Th2 cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells

• Published in: Allergy (Copenhagen) Vol. 70; no. 8; pp. 910 - 920
• Main Authors: Contoli, M., Ito, K., Padovani, A., Poletti, D., Marku, B., Edwards, M. R., Stanciu, L. A., Gnesini, G., Pastore, A., Spanevello, A., Morelli, P., Johnston, S. L., Caramori, G., Papi, A.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.08.2015
• Subjects: asthma; Asthma - immunology; Asthma - metabolism; Bronchi - cytology; Cells, Cultured; Cytokines; Cytokines - immunology; Cytokines - metabolism; Disease Susceptibility; Enzyme-Linked Immunosorbent Assay; Epithelial Cells - immunology; Epithelial Cells - metabolism; Humans; Immunity, Innate - immunology; Infections; innate immunity; Interferon; Interleukin-13 - immunology; Interleukin-13 - metabolism; Interleukin-4 - immunology; Interleukin-4 - metabolism; NF-kappa B - immunology; NF-kappa B - metabolism; Real-Time Polymerase Chain Reaction; Respiratory Mucosa - immunology; Respiratory Mucosa - metabolism; Rhinovirus - immunology; Th2 Cells - immunology; Th2 Cells - metabolism; Th2 inflammation; Toll-Like Receptor 3 - immunology; Toll-Like Receptor 3 - metabolism; Viral infections; virus; asthma; innate immunity; interferon; Th2 inflammation; virus
• ISSN: 0105-4538; 1398-9995; 1398-9995
• DOI: 10.1111/all.12627

Background Asthma and other Th2 inflammatory conditions have been associated with increased susceptibility to viral infections. The mechanisms by which Th2 cytokines can influence immune responses to infections are largely unknown. Methods We measured the effects of Th2 cytokines (IL‐4 and IL‐13) on...