Immunologic basis for the rare occurrence of true nonsecretory plasma cell dyscrasias

Lymphocytes and plasma cells are major actors of the adaptive immune response and can rightly be considered as human health keepers. However, recombination and mutation events occurring at high rate in the B cell lineage also expose these cells to gene alterations, potentially resulting in uncontrol...

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Published inJournal of leukocyte biology Vol. 76; no. 3; pp. 528 - 536
Main Authors Decourt, Catherine, Galea, Horia Radu, Sirac, Christophe, Cogné, Michel
Format Journal Article
LanguageEnglish
Published United States Society for Leukocyte Biology 01.09.2004
Subjects
Animals
B cells
Cell Differentiation
Cell Differentiation - genetics
Cell Differentiation - immunology
Cell Lineage
Cell Lineage - genetics
Cell Transformation, Neoplastic
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - immunology
Humans
immunoglobulin secretion
Immunoglobulins
Immunoglobulins - immunology
Immunoglobulins - metabolism
Immunologic Surveillance
Immunologic Surveillance - genetics
Immunologic Surveillance - immunology
Immunology
immunoproliferative
Life Sciences
Multiple Myeloma
Multiple Myeloma - genetics
Multiple Myeloma - immunology
Multiple Myeloma - metabolism
myeloma
Paraproteinemias
Paraproteinemias - genetics
Paraproteinemias - immunology
Paraproteinemias - metabolism
Plasma Cells
Plasma Cells - immunology
Plasma Cells - metabolism
Plasma Cells - secretion
immunoproliferative
myeloma
B cells
immunoglobulin secretion
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Abstract Lymphocytes and plasma cells are major actors of the adaptive immune response and can rightly be considered as human health keepers. However, recombination and mutation events occurring at high rate in the B cell lineage also expose these cells to gene alterations, potentially resulting in uncontrolled and life‐threatening cell proliferation. Although in cultured cell lines, such gene alterations frequently generate nonsecretory variants, most immunoproliferative B cell disorders feature in vivo immunoglobulin (Ig) secretion. In this paper, we review the molecular mechanisms involved in various instances of the rare, nonsecretory myelomas, in light of current notions about the molecular control of Ig production, assembly, and secretion in normal B cells. We finallydocument the attractive hypothesis that B cell clones, which retain nonsecretable, intracellular Igs, may be ideal, in vivo targets for efficient anti‐idiotypic immune responses, and clones featuring an abundant secretion may by contrast easily induce T cell anergy and escape the anti‐tumoral immune surveillance.
AbstractList Lymphocytes and plasma cells are major actors of the adaptive immune response and can rightly be considered as human health keepers. However, recombination and mutation events occurring at high rate in the B cell lineage also expose these cells to gene alterations, potentially resulting in uncontrolled and life-threatening cell proliferation. Although in cultured cell lines, such gene alterations frequently generate nonsecretory variants, most immunoproliferative B cell disorders feature in vivo immunoglobulin (Ig) secretion. In this paper, we review the molecular mechanisms involved in various instances of the rare, nonsecretory myelomas, in light of current notions about the molecular control of Ig production, assembly, and secretion in normal B cells. We finally document the attractive hypothesis that B cell clones, which retain nonsecretable, intracellular Igs, may be ideal, in vivo targets for efficient anti-idiotypic immune responses, and clones featuring an abundant secretion may by contrast easily induce T cell anergy and escape the anti-tumoral immune surveillance.
Lymphocytes and plasma cells are major actors of the adaptive immune response and can rightly be considered as human health keepers. However, recombination and mutation events occurring at high rate in the B cell lineage also expose these cells to gene alterations, potentially resulting in uncontrolled and life‐threatening cell proliferation. Although in cultured cell lines, such gene alterations frequently generate nonsecretory variants, most immunoproliferative B cell disorders feature in vivo immunoglobulin (Ig) secretion. In this paper, we review the molecular mechanisms involved in various instances of the rare, nonsecretory myelomas, in light of current notions about the molecular control of Ig production, assembly, and secretion in normal B cells. We finallydocument the attractive hypothesis that B cell clones, which retain nonsecretable, intracellular Igs, may be ideal, in vivo targets for efficient anti‐idiotypic immune responses, and clones featuring an abundant secretion may by contrast easily induce T cell anergy and escape the anti‐tumoral immune surveillance.
Abstract Lymphocytes and plasma cells are major actors of the adaptive immune response and can rightly be considered as human health keepers. However, recombination and mutation events occurring at high rate in the B cell lineage also expose these cells to gene alterations, potentially resulting in uncontrolled and life-threatening cell proliferation. Although in cultured cell lines, such gene alterations frequently generate nonsecretory variants, most immunoproliferative B cell disorders feature in vivo immunoglobulin (Ig) secretion. In this paper, we review the molecular mechanisms involved in various instances of the rare, nonsecretory myelomas, in light of current notions about the molecular control of Ig production, assembly, and secretion in normal B cells. We finallydocument the attractive hypothesis that B cell clones, which retain nonsecretable, intracellular Igs, may be ideal, in vivo targets for efficient anti-idiotypic immune responses, and clones featuring an abundant secretion may by contrast easily induce T cell anergy and escape the anti-tumoral immune surveillance.
Author Michel Cogné
Catherine Decourt
Horia Radu Galea
Christophe Sirac
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Issue 3
Keywords immunoproliferative
myeloma
B cells
immunoglobulin secretion
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Snippet Lymphocytes and plasma cells are major actors of the adaptive immune response and can rightly be considered as human health keepers. However, recombination and...
Abstract Lymphocytes and plasma cells are major actors of the adaptive immune response and can rightly be considered as human health keepers. However,...
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SubjectTerms Animals
B cells
Cell Differentiation
Cell Differentiation - genetics
Cell Differentiation - immunology
Cell Lineage
Cell Lineage - genetics
Cell Transformation, Neoplastic
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - immunology
Humans
immunoglobulin secretion
Immunoglobulins
Immunoglobulins - immunology
Immunoglobulins - metabolism
Immunologic Surveillance
Immunologic Surveillance - genetics
Immunologic Surveillance - immunology
Immunology
immunoproliferative
Life Sciences
Multiple Myeloma
Multiple Myeloma - genetics
Multiple Myeloma - immunology
Multiple Myeloma - metabolism
myeloma
Paraproteinemias
Paraproteinemias - genetics
Paraproteinemias - immunology
Paraproteinemias - metabolism
Plasma Cells
Plasma Cells - immunology
Plasma Cells - metabolism
Plasma Cells - secretion
Title Immunologic basis for the rare occurrence of true nonsecretory plasma cell dyscrasias
URI http://www.jleukbio.org/content/76/3/528.abstract
https://onlinelibrary.wiley.com/doi/abs/10.1189%2Fjlb.0803382
https://www.ncbi.nlm.nih.gov/pubmed/15155772
https://search.proquest.com/docview/17735579
https://search.proquest.com/docview/66814258
https://hal.science/hal-00023271
Volume 76
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