Age-related changes of serum sex hormones, insulin-like growth factor-1 and sex-hormone binding globulin levels in men: cross-sectional data from a healthy male cohort

• Published in: Clinical endocrinology (Oxford) Vol. 53; no. 6; pp. 689 - 695
• Main Authors: Leifke, Eckhard, Gorenoi, Vitali, Wichers, Christian, Von Zur Mühlen, Alexander, Von Büren, Erico, Brabant, Georg
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.12.2000; Blackwell; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aged, 80 and over; Aging - blood; Biological and medical sciences; Body Mass Index; Cross-Sectional Studies; Estradiol - blood; Functional investigation of endocrine glands and genital system; Gonadal Steroid Hormones - blood; Humans; Insulin-Like Growth Factor I - analysis; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Multivariate Analysis; Serum Albumin - analysis; Sex Hormone-Binding Globulin - analysis; Testosterone - blood; Human; Androgen; Healthy subject; Sex hormone binding protein; Male; Concentration; Insulin like growth factor 1; Body composition; Testosterone; Bone mass; Muscle; Physiology; Testicular hormone; Hormonal investigation; Sex steroid hormone; Age; Muscle mass
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1046/j.1365-2265.2000.01159.x

The age‐dependent decline of the gonadal and somatotopic axis has been causally linked to frailty in the elderly by their effects on muscle mass and bone mineral density. However, for healthy men data on serum oestrogens and androgens, as well as IGF‐1, as a common outcome measure covering the whole...