_primary_10_1016_j_celrep_2025_115422 crossref_primary_10_1212_WNL_0000000000008835 crossref_primary_10_1001_jamaneurol_2019_3606 crossref_primary_10_1212_WNL_0000000000007747 crossref_primary_10_1038_s41374_018_0166_9 crossref_primary_10_1038_s41583_019_0240_3 crossref_primary_10_1002_syn_22183 crossref_primary_10_1111_aos_13319 crossref_primary_10_1007_s00702_021_02338_8 crossref_primary_10_1038_s41598_020_57785_2 crossref_primary_10_2967_jnumed_118_225508 crossref_primary_10_1126_scitranslmed_aad9704 crossref_primary_10_1007_s00401_024_02839_2 crossref_primary_10_1093_jnen_nlaa025 crossref_primary_10_1016_j_bionps_2021_100041 crossref_primary_10_3389_fnagi_2020_572337 crossref_primary_10_1016_j_expneurol_2014_12_008 crossref_primary_10_3389_fnimg_2023_1207844 crossref_primary_10_1038_s41598_020_71368_1 crossref_primary_10_1038_s41380_023_02041_y crossref_primary_10_1074_jbc_RA118_006943 crossref_primary_10_1113_JP277459 crossref_primary_10_3233_JAD_180218 crossref_primary_10_1038_s41591_020_0762_2 crossref_primary_10_1515_jcim_2023_0114 crossref_primary_10_1007_s13205_024_04034_2 crossref_primary_10_1038_s41467_024_46899_0 crossref_primary_10_1007_s10571_022_01234_3 crossref_primary_10_3389_fneur_2020_572850 crossref_primary_10_1002_alz_13869 crossref_primary_10_1002_mp_16223 crossref_primary_10_1016_j_nicl_2017_04_001 crossref_primary_10_3389_fnins_2015_00482 crossref_primary_10_1111_nan_12917 crossref_primary_10_3233_JAD_170669 crossref_primary_10_3389_fnins_2021_778822 crossref_primary_10_3233_JAD_201411 crossref_primary_10_3389_fnins_2015_00245 crossref_primary_10_1007_s00401_020_02248_1 crossref_primary_10_3233_JAD_190028 crossref_primary_10_1016_S1474_4422_14_70194_2 crossref_primary_10_1186_s13195_024_01466_z crossref_primary_10_1016_j_brainres_2017_03_005 crossref_primary_10_3389_fnagi_2018_00175 crossref_primary_10_1038_s41598_017_17313_1 crossref_primary_10_3233_JAD_210356 crossref_primary_10_1002_dad2_12348 crossref_primary_10_3390_biomedicines11123232 crossref_primary_10_1038_srep09659 crossref_primary_10_1016_j_brainresbull_2019_08_007 crossref_primary_10_1016_j_freeradbiomed_2019_01_025 crossref_primary_10_1093_jnen_nlx104 crossref_primary_10_1002_alz_12503 crossref_primary_10_1186_s40478_018_0640_z crossref_primary_10_3233_JAD_221279 crossref_primary_10_1097_WCO_0b013e32835a3432 crossref_primary_10_1002_alz_13839 crossref_primary_10_1016_j_neuroimage_2017_12_042 crossref_primary_10_1523_ENEURO_0260_24_2024 crossref_primary_10_1177_1073858414529828 crossref_primary_10_3233_JAD_210385 crossref_primary_10_1016_j_brainresbull_2016_08_018 crossref_primary_10_1111_bpa_12924 crossref_primary_10_3724_abbs_2024101 crossref_primary_10_1093_braincomms_fcae096 crossref_primary_10_1186_alzrt277 crossref_primary_10_1093_ntr_ntv075 crossref_primary_10_1002_ana_26813 crossref_primary_10_1186_s40478_020_0886_0 crossref_primary_10_1016_j_envres_2016_06_026 crossref_primary_10_1093_jnen_nlw002 crossref_primary_10_1002_alz_13604 crossref_primary_10_1186_s40035_018_0139_3 crossref_primary_10_1002_mrm_29088 crossref_primary_10_15252_emmm_202012025 crossref_primary_10_1016_S1474_4422_17_30044_3 crossref_primary_10_1016_j_mric_2016_12_003 crossref_primary_10_1016_j_rmclc_2016_06_004 crossref_primary_10_1002_dad2_12565 crossref_primary_10_3389_fnins_2024_1375530 crossref_primary_10_3233_JAD_180688 crossref_primary_10_3390_nu15173688 crossref_primary_10_1016_j_neurobiolaging_2020_06_006 crossref_primary_10_1093_brain_aww117 crossref_primary_10_1016_j_mcn_2018_12_001 crossref_primary_10_1186_s40478_017_0415_y crossref_primary_10_1007_s00401_020_02148_4 crossref_primary_10_1016_j_jalz_2014_09_004 crossref_primary_10_1001_jamanetworkopen_2019_17126 crossref_primary_10_1002_alz_12328 crossref_primary_10_1364_OPTCON_471544 crossref_primary_10_1080_15548627_2018_1461294 crossref_primary_10_3233_JAD_220125 crossref_primary_10_3389_fnagi_2022_1026260 crossref_primary_10_3390_life13101954 crossref_primary_10_1002_alz_12572 crossref_primary_10_1038_s41380_018_0342_8 crossref_primary_10_1038_s41582_022_00642_9 crossref_primary_10_1007_s00115_012_3688_1 crossref_primary_10_3389_fnagi_2023_1081058 crossref_primary_10_1016_S1634_7072_21_45320_1 crossref_primary_10_1016_j_biopsych_2012_11_028 crossref_primary_10_1016_j_neurobiolaging_2018_10_014 crossref_primary_10_3390_ijerph20116049 crossref_primary_10_3233_JAD_160882 crossref_primary_10_1111_bpa_13213 crossref_primary_10_1002_acn3_50818 crossref_primary_10_1016_j_arr_2016_03_004 crossref_primary_10_1016_j_tics_2021_10_009 crossref_primary_10_1021_acs_jmedchem_2c00859 crossref_primary_10_3389_fpsyg_2022_957308 crossref_primary_10_3389_fninf_2018_00026 crossref_primary_10_1186_s13195_019_0511_2 crossref_primary_10_1186_s40478_020_01047_9 crossref_primary_10_14283_jpad_2023_127 crossref_primary_10_1146_annurev_clinpsy_032814_112814 crossref_primary_10_1007_s00401_016_1633_2 crossref_primary_10_1111_joim_13755 crossref_primary_10_1002_mds_26809 crossref_primary_10_1016_j_fct_2018_04_064 crossref_primary_10_2139_ssrn_4068682 crossref_primary_10_1016_j_biopsych_2017_04_003 crossref_primary_10_1073_pnas_2221686120 crossref_primary_10_1111_ggi_12280 crossref_primary_10_1016_j_jocn_2018_10_024 crossref_primary_10_1007_s00401_023_02646_1 crossref_primary_10_1016_j_cortex_2025_02_003 crossref_primary_10_1186_s13195_024_01486_9 crossref_primary_10_3390_molecules28155769 crossref_primary_10_1016_j_mcn_2019_02_001 crossref_primary_10_1002_alz_12345 crossref_primary_10_1093_brain_awx065 crossref_primary_10_1093_braincomms_fcad146 crossref_primary_10_1093_braincomms_fcad147 crossref_primary_10_3389_fneur_2019_00980 crossref_primary_10_1007_s00401_024_02772_4 crossref_primary_10_3233_JAD_231034 crossref_primary_10_1016_j_biopsych_2020_01_023 crossref_primary_10_1111_bpa_12592 crossref_primary_10_1016_j_brainresbull_2020_04_009 crossref_primary_10_3389_fnmol_2023_1225227 crossref_primary_10_1002_acn3_390 crossref_primary_10_1016_j_pneurobio_2016_03_003 crossref_primary_10_1007_s41105_024_00512_5 crossref_primary_10_1097_MD_0000000000034017 crossref_primary_10_1007_s10741_022_10289_9 crossref_primary_10_1111_bpa_12335 crossref_primary_10_1186_s40478_022_01375_y crossref_primary_10_1186_s40478_019_0837_9 crossref_primary_10_3389_fnins_2023_1264253 crossref_primary_10_1017_cjn_2023_322 crossref_primary_10_1097_NEN_0000000000000013 crossref_primary_10_1186_s13195_014_0079_9 crossref_primary_10_1016_j_molstruc_2024_140589 crossref_primary_10_1146_annurev_pharmtox_040323_031929 crossref_primary_10_3233_JAD_190035 crossref_primary_10_2174_0115672050324909240823104209 crossref_primary_10_1155_2017_7829507 crossref_primary_10_1007_s13670_020_00341_7 crossref_primary_10_3233_JAD_170446 crossref_primary_10_1016_j_imbio_2016_09_017 crossref_primary_10_1038_s41467_024_48490_z crossref_primary_10_3390_ijms21228630 crossref_primary_10_3233_JAD_200544 crossref_primary_10_3389_fmmed_2023_1075805 crossref_primary_10_3390_brainsci13050806 crossref_primary_10_3233_JAD_200783 crossref_primary_10_3389_fnsys_2018_00067 crossref_primary_10_1186_s40478_021_01251_1 crossref_primary_10_7717_peerj_10828 crossref_primary_10_1002_alz_12321 crossref_primary_10_1016_j_envres_2018_06_027 crossref_primary_10_1016_j_pneurobio_2019_101644 crossref_primary_10_1186_s13024_017_0192_x crossref_primary_10_1093_braincomms_fcae457 crossref_primary_10_3390_ijms241310808 crossref_primary_10_1093_brain_awz268 crossref_primary_10_1523_JNEUROSCI_1590_19_2019 crossref_primary_10_1038_s41593_020_00737_w crossref_primary_10_3389_fnana_2017_00080 crossref_primary_10_3390_ph14020095 crossref_primary_10_1038_s43856_023_00324_7 crossref_primary_10_7554_eLife_62929 crossref_primary_10_1016_j_smrv_2022_101592 crossref_primary_10_3233_JAD_150884 crossref_primary_10_1002_mrm_30463 crossref_primary_10_1186_s13195_024_01649_8 crossref_primary_10_1126_scitranslmed_adg4122 crossref_primary_10_1016_j_neurobiolaging_2021_01_031 crossref_primary_10_1007_s12149_022_01792_y crossref_primary_10_2337_db12_0866 crossref_primary_10_1093_brain_awv097 crossref_primary_10_1002_alz_14317 crossref_primary_10_1016_j_arr_2024_102578 crossref_primary_10_1093_brain_aww187 crossref_primary_10_2967_jnumed_118_209650 crossref_primary_10_3390_ijms232112957 crossref_primary_10_1002_dad2_12513 crossref_primary_10_1002_alz_13461 crossref_primary_10_2139_ssrn_4093861 crossref_primary_10_3233_JAD_170261 crossref_primary_10_4236_abb_2022_1312035 crossref_primary_10_1523_ENEURO_0004_24_2024 crossref_primary_10_2217_nmt_13_20 crossref_primary_10_1001_jamanetworkopen_2024_27248 crossref_primary_10_1038_s43587_023_00469_z crossref_primary_10_1093_epirev_mxs007 crossref_primary_10_31083_j_jin2206172 crossref_primary_10_1007_s00401_018_1922_z crossref_primary_10_3233_JAD_210503 crossref_primary_10_1016_j_neurobiolaging_2023_10_001 crossref_primary_10_1038_nrneurol_2012_275 crossref_primary_10_3389_fnagi_2020_537712 crossref_primary_10_1016_j_neurobiolaging_2021_01_024 crossref_primary_10_3389_fnins_2020_549772 crossref_primary_10_1007_s11682_017_9686_y crossref_primary_10_1093_brain_awx261 crossref_primary_10_1007_s00401_013_1154_1 crossref_primary_10_3233_JAD_200716 crossref_primary_10_1002_alz_14327 crossref_primary_10_1002_ana_23937 crossref_primary_10_1007_s00401_018_1855_6 crossref_primary_10_1016_j_neuron_2017_02_004 crossref_primary_10_3390_geriatrics10020037 crossref_primary_10_1021_acschemneuro_1c00010 crossref_primary_10_1016_j_neubiorev_2022_104998 crossref_primary_10_1002_alz_12384 crossref_primary_10_1016_j_pneurobio_2016_04_001 crossref_primary_10_1016_j_pneurobio_2020_101902 crossref_primary_10_1093_brain_awab452 crossref_primary_10_3390_biomedicines11041033 crossref_primary_10_1007_s12640_016_9643_3 crossref_primary_10_1002_hipo_23290 crossref_primary_10_3233_JAD_230349 crossref_primary_10_1186_s12883_014_0169_0 crossref_primary_10_1016_j_dadm_2016_08_004 crossref_primary_10_1038_s41582_023_00883_2 crossref_primary_10_1002_alz_13438 crossref_primary_10_1155_2019_6856327 crossref_primary_10_3233_JAD_240389 crossref_primary_10_1016_j_neubiorev_2019_02_021 crossref_primary_10_1038_s41467_020_15410_w crossref_primary_10_2337_dc12_0922 crossref_primary_10_1016_j_neuroimage_2020_117487 crossref_primary_10_1016_j_jalz_2017_11_005 crossref_primary_10_1007_s00406_013_0449_5 crossref_primary_10_1093_brain_awy146 crossref_primary_10_3233_JAD_230593 crossref_primary_10_1146_annurev_pathol_020712_163927 crossref_primary_10_3233_JAD_150415 crossref_primary_10_1002_hipo_23042 crossref_primary_10_1097_WCO_0b013e32835a30f4 crossref_primary_10_1016_j_neubiorev_2016_12_020 crossref_primary_10_3389_fnagi_2015_00025 crossref_primary_10_1002_adtp_202300181 crossref_primary_10_1177_23982128231191046 crossref_primary_10_1016_j_arr_2016_02_003 crossref_primary_10_1016_j_ajpath_2016_12_010 crossref_primary_10_3390_geriatrics10010020 crossref_primary_10_3233_JAD_240167 crossref_primary_10_1002_alz_12124 crossref_primary_10_1016_j_neuroscience_2022_06_006 crossref_primary_10_2217_fvl_12_81 crossref_primary_10_3233_JAD_200735 crossref_primary_10_1016_j_envres_2020_109226 crossref_primary_10_1093_brain_awx046 crossref_primary_10_1002_ardp_202300201 crossref_primary_10_1002_cbdv_202301965 crossref_primary_10_1016_j_neuroscience_2018_01_059 crossref_primary_10_1097_NEN_0000000000000228 crossref_primary_10_1016_j_neubiorev_2023_105422 crossref_primary_10_1097_GME_0000000000001991 crossref_primary_10_1016_j_cortex_2022_10_015 crossref_primary_10_1097_RLU_0000000000003668 crossref_primary_10_1111_ejn_15636 crossref_primary_10_1016_j_neurobiolaging_2017_09_007 crossref_primary_10_1371_journal_pone_0137342 crossref_primary_10_1111_bph_14582 crossref_primary_10_3389_fncel_2019_00438 crossref_primary_10_1016_j_chest_2019_12_012 crossref_primary_10_1002_alz_14477 crossref_primary_10_1016_j_bbi_2022_12_021 crossref_primary_10_1016_j_clinph_2024_06_018 crossref_primary_10_1038_s41467_021_25060_1 crossref_primary_10_1155_2013_161687 crossref_primary_10_1002_ana_27022 crossref_primary_10_1007_s11357_022_00527_1 crossref_primary_10_1111_bpa_13058 crossref_primary_10_3389_fpsyg_2022_871391 crossref_primary_10_1111_nan_12387 crossref_primary_10_1111_nan_12386 crossref_primary_10_1016_j_neurobiolaging_2014_12_036 crossref_primary_10_3233_JAD_170187 crossref_primary_10_1186_s12967_024_04987_1 crossref_primary_10_1016_j_neuroimage_2022_119511 crossref_primary_10_3390_biom12071006 crossref_primary_10_3390_ijerph19159386 crossref_primary_10_1007_s00401_013_1080_2 crossref_primary_10_1007_s11920_012_0305_8 crossref_primary_10_12688_f1000research_10652_1 crossref_primary_10_3389_fpsyg_2022_908651 crossref_primary_10_1093_noajnl_vdae118 crossref_primary_10_1007_s00401_022_02477_6 crossref_primary_10_1093_braincomms_fcad309 crossref_primary_10_1186_s13024_024_00786_w crossref_primary_10_1002_alz_12068 crossref_primary_10_1002_alz_14487 crossref_primary_10_3390_ijms18122672 crossref_primary_10_3233_JAD_171041 crossref_primary_10_1093_braincomms_fcad302 crossref_primary_10_1007_s00428_024_03781_0 crossref_primary_10_20900_agmr20200018 crossref_primary_10_3233_JAD_230101 crossref_primary_10_1002_ardp_202100113 crossref_primary_10_1186_s12860_020_00320_y crossref_primary_10_1186_s40478_022_01370_3 crossref_primary_10_1016_j_nbd_2018_12_006 crossref_primary_10_1016_j_stemcr_2017_08_019 crossref_primary_10_1111_bpa_13028 crossref_primary_10_1016_j_neuropsychologia_2013_12_020 crossref_primary_10_3390_jcm13020536 crossref_primary_10_1016_j_jneumeth_2014_01_030 crossref_primary_10_1007_s00401_018_1872_5 crossref_primary_10_1523_JNEUROSCI_1230_17_2017 crossref_primary_10_1016_j_trci_2015_06_004 crossref_primary_10_1016_j_neurol_2022_12_006 crossref_primary_10_3389_fnmol_2018_00254 crossref_primary_10_1007_s00401_015_1449_5 crossref_primary_10_3233_JAD_200925 crossref_primary_10_1007_s11910_014_0498_9 crossref_primary_10_1016_j_envres_2014_12_012 crossref_primary_10_1126_scitranslmed_abj2511 crossref_primary_10_1371_journal_pone_0266405 crossref_primary_10_1038_s41398_018_0345_x crossref_primary_10_1016_j_psc_2021_04_003 crossref_primary_10_1007_s00401_020_02254_3 crossref_primary_10_3233_JAD_230553 crossref_primary_10_1016_j_ajhg_2023_12_015 crossref_primary_10_1186_s13148_019_0672_7 crossref_primary_10_1093_cercor_bhy311 crossref_primary_10_3390_molecules26196038 crossref_primary_10_3233_JAD_230318 crossref_primary_10_1016_j_mcn_2018_02_004 crossref_primary_10_1590_1516_4446_2019_0735 crossref_primary_10_3390_molecules26175113 crossref_primary_10_1017_S146342361400036X crossref_primary_10_3390_ijms23116143 crossref_primary_10_1212_WNL_0000000000000438 crossref_primary_10_1002_alz_13133 crossref_primary_10_3389_fnins_2018_00464 crossref_primary_10_1212_CON_0000000000000697 crossref_primary_10_1016_j_drudis_2020_12_004 crossref_primary_10_1038_s41598_024_66238_z crossref_primary_10_1007_s00401_017_1703_0 crossref_primary_10_3390_ijms25137035 crossref_primary_10_1292_jvms_23_0313 crossref_primary_10_3233_JAD_150128 crossref_primary_10_3390_brainsci10120994 crossref_primary_10_1016_j_gaitpost_2016_12_021 crossref_primary_10_1186_s13195_022_01082_9 crossref_primary_10_1093_hmg_ddt555 crossref_primary_10_1007_s11682_021_00531_7 crossref_primary_10_1016_j_neuint_2024_105773 crossref_primary_10_1186_s40478_017_0458_0 crossref_primary_10_1002_bies_202100287 crossref_primary_10_1016_j_brainres_2017_09_035 crossref_primary_10_1002_alz_14037 crossref_primary_10_1111_ene_70068 crossref_primary_10_1016_j_conb_2019_11_008 crossref_primary_10_1016_j_bbr_2023_114305 crossref_primary_10_1016_j_brainres_2018_01_001 crossref_primary_10_1074_jbc_M115_657924 crossref_primary_10_3233_JAD_215372 crossref_primary_10_1038_s41598_024_58223_3 crossref_primary_10_1007_s10334_016_0590_z crossref_primary_10_1016_j_biopsycho_2024_108847 crossref_primary_10_1002_syn_21893 crossref_primary_10_1016_S1474_4422_21_00066_1 crossref_primary_10_3233_JAD_230772 crossref_primary_10_3389_fnagi_2022_847315 crossref_primary_10_3390_molecules29143308 crossref_primary_10_1002_alz_12097 crossref_primary_10_1177_1073858420912404 crossref_primary_10_1016_j_biopha_2023_114290 crossref_primary_10_1007_s00702_012_0839_2 crossref_primary_10_3389_fnagi_2023_1236335 crossref_primary_10_1038_s41598_019_52357_5 crossref_primary_10_2174_1570161117666190710151545 crossref_primary_10_1212_WNL_0000000000009462 crossref_primary_10_1080_17568919_2024_2366159 crossref_primary_10_3389_fnagi_2016_00315 crossref_primary_10_1016_j_bbrc_2024_150201 crossref_primary_10_1038_s41598_020_60894_7 crossref_primary_10_1093_texcom_tgad010 crossref_primary_10_3389_fnmol_2018_00002 crossref_primary_10_3389_fnins_2018_00401 crossref_primary_10_3390_brainsci14060575 crossref_primary_10_1007_s00401_016_1537_1 crossref_primary_10_1016_j_ejmech_2024_117158 crossref_primary_10_1038_s41562_019_0731_2 crossref_primary_10_1016_j_sleep_2020_05_029 crossref_primary_10_1186_s40478_018_0559_4 crossref_primary_10_3390_brainsci10120972 crossref_primary_10_3389_fpsyt_2022_872594 crossref_primary_10_3233_JAD_230503 crossref_primary_10_1080_10253890_2016_1183119 crossref_primary_10_1111_jon_12178 crossref_primary_10_1016_j_autneu_2021_102900 crossref_primary_10_1016_j_autneu_2021_102901 crossref_primary_10_1186_s40478_020_01117_y crossref_primary_10_1101_cshperspect_a041201 crossref_primary_10_1172_JCI130513 crossref_primary_10_53053_YQHL5608 crossref_primary_10_3389_fneur_2024_1445479 crossref_primary_10_1126_sciadv_adf3775 crossref_primary_10_1007_s12035_020_01955_w crossref_primary_10_1097_QAD_0b013e32835a117c crossref_primary_10_1002_alz_13164 crossref_primary_10_3389_fnagi_2021_711579 crossref_primary_10_1073_pnas_1322360111 crossref_primary_10_4132_jptm_2019_03_14 crossref_primary_10_1148_rg_2016150172 crossref_primary_10_1016_j_crmeth_2022_100292 crossref_primary_10_1016_j_neurol_2022_02_456 crossref_primary_10_1186_s40478_019_0823_2 crossref_primary_10_1016_j_semcdb_2021_05_013 crossref_primary_10_1186_s40478_015_0210_6 crossref_primary_10_1007_s00401_024_02821_y crossref_primary_10_1016_j_jalz_2017_02_008 crossref_primary_10_3389_fnagi_2017_00093 crossref_primary_10_3945_ajcn_117_157834 crossref_primary_10_1093_brain_awz193 crossref_primary_10_1126_sciadv_adr8055 crossref_primary_10_1016_j_jalz_2017_02_003 crossref_primary_10_1093_jnen_nlad064 crossref_primary_10_1002_acn3_339 crossref_primary_10_1186_s13195_020_00674_7 crossref_primary_10_1073_pnas_2316175121 crossref_primary_10_1186_s13195_021_00880_x crossref_primary_10_1007_s00401_015_1458_4 crossref_primary_10_1016_j_brainresbull_2022_10_006 crossref_primary_10_3389_fnagi_2014_00325 crossref_primary_10_1126_sciadv_abh1448 crossref_primary_10_1016_j_ensci_2021_100343 crossref_primary_10_1007_s00401_018_1890_3 crossref_primary_10_1038_s41598_018_35130_y crossref_primary_10_1038_s41583_018_0054_8 crossref_primary_10_1093_jnen_nlz141 crossref_primary_10_1186_s12974_016_0482_1 crossref_primary_10_1007_s00401_017_1709_7 crossref_primary_10_3233_JAD_190624 crossref_primary_10_1002_path_5203 crossref_primary_10_1016_j_str_2024_06_018 crossref_primary_10_3995_jstroke_11284 crossref_primary_10_1007_s00428_015_1772_1 crossref_primary_10_1111_nan_12788 crossref_primary_10_1016_j_arr_2018_03_003 crossref_primary_10_1016_j_neuropharm_2015_09_003 crossref_primary_10_1111_sjop_12157 crossref_primary_10_3233_JAD_161299 crossref_primary_10_1016_j_smrv_2019_101250 crossref_primary_10_1038_s41593_020_00764_7 crossref_primary_10_1093_brain_awt273 crossref_primary_10_1111_jnc_14724 crossref_primary_10_1523_ENEURO_0483_22_2022 crossref_primary_10_3390_life11080750 crossref_primary_10_1111_jnc_13632 crossref_primary_10_3233_JAD_215334 crossref_primary_10_18632_oncotarget_21475 crossref_primary_10_1016_j_molstruc_2023_137417 crossref_primary_10_1016_j_dadm_2018_06_002 crossref_primary_10_1016_j_ibneur_2022_09_007 crossref_primary_10_1038_s41593_020_0687_6 crossref_primary_10_1007_s00401_015_1507_z crossref_primary_10_3389_fncel_2024_1351734 crossref_primary_10_1016_j_freeradbiomed_2022_09_027 crossref_primary_10_3390_cells11050840 crossref_primary_10_3233_JAD_201177 crossref_primary_10_1016_j_exger_2018_07_023 crossref_primary_10_1007_s13311_021_01146_y crossref_primary_10_1177_13872877251323787 crossref_primary_10_1146_annurev_pharmtox_010715_103617 crossref_primary_10_4199_C00095ED1V01Y201310ALZ001 crossref_primary_10_1016_j_envres_2018_03_023 crossref_primary_10_1016_j_neurobiolaging_2018_02_021 crossref_primary_10_1007_s00702_020_02232_9 crossref_primary_10_3233_JAD_215567 crossref_primary_10_1021_acschemneuro_3c00626 crossref_primary_10_3389_fnagi_2024_1328301 crossref_primary_10_1126_scitranslmed_abk1051 crossref_primary_10_1007_s00429_017_1504_1 crossref_primary_10_1016_j_neubiorev_2023_105287 crossref_primary_10_1002_psp4_12628 crossref_primary_10_1111_neup_12367 crossref_primary_10_1038_s42003_024_05996_y crossref_primary_10_3390_biom12050714 crossref_primary_10_1038_s41598_021_89230_3 crossref_primary_10_3389_fnins_2022_1014485 crossref_primary_10_1007_s00401_019_02054_4 crossref_primary_10_1186_s12929_025_01127_9 crossref_primary_10_1002_dad2_12374 crossref_primary_10_1016_j_csbj_2022_11_049 crossref_primary_10_1007_s00401_015_1407_2 crossref_primary_10_3233_JAD_161078 crossref_primary_10_1016_j_cub_2023_11_010 crossref_primary_10_1007_s11682_018_0019_6 crossref_primary_10_1186_s40478_018_0520_6 crossref_primary_10_1021_acs_est_1c04706 crossref_primary_10_1093_brain_awv236 crossref_primary_10_1016_j_jalz_2016_06_003 crossref_primary_10_1002_mp_17095 crossref_primary_10_1016_j_smrv_2016_02_002 crossref_primary_10_1111_apha_14191 crossref_primary_10_1177_09636897231164712 crossref_primary_10_3390_ijms22137232 crossref_primary_10_1080_1028415X_2017_1345425 crossref_primary_10_1124_pharmrev_123_000823 crossref_primary_10_1371_journal_pbio_3000851 crossref_primary_10_1111_ene_15203 crossref_primary_10_1016_j_neurobiolaging_2017_07_006 crossref_primary_10_3389_fnagi_2022_854733 crossref_primary_10_1186_s40478_016_0299_2 crossref_primary_10_3390_ijms24043506 crossref_primary_10_1186_s40478_022_01324_9 crossref_primary_10_1111_ene_15691 crossref_primary_10_18632_aging_102328 crossref_primary_10_1007_s11356_022_23703_4 crossref_primary_10_3389_fnana_2015_00026 crossref_primary_10_3390_ijms25158118 crossref_primary_10_1016_j_molstruc_2023_136582 crossref_primary_10_1016_j_ynstr_2023_100561 crossref_primary_10_1186_s40478_015_0187_1 crossref_primary_10_1002_hbm_26324 crossref_primary_10_1186_s13024_019_0324_6 crossref_primary_10_1016_j_tins_2024_09_004 crossref_primary_10_1155_2013_257953 crossref_primary_10_1007_s12035_022_03188_5 crossref_primary_10_1016_j_semcdb_2020_12_010 crossref_primary_10_1186_s40478_021_01127_4 crossref_primary_10_2174_1567205020666230721144603 crossref_primary_10_3233_JAD_201125 crossref_primary_10_1016_j_jalz_2016_08_005 crossref_primary_10_1016_j_jneuroling_2023_101190 crossref_primary_10_1371_journal_pcbi_1012085 crossref_primary_10_1016_j_jmb_2023_168114 crossref_primary_10_2967_jnumed_120_258962 crossref_primary_10_3233_JAD_200276 crossref_primary_10_1111_ejn_16362 crossref_primary_10_3390_cimb46090607 crossref_primary_10_1016_j_neurobiolaging_2015_05_020 crossref_primary_10_1016_j_jalz_2012_01_011 crossref_primary_10_1016_j_brainresbull_2013_12_004 crossref_primary_10_1016_j_neurobiolaging_2021_06_012 crossref_primary_10_1038_s41591_021_01456_w crossref_primary_10_1038_s41583_021_00533_w crossref_primary_10_1016_j_jalz_2016_08_010 crossref_primary_10_1016_j_jalz_2017_01_027 crossref_primary_10_1016_j_jalz_2017_01_028 crossref_primary_10_3390_ijms25147890 crossref_primary_10_3390_molecules28248128 crossref_primary_10_1093_brain_awae051 crossref_primary_10_1186_s12929_018_0457_x crossref_primary_10_1523_JNEUROSCI_3263_16_2017 crossref_primary_10_1159_000337230 crossref_primary_10_1017_cjn_2022_34 crossref_primary_10_1186_s40478_020_00934_5 crossref_primary_10_1186_s13195_023_01281_y crossref_primary_10_1016_j_phrs_2024_107171 crossref_primary_10_1002_alz_12937 crossref_primary_10_1016_j_ijpsycho_2023_08_014 crossref_primary_10_1016_j_neurobiolaging_2014_10_041 crossref_primary_10_3389_fnagi_2021_686598 crossref_primary_10_1007_s11682_018_9847_7 crossref_primary_10_1111_ejn_15045 crossref_primary_10_3389_fnagi_2021_704661 crossref_primary_10_1007_s00259_019_04379_4 crossref_primary_10_1038_s41591_021_01369_8 crossref_primary_10_1111_j_1582_4934_2011_01507_x crossref_primary_10_3389_fnins_2022_968767 crossref_primary_10_1111_jnc_13447 crossref_primary_10_1111_joim_12909 crossref_primary_10_1186_s13024_021_00460_5 crossref_primary_10_1007_s12017_024_08815_z crossref_primary_10_1007_s12035_023_03281_3 crossref_primary_10_3390_ijerph16193659 crossref_primary_10_1186_s13024_025_00819_y crossref_primary_10_2142_biophysico_bppb_v21_0023 crossref_primary_10_3233_JAD_201382 crossref_primary_10_1186_s40478_022_01311_0 crossref_primary_10_1093_jnen_nlw092 crossref_primary_10_1186_s13195_020_00765_5 crossref_primary_10_1016_j_jalz_2014_04_009 crossref_primary_10_1515_almed_2020_0090 crossref_primary_10_1007_s00401_024_02691_4 crossref_primary_10_1007_s10072_017_3053_z crossref_primary_10_1007_s10548_018_0674_3 crossref_primary_10_1093_jnen_nlz123 crossref_primary_10_1186_s40478_021_01280_w crossref_primary_10_1111_ner_13305 crossref_primary_10_1038_s41467_019_14159_1 crossref_primary_10_1002_hbm_70016 crossref_primary_10_1007_s12640_012_9355_2 crossref_primary_10_1007_s00401_022_02444_1 crossref_primary_10_1055_s_0045_1802960 crossref_primary_10_1007_s00259_024_07016_x crossref_primary_10_1002_mds_29589 crossref_primary_10_1038_s41386_022_01293_6 crossref_primary_10_1093_brain_awad189 crossref_primary_10_1007_s11682_021_00562_0 crossref_primary_10_1007_s00401_024_02749_3 crossref_primary_10_2217_WHE_13_22 crossref_primary_10_1186_s13023_023_02863_7 crossref_primary_10_1186_s12915_023_01582_6 crossref_primary_10_1007_s10654_016_0144_8 crossref_primary_10_1097_QAD_0000000000002336 crossref_primary_10_3233_JAD_210091 crossref_primary_10_3233_JAD_215546 crossref_primary_10_1053_j_jvca_2014_04_014 crossref_primary_10_3233_JAD_215303 crossref_primary_10_1007_s11910_020_01063_1 crossref_primary_10_1093_sleep_zsaa133 crossref_primary_10_1097_NEN_0000000000000191 crossref_primary_10_1038_s41380_019_0437_x crossref_primary_10_1097_NEN_0000000000000193 crossref_primary_10_1016_j_dadm_2019_02_001 crossref_primary_10_1111_apha_70022 crossref_primary_10_1002_glia_23794 crossref_primary_10_1038_s41467_024_53891_1 crossref_primary_10_1016_j_brainresbull_2023_110733 crossref_primary_10_1016_j_arr_2020_101046 crossref_primary_10_1016_j_arr_2021_101322 crossref_primary_10_1038_nrd_2017_155 crossref_primary_10_2174_1568026623666221228140450 crossref_primary_10_1093_brain_aww023 crossref_primary_10_3233_JAD_190331 crossref_primary_10_3389_fnagi_2018_00266 crossref_primary_10_1038_s41572_021_00269_y crossref_primary_10_1097_WCO_0000000000000502 crossref_primary_10_1373_clinchem_2013_202937 crossref_primary_10_1002_ana_25642 crossref_primary_10_1016_j_neurobiolaging_2015_09_019 crossref_primary_10_3390_cells12050753 crossref_primary_10_1089_neu_2018_6348 crossref_primary_10_1371_journal_pone_0203627 crossref_primary_10_1016_j_jalz_2011_10_007 crossref_primary_10_3389_fnagi_2023_1264448 crossref_primary_10_1073_pnas_1912954116 crossref_primary_10_3233_JAD_200246 crossref_primary_10_1016_j_nbd_2014_08_032 crossref_primary_10_1002_brb3_1145 crossref_primary_10_1016_j_lfs_2023_121568 crossref_primary_10_1021_acs_bioconjchem_8b00548 crossref_primary_10_1002_glia_23782 crossref_primary_10_1016_j_neurobiolaging_2018_07_007 crossref_primary_10_3233_ADR_170021 crossref_primary_10_1097_NEN_0b013e31825018f7 crossref_primary_10_3390_ijms222313002 crossref_primary_10_3389_fnhum_2024_1411849 crossref_primary_10_1093_brain_aww256 crossref_primary_10_1136_jnnp_2019_321567 crossref_primary_10_3233_JAD_190342 crossref_primary_10_1016_j_jneumeth_2013_10_003 crossref_primary_10_1093_braincomms_fcae198 crossref_primary_10_1152_physrev_00015_2020 crossref_primary_10_1523_ENEURO_0242_23_2023 crossref_primary_10_31491_APT_2022_03_078 crossref_primary_10_1002_ana_24321 crossref_primary_10_1007_s11064_021_03338_6 crossref_primary_10_1016_j_tma_2023_11_001 crossref_primary_10_1007_s00221_023_06618_5 crossref_primary_10_1007_s11910_020_01087_7 crossref_primary_10_1038_s41386_022_01269_6 crossref_primary_10_3389_fnmol_2019_00141 crossref_primary_10_1016_j_bmcl_2021_128164 crossref_primary_10_1002_alz_13912 crossref_primary_10_1093_jnen_nlab017 crossref_primary_10_1016_j_envres_2020_109137 crossref_primary_10_1111_cns_70214 crossref_primary_10_1016_j_envres_2020_110139 crossref_primary_10_14336_AD_2023_0607 crossref_primary_10_1038_s41467_022_28986_2 crossref_primary_10_1002_npr2_12281 crossref_primary_10_1177_25424823251328300 crossref_primary_10_1016_j_neuroimage_2020_117560 crossref_primary_10_2967_jnumed_118_224113 crossref_primary_10_1007_s00401_013_1162_1 crossref_primary_10_3233_JAD_180514 crossref_primary_10_1007_s41133_019_0021_6 crossref_primary_10_3390_ph16091278 crossref_primary_10_1007_s00391_019_01560_0 crossref_primary_10_1016_j_neubiorev_2015_05_008 crossref_primary_10_1186_s13195_025_01701_1 crossref_primary_10_1186_s40064_014_0777_6 crossref_primary_10_1523_JNEUROSCI_2097_17_2017 crossref_primary_10_3233_JAD_201116 crossref_primary_10_7554_eLife_46179 crossref_primary_10_1111_nan_12618 crossref_primary_10_3233_JAD_170728 crossref_primary_10_1093_brain_aww270 crossref_primary_10_3389_fneur_2020_00371 crossref_primary_10_1002_jmri_29022 crossref_primary_10_1016_j_nicl_2020_102482 crossref_primary_10_1038_s41380_024_02664_9 crossref_primary_10_1093_jnen_nlaa153 crossref_primary_10_1016_j_jad_2022_07_073 crossref_primary_10_51483_AFJPS_3_1_2023_31_41 crossref_primary_10_1002_glia_23510 crossref_primary_10_1007_s00406_013_0472_6 crossref_primary_10_1002_slct_202400684 crossref_primary_10_1007_s00401_022_02524_2 crossref_primary_10_1016_j_jagp_2016_05_005 crossref_primary_10_1016_j_tins_2018_12_001 crossref_primary_10_1016_j_cortex_2017_09_025 crossref_primary_10_1038_s41598_023_32664_8 crossref_primary_10_1016_j_brainresbull_2023_110777 crossref_primary_10_1126_sciadv_aba1394 crossref_primary_10_3389_fnagi_2022_944283 crossref_primary_10_1002_alz_12656 crossref_primary_10_1016_j_neuroimage_2020_117301 crossref_primary_10_1523_JNEUROSCI_2590_20_2021 crossref_primary_10_3233_JAD_231183 crossref_primary_10_1002_dad2_12239 crossref_primary_10_1186_s13195_020_00626_1 crossref_primary_10_1016_j_jalz_2019_01_010 crossref_primary_10_1016_j_neurobiolaging_2015_08_007 crossref_primary_10_1016_j_jbc_2024_107306 crossref_primary_10_1007_s00401_024_02805_y crossref_primary_10_1007_s00115_018_0488_2 crossref_primary_10_1007_s00401_020_02138_6 crossref_primary_10_1016_j_neurobiolaging_2019_11_016 crossref_primary_10_1038_s41582_018_0013_z crossref_primary_10_1016_j_neuroscience_2013_04_042 crossref_primary_10_1109_JSTSP_2016_2601695 crossref_primary_10_3389_fnagi_2022_903973 crossref_primary_10_1186_alzrt170 crossref_primary_10_1007_s00401_022_02426_3 crossref_primary_10_1016_j_yfrne_2017_02_004 crossref_primary_10_1017_S1355617722000881 crossref_primary_10_1007_s00702_014_1342_8 crossref_primary_10_3233_JAD_180340 crossref_primary_10_1016_j_jalz_2018_07_215 crossref_primary_10_2174_1567205019666220805100008 crossref_primary_10_3390_biom12030458 crossref_primary_10_1002_trc2_12234 crossref_primary_10_1186_s40035_019_0172_x crossref_primary_10_1002_trc2_12231 crossref_primary_10_1111_jnc_15900 crossref_primary_10_3389_fnins_2017_00217 crossref_primary_10_1038_s42003_024_06446_5 crossref_primary_10_1016_j_neurobiolaging_2015_08_017 crossref_primary_10_1089_neu_2018_5694 crossref_primary_10_1016_j_neuron_2024_12_015 crossref_primary_10_1093_arclin_acz023 crossref_primary_10_2174_1567205020666230811092956 crossref_primary_10_1002_cne_24576 crossref_primary_10_1038_embor_2013_15 crossref_primary_10_1016_j_arr_2021_101307 crossref_primary_10_1212_WNL_0000000000210062 crossref_primary_10_61096_ijamscr_v11_iss4_2023_379_391 crossref_primary_10_1016_j_nicl_2019_101788 crossref_primary_10_3390_biomedicines10051140 crossref_primary_10_1016_j_neurobiolaging_2022_11_017 crossref_primary_10_1097_NEN_0000000000000176 crossref_primary_10_3389_fncel_2022_908758 crossref_primary_10_1212_WNL_0000000000004569 crossref_primary_10_1016_j_neuron_2013_07_037 crossref_primary_10_1002_ana_25860 crossref_primary_10_2217_nmt_14_54 crossref_primary_10_3390_ijms22137030 crossref_primary_10_1016_j_neurobiolaging_2013_04_010 crossref_primary_10_1016_j_lpmfor_2022_01_014 crossref_primary_10_1016_j_neurobiolaging_2025_01_007 crossref_primary_10_1038_s41467_025_57144_7 crossref_primary_10_18632_aging_102641 crossref_primary_10_1016_j_arr_2023_101916 crossref_primary_10_1016_j_cortex_2017_09_018 crossref_primary_10_1186_s13195_024_01619_0 crossref_primary_10_1002_alz_12638 crossref_primary_10_3233_JAD_150937 crossref_primary_10_3389_fnins_2020_00228 crossref_primary_10_1001_jamaneurol_2021_4654 crossref_primary_10_1111_acel_12018 crossref_primary_10_1038_s41467_024_48926_6 crossref_primary_10_1038_s41598_020_63398_6 crossref_primary_10_3233_JAD_160730 crossref_primary_10_3389_fnins_2019_00529 crossref_primary_10_1371_journal_pone_0064368 crossref_primary_10_1186_s40478_025_01957_6 crossref_primary_10_3390_cells14030168 crossref_primary_10_1186_s13195_021_00887_4 crossref_primary_10_1002_alz_13731 crossref_primary_10_1016_j_neurobiolaging_2022_11_002 crossref_primary_10_1093_jnen_nlw117 crossref_primary_10_1007_s10072_013_1424_7 crossref_primary_10_1177_13872877241297382 crossref_primary_10_1186_s13024_016_0119_y crossref_primary_10_1002_ana_25858 crossref_primary_10_3389_fphys_2023_1272980 crossref_primary_10_1007_s40496_019_0219_1 crossref_primary_10_1242_jcs_260888 crossref_primary_10_1007_s11356_023_29748_3 crossref_primary_10_1038_nm_4443 crossref_primary_10_1001_jamaneurol_2023_2560 crossref_primary_10_3389_fneur_2020_590199 crossref_primary_10_1017_S135561771700100X crossref_primary_10_1186_s12911_020_01341_5 crossref_primary_10_1016_j_neuroscience_2021_10_023 crossref_primary_10_1016_j_neulet_2016_06_066 crossref_primary_10_1177_0271678X211004312 crossref_primary_10_1001_jamanetworkopen_2020_32538 crossref_primary_10_1016_j_febslet_2012_10_050 crossref_primary_10_3233_JAD_220486 crossref_primary_10_1093_brain_awx194 crossref_primary_10_3233_JAD_180373 crossref_primary_10_1093_brain_awaa219 crossref_primary_10_1111_acel_14405 crossref_primary_10_1177_08919887211044755 crossref_primary_10_18632_aging_204698 crossref_primary_10_3390_cells13231945 crossref_primary_10_1016_j_cell_2012_02_040 crossref_primary_10_3389_fneur_2019_00635 crossref_primary_10_1212_WNL_0000000000008905 crossref_primary_10_1089_brain_2014_0236 crossref_primary_10_1186_s40478_021_01152_3 crossref_primary_10_1227_NEU_0000000000000722 crossref_primary_10_1016_j_mrrev_2020_108323 crossref_primary_10_1016_j_biopsych_2012_06_013 crossref_primary_10_1111_bpa_13317 crossref_primary_10_1007_s11910_023_01324_9 crossref_primary_10_1002_hipo_23588 crossref_primary_10_3389_fnagi_2022_793353 crossref_primary_10_3389_fnagi_2023_1123456 crossref_primary_10_1016_j_bbi_2024_05_002 crossref_primary_10_1007_s00401_015_1435_y crossref_primary_10_1038_s41598_020_59869_5 crossref_primary_10_3233_JAD_200634 crossref_primary_10_5665_sleep_5846 crossref_primary_10_1016_j_nbscr_2016_08_002 crossref_primary_10_1038_nrneurol_2013_29 crossref_primary_10_1093_braincomms_fcad269 crossref_primary_10_1093_braincomms_fcz046 crossref_primary_10_3171_2016_2_FOCUS15609 crossref_primary_10_1007_s12035_023_03818_6 crossref_primary_10_1038_s12276_020_00494_7 crossref_primary_10_1186_s40478_021_01141_6 crossref_primary_10_1212_WNL_0000000000012145 crossref_primary_10_3233_JAD_220267 crossref_primary_10_1186_s13195_024_01485_w crossref_primary_10_1007_s12264_019_00401_9 crossref_primary_10_1126_sciadv_ade1474 crossref_primary_10_1016_j_immuni_2024_03_010 crossref_primary_10_1016_j_neurobiolaging_2013_08_027 crossref_primary_10_1111_apha_13887 crossref_primary_10_1055_s_0040_1713628 crossref_primary_10_3233_JAD_230032 crossref_primary_10_1038_s41593_021_00999_y crossref_primary_10_1007_s00401_019_02028_6 crossref_primary_10_1016_j_neubiorev_2021_10_030 crossref_primary_10_1016_j_neurobiolaging_2018_05_021 crossref_primary_10_1016_j_neurobiolaging_2018_05_020 crossref_primary_10_1002_alz_13529 crossref_primary_10_2217_iim_12_27 crossref_primary_10_1186_s13195_021_00856_x crossref_primary_10_1016_j_neurobiolaging_2024_11_008 crossref_primary_10_1101_cshperspect_a028035 crossref_primary_10_1136_jnnp_2016_313476 crossref_primary_10_1038_s41562_019_0715_2 crossref_primary_10_1186_s13041_021_00774_x crossref_primary_10_3389_fneur_2020_00739 crossref_primary_10_1093_braincomms_fcae141 crossref_primary_10_2174_1381612826666201021140904 crossref_primary_10_1007_s00406_013_0415_2 crossref_primary_10_1038_s41598_022_18415_1 crossref_primary_10_1101_cshperspect_a023630 crossref_primary_10_1523_JNEUROSCI_0275_18_2018 crossref_primary_10_3389_fnagi_2023_1275793 crossref_primary_10_3390_brainsci12010053 crossref_primary_10_1016_j_neuroimage_2017_09_042 crossref_primary_10_1007_s11011_021_00673_z crossref_primary_10_2174_1874205X01408010022 crossref_primary_10_1016_j_neuroimage_2020_117147 crossref_primary_10_1126_scitranslmed_aba7394 crossref_primary_10_1186_s13024_022_00566_4 crossref_primary_10_1093_brain_awaa014 crossref_primary_10_1042_BST20120034 crossref_primary_10_3389_fnagi_2018_00223 crossref_primary_10_1186_s40478_017_0503_z crossref_primary_10_3109_13697137_2014_933411 crossref_primary_10_1093_brain_awaa012 crossref_primary_10_1186_s40478_024_01907_8 crossref_primary_10_1038_s41380_023_02177_x crossref_primary_10_3233_JAD_231108 crossref_primary_10_1097_MAO_0000000000002381 crossref_primary_10_3390_ijms19103082 crossref_primary_10_1186_s13024_020_00391_7 crossref_primary_10_1212_WNL_0000000000013206 crossref_primary_10_3390_neuroglia1010010 crossref_primary_10_3389_fnagi_2022_1038343 crossref_primary_10_1146_annurev_pathol_012615_044216 crossref_primary_10_3389_fnagi_2016_00163 crossref_primary_10_1212_WNL_0000000000004733 crossref_primary_10_1016_j_neuron_2016_01_028 crossref_primary_10_1093_braincomms_fcae159 crossref_primary_10_1146_annurev_pathmechdis_051222_120750 crossref_primary_10_1172_jci_insight_142514 crossref_primary_10_1093_brain_aww057 crossref_primary_10_1002_alz_12261 crossref_primary_10_1186_s13024_019_0309_5 crossref_primary_10_1016_j_neuroimage_2019_116164 crossref_primary_10_3390_antiox9100937 crossref_primary_10_1016_j_pathol_2024_10_006 crossref_primary_10_1631_jzus_B1900262 crossref_primary_10_1111_ejn_14766 crossref_primary_10_3390_genes12111753 crossref_primary_10_1002_alz_14406 crossref_primary_10_1038_s41591_023_02729_2 crossref_primary_10_1186_s13195_024_01483_y crossref_primary_10_3390_molecules30050990 crossref_primary_10_1007_s11916_015_0522_z crossref_primary_10_1016_j_cger_2018_06_008 crossref_primary_10_3389_fnagi_2017_00234 crossref_primary_10_1007_s00401_020_02210_1 crossref_primary_10_1016_j_jalz_2016_03_009 crossref_primary_10_1212_NXG_0000000000200053 crossref_primary_10_1016_j_tins_2015_08_006 crossref_primary_10_21307_ane_2020_021 crossref_primary_10_1016_j_jalz_2018_12_004 crossref_primary_10_1093_braincomms_fcae128 crossref_primary_10_3389_fgene_2023_1166831 crossref_primary_10_1016_j_neulet_2020_134919 crossref_primary_10_3233_JAD_190196 crossref_primary_10_3390_ijms241814151 crossref_primary_10_3233_JAD_170364 crossref_primary_10_1007_s11357_023_00834_1 crossref_primary_10_3233_JAD_210404 crossref_primary_10_1371_journal_pone_0106431 crossref_primary_10_1002_prca_201400192 crossref_primary_10_1016_j_expneurol_2015_06_003 crossref_primary_10_1016_j_nbd_2017_03_014 crossref_primary_10_1016_j_ajpath_2021_11_013 crossref_primary_10_3390_ijms23094789 crossref_primary_10_1007_s00401_013_1153_2 crossref_primary_10_3233_JAD_240043 crossref_primary_10_1002_alz_14426 crossref_primary_10_1016_j_cccb_2023_100171 crossref_primary_10_1002_ana_23836 crossref_primary_10_1093_brain_awy252 crossref_primary_10_3390_ijms24119552 crossref_primary_10_3389_fnagi_2015_00152 crossref_primary_10_1002_alz_12480 crossref_primary_10_1093_cercor_bhab475 crossref_primary_10_1016_j_neulet_2017_09_033 crossref_primary_10_1172_JCI143775 crossref_primary_10_3174_ajnr_A3307 crossref_primary_10_1016_j_nbd_2025_106845 crossref_primary_10_1016_j_nicl_2016_05_013 crossref_primary_10_1093_brain_awaa180 crossref_primary_10_1016_j_neurobiolaging_2025_03_005 crossref_primary_10_3389_fnins_2023_1159314 crossref_primary_10_1038_s43587_023_00497_9 crossref_primary_10_1097_QAD_0000000000001927 crossref_primary_10_1038_s41398_023_02572_6 crossref_primary_10_1007_s00018_016_2361_4 crossref_primary_10_1515_tnsci_2016_0016 crossref_primary_10_1016_j_jagp_2020_04_026 crossref_primary_10_1093_brain_awz099 crossref_primary_10_1007_s41465_017_0051_2 crossref_primary_10_1093_nar_gkae697 crossref_primary_10_1002_alz_12173 crossref_primary_10_1371_journal_pgen_1010681 crossref_primary_10_3389_fnhum_2025_1490864 crossref_primary_10_1016_j_neubiorev_2023_105311 crossref_primary_10_3233_JAD_230214 crossref_primary_10_1007_s13365_023_01181_9 crossref_primary_10_1093_brain_awab262 crossref_primary_10_3233_JAD_150435 crossref_primary_10_2967_jnumed_116_182980 crossref_primary_10_3389_fnins_2023_1089134 crossref_primary_10_1523_ENEURO_0345_23_2023 crossref_primary_10_1002_gps_5470 crossref_primary_10_1016_j_autneu_2021_102858 crossref_primary_10_7248_jjrhi_60_509 crossref_primary_10_1038_nrneurol_2012_236 crossref_primary_10_1016_j_neurobiolaging_2021_11_006 crossref_primary_10_3390_cells10071829 crossref_primary_10_1007_s11548_021_02528_5 crossref_primary_10_1523_JNEUROSCI_2092_14_2015 crossref_primary_10_2174_1570159X20666220327221830 crossref_primary_10_1016_j_neurobiolaging_2021_11_004 crossref_primary_10_1038_s41380_021_01409_2 crossref_primary_10_1016_j_neuroimage_2021_118047 crossref_primary_10_1093_jnen_nlz090 crossref_primary_10_1016_j_cortex_2018_08_011 crossref_primary_10_3233_JAD_230223 crossref_primary_10_3233_JAD_231312 crossref_primary_10_1038_s41582_024_00962_y crossref_primary_10_3390_jpm10030114 crossref_primary_10_1016_j_jalz_2018_03_002 crossref_primary_10_3233_JAD_150225 crossref_primary_10_3233_JAD_170274 crossref_primary_10_1016_j_pneurobio_2017_03_004 crossref_primary_10_1111_epi_16375 crossref_primary_10_3389_fnagi_2022_949361 crossref_primary_10_1007_s00401_021_02315_1 crossref_primary_10_2142_biophysico_bppb_v21_s008 crossref_primary_10_3389_fnhum_2023_1297467 crossref_primary_10_5812_ijpbs_126596 crossref_primary_10_1007_s11307_021_01584_2 crossref_primary_10_1016_j_neurobiolaging_2024_09_006 crossref_primary_10_1016_j_rechem_2024_101503 crossref_primary_10_3389_fncel_2019_00538 crossref_primary_10_1007_s00401_019_02035_7 crossref_primary_10_1172_jci_insight_172008 crossref_primary_10_3233_JAD_220898 crossref_primary_10_3390_brainsci14010008 crossref_primary_10_3390_ijms22094861 crossref_primary_10_3389_fnagi_2023_1204852 crossref_primary_10_1007_s00429_024_02797_1 crossref_primary_10_1016_j_neurobiolaging_2019_06_011 crossref_primary_10_1093_brain_awab248 crossref_primary_10_3389_fcell_2019_00134 crossref_primary_10_1111_jnc_14224 crossref_primary_10_3390_antiox14030255 crossref_primary_10_1007_s11357_023_00730_8 crossref_primary_10_1016_j_cortex_2023_12_005 crossref_primary_10_1016_j_jalz_2016_06_2362 crossref_primary_10_1186_s13024_021_00456_1 crossref_primary_10_3390_ijms25116222 crossref_primary_10_1002_prot_24988 crossref_primary_10_1016_j_ejps_2024_106869 crossref_primary_10_1001_jamanetworkopen_2022_0729 crossref_primary_10_1007_s00702_014_1360_6 crossref_primary_10_3233_ADR_220047 crossref_primary_10_1093_cercor_bhae261 crossref_primary_10_1186_s40659_024_00523_z crossref_primary_10_3389_fnmol_2020_619639 crossref_primary_10_1016_j_neuroimage_2022_119658 crossref_primary_10_1523_JNEUROSCI_1483_17_2017 crossref_primary_10_3233_JAD_240479 crossref_primary_10_1186_1750_1326_7_8 crossref_primary_10_3389_fnagi_2022_841942 crossref_primary_10_1016_j_shpsc_2020_101291 crossref_primary_10_1016_j_tics_2016_01_001 crossref_primary_10_3233_JAD_240483 crossref_primary_10_1007_s00401_016_1591_8 crossref_primary_10_1111_acel_12978 crossref_primary_10_1007_s00702_024_02859_y crossref_primary_10_1093_brain_awac329 crossref_primary_10_1002_alz_13016 crossref_primary_10_1038_s41467_023_36058_2 crossref_primary_10_3390_ijms241915023 crossref_primary_10_1016_j_intimp_2023_110649 crossref_primary_10_1080_14789450_2021_1886929 crossref_primary_10_3389_fnagi_2019_00147 crossref_primary_10_1111_bpa_12059 crossref_primary_10_1016_j_jpain_2024_01_006 crossref_primary_10_1126_scitranslmed_adn3504 crossref_primary_10_1002_alz_14582 crossref_primary_10_1038_s43587_024_00626_y crossref_primary_10_1084_jem_20161731 crossref_primary_10_1126_scitranslmed_abc0655 crossref_primary_10_1016_j_pnpbp_2017_08_004 crossref_primary_10_1007_s10072_019_04111_y crossref_primary_10_1016_j_medp_2024_100060 crossref_primary_10_1124_jpet_120_265058 crossref_primary_10_1186_s12964_023_01373_0 crossref_primary_10_1016_j_neurobiolaging_2013_08_005 crossref_primary_10_1111_nan_12229 crossref_primary_10_1111_bcp_16160 crossref_primary_10_1111_bpa_12289 crossref_primary_10_1007_s12031_016_0810_z crossref_primary_10_1038_s41467_024_54777_y crossref_primary_10_1039_C9EM00068B crossref_primary_10_3233_ADR_200218 crossref_primary_10_1007_s00401_020_02251_6 crossref_primary_10_1515_almed_2020_0109 crossref_primary_10_1016_S1474_4422_20_30440_3 crossref_primary_10_1038_s43856_024_00497_9 crossref_primary_10_1177_0271678X221082016 crossref_primary_10_1007_s10571_020_00972_6 crossref_primary_10_3892_mmr_2017_8289 crossref_primary_10_1016_j_neuron_2021_02_010 crossref_primary_10_1080_14737175_2024_2367016 crossref_primary_10_3233_JAD_150233 crossref_primary_10_1093_database_bay050 crossref_primary_10_3390_genes13061034 crossref_primary_10_1016_j_exger_2012_05_023 crossref_primary_10_1007_s00429_020_02153_z crossref_primary_10_1016_j_bcp_2014_01_009 crossref_primary_10_1016_j_neuroimage_2015_02_045 crossref_primary_10_3233_JAD_160037 crossref_primary_10_2174_1874467214666210910114324 crossref_primary_10_3390_antiox10010061 crossref_primary_10_1016_j_neuropharm_2017_01_010 crossref_primary_10_1093_brain_awz286 crossref_primary_10_3390_inorganics11110443 crossref_primary_10_1038_s42003_025_07575_1 crossref_primary_10_1016_j_neurobiolaging_2013_11_020 crossref_primary_10_1111_bpa_13122 crossref_primary_10_1038_s41398_021_01602_5 crossref_primary_10_1093_brain_awad232 crossref_primary_10_1111_j_1528_1167_2012_03476_x crossref_primary_10_1007_s13365_019_00761_y crossref_primary_10_2174_1567205018666210608114044 crossref_primary_10_3390_ijerph20021007 crossref_primary_10_1186_s13195_024_01500_0 crossref_primary_10_1186_s13024_021_00467_y crossref_primary_10_3390_molecules27144552 crossref_primary_10_1093_cercor_bhx157 crossref_primary_10_1016_j_biopsych_2019_12_021 crossref_primary_10_1097_WCO_0b013e32835a3ee0 crossref_primary_10_1186_s40478_023_01588_9 crossref_primary_10_1007_s00401_014_1356_1 crossref_primary_10_1111_bph_16212 crossref_primary_10_1371_journal_pone_0262367 crossref_primary_10_3390_biomedicines11051477 crossref_primary_10_3233_ADR_210052 crossref_primary_10_1002_alz_12192 crossref_primary_10_1002_mds_27682 crossref_primary_10_1016_j_neurobiolaging_2024_08_008 crossref_primary_10_1007_s00401_015_1390_7 crossref_primary_10_3390_jcm13144100 crossref_primary_10_1111_jnc_15598 crossref_primary_10_1186_s40478_021_01246_y crossref_primary_10_1002_alz_14131 crossref_primary_10_1523_JNEUROSCI_1929_23_2024 crossref_primary_10_1016_j_jalz_2012_07_005 crossref_primary_10_1016_j_neurobiolaging_2020_02_025 crossref_primary_10_3389_fnagi_2022_930315 crossref_primary_10_3233_JAD_230639 crossref_primary_10_3233_ADR_200250 crossref_primary_10_1111_neup_12290 crossref_primary_10_1016_j_jmbbm_2017_03_001 crossref_primary_10_3233_JAD_240434 crossref_primary_10_1159_000486200 crossref_primary_10_1016_j_biopsych_2013_05_024 crossref_primary_10_1093_jnen_nlae032 crossref_primary_10_1111_cts_12645 crossref_primary_10_1093_jnen_nlac095 crossref_primary_10_1097_WCO_0000000000001042 crossref_primary_10_3389_fneur_2020_607680 crossref_primary_10_1002_alz_14385 crossref_primary_10_1186_s40478_019_0748_9 crossref_primary_10_1111_jnc_14036 crossref_primary_10_1093_cercor_bhad137 crossref_primary_10_1016_j_molliq_2023_123911 crossref_primary_10_1038_s41467_024_53168_7 crossref_primary_10_1212_WNL_0b013e318289714a crossref_primary_10_3389_fnmol_2022_937056 crossref_primary_10_1016_j_neuroimage_2012_02_019 crossref_primary_10_3390_cells13191608 crossref_primary_10_1007_s00401_019_02053_5 crossref_primary_10_1111_bpa_12919 crossref_primary_10_14283_jarlife_2023_9 crossref_primary_10_1016_j_jalz_2018_02_018 crossref_primary_10_1177_25424823241307617 crossref_primary_10_1186_s13195_016_0230_x crossref_primary_10_2967_jnumed_121_263201 crossref_primary_10_1002_gps_5615 crossref_primary_10_1038_s41386_019_0478_5 crossref_primary_10_1212_WNL_0000000000002923 crossref_primary_10_3389_fncel_2024_1371213 crossref_primary_10_1016_j_neurobiolaging_2022_07_010 crossref_primary_10_1186_s13195_021_00902_8 crossref_primary_10_1016_j_npbr_2016_01_001 crossref_primary_10_1016_j_brainres_2022_148070 crossref_primary_10_1177_15333175231160010 crossref_primary_10_1002_syn_22265 crossref_primary_10_1002_trc2_12203 crossref_primary_10_1162_imag_a_00367 crossref_primary_10_1016_j_neubiorev_2020_07_038 crossref_primary_10_1016_j_arcmed_2012_09_009 crossref_primary_10_1038_sdata_2018_142 crossref_primary_10_1016_j_neurobiolaging_2014_02_015 crossref_primary_10_1002_acn3_51237 crossref_primary_10_1080_19336896_2016_1228507 crossref_primary_10_1001_jamanetworkopen_2018_1724 crossref_primary_10_3143_geriatrics_55_562 crossref_primary_10_1093_sleep_zsab057 crossref_primary_10_1080_00207454_2020_1758087 crossref_primary_10_1016_j_cell_2022_11_021 crossref_primary_10_1212_WNL_0000000000008696 crossref_primary_10_3233_JAD_230616 crossref_primary_10_3390_brainsci11080958 crossref_primary_10_2174_1874467214666210906125318 crossref_primary_10_3389_fncel_2022_886803 crossref_primary_10_1038_s41591_023_02326_3 crossref_primary_10_1016_j_cmpb_2024_108378 crossref_primary_10_1007_s00702_021_02426_9 crossref_primary_10_1146_annurev_psych_122414_033540 crossref_primary_10_1186_s13195_020_00742_y crossref_primary_10_1186_s40708_019_0096_3 crossref_primary_10_1111_epi_17086 crossref_primary_10_1155_2017_6031478 crossref_primary_10_1186_s13024_023_00653_0 crossref_primary_10_1002_acn3_40 crossref_primary_10_1523_JNEUROSCI_0881_13_2013 crossref_primary_10_2217_imt_2016_0019 crossref_primary_10_1111_nan_12674 crossref_primary_10_1111_j_1365_2990_2011_01244_x crossref_primary_10_1186_2051_5960_1_82 crossref_primary_10_1186_s40478_023_01693_9 crossref_primary_10_3233_JAD_180917 crossref_primary_10_3233_JAD_180919 crossref_primary_10_1186_s40478_024_01792_1 crossref_primary_10_1007_s00401_022_02521_5 crossref_primary_10_1186_s13195_022_01089_2 crossref_primary_10_1016_j_neurobiolaging_2023_01_016 crossref_primary_10_1523_JNEUROSCI_1353_14_2014 crossref_primary_10_3233_JAD_142682 crossref_primary_10_1055_s_0040_1715134 crossref_primary_10_1093_brain_awab092 crossref_primary_10_1016_j_pneurobio_2012_03_005 crossref_primary_10_1111_ene_15556 crossref_primary_10_3389_fneur_2021_794071 crossref_primary_10_1038_nrneurol_2015_251 crossref_primary_10_1016_j_arr_2022_101784 crossref_primary_10_1093_biohorizons_hzu002 crossref_primary_10_1093_jnen_nlac068 crossref_primary_10_1212_CON_0000000000001499 crossref_primary_10_1111_bph_14637 crossref_primary_10_1093_brain_awae116 crossref_primary_10_3390_biomedicines12092113 crossref_primary_10_1055_a_1973_3038 crossref_primary_10_1007_s00702_017_1781_0 crossref_primary_10_1212_WNL_0000000000005163 crossref_primary_10_3233_JAD_179936 crossref_primary_10_1093_hmg_ddab262 crossref_primary_10_1186_s40478_015_0199_x crossref_primary_10_1038_nrneurol_2017_96 crossref_primary_10_1176_appi_neuropsych_19010021 crossref_primary_10_1093_jnen_nlx099 crossref_primary_10_1016_j_npg_2024_08_002 crossref_primary_10_1038_labinvest_2015_54 crossref_primary_10_1016_j_brainres_2019_146535 crossref_primary_10_1016_j_tins_2022_11_006 crossref_primary_10_1038_s41573_022_00391_w crossref_primary_10_4103_1673_5374_303023 crossref_primary_10_1016_j_tins_2018_01_010 crossref_primary_10_1097_QAD_0000000000002893 crossref_primary_10_1016_j_ymeth_2012_03_023 crossref_primary_10_1080_87565641_2018_1447575 crossref_primary_10_1111_nan_12455 crossref_primary_10_1002_alz_13096 crossref_primary_10_1186_s13195_022_00993_x crossref_primary_10_1007_s00401_013_1170_1 crossref_primary_10_1038_s41598_021_91621_5 crossref_primary_10_3233_JAD_201248 crossref_primary_10_1016_j_neubiorev_2017_02_001 crossref_primary_10_1007_s00401_018_1918_8 crossref_primary_10_3233_JAD_201005 crossref_primary_10_3233_JAD_230807 crossref_primary_10_1002_brb3_3019 crossref_primary_10_1007_s00401_019_02075_z crossref_primary_10_1016_j_neurobiolaging_2014_03_027 crossref_primary_10_1186_s13195_025_01674_1 crossref_primary_10_1212_WNL_0000000000010986 crossref_primary_10_1073_pnas_1903671116 crossref_primary_10_3928_00485713_20170407_01 crossref_primary_10_1002_gps_5418 crossref_primary_10_3389_fnagi_2022_926904 crossref_primary_10_1016_j_bbr_2019_111937 crossref_primary_10_1016_j_ejrad_2013_03_019 crossref_primary_10_1111_ejn_16482 crossref_primary_10_1007_s00401_015_1406_3 crossref_primary_10_1016_j_exger_2024_112535 crossref_primary_10_1016_j_ynirp_2020_100002 crossref_primary_10_1038_s41380_024_02672_9 crossref_primary_10_1111_nan_12869 crossref_primary_10_1111_acer_13102 crossref_primary_10_3389_fnins_2018_00372 crossref_primary_10_1007_s00401_012_1003_7 crossref_primary_10_3892_ijmm_2022_5208 crossref_primary_10_1074_jbc_M113_494922 crossref_primary_10_1186_s13024_017_0189_5 crossref_primary_10_1186_s13063_024_07943_y crossref_primary_10_4161_pri_27661 crossref_primary_10_1016_j_nbd_2019_01_008 crossref_primary_10_3109_13697137_2014_929650 crossref_primary_10_1038_s41541_019_0118_4 crossref_primary_10_1007_s40473_015_0056_z crossref_primary_10_1155_2014_648740 crossref_primary_10_1007_s40520_022_02097_w crossref_primary_10_3390_brainsci12040496 crossref_primary_10_1007_s00401_013_1139_0 crossref_primary_10_4044_joma_126_99 crossref_primary_10_2174_0115672026305417240209062508 crossref_primary_10_1586_14737175_2016_1140039 crossref_primary_10_1002_ana_26880 crossref_primary_10_3389_fnagi_2021_672077 crossref_primary_10_1016_j_nbd_2020_105138 crossref_primary_10_1016_j_neubiorev_2024_105647 crossref_primary_10_1186_2051_5960_1_31 crossref_primary_10_1186_s13293_023_00545_4 crossref_primary_10_3389_fnagi_2024_1376764 crossref_primary_10_1016_j_jchemneu_2016_02_001 crossref_primary_10_3390_brainsci9120338 crossref_primary_10_1016_j_bbr_2021_113354 crossref_primary_10_1289_EHP14344 crossref_primary_10_1016_j_neurobiolaging_2013_10_081 crossref_primary_10_1002_mus_25049 crossref_primary_10_1186_s12974_020_01960_9 crossref_primary_10_1212_WNL_0000000000006469 crossref_primary_10_1186_s40478_022_01432_6 crossref_primary_10_1007_s00401_021_02326_y crossref_primary_10_1016_j_brainres_2018_08_014 crossref_primary_10_1016_j_neubiorev_2023_105358 crossref_primary_10_2967_jnumed_122_264434 crossref_primary_10_3233_JAD_180958 crossref_primary_10_1042_NS20220086 crossref_primary_10_1186_s40478_024_01800_4 crossref_primary_10_3389_fphar_2020_581098 crossref_primary_10_1002_hbm_25121 crossref_primary_10_12688_f1000research_2_50_v1 crossref_primary_10_1016_j_nbd_2022_105748 crossref_primary_10_1016_j_redox_2016_09_001 crossref_primary_10_3390_biom6010007 crossref_primary_10_1002_ctm2_397 crossref_primary_10_1038_s41380_024_02467_y crossref_primary_10_3233_JAD_200187 crossref_primary_10_1007_s11065_014_9268_3 crossref_primary_10_1038_s41467_024_49205_0 crossref_primary_10_1017_S1092852924000427 crossref_primary_10_1186_s40478_024_01748_5 crossref_primary_10_1371_journal_pgen_1008775 crossref_primary_10_1016_j_ssmph_2022_101312 crossref_primary_10_1007_s00401_014_1349_0 crossref_primary_10_1093_brain_awt362 crossref_primary_10_1093_sleep_zsaa195 crossref_primary_10_3233_JAD_180721 crossref_primary_10_1111_jnc_13107 crossref_primary_10_18632_aging_206143 crossref_primary_10_1007_s40675_024_00316_6 crossref_primary_10_1093_brain_awad059 crossref_primary_10_1093_brain_aws277 crossref_primary_10_1038_tp_2016_280 crossref_primary_10_1111_jnc_13588 |
| Cites_doi | 10.1007/s00401-011-0825-z 10.1111/j.1750-3639.2008.00147.x 10.1002/1531-8249(200101)49:1<53::AID-ANA30>3.0.CO;2-Q 10.1007/s00401-011-0826-y 10.1007/s00401-009-0486-3 10.1007/s12035-010-8137-1 10.1111/j.1750-3639.2007.00053.x 10.1126/science.1072994 10.1111/j.1365-2990.2008.00997.x 10.1016/j.neuron.2004.07.003 10.1016/0306-4522(95)90397-P 10.1001/archneur.60.3.337 10.1007/s00401-007-0207-8 10.1111/j.1750-3639.1991.tb00661.x 10.1006/exnr.1997.6777 10.2174/156720508785132307 10.1007/BF00293315 10.1016/j.neurobiolaging.2006.02.007 10.1007/s00401-010-0716-8 10.1016/j.neurobiolaging.2003.09.009 10.1126/science.1062097 10.1159/000113716 10.1006/nbdi.1996.0003 10.1212/WNL.58.12.1791 10.1016/0197-4580(94)90031-0 10.1016/0306-4522(83)90023-4 10.1016/j.tins.2010.04.003 10.1016/0165-0173(89)90017-9 10.3233/JAD-2006-9S323 10.1016/0304-3940(87)90204-7 10.1097/NEN.0b013e3181919a48 10.1016/S0072-9752(07)01251-1 10.1083/jcb.200108057 10.1038/nrn2573 10.1126/science.1132814 10.1007/s004019900178 10.1159/000283478 10.1007/s00401-006-0127-z 10.1007/s00401-010-0789-4 10.1111/j.1365-2990.2009.01038.x 10.1002/ana.21509 10.1093/jnen/59.8.733 10.1097/NEN.0b013e3181c6c13d 10.1007/BF00308809 10.2174/156720508784533286 10.1371/journal.pone.0016648 10.1016/S0197-4580(97)00035-3 10.1111/j.1440-1789.2006.00725.x 10.1007/978-3-540-37652-1_47 10.1016/S0006-8993(98)00441-7 10.1074/jbc.M110.209296 10.1038/nature08983 10.3233/JAD-2010-100498 10.1007/978-3-540-37652-1_15 10.1146/annurev.neuro.28.061604.135709 10.1111/j.1750-3639.2009.00326.x 10.1016/j.neurobiolaging.2003.12.015 10.1126/science.1058189 10.1097/NEN.0b013e31816a1df3 10.1097/00005072-199902000-00008 10.1523/JNEUROSCI.4521-10.2010 10.1016/S0197-4580(97)00056-0 10.1007/s00401-010-0664-3 10.1002/ana.410240210 10.1016/j.jalz.2007.11.008 10.1016/0306-4522(87)90123-0 10.1016/S1474-4422(09)70299-6 10.1016/j.biocel.2008.12.015 10.1073/pnas.90.11.5066 10.1146/annurev.pathmechdis.2.010506.092044 10.1093/brain/awm305 10.1016/S0197-4580(02)00065-9 |
| ContentType | Journal Article |
| Copyright | 2011 American Association of Neuropathologists, Inc 2015 INIST-CNRS Copyright Lippincott Williams & Wilkins Nov 2011 |
| Copyright_xml | – notice: 2011 American Association of Neuropathologists, Inc – notice: 2015 INIST-CNRS – notice: Copyright Lippincott Williams & Wilkins Nov 2011 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 88G 88I 8AF 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. M0S M1P M2P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS Q9U S0X 7X8 |
| DOI | 10.1097/NEN.0b013e318232a379 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Medical Database Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic SIRS Editorial MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials SIRS Editorial ProQuest Health & Medical Complete (Alumni) ProQuest AP Science ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic ProQuest Central Student |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1554-6578 |
| EndPage | 969 |
| ExternalDocumentID | 2522041921 22002422 24734607 10_1097_NEN_0b013e318232a379 10.1097/NEN.0b013e318232a379 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- .55 .GJ .Z2 01R 0R~ 1TH 29L 3O- 40H 48X 5GY 5RE 5VS 5WD 71W 77Y 7O~ 7X7 88E 88I 8AF 8FI 8FJ 8R4 8R5 AABZA AACZT AAIMJ AAJQQ AAKAS AAMDB AAMVS AAPGJ AAPQZ AAPXW AARHZ AASOK AAUAY AAUQX AAVAP AAWDT ABBUW ABDFA ABEJV ABEUO ABGNP ABIVO ABIXL ABJNI ABLJU ABMNT ABNHQ ABPQP ABPTD ABQNK ABSMQ ABUWG ABVGC ABWST ABXVV ABXZS ABZAD ACCCW ACDDN ACFRR ACGFO ACGFS ACGOD ACUFI ACUTJ ACVCV ACWDW ACWRI ACZBC ADBBV ADBIZ ADFPA ADGKP ADGZP ADHKW ADIPN ADMTO ADNBA ADQBN ADRTK ADVEK ADZCM AE3 AELWJ AEMDU AEMQT AENEX AENZO AEPUE AETBJ AEWNT AFFNX AFFQV AFFZL AFGWE AFIYH AFKRA AFOFC AFTRI AFUWQ AFXAL AFYAG AGINI AGINJ AGKRT AGMDO AGORE AGQXC AGSYK AGUTN AHGBF AHMBA AHMMS AHRYX AHVBC AI. AIZYK AJBYB AJDVS AJEEA AJNCP ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APJGH AQDSO AQKUS ARIXL ATGXG AVNTJ AVWKF AYOIW AZQEC BAYMD BCRHZ BENPR BHONS BOYCO BPHCQ BQDIO BS7 BSWAC BTRTY BVRKM BVXVI BZKNY C45 CCPQU CDBKE CS3 DAKXR DILTD DU5 DWQXO E.X EBS EIHJH EJD ENERS EX3 F2K F2L F2M F2N F5P FECEO FHSFR FL- FLUFQ FOEOM FOTVD FQBLK FW0 FYUFA GAUVT GJXCC GNUQQ H0~ H13 HCIFZ HMCUK HZ~ IAO IHR INH IN~ ITC J21 JK3 JK8 JXSIZ K8S KBUDW KD2 KMI KOP KQ8 KSI KSN L7B M1P M2M M2P M2Q MBLQV MHKGH N9A NLBLG NOMLY NOYVH NVLIB N~7 N~B N~M OAUYM OAWHX OBFPC OBOKY OCUKA OCZFY ODA ODMLO OJQWA OJZSN OK1 OLG OLH OLV OLZ OPAEJ ORVUJ OVD OWPYF P-K P2P PAFKI PEELM PHGZM PHGZT PQQKQ PROAC PSQYO Q2X R58 ROX ROZ RUSNO RWL S0X S4R S4S TAE TEORI TLC TMA UKHRP V2I VH1 W3M WH7 WOQ WOW X3V X3W X7M XJT YAYTL YKOAZ YXANX ZGI ZXP ZY1 AAYXX CITATION IQODW NU- PJZUB PPXIY CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK K9. PKEHL PQEST PQUKI PRINS Q9U 7X8 |
| ID | FETCH-LOGICAL-c5249-c125f4d905d557c89c46a9a5c4c730ca901490216f7e01a257196f02532c7b983 |
| IEDL.DBID | 7X7 |
| ISSN | 0022-3069 1554-6578 |
| IngestDate | Fri Jul 11 07:34:34 EDT 2025 Fri Aug 15 20:04:21 EDT 2025 Mon Jul 21 05:58:53 EDT 2025 Mon Jul 21 09:13:47 EDT 2025 Tue Jul 01 03:11:19 EDT 2025 Thu Apr 24 23:00:15 EDT 2025 Fri May 16 04:03:52 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | Nervous system diseases Phosphorylation Alzheimer disease Brain stem Central nervous system Brainstem Neurofibrillary tangle Encephalon Cerebral disorder Thread Pretangles/neurofibrillary tangles Neuropil threads Tau protein β Amyloid protein Central nervous system disease Hyper-phosphorylated tau protein Degenerative disease Microtubule associated protein Age Locus coeruleus β-amyloid |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5249-c125f4d905d557c89c46a9a5c4c730ca901490216f7e01a257196f02532c7b983 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://academic.oup.com/jnen/article-pdf/70/11/960/17418183/70-11-960.pdf |
| PMID | 22002422 |
| PQID | 906522093 |
| PQPubID | 40718 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_900631635 proquest_journals_906522093 pubmed_primary_22002422 pascalfrancis_primary_24734607 crossref_citationtrail_10_1097_NEN_0b013e318232a379 crossref_primary_10_1097_NEN_0b013e318232a379 wolterskluwer_health_10_1097_NEN_0b013e318232a379 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2011-November |
| PublicationDateYYYYMMDD | 2011-11-01 |
| PublicationDate_xml | – month: 11 year: 2011 text: 2011-November |
| PublicationDecade | 2010 |
| PublicationPlace | Hagerstown, MD |
| PublicationPlace_xml | – name: Hagerstown, MD – name: England – name: Cary |
| PublicationTitle | Journal of neuropathology and experimental neurology |
| PublicationTitleAlternate | J Neuropathol Exp Neurol |
| PublicationYear | 2011 |
| Publisher | American Association of Neuropathologists, Inc Lippincott Williams & Wilkins Oxford University Press |
| Publisher_xml | – name: American Association of Neuropathologists, Inc – name: Lippincott Williams & Wilkins – name: Oxford University Press |
| References | 2016030320303487000_70.11.960.63 2016030320303487000_70.11.960.20 2016030320303487000_70.11.960.64 2016030320303487000_70.11.960.21 2016030320303487000_70.11.960.65 2016030320303487000_70.11.960.22 2016030320303487000_70.11.960.66 2016030320303487000_70.11.960.60 2016030320303487000_70.11.960.61 2016030320303487000_70.11.960.62 2016030320303487000_70.11.960.27 2016030320303487000_70.11.960.28 2016030320303487000_70.11.960.29 2016030320303487000_70.11.960.23 2016030320303487000_70.11.960.67 2016030320303487000_70.11.960.24 2016030320303487000_70.11.960.68 2016030320303487000_70.11.960.25 2016030320303487000_70.11.960.69 2016030320303487000_70.11.960.26 Thal (2016030320303487000_70.11.960.5) 2000; 59 Alafuzoff (2016030320303487000_70.11.960.7) 2008; 18 2016030320303487000_70.11.960.52 2016030320303487000_70.11.960.53 2016030320303487000_70.11.960.54 2016030320303487000_70.11.960.11 2016030320303487000_70.11.960.50 2016030320303487000_70.11.960.51 2016030320303487000_70.11.960.17 2016030320303487000_70.11.960.18 2016030320303487000_70.11.960.19 Patten (2016030320303487000_70.11.960.48) 2010; 20 2016030320303487000_70.11.960.56 Trojanowski (2016030320303487000_70.11.960.10) 2000; 924 2016030320303487000_70.11.960.13 2016030320303487000_70.11.960.57 2016030320303487000_70.11.960.14 2016030320303487000_70.11.960.58 2016030320303487000_70.11.960.15 2016030320303487000_70.11.960.59 2016030320303487000_70.11.960.41 2016030320303487000_70.11.960.42 2016030320303487000_70.11.960.43 Goedert (2016030320303487000_70.11.960.12) 2006; 9 2016030320303487000_70.11.960.44 Del (2016030320303487000_70.11.960.55) 2008; 29 2016030320303487000_70.11.960.40 2016030320303487000_70.11.960.49 2016030320303487000_70.11.960.45 2016030320303487000_70.11.960.46 2016030320303487000_70.11.960.47 2016030320303487000_70.11.960.6 2016030320303487000_70.11.960.3 2016030320303487000_70.11.960.4 2016030320303487000_70.11.960.1 2016030320303487000_70.11.960.2 2016030320303487000_70.11.960.30 2016030320303487000_70.11.960.74 2016030320303487000_70.11.960.31 2016030320303487000_70.11.960.75 Dickson (2016030320303487000_70.11.960.16) 2009; 25 2016030320303487000_70.11.960.32 2016030320303487000_70.11.960.33 2016030320303487000_70.11.960.70 2016030320303487000_70.11.960.71 2016030320303487000_70.11.960.72 2016030320303487000_70.11.960.73 2016030320303487000_70.11.960.38 2016030320303487000_70.11.960.39 2016030320303487000_70.11.960.9 2016030320303487000_70.11.960.34 2016030320303487000_70.11.960.35 2016030320303487000_70.11.960.36 2016030320303487000_70.11.960.8 2016030320303487000_70.11.960.37 |
| References_xml | – ident: 2016030320303487000_70.11.960.73 doi: 10.1007/s00401-011-0825-z – volume: 18 start-page: 484 year: 2008 ident: 2016030320303487000_70.11.960.7 article-title: Staging of neurofibrillary pathology in Alzheimer's disease: A study for the BrainNet Europe Consortium publication-title: Brain Pathol doi: 10.1111/j.1750-3639.2008.00147.x – ident: 2016030320303487000_70.11.960.26 doi: 10.1002/1531-8249(200101)49:1<53::AID-ANA30>3.0.CO;2-Q – ident: 2016030320303487000_70.11.960.50 doi: 10.1007/s00401-011-0826-y – ident: 2016030320303487000_70.11.960.58 doi: 10.1007/s00401-009-0486-3 – ident: 2016030320303487000_70.11.960.46 doi: 10.1007/s12035-010-8137-1 – volume: 924 start-page: 62 year: 2000 ident: 2016030320303487000_70.11.960.10 article-title: "Fatal attractions” of proteins publication-title: A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders. Ann N Y Acad Sci – ident: 2016030320303487000_70.11.960.14 doi: 10.1111/j.1750-3639.2007.00053.x – ident: 2016030320303487000_70.11.960.63 doi: 10.1126/science.1072994 – ident: 2016030320303487000_70.11.960.27 doi: 10.1111/j.1365-2990.2008.00997.x – ident: 2016030320303487000_70.11.960.71 doi: 10.1016/j.neuron.2004.07.003 – ident: 2016030320303487000_70.11.960.51 doi: 10.1016/0306-4522(95)90397-P – ident: 2016030320303487000_70.11.960.32 doi: 10.1001/archneur.60.3.337 – ident: 2016030320303487000_70.11.960.56 doi: 10.1007/s00401-007-0207-8 – ident: 2016030320303487000_70.11.960.20 doi: 10.1111/j.1750-3639.1991.tb00661.x – ident: 2016030320303487000_70.11.960.54 doi: 10.1006/exnr.1997.6777 – ident: 2016030320303487000_70.11.960.57 doi: 10.2174/156720508785132307 – ident: 2016030320303487000_70.11.960.42 doi: 10.1007/BF00293315 – ident: 2016030320303487000_70.11.960.35 doi: 10.1016/j.neurobiolaging.2006.02.007 – ident: 2016030320303487000_70.11.960.59 doi: 10.1007/s00401-010-0716-8 – ident: 2016030320303487000_70.11.960.65 doi: 10.1016/j.neurobiolaging.2003.09.009 – ident: 2016030320303487000_70.11.960.69 doi: 10.1126/science.1062097 – ident: 2016030320303487000_70.11.960.36 doi: 10.1159/000113716 – ident: 2016030320303487000_70.11.960.53 doi: 10.1006/nbdi.1996.0003 – ident: 2016030320303487000_70.11.960.6 doi: 10.1212/WNL.58.12.1791 – ident: 2016030320303487000_70.11.960.49 doi: 10.1016/0197-4580(94)90031-0 – ident: 2016030320303487000_70.11.960.39 doi: 10.1016/0306-4522(83)90023-4 – ident: 2016030320303487000_70.11.960.74 doi: 10.1016/j.tins.2010.04.003 – ident: 2016030320303487000_70.11.960.25 doi: 10.1016/0165-0173(89)90017-9 – volume: 9 start-page: 195 issue: Suppl year: 2006 ident: 2016030320303487000_70.11.960.12 article-title: Tau protein, the paired helical filament and Alzheimer's disease publication-title: J Alzheimers Dis doi: 10.3233/JAD-2006-9S323 – ident: 2016030320303487000_70.11.960.17 doi: 10.1016/0304-3940(87)90204-7 – ident: 2016030320303487000_70.11.960.1 doi: 10.1097/NEN.0b013e3181919a48 – ident: 2016030320303487000_70.11.960.19 doi: 10.1016/S0072-9752(07)01251-1 – ident: 2016030320303487000_70.11.960.60 doi: 10.1083/jcb.200108057 – ident: 2016030320303487000_70.11.960.38 doi: 10.1038/nrn2573 – ident: 2016030320303487000_70.11.960.11 doi: 10.1126/science.1132814 – ident: 2016030320303487000_70.11.960.61 doi: 10.1007/s004019900178 – ident: 2016030320303487000_70.11.960.15 doi: 10.1159/000283478 – ident: 2016030320303487000_70.11.960.4 doi: 10.1007/s00401-006-0127-z – ident: 2016030320303487000_70.11.960.8 doi: 10.1007/s00401-010-0789-4 – ident: 2016030320303487000_70.11.960.29 doi: 10.1111/j.1365-2990.2009.01038.x – ident: 2016030320303487000_70.11.960.52 doi: 10.1002/ana.21509 – volume: 59 start-page: 733 year: 2000 ident: 2016030320303487000_70.11.960.5 article-title: Sequence of Ab-protein deposition in the human medial temporal lobe publication-title: J Neuropathol Exp Neurol doi: 10.1093/jnen/59.8.733 – ident: 2016030320303487000_70.11.960.23 doi: 10.1097/NEN.0b013e3181c6c13d – ident: 2016030320303487000_70.11.960.2 doi: 10.1007/BF00308809 – ident: 2016030320303487000_70.11.960.37 doi: 10.2174/156720508784533286 – ident: 2016030320303487000_70.11.960.72 doi: 10.1371/journal.pone.0016648 – ident: 2016030320303487000_70.11.960.31 doi: 10.1016/S0197-4580(97)00035-3 – ident: 2016030320303487000_70.11.960.34 doi: 10.1111/j.1440-1789.2006.00725.x – ident: 2016030320303487000_70.11.960.13 doi: 10.1007/978-3-540-37652-1_47 – ident: 2016030320303487000_70.11.960.40 doi: 10.1016/S0006-8993(98)00441-7 – volume: 25 start-page: 1 year: 2009 ident: 2016030320303487000_70.11.960.16 article-title: Neuropathology of non-Alzheimer degenerative disorders publication-title: Int J Clin Exp Pathol – ident: 2016030320303487000_70.11.960.75 doi: 10.1074/jbc.M110.209296 – ident: 2016030320303487000_70.11.960.44 doi: 10.1038/nature08983 – volume: 20 start-page: 357 year: 2010 ident: 2016030320303487000_70.11.960.48 article-title: Reactive oxygen species: Stuck in the middle of neurodegeneration publication-title: J Alzheimers Dis doi: 10.3233/JAD-2010-100498 – ident: 2016030320303487000_70.11.960.62 doi: 10.1007/978-3-540-37652-1_15 – ident: 2016030320303487000_70.11.960.33 doi: 10.1146/annurev.neuro.28.061604.135709 – volume: 29 start-page: 1133 year: 2008 ident: 2016030320303487000_70.11.960.55 article-title: Neurofibrillary changes of the Alzheimer type in very elderly individuals: Neither inevitable nor benign publication-title: Commentary on “No disease in the brain of a 115-year-old woman.” Neurobiol Aging – ident: 2016030320303487000_70.11.960.47 doi: 10.1111/j.1750-3639.2009.00326.x – ident: 2016030320303487000_70.11.960.64 doi: 10.1016/j.neurobiolaging.2003.12.015 – ident: 2016030320303487000_70.11.960.70 doi: 10.1126/science.1058189 – ident: 2016030320303487000_70.11.960.28 doi: 10.1097/NEN.0b013e31816a1df3 – ident: 2016030320303487000_70.11.960.41 doi: 10.1097/00005072-199902000-00008 – ident: 2016030320303487000_70.11.960.45 doi: 10.1523/JNEUROSCI.4521-10.2010 – ident: 2016030320303487000_70.11.960.3 doi: 10.1016/S0197-4580(97)00056-0 – ident: 2016030320303487000_70.11.960.22 doi: 10.1007/s00401-010-0664-3 – ident: 2016030320303487000_70.11.960.30 doi: 10.1002/ana.410240210 – ident: 2016030320303487000_70.11.960.66 doi: 10.1016/j.jalz.2007.11.008 – ident: 2016030320303487000_70.11.960.24 doi: 10.1016/0306-4522(87)90123-0 – ident: 2016030320303487000_70.11.960.68 doi: 10.1016/S1474-4422(09)70299-6 – ident: 2016030320303487000_70.11.960.67 doi: 10.1016/j.biocel.2008.12.015 – ident: 2016030320303487000_70.11.960.9 doi: 10.1073/pnas.90.11.5066 – ident: 2016030320303487000_70.11.960.43 doi: 10.1146/annurev.pathmechdis.2.010506.092044 – ident: 2016030320303487000_70.11.960.18 doi: 10.1093/brain/awm305 – ident: 2016030320303487000_70.11.960.21 doi: 10.1016/S0197-4580(02)00065-9 |
| SSID | ssj0009094 |
| Score | 2.5959055 |
| Snippet | Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas... |
| SourceID | proquest pubmed pascalfrancis crossref wolterskluwer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 960 |
| SubjectTerms | Adolescent Adult Aged Aged, 80 and over Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Biological and medical sciences Brain Brain - metabolism Brain - pathology Child Child, Preschool Cloning Cohort Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Humans Infant Male Medical research Medical sciences Middle Aged Neurofibrillary Tangles - pathology Neurology Neurons - metabolism Neurons - pathology Silver Staining - methods Statistics, Nonparametric tau Proteins - metabolism Young Adult |
| Title | Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22002422 https://www.proquest.com/docview/906522093 https://www.proquest.com/docview/900631635 |
| Volume | 70 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3daxQxEB-0BRFE_HatHnnwNXQ_kk3ii5z1jqL0qGLh-rQk2Wwttrvn7RXBv97JbnavFamPyyYhZDIzv8wnwNssL4VGwU8T4zRlwqbUGGmoYomNTYUapvQG_aNFfnjCPi35MsTmtCGscpCJnaAuG-tt5PsKdWWa4vv7_eon9U2jvHM1dNC4C7u-cpmP6BJLsa25Gys2FguPczVkzimxX7t6awJEUKEzH8t1TTM9WOkWD6nqu1v8C37imF-N92i3P7qA9mtqaf4IHgY8Sab9BXgMd1z9BO4dBY_5UzhFNHnmWtJUBKEeOdabIO5ISBEg5zWZXvz-7s4v3Zp87P0178j0zJEDX0Wi8W9pMl83lyQhm4YkcUxOkT3aZ3Ayn307OKShnQK1HB9Z1CKWqVipYl5yLqxUluVaaW6ZRTa32jtUFar8vBIuTjTyMnJnhZgoS60wSmbPYaduavcSiJS5cJk0zlSOMc_FxtcV5LLkiH-kjSAbjrKwoda4b3lxUQw-78VsUfxNgAjoOGvV19r4z_jJDSqNk1ImMpbHIoK9gWxFYM22GC9SBGT8izzlHSW6ds2VH4LADYEqj-BFT-zt0mmHatIIkhvUL_q01Vv3--rW7ezB_c5e3eU5voadzfrKvUHAszGT7lpPYPfDbHH8Fb8-f5F_AC9q-es |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dTxQxEJ_gkaiJMX67otgHfWzYj-52a2LMCXc5hNsQAwk8LW23i0TYPW-PEP2f_B-d7teBMfjEcz_SdKYzv5npzAC8C6KMSxT81FNGUsa1T5WKFRXM067KUcNk1qE_TaLJAftyGB6uwO8uF8Z-q-xkYi2os1JbH_mGQF3p-2h_f5r9oLZplA2udh00Gq7YMT8v0WKrPm5vIXnf-_54tL85oW1TAapDNDWoRo2es0y4YRaGXMdCs0gKGWqmkdm1tGFFgYovyrlxPYkcjTyaIzIIfM2ViAPc9w6ssgAtmQGsfh4le1-XVX5dwfry5G4kulw9wTcKUyydjghjZGB_j13RhQ9mskKy5E0_jX8BXpxzWdoYevW9_kJ_RRGOH8HDFsGSYcNyj2HFFE_g7rSN0T-FI8SvJ6YiZU4QXJI9uWgFLGmTEshpQYZnv76Z03MzJ1tNhOgDGZ4YsmnrVpTWeifjeXlOPLIoiee65AivvnoGB7dy189hUJSFeQkkjiNuglgZlRvGrNxQtpJhGGchIq5YOxB0V5nqtrq5bbJxlnZR9mSUpH8TwAHar5o11T3-M3_9GpX6RT7jAYtc7sBaR7a0FQZV2rOuA6QfxVdsQzOyMOWFnYJQEaFx6MCLhtjLrf0aR_kOeNeonzaJsjee99WNx3kL9yb70910dzvZWYP7tbe8zrJ8DYPF_MK8Qbi1UOstkxM4vu139QeHIzK6 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bTxQxFD5BSIiJMeJ1BLEP-tjsXNrp1MSYDcsGRDY8SLI8jW2ng0SYWXeWEP1n_jtO57ZgDD7xPJ2m6bl9p-cG8C6KM6FQ8dNAW0WZMCHVOtFUssD4OkcLk7kH_cNJvHfMPk_5dAX-dLUwLq2y04m1os5K497IBxJtZRii_z3I26yIo9H40-wndQOkXKC1m6bRcMiB_XWF3lv1cX-EpH4fhuPdrzt7tB0wQA1Ht4MatO45y6TPM86FSaRhsZKKG2aQ8Y1yIUaJRjDOhfUDhdyN_JojSohCI7RMItz3AayJiAdOxMRULPv9-pL1jcr9WHZVe1IMClssnx8R0KjI5ZHdsIqPZqpCAuXNZI1_QV9cc1W6aHr1o06mv2ESx0_gcYtlybBhvg1YscVTWD9so_XP4ASR7KmtSJkThJnkSC1aVUva8gRyVpDh-e_v9uzCzsmoiRV9IMNTS3ZcB4vS-fFkPC8vSEAWJQl8n5zgxVfP4fhebvoFrBZlYV8BSZJY2CjRVueWMadBtOtpyJOMI_ZKjAdRd5Wpafucu3Eb52kXb5_sTtK_CeAB7f-aNX0-_rN--xaV-p9CJiIW-8KDzY5saasWqrRnYg9I_xXl2QVpVGHLS7cEQSOCZO7By4bYy63DGlGFHgS3qJ82JbN3nvf1ncd5C-soTemX_cnBJjysn83rcsstWF3ML-0bxF0LvV1zOIFv9y1S1-08NYo |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Stages+of+the+pathologic+process+in+Alzheimer+disease%3A+age+categories+from+1+to+100+years&rft.jtitle=Journal+of+neuropathology+and+experimental+neurology&rft.au=Braak%2C+Heiko&rft.au=Thal%2C+Dietmar+R&rft.au=Ghebremedhin%2C+Estifanos&rft.au=Del+Tredici%2C+Kelly&rft.date=2011-11-01&rft.eissn=1554-6578&rft.volume=70&rft.issue=11&rft.spage=960&rft_id=info:doi/10.1097%2FNEN.0b013e318232a379&rft_id=info%3Apmid%2F22002422&rft.externalDocID=22002422 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3069&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3069&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3069&client=summon |