Adipokines regulate the development and progression of MASLD through organellar oxidative stress

• Published in: Hepatology communications Vol. 9; no. 2
• Main Authors: Zhao, Ke, Zhang, Heng, Ding, Wenyu, Yu, Xiaoshuai, Hou, Yanli, Liu, Xihong, Li, Xinhua, Wang, Xiaolei
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.02.2025; Wolters Kluwer Health/LWW
• Subjects: Adipokines - metabolism; Adipokines - physiology; Adipose Tissue - metabolism; Animals; Disease Progression; Endoplasmic Reticulum Stress; Fatty Liver - etiology; Fatty Liver - metabolism; Humans; Mitochondria - metabolism; Oxidative Stress - physiology; Reactive Oxygen Species - metabolism; Review; adiponectin; fatty liver; mitochondrial dysfunction; FGF-21; endoplasmic reticulum stress

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), which is increasingly being recognized as a leading cause of chronic liver pathology globally, is increasing. The pathophysiological underpinnings of its progression, which is currently under active investigation, in...