Association Between Gut Microbiota and Bone Health: Potential Mechanisms and Prospective
ContextIt has been well established that the human gut microbiome plays a critical role in the regulation of important biological processes and the mechanisms underlying numerous complex diseases. Although researchers have only recently begun to study the relationship between the gut microbiota and...
Saved in:
| Published in | The journal of clinical endocrinology and metabolism Vol. 102; no. 10; pp. 3635 - 3646 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
Endocrine Society
01.10.2017
Copyright Oxford University Press Oxford University Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-972X 1945-7197 1945-7197 |
| DOI | 10.1210/jc.2017-00513 |
Cover
Loading…
| Abstract | ContextIt has been well established that the human gut microbiome plays a critical role in the regulation of important biological processes and the mechanisms underlying numerous complex diseases. Although researchers have only recently begun to study the relationship between the gut microbiota and bone metabolism, early efforts have provided increased evidence to suggest an important association.Evidence AcquisitionIn this study, we attempt to comprehensively summarize the relationship between the gut microbiota and bone metabolism by detailing the regulatory effects of the microbiome on various biological processes, including nutrient absorption and the intestinal mucosal barrier, immune system functionality, the gut–brain axis, and excretion of functional byproducts. In this review, we incorporate evidence from various types of studies, including observational, in vitro and in vivo animal experiments, as well as small efficacy clinic trails.Evidence SynthesisWe review the various potential mechanisms of influence for the gut microbiota on the regulation of bone metabolism and discuss the importance of further examining the potential effects of the gut microbiota on the risk of osteoporosis in humans. Furthermore, we outline some useful tools/approaches for metagenomics research and present some prominent examples of metagenomics association studies in humans.ConclusionCurrent research efforts, although limited, clearly indicate that the gut microbiota may be implicated in bone metabolism, and therefore, further exploration of this relationship is a promising area of focus in bone health and osteoporosis research. Although most existing studies investigate this relationship using animal models, human studies are both needed and on the horizon.We summarized potential mechanisms of gut microbiota on regulation of bone mass, outlined some useful tools for metagenomics, and presented examples of metagenome-wide association studies. |
|---|---|
| AbstractList | ContextIt has been well established that the human gut microbiome plays a critical role in the regulation of important biological processes and the mechanisms underlying numerous complex diseases. Although researchers have only recently begun to study the relationship between the gut microbiota and bone metabolism, early efforts have provided increased evidence to suggest an important association.Evidence AcquisitionIn this study, we attempt to comprehensively summarize the relationship between the gut microbiota and bone metabolism by detailing the regulatory effects of the microbiome on various biological processes, including nutrient absorption and the intestinal mucosal barrier, immune system functionality, the gut–brain axis, and excretion of functional byproducts. In this review, we incorporate evidence from various types of studies, including observational, in vitro and in vivo animal experiments, as well as small efficacy clinic trails.Evidence SynthesisWe review the various potential mechanisms of influence for the gut microbiota on the regulation of bone metabolism and discuss the importance of further examining the potential effects of the gut microbiota on the risk of osteoporosis in humans. Furthermore, we outline some useful tools/approaches for metagenomics research and present some prominent examples of metagenomics association studies in humans.ConclusionCurrent research efforts, although limited, clearly indicate that the gut microbiota may be implicated in bone metabolism, and therefore, further exploration of this relationship is a promising area of focus in bone health and osteoporosis research. Although most existing studies investigate this relationship using animal models, human studies are both needed and on the horizon. We summarized potential mechanisms of gut microbiota on regulation of bone mass, outlined some useful tools for metagenomics, and presented examples of metagenome-wide association studies. Abstract It has been well established that the human gut microbiome plays a critical role in the regulation of important biological processes and the mechanisms underlying numerous complex diseases. Although researchers have only recently begun to study the relationship between the gut microbiota and bone metabolism, early efforts have provided increased evidence to suggest an important association. In this study, we attempt to comprehensively summarize the relationship between the gut microbiota and bone metabolism by detailing the regulatory effects of the microbiome on various biological processes, including nutrient absorption and the intestinal mucosal barrier, immune system functionality, the gut-brain axis, and excretion of functional byproducts. In this review, we incorporate evidence from various types of studies, including observational, in vitro and in vivo animal experiments, as well as small efficacy clinic trails. We review the various potential mechanisms of influence for the gut microbiota on the regulation of bone metabolism and discuss the importance of further examining the potential effects of the gut microbiota on the risk of osteoporosis in humans. Furthermore, we outline some useful tools/approaches for metagenomics research and present some prominent examples of metagenomics association studies in humans. Current research efforts, although limited, clearly indicate that the gut microbiota may be implicated in bone metabolism, and therefore, further exploration of this relationship is a promising area of focus in bone health and osteoporosis research. Although most existing studies investigate this relationship using animal models, human studies are both needed and on the horizon. We summarized potential mechanisms of gut microbiota on regulation of bone mass, outlined some useful tools for metagenomics, and presented examples of metagenome-wide association studies. It has been well established that the human gut microbiome plays a critical role in the regulation of important biological processes and the mechanisms underlying numerous complex diseases. Although researchers have only recently begun to study the relationship between the gut microbiota and bone metabolism, early efforts have provided increased evidence to suggest an important association. In this study, we attempt to comprehensively summarize the relationship between the gut microbiota and bone metabolism by detailing the regulatory effects of the microbiome on various biological processes, including nutrient absorption and the intestinal mucosal barrier, immune system functionality, the gut-brain axis, and excretion of functional byproducts. In this review, we incorporate evidence from various types of studies, including observational, in vitro and in vivo animal experiments, as well as small efficacy clinic trails. We review the various potential mechanisms of influence for the gut microbiota on the regulation of bone metabolism and discuss the importance of further examining the potential effects of the gut microbiota on the risk of osteoporosis in humans. Furthermore, we outline some useful tools/approaches for metagenomics research and present some prominent examples of metagenomics association studies in humans. Current research efforts, although limited, clearly indicate that the gut microbiota may be implicated in bone metabolism, and therefore, further exploration of this relationship is a promising area of focus in bone health and osteoporosis research. Although most existing studies investigate this relationship using animal models, human studies are both needed and on the horizon. ContextIt has been well established that the human gut microbiome plays a critical role in the regulation of important biological processes and the mechanisms underlying numerous complex diseases. Although researchers have only recently begun to study the relationship between the gut microbiota and bone metabolism, early efforts have provided increased evidence to suggest an important association.Evidence AcquisitionIn this study, we attempt to comprehensively summarize the relationship between the gut microbiota and bone metabolism by detailing the regulatory effects of the microbiome on various biological processes, including nutrient absorption and the intestinal mucosal barrier, immune system functionality, the gut–brain axis, and excretion of functional byproducts. In this review, we incorporate evidence from various types of studies, including observational, in vitro and in vivo animal experiments, as well as small efficacy clinic trails.Evidence SynthesisWe review the various potential mechanisms of influence for the gut microbiota on the regulation of bone metabolism and discuss the importance of further examining the potential effects of the gut microbiota on the risk of osteoporosis in humans. Furthermore, we outline some useful tools/approaches for metagenomics research and present some prominent examples of metagenomics association studies in humans.ConclusionCurrent research efforts, although limited, clearly indicate that the gut microbiota may be implicated in bone metabolism, and therefore, further exploration of this relationship is a promising area of focus in bone health and osteoporosis research. Although most existing studies investigate this relationship using animal models, human studies are both needed and on the horizon.We summarized potential mechanisms of gut microbiota on regulation of bone mass, outlined some useful tools for metagenomics, and presented examples of metagenome-wide association studies. It has been well established that the human gut microbiome plays a critical role in the regulation of important biological processes and the mechanisms underlying numerous complex diseases. Although researchers have only recently begun to study the relationship between the gut microbiota and bone metabolism, early efforts have provided increased evidence to suggest an important association.ContextIt has been well established that the human gut microbiome plays a critical role in the regulation of important biological processes and the mechanisms underlying numerous complex diseases. Although researchers have only recently begun to study the relationship between the gut microbiota and bone metabolism, early efforts have provided increased evidence to suggest an important association.In this study, we attempt to comprehensively summarize the relationship between the gut microbiota and bone metabolism by detailing the regulatory effects of the microbiome on various biological processes, including nutrient absorption and the intestinal mucosal barrier, immune system functionality, the gut-brain axis, and excretion of functional byproducts. In this review, we incorporate evidence from various types of studies, including observational, in vitro and in vivo animal experiments, as well as small efficacy clinic trails.Evidence AcquisitionIn this study, we attempt to comprehensively summarize the relationship between the gut microbiota and bone metabolism by detailing the regulatory effects of the microbiome on various biological processes, including nutrient absorption and the intestinal mucosal barrier, immune system functionality, the gut-brain axis, and excretion of functional byproducts. In this review, we incorporate evidence from various types of studies, including observational, in vitro and in vivo animal experiments, as well as small efficacy clinic trails.We review the various potential mechanisms of influence for the gut microbiota on the regulation of bone metabolism and discuss the importance of further examining the potential effects of the gut microbiota on the risk of osteoporosis in humans. Furthermore, we outline some useful tools/approaches for metagenomics research and present some prominent examples of metagenomics association studies in humans.Evidence SynthesisWe review the various potential mechanisms of influence for the gut microbiota on the regulation of bone metabolism and discuss the importance of further examining the potential effects of the gut microbiota on the risk of osteoporosis in humans. Furthermore, we outline some useful tools/approaches for metagenomics research and present some prominent examples of metagenomics association studies in humans.Current research efforts, although limited, clearly indicate that the gut microbiota may be implicated in bone metabolism, and therefore, further exploration of this relationship is a promising area of focus in bone health and osteoporosis research. Although most existing studies investigate this relationship using animal models, human studies are both needed and on the horizon.ConclusionCurrent research efforts, although limited, clearly indicate that the gut microbiota may be implicated in bone metabolism, and therefore, further exploration of this relationship is a promising area of focus in bone health and osteoporosis research. Although most existing studies investigate this relationship using animal models, human studies are both needed and on the horizon. |
| Author | Deng, Hong-Wen Chen, Yuan-Cheng Shen, Hui Greenbaum, Jonathan |
| AuthorAffiliation | 1Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, PR China 2Center of Bioinformatics and Genomics, Tulane University, New Orleans, Louisiana 70112 3Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112 |
| AuthorAffiliation_xml | – name: 1Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, PR China 2Center of Bioinformatics and Genomics, Tulane University, New Orleans, Louisiana 70112 3Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112 – name: 1Department of Endocrinology and Metabolism, the Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, PR China 2Center of Bioinformatics and Genomics, Tulane University, New Orleans, LA 70112, USA 3Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA |
| Author_xml | – sequence: 1 givenname: Yuan-Cheng surname: Chen fullname: Chen, Yuan-Cheng organization: 1Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, PR China – sequence: 2 givenname: Jonathan surname: Greenbaum fullname: Greenbaum, Jonathan organization: 2Center of Bioinformatics and Genomics, Tulane University, New Orleans, Louisiana 70112 – sequence: 3 givenname: Hui surname: Shen fullname: Shen, Hui organization: 2Center of Bioinformatics and Genomics, Tulane University, New Orleans, Louisiana 70112 – sequence: 4 givenname: Hong-Wen surname: Deng fullname: Deng, Hong-Wen email: hdeng2@tulane.edu organization: 1Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, PR China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28973392$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1vFCEYxompsdvq0auZxEsvU_kcBg8mbaNtkzb20ENvhGHBZZ2FFZhu_O9lZ3etbtJyIcDved735TkCBz54A8B7BE8RRvDTXJ9iiHgNIUPkFZggQVnNkeAHYAIhRrXg-OEQHKU0hxBRysgbcIhbwQkReAIezlIK2qnsgq_OTV4Z46vLIVe3TsfQuZBVpfy0Oi9Vqyuj-jz7XN2FbHx2qq9ujZ4p79IijdRdDGlpdHaP5i14bVWfzLvtfgzuv329v7iqb75fXl-c3dSaYUpqTVvI2imjgnQda6i1GHWG0bZV06bTUFNIObIts8waw4S1yHKhKMSEkaYhx-DLxnY5dAsz1aWvqHq5jG6h4m8ZlJP_v3g3kz_Co2QNgZjBYnCyNYjh12BSlguXtOl75U0Ykiz_yaFo2Vjr4x46D0P0ZTpJUEMJF4S3L1FINBxShjgv1Id_-_7b8C6ZApANUGJIKRortctjTGUM10sE5Tp_Oddynb8c8y-qek-1M36ORxt-FfpsYvrZDysT5WwMel9T7zT0BQ0siza8rdcKtD7V49XTR4dh-VxX2wp_AJb723k |
| CitedBy_id | crossref_primary_10_3389_fnut_2022_843360 crossref_primary_10_3389_fendo_2023_1229796 crossref_primary_10_3390_ani12223108 crossref_primary_10_2174_0109298673314861240429072352 crossref_primary_10_12677_ACM_2020_1010365 crossref_primary_10_7759_cureus_46299 crossref_primary_10_3390_jcm9103253 crossref_primary_10_5312_wjo_v10_i3_123 crossref_primary_10_1080_19490976_2024_2410478 crossref_primary_10_3390_cells11040743 crossref_primary_10_3889_oamjms_2019_047 crossref_primary_10_1007_s40520_019_01223_5 crossref_primary_10_5713_ab_21_0455 crossref_primary_10_1186_s12934_022_01858_6 crossref_primary_10_2991_efood_k_200427_001 crossref_primary_10_1111_lam_13333 crossref_primary_10_3390_ijms20174270 crossref_primary_10_1093_jbmr_zjad017 crossref_primary_10_3389_fmicb_2023_1268935 crossref_primary_10_3390_jcm12041621 crossref_primary_10_1038_s41598_024_60514_8 crossref_primary_10_1038_s41574_019_0282_7 crossref_primary_10_1016_j_nutres_2021_07_001 crossref_primary_10_3928_01477447_20220608_07 crossref_primary_10_1016_j_bone_2020_115317 crossref_primary_10_3390_bioengineering10080896 crossref_primary_10_1002_jbm4_10805 crossref_primary_10_3389_fcimb_2022_821429 crossref_primary_10_1016_j_fbio_2025_105977 crossref_primary_10_1080_10408398_2021_1998760 crossref_primary_10_3390_nu11040747 crossref_primary_10_1002_imt2_270 crossref_primary_10_1177_0300060519860027 crossref_primary_10_3389_fcell_2023_1324649 crossref_primary_10_1002_jbmr_4518 crossref_primary_10_3389_fnut_2022_860086 crossref_primary_10_1080_10408398_2020_1836605 crossref_primary_10_1007_s11657_024_01438_8 crossref_primary_10_3389_fcimb_2023_1281745 crossref_primary_10_1186_s13018_023_03869_4 crossref_primary_10_1002_advs_202303015 crossref_primary_10_3390_app10176000 crossref_primary_10_3389_fphar_2022_803880 crossref_primary_10_1186_s12891_023_07057_7 crossref_primary_10_1016_j_jnutbio_2020_108492 crossref_primary_10_1093_ajcn_nqab037 crossref_primary_10_1007_s11914_022_00754_7 crossref_primary_10_1002_jcla_23471 crossref_primary_10_1038_s41467_023_42005_y crossref_primary_10_3389_fcimb_2022_853499 crossref_primary_10_1186_s12967_022_03700_4 crossref_primary_10_3389_fendo_2024_1487998 crossref_primary_10_1016_j_bone_2024_117239 crossref_primary_10_1016_j_bmt_2022_11_007 crossref_primary_10_1186_s40168_020_00988_6 crossref_primary_10_1002_jbmr_3966 crossref_primary_10_1016_j_jts_2024_10_003 crossref_primary_10_3389_fphar_2020_571535 crossref_primary_10_1007_s12602_020_09670_7 crossref_primary_10_1111_1751_7915_13953 crossref_primary_10_3389_fmicb_2024_1433892 crossref_primary_10_33619_2414_2948_65_16 crossref_primary_10_1007_s00586_022_07513_3 crossref_primary_10_3390_nu15183934 crossref_primary_10_1002_star_202000036 crossref_primary_10_1021_acsnano_4c07332 crossref_primary_10_1007_s11914_021_00691_x crossref_primary_10_3389_fphys_2022_887207 crossref_primary_10_3389_fphys_2020_553929 crossref_primary_10_1128_cmr_00163_22 crossref_primary_10_3390_ijms21238887 crossref_primary_10_3389_fendo_2024_1388772 crossref_primary_10_1097_BRS_0000000000004974 crossref_primary_10_1111_1471_0307_12708 crossref_primary_10_1007_s00774_023_01415_0 crossref_primary_10_1016_j_bonr_2021_101123 crossref_primary_10_1038_s41598_018_33524_6 crossref_primary_10_3389_fmicb_2018_02890 crossref_primary_10_3390_jfb14030132 crossref_primary_10_3389_fcimb_2020_541178 crossref_primary_10_3390_medicina57030248 crossref_primary_10_1111_jam_14852 crossref_primary_10_1007_s00394_021_02597_x crossref_primary_10_3389_fnut_2022_829396 crossref_primary_10_1007_s10068_024_01745_3 crossref_primary_10_1055_a_2462_4844 crossref_primary_10_3389_fnut_2022_810453 crossref_primary_10_1007_s12602_024_10247_x crossref_primary_10_3389_fcimb_2022_827575 crossref_primary_10_1155_2020_3686749 crossref_primary_10_1055_s_0043_1778661 crossref_primary_10_3389_fcimb_2022_983608 crossref_primary_10_1155_2021_5537811 crossref_primary_10_1302_2046_3758_98_BJR_2020_0089_R1 crossref_primary_10_1590_fst_38321 crossref_primary_10_1124_jpet_120_000410 crossref_primary_10_31665_JFB_2018_3153 crossref_primary_10_1186_s40104_021_00627_6 crossref_primary_10_1210_clinem_dgab883 crossref_primary_10_1093_jbmrpl_ziae021 crossref_primary_10_1038_s41598_018_26322_7 crossref_primary_10_1016_j_pharmthera_2022_108168 crossref_primary_10_1016_j_intimp_2021_108179 crossref_primary_10_1111_cpr_13075 crossref_primary_10_2147_DMSO_S291828 crossref_primary_10_52586_E879 |
| Cites_doi | 10.1126/scitranslmed.3008599 10.1210/me.2014-1108 10.1038/nbt.2942 10.1080/15592294.2016.1155011 10.1016/S0140-6736(89)91183-5 10.1186/s12866-016-0891-4 10.1038/ng.3695 10.1172/JCI86062 10.1089/jmf.2011.0296 10.1007/s00253-012-4675-y 10.1038/nm.4358 10.1038/nature07540 10.3389/fpls.2014.00209 10.1038/nbt.2548 10.1016/j.archoralbio.2008.02.016 10.1016/j.bbagen.2013.12.013 10.1161/CIRCRESAHA.117.309715 10.1038/nature11400 10.1093/bioinformatics/btq461 10.1038/nature11053 10.1182/blood-2002-08-2622 10.1016/j.cell.2014.09.053 10.1038/nrmicro2540 10.1038/nature08821 10.1002/9780471729259.mc01e05s27 10.1016/B978-0-12-407863-5.00021-6 10.1556/1886.2016.00036 10.1016/S0889-8553(05)70005-4 10.1111/j.1469-0691.2012.03865.x 10.1038/nature12506 10.1128/AEM.06516-11 10.2337/db06-1491 10.1002/iub.1374 10.1371/journal.pone.0025792 10.1086/341914 10.21307/ane-2017-033 10.1038/ncomms7528 10.1002/jbmr.2887 10.1007/s00394-004-0535-6 10.1016/j.bone.2006.06.009 10.1126/scitranslmed.3001626 10.1002/jbmr.1588 10.1002/jcp.24636 10.1016/j.neuropharm.2016.07.002 10.1093/dnares/dsn027 10.1053/j.gastro.2014.01.049 10.1055/s-0033-1361817 10.1016/j.copbio.2015.09.001 10.1016/j.cell.2014.05.052 10.1038/nm.3914 10.1152/ajpgi.00029.2015 10.1016/j.parkreldis.2016.08.019 10.1093/nar/gkr1060 10.1038/nature11553 10.1016/j.bone.2011.04.011 10.1038/nature11552 10.3164/jcbn.15-152 10.1007/s00125-014-3274-0 10.1093/bioinformatics/btq455 10.1016/j.clnu.2005.05.022 10.1271/bbb.59.236 10.1038/nature11450 10.1017/S0007114512003777 10.1080/10408398.2016.1211616 10.3748/wjg.15.5936 10.1007/s00394-017-1445-8 10.1007/s00394-004-0441-y 10.1128/AEM.01541-09 10.1093/bioinformatics/btr186 10.1186/s13059-015-0759-1 10.1007/s11695-015-1724-5 10.1002/pmic.201400563 10.1016/j.jprot.2016.04.033 10.1007/s00198-013-2480-9 10.1155/2013/486186 10.4049/jimmunol.170.7.3688 10.1093/bioinformatics/bts565 10.3389/fmicb.2016.01144 10.1126/science.aad8588 10.1038/nm.2098 10.1371/journal.pone.0038581 10.1016/j.sjbs.2015.06.005 10.1186/1479-5876-10-253 10.1186/1756-0381-4-19 10.1161/JAHA.115.002699 10.1016/j.cell.2014.03.011 10.1038/ncomms8486 10.1038/nmeth0910-668b 10.1128/mBio.01703-16 10.1038/ejcn.2010.19 10.1101/gr.112730.110 10.1093/bioinformatics/btr216 10.1079/BJN19810064 10.1038/nrgastro.2014.40 10.1210/me.2006-0061 10.1016/j.it.2014.09.007 10.1186/1471-2105-4-41 10.1016/j.immuni.2015.08.011 10.1371/journal.pone.0092368 10.1097/MCO.0b013e3283638eb3 10.1023/A:1010722314493 10.1093/nar/gkt1223 10.1155/2015/843089 10.1016/S0140-6736(00)04259-8 10.1111/nyas.13033 10.1016/j.abb.2013.09.018 10.1016/j.ijfoodmicro.2006.08.015 10.1155/2013/181849 10.1111/bcp.12777 10.1079/BJN2001430 10.1038/nrmicro2974 10.1007/s11908-016-0536-7 10.1038/nature05414 10.3892/ijmm.2013.1406 10.1038/nbt.2939 |
| ContentType | Journal Article |
| Copyright | Copyright © 2017 Endocrine Society 2017 Copyright © Oxford University Press 2015 Copyright © 2017 Endocrine Society |
| Copyright_xml | – notice: Copyright © 2017 Endocrine Society 2017 – notice: Copyright © Oxford University Press 2015 – notice: Copyright © 2017 Endocrine Society |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QP 7T5 7TM 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH H94 K9. M0S M1P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM |
| DOI | 10.1210/jc.2017-00513 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Immunology Abstracts Nucleic Acids Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Academic Middle East (New) Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts ProQuest One Academic Middle East (New) MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1945-7197 |
| EndPage | 3646 |
| ExternalDocumentID | PMC5630250 28973392 10_1210_jc_2017_00513 10.1210/jc.2017-00513 00004678-201710000-00004 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: FIC NIH HHS grantid: D43 TW009107 – fundername: NIGMS NIH HHS grantid: P20 GM109036 – fundername: NIAMS NIH HHS grantid: R01 AR059781 – fundername: NIGMS NIH HHS grantid: R01 GM109068 – fundername: NIMH NIH HHS grantid: R01 MH104680 – fundername: NIAMS NIH HHS grantid: R01 AR057049 – fundername: NIMH NIH HHS grantid: R01 MH107354 – fundername: NIAMS NIH HHS grantid: P50 AR055081 – fundername: NIA NIH HHS grantid: U19 AG055373 |
| GroupedDBID | --- -~X .55 .GJ .XZ 08P 0R~ 18M 1TH 29K 2WC 34G 354 39C 3O- 3V. 4.4 48X 53G 5GY 5RS 5YH 7X7 88E 8F7 8FI 8FJ AABZA AACZT AAIMJ AAJQQ AAKAS AAPGJ AAPQZ AAPXW AAQQT AARHZ AAUAY AAUQX AAVAP AAWDT AAWTL AAYJJ ABBLC ABDFA ABDPE ABEJV ABGNP ABJNI ABLJU ABMNT ABNHQ ABOCM ABPMR ABPPZ ABPQP ABPTD ABQNK ABUWG ABVGC ABWST ABXVV ACFRR ACGFO ACGFS ACPRK ACUTJ ACYHN ACZBC ADBBV ADGKP ADGZP ADHKW ADQBN ADRTK ADVEK ADZCM AELWJ AEMDU AENEX AENZO AERZD AETBJ AEWNT AFCHL AFFNX AFFQV AFFZL AFGWE AFKRA AFOFC AFRAH AFXAL AFYAG AGINJ AGKRT AGMDO AGQXC AGUTN AHMBA AHMMS AI. AJEEA ALMA_UNASSIGNED_HOLDINGS APIBT APJGH AQDSO AQKUS ARIXL ASPBG ATGXG AVWKF AZFZN BAWUL BAYMD BCRHZ BENPR BEYMZ BPHCQ BSWAC BTRTY BVXVI C45 CCPQU CDBKE CS3 D-I DAKXR DIK E3Z EBS EIHJH EJD EMOBN ENERS F5P FECEO FEDTE FHSFR FLUFQ FOEOM FOTVD FQBLK FYUFA GAUVT GJXCC GX1 H13 HMCUK HVGLF HZ~ H~9 IAO IHR INH ITC J5H KBUDW KOP KQ8 KSI KSN L7B M1P M5~ MBLQV MHKGH MJL N4W N9A NLBLG NOMLY NOYVH NVLIB O9- OAUYM OBH OCB ODMLO OFXIZ OGEVE OHH OJZSN OK1 OPAEJ OVD OVIDX P2P P6G PQQKQ PROAC PSQYO REU ROX ROZ TEORI TJX TLC TMA TR2 TWZ UKHRP VH1 VVN W8F WHG WOQ X52 X7M YBU YFH YHG YOC YSK ZGI ZXP ZY1 ~02 ~H1 ABXZS ADNBA AEMQT AEOTA AGORE AJBYB ALXQX NU- PHGZM PHGZT AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QP 7T5 7TM 7XB 8FK H94 K9. PJZUB PKEHL PPXIY PQEST PQUKI PRINS 7X8 5PM |
| ID | FETCH-LOGICAL-c5243-c48058d5493bb564ff21be5488ad6bc0c40471f85f5fee59ff1f79a402353663 |
| IEDL.DBID | 7X7 |
| ISSN | 0021-972X 1945-7197 |
| IngestDate | Thu Aug 21 18:14:37 EDT 2025 Fri Jul 11 00:00:27 EDT 2025 Fri Jul 25 22:12:44 EDT 2025 Fri Jul 25 19:53:26 EDT 2025 Thu Apr 03 07:00:08 EDT 2025 Tue Jul 01 01:10:46 EDT 2025 Thu Apr 24 22:50:31 EDT 2025 Fri May 16 04:03:00 EDT 2025 Fri May 16 03:42:47 EDT 2025 Fri Feb 07 10:35:23 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5243-c48058d5493bb564ff21be5488ad6bc0c40471f85f5fee59ff1f79a402353663 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 These authors contributed equally to this study. |
| PMID | 28973392 |
| PQID | 1967045177 |
| PQPubID | 2046206 |
| PageCount | 12 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5630250 proquest_miscellaneous_1947098566 proquest_journals_3164379378 proquest_journals_1967045177 pubmed_primary_28973392 crossref_citationtrail_10_1210_jc_2017_00513 crossref_primary_10_1210_jc_2017_00513 wolterskluwer_health_10_1210_jc_2017-00513 wolterskluwer_health_00004678-201710000-00004 oup_primary_10_1210_jc_2017-00513 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2017-October-01 |
| PublicationDateYYYYMMDD | 2017-10-01 |
| PublicationDate_xml | – month: 10 year: 2017 text: 2017-October-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Washington, DC |
| PublicationPlace_xml | – name: Washington, DC – name: United States – name: Washington |
| PublicationTitle | The journal of clinical endocrinology and metabolism |
| PublicationTitleAlternate | J Clin Endocrinol Metab |
| PublicationYear | 2017 |
| Publisher | Endocrine Society Copyright Oxford University Press Oxford University Press |
| Publisher_xml | – name: Endocrine Society – name: Copyright Oxford University Press – name: Oxford University Press |
| References | Mohanty (2020071621284221600_B43) 2016; 23 Patil (2020071621284221600_B117) 2012; 7 Leung (2020071621284221600_B118) 2011; 27 Nobel (2020071621284221600_B45) 2015; 6 Cani (2020071621284221600_B59) 2007; 56 Zhang (2020071621284221600_B25) 2015; 21 Gosalbes (2020071621284221600_B89) 2012; 18 Narva (2020071621284221600_B42) 2004; 43 Flores (2020071621284221600_B73) 2012; 10 Turnbaugh (2020071621284221600_B14) 2006; 444 Qin (2020071621284221600_B77) 2010; 464 Fu (2020071621284221600_B112) 2012; 28 Chiang (2020071621284221600_B72) 2013; 97 Cho (2020071621284221600_B9) 2012; 488 Nielsen (2020071621284221600_B10) 2014; 32 Fiebiger (2020071621284221600_B7) 2016; 6 Wagner (2020071621284221600_B78) 2016; 16 Liu (2020071621284221600_B66) 2017; 23 Kadooka (2020071621284221600_B102) 2010; 64 Younes (2020071621284221600_B36) 2001; 86 Haas (2020071621284221600_B109) 2011; 21 Feng (2020071621284221600_B22) 2015; 6 Sharpton (2020071621284221600_B79) 2014; 5 Edgar (2020071621284221600_B111) 2010; 26 Qin (2020071621284221600_B21) 2012; 490 Tatusov (2020071621284221600_B85) 2003; 4 Sjogren (2020071621284221600_B31) 2012; 27 Noguchi (2020071621284221600_B119) 2008; 15 Hamilton (2020071621284221600_B58) 2015; 308 Brown (2020071621284221600_B84) 2011; 6 Guo (2020071621284221600_B57) 2015; 2015 Brown (2020071621284221600_B38) 2004; 7 Kotake (2020071621284221600_B63) 2014; 1840 Weinstock (2020071621284221600_B80) 2012; 489 Quigley (2020071621284221600_B49) 2013; 9 Schloss (2020071621284221600_B113) 2009; 75 Hernandez (2020071621284221600_B26) 2016; 31 Kuczynski (2020071621284221600_B114) Clarke (2020071621284221600_B50) 2014; 28 Goodrich (2020071621284221600_B94) 2014; 159 Spor (2020071621284221600_B93) 2011; 9 Hage (2020071621284221600_B65) 2014; 25 Peng (2020071621284221600_B115) 2011; 27 Katono (2020071621284221600_B70) 2008; 53 Unger (2020071621284221600_B23) 2016; 32 Goll (2020071621284221600_B120) 2010; 26 Palmer (2020071621284221600_B48) 1981; 46 Rodrigues (2020071621284221600_B46) 2012; 15 Blekhman (2020071621284221600_B4) 2015; 16 Britton (2020071621284221600_B39) 2014; 229 Mitsui (2020071621284221600_B29) 2005; 24 Powell (2020071621284221600_B86) 2012; 40 Finegold (2020071621284221600_B106) 2002; 35 Kennedy (2020071621284221600_B17) 2017; 112 Faderl (2020071621284221600_B3) 2015; 67 2020071621284221600_B95 Cox (2020071621284221600_B44) 2014; 158 Haft (2020071621284221600_B88) 2013; 41 Riddle (2020071621284221600_B8) 2016; 18 Kalliomäki (2020071621284221600_B104) 2001; 357 Huson (2020071621284221600_B116) 2013; 531 Lyra (2020071621284221600_B19) 2009; 15 Putignani (2020071621284221600_B97) 2016; 147 Schwarzer (2020071621284221600_B32) 2016; 351 Turnbaugh (2020071621284221600_B18) 2009; 457 Rahman (2020071621284221600_B71) 2003; 101 Wright (2020071621284221600_B110) 2012; 78 Kitaura (2020071621284221600_B62) 2013; 2013 Cortese (2020071621284221600_B98) 2016; 11 Yatsunenko (2020071621284221600_B6) 2012; 486 Bliziotes (2020071621284221600_B67) 2006; 39 Yin (2020071621284221600_B24) 2015; 4 Aagaard (2020071621284221600_B2) 2014; 6(237) Erten (2020071621284221600_B107) 2011; 4 de Goffau (2020071621284221600_B20) 2014; 57 Ma (2020071621284221600_B82) 2014; 32 Vaughn (2020071621284221600_B54) 2017; 77 Sommer (2020071621284221600_B1) 2013; 11 Yang (2020071621284221600_B47) 2013; 109 Raschka (2020071621284221600_B35) 2005; 44 van Wijngaarden (2020071621284221600_B51) 2013; 2013 Olle (2020071621284221600_B101) 2013; 31 Tremaroli (2020071621284221600_B15) 2012; 489 Lee (2020071621284221600_B69) 2006; 20 Tang (2020071621284221600_B74) 2017; 120 Graf (2020071621284221600_B5) 2015; 26 Chonan (2020071621284221600_B37) 1995; 59 Fransen (2020071621284221600_B33) 2015; 43 Itoh (2020071621284221600_B61) 2003; 170 Young (2020071621284221600_B90) 2015; 15 Vernocchi (2020071621284221600_B91) 2016; 7 Mondot (2020071621284221600_B92) 2016; 1372 Bennet (2020071621284221600_B103) 1989; 1 Luo (2020071621284221600_B76) 2016; 81 Nguyen (2020071621284221600_B105) 2007; 113 Di Stefano (2020071621284221600_B27) 2001; 46 Ohlsson (2020071621284221600_B41) 2014; 9 Liu (2020071621284221600_B64) 2016; 26 Andoh (2020071621284221600_B83) 2016; 59 Hutkins (2020071621284221600_B34) 2016; 37 Alenghat (2020071621284221600_B96) 2014; 35 Li (2020071621284221600_B40) 2016; 126 Li (2020071621284221600_B11) 2014; 32 O’Connor (2020071621284221600_B13) 2013; 16 Scheid (2020071621284221600_B75) 2011; 49 Hou (2020071621284221600_B60) 2013; 32 Sonnenburg (2020071621284221600_B100) 2011; 3 Rodríguez (2020071621284221600_B53) 2013; 540 Reeder (2020071621284221600_B108) 2010; 7 2020071621284221600_B52 Saltzman (2020071621284221600_B30) 1998; 27 Stotzer (2020071621284221600_B28) 2003; 50 2020071621284221600_B55 Belkaid (2020071621284221600_B16) 2014; 157 Yadav (2020071621284221600_B68) 2010; 16 Le Chatelier (2020071621284221600_B99) 2013; 500 Li (2020071621284221600_B56) 2017; 8 Collins (2020071621284221600_B12) 2014; 11 Morgan (2020071621284221600_B81) 2014; 146 Finn (2020071621284221600_B87) 2014; 42 24060133 - Methods Enzymol. 2013;531:465-85 24751910 - Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):497-505 16728531 - Mol Endocrinol. 2006 Oct;20(10):2432-43 27980855 - Eur J Microbiol Immunol (Bp). 2016 Dec 01;6(4):253-271 19043404 - Nature. 2009 Jan 22;457(7228):480-4 26106258 - Mediators Inflamm. 2015;2015:843089 23184592 - Curr Protoc Microbiol. 2012 Nov;Chapter 1:Unit 1E.5. 25443494 - Trends Immunol. 2014 Nov;35(11):518-25 24729765 - Gastroenterol Hepatol (N Y). 2013 Sep;9(9):560-9 26912894 - Science. 2016 Feb 19;351(6275):854-7 26214836 - Nat Med. 2015 Aug;21(8):895-905 14571751 - Hepatogastroenterology. 2003 Sep-Oct;50(53):1415-8 27317164 - J Bone Miner Res. 2016 Sep;31(9):1638-46 18940874 - DNA Res. 2008 Dec;15(6):387-96 26945826 - Ann N Y Acad Sci. 2016 May;1372(1):9-19 25126780 - Cell. 2014 Aug 14;158(4):705-721 21699738 - BioData Min. 2011 Jun 24;4:19 24486053 - Gastroenterology. 2014 May;146(6):1437-1448.e1 22914093 - Nature. 2012 Aug 30;488(7413):621-6 20798169 - Bioinformatics. 2010 Oct 15;26(20):2631-2 23060610 - Bioinformatics. 2012 Dec 1;28(23):3150-2 27591074 - Parkinsonism Relat Disord. 2016 Nov;32:66-72 27499582 - J Clin Biochem Nutr. 2016 Jul;59(1):65-70 22950799 - Br J Nutr. 2013 May 28;109(10):1779-88 7317349 - Br J Nutr. 1981 Nov;46(3):549-58 15481739 - Nutr Clin Care. 2004 Apr-Jun;7(2):56-68 22699611 - Nature. 2012 May 09;486(7402):222-7 12969510 - BMC Bioinformatics. 2003 Sep 11;4:41 25747351 - Am J Physiol Gastrointest Liver Physiol. 2015 May 15;308(10):G840-51 23509616 - J Nutr Metab. 2013;2013:486186 24096173 - Arch Biochem Biophys. 2013 Dec;540(1-2):19-25 9650019 - Gastroenterol Clin North Am. 1998 Jun;27(2):309-24 28360349 - Circ Res. 2017 Mar 31;120(7):1183-1196 24930037 - Diabetologia. 2014 Aug;57(8):1569-77 22647049 - Clin Microbiol Infect. 2012 Jul;18 Suppl 4:47-9 17140690 - Int J Food Microbiol. 2007 Feb 15;113(3):358-61 24390915 - Semin Reprod Med. 2014 Jan;32(1):5-13 12646634 - J Immunol. 2003 Apr 1;170(7):3688-95 11341652 - Dig Dis Sci. 2001 May;46(5):1077-82 24997787 - Nat Biotechnol. 2014 Aug;32(8):822-8 20139991 - Nat Med. 2010 Mar;16(3):308-12 11297958 - Lancet. 2001 Apr 7;357(9262):1076-9 28379213 - Acta Neurobiol Exp (Wars). 2017;77(1):18-30 24361610 - Biochim Biophys Acta. 2014 Mar;1840(3):1209-13 23259758 - J Transl Med. 2012 Dec 21;10:253 27507964 - Front Microbiol. 2016 Jul 26;7:1144 23197656 - Nucleic Acids Res. 2013 Jan;41(Database issue):D387-95 20805793 - Nat Methods. 2010 Sep;7(9):668-9 23435359 - Nat Rev Microbiol. 2013 Apr;11(4):227-38 20709691 - Bioinformatics. 2010 Oct 1;26(19):2460-1 24637895 - PLoS One. 2014 Mar 17;9(3):e92368 23762085 - Clin Dev Immunol. 2013;2013:181849 12173102 - Clin Infect Dis. 2002 Sep 1;35(Suppl 1):S6-S16 21490274 - Sci Transl Med. 2011 Apr 13;3(78):78ps12 27579006 - Saudi J Biol Sci. 2016 Sep;23(5):577-83 2563083 - Lancet. 1989 Jan 21;1(8630):164 15083312 - Eur J Nutr. 2004 Apr;43(2):61-8 26909656 - Epigenetics. 2016 Mar 3;11(3):205-15 27437760 - Crit Rev Food Sci Nutr. 2017 Dec 12;57(18):3959-3970 27842515 - BMC Microbiol. 2016 Nov 14;16(1):274 16884969 - Bone. 2006 Dec;39(6):1313-21 23023125 - Nature. 2012 Oct 4;490(7418):55-60 24997786 - Nat Biotechnol. 2014 Aug;32(8):834-41 27723756 - Nat Genet. 2016 Nov;48(11):1396-1406 15490199 - Eur J Nutr. 2005 Sep;44(6):360-4 26362264 - Immunity. 2015 Sep 15;43(3):527-40 23852088 - Curr Opin Clin Nutr Metab Care. 2013 Sep;16(5):509-16 24288371 - Nucleic Acids Res. 2014 Jan;42(Database issue):D222-30 22745671 - PLoS One. 2012;7(6):e38581 20014457 - World J Gastroenterol. 2009 Dec 21;15(47):5936-45 22101057 - Appl Environ Microbiol. 2012 Feb;78(3):717-25 17183312 - Nature. 2006 Dec 21;444(7122):1027-31 21685107 - Bioinformatics. 2011 Jul 1;27(13):i94-101 28119466 - MBio. 2017 Jan 24;8(1):null 26374288 - Genome Biol. 2015 Sep 15;16:191 22972298 - Nature. 2012 Sep 13;489(7415):250-6 26077811 - Proteomics. 2015 Oct;15(20):3463-73 20203603 - Nature. 2010 Mar 4;464(7285):59-65 22043294 - PLoS One. 2011;6(10):e25792 24679531 - Cell. 2014 Mar 27;157(1):121-41 27130534 - J Proteomics. 2016 Sep 16;147:3-20 26597155 - J Am Heart Assoc. 2015 Nov 23;4(11):null 27392632 - Neuropharmacology. 2017 Jan;112(Pt B):399-412 16298023 - Clin Nutr. 2005 Dec;24(6):920-4 20216555 - Eur J Clin Nutr. 2010 Jun;64(6):636-43 28628112 - Nat Med. 2017 Jul;23 (7):859-868 22510044 - J Med Food. 2012 Jul;15(7):664-70 22096231 - Nucleic Acids Res. 2012 Jan;40(Database issue):D284-9 21549231 - Bone. 2011 Aug;49(2):194-201 17456850 - Diabetes. 2007 Jul;56(7):1761-72 21493653 - Bioinformatics. 2011 Jun 1;27(11):1489-95 25914114 - IUBMB Life. 2015 Apr;67(4):275-85 24677054 - J Cell Physiol. 2014 Nov;229(11):1822-30 23740407 - Int J Mol Med. 2013 Aug;32(2):503-10 27447891 - Curr Infect Dis Rep. 2016 Sep;18(9):29 26123276 - Nat Commun. 2015 Jun 30;6:7486 24892638 - Mol Endocrinol. 2014 Aug;28(8):1221-38 25417156 - Cell. 2014 Nov 6;159(4):789-99 11591235 - Br J Nutr. 2001 Oct;86(4):479-85 28393285 - Eur J Nutr. 2017 Apr 9;:null 12511413 - Blood. 2003 May 1;101(9):3451-9 23318837 - Appl Microbiol Biotechnol. 2013 Feb;97(4):1489-500 23985870 - Nature. 2013 Aug 29;500(7464):541-6 24848255 - Sci Transl Med. 2014 May 21;6(237):237ra65 21407244 - Nat Rev Microbiol. 2011 Apr;9(4):279-90 19801464 - Appl Environ Microbiol. 2009 Dec;75(23):7537-41 25656825 - Microb Ecol Health Dis. 2015 Feb 04;26:26164 25982806 - Obes Surg. 2016 Jan;26(1):91-7 24008401 - Osteoporos Int. 2014 Feb;25(2):423-39 22972297 - Nature. 2012 Sep 13;489(7415):242-9 7766023 - Biosci Biotechnol Biochem. 1995 Feb;59(2):236-9 26431716 - Curr Opin Biotechnol. 2016 Feb;37:1-7 24982662 - Front Plant Sci. 2014 Jun 16;5:209 18406397 - Arch Oral Biol. 2008 Oct;53(10):903-9 27111232 - J Clin Invest. 2016 Jun 1;126(6):2049-63 25758642 - Nat Commun. 2015 Mar 11;6:6528 21212162 - Genome Res. 2011 Mar;21(3):494-504 23563425 - Nat Biotechnol. 2013 Apr;31(4):309-15 27099876 - Br J Clin Pharmacol. 2016 Jan;81(1):78-88 22407806 - J Bone Miner Res. 2012 Jun;27(6):1357-67 |
| References_xml | – volume: 6(237) start-page: 237ra65 year: 2014 ident: 2020071621284221600_B2 article-title: The placenta harbors a unique microbiome publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3008599 – volume: 28 start-page: 1221 issue: 8 year: 2014 ident: 2020071621284221600_B50 article-title: Minireview: gut microbiota: the neglected endocrine organ publication-title: Mol Endocrinol doi: 10.1210/me.2014-1108 – volume: 32 start-page: 834 issue: 8 year: 2014 ident: 2020071621284221600_B11 article-title: An integrated catalog of reference genes in the human gut microbiome publication-title: Nat Biotechnol doi: 10.1038/nbt.2942 – volume: 11 start-page: 205 issue: 3 year: 2016 ident: 2020071621284221600_B98 article-title: Epigenome-Microbiome crosstalk: a potential new paradigm influencing neonatal susceptibility to disease publication-title: Epigenetics doi: 10.1080/15592294.2016.1155011 – volume: 1 start-page: 164 issue: 8630 year: 1989 ident: 2020071621284221600_B103 article-title: Treatment of ulcerative colitis by implantation of normal colonic flora publication-title: Lancet doi: 10.1016/S0140-6736(89)91183-5 – volume: 16 start-page: 274 issue: 1 year: 2016 ident: 2020071621284221600_B78 article-title: Evaluation of PacBio sequencing for full-length bacterial 16S rRNA gene classification publication-title: BMC Microbiol doi: 10.1186/s12866-016-0891-4 – ident: 2020071621284221600_B95 doi: 10.1038/ng.3695 – volume: 126 start-page: 2049 issue: 6 year: 2016 ident: 2020071621284221600_B40 article-title: Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics publication-title: J Clin Invest doi: 10.1172/JCI86062 – volume: 15 start-page: 664 issue: 7 year: 2012 ident: 2020071621284221600_B46 article-title: Yacon flour and Bifidobacterium longum modulate bone health in rats publication-title: J Med Food doi: 10.1089/jmf.2011.0296 – volume: 97 start-page: 1489 issue: 4 year: 2013 ident: 2020071621284221600_B72 article-title: Beneficial effects of phytoestrogens and their metabolites produced by intestinal microflora on bone health publication-title: Appl Microbiol Biotechnol doi: 10.1007/s00253-012-4675-y – volume: 23 start-page: 859 issue: 7 year: 2017 ident: 2020071621284221600_B66 article-title: Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention publication-title: Nat Med doi: 10.1038/nm.4358 – volume: 457 start-page: 480 issue: 7228 year: 2009 ident: 2020071621284221600_B18 article-title: A core gut microbiome in obese and lean twins publication-title: Nature doi: 10.1038/nature07540 – volume: 5 start-page: 209 year: 2014 ident: 2020071621284221600_B79 article-title: An introduction to the analysis of shotgun metagenomic data publication-title: Front Plant Sci doi: 10.3389/fpls.2014.00209 – volume: 31 start-page: 309 issue: 4 year: 2013 ident: 2020071621284221600_B101 article-title: Medicines from microbiota publication-title: Nat Biotechnol doi: 10.1038/nbt.2548 – volume: 53 start-page: 903 issue: 10 year: 2008 ident: 2020071621284221600_B70 article-title: Sodium butyrate stimulates mineralized nodule formation and osteoprotegerin expression by human osteoblasts publication-title: Arch Oral Biol doi: 10.1016/j.archoralbio.2008.02.016 – volume: 1840 start-page: 1209 issue: 3 year: 2014 ident: 2020071621284221600_B63 article-title: Effect of TNFα on osteoblastogenesis from mesenchymal stem cells publication-title: Biochim Biophys Acta doi: 10.1016/j.bbagen.2013.12.013 – volume: 120 start-page: 1183 issue: 7 year: 2017 ident: 2020071621284221600_B74 article-title: Gut microbiota in cardiovascular health and disease publication-title: Circ Res doi: 10.1161/CIRCRESAHA.117.309715 – volume: 488 start-page: 621 issue: 7413 year: 2012 ident: 2020071621284221600_B9 article-title: Antibiotics in early life alter the murine colonic microbiome and adiposity publication-title: Nature doi: 10.1038/nature11400 – volume: 26 start-page: 2460 issue: 19 year: 2010 ident: 2020071621284221600_B111 article-title: Search and clustering orders of magnitude faster than BLAST publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq461 – volume: 486 start-page: 222 issue: 7402 year: 2012 ident: 2020071621284221600_B6 article-title: Human gut microbiome viewed across age and geography publication-title: Nature doi: 10.1038/nature11053 – volume: 101 start-page: 3451 issue: 9 year: 2003 ident: 2020071621284221600_B71 article-title: Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages publication-title: Blood doi: 10.1182/blood-2002-08-2622 – volume: 159 start-page: 789 issue: 4 year: 2014 ident: 2020071621284221600_B94 article-title: Human genetics shape the gut microbiome publication-title: Cell doi: 10.1016/j.cell.2014.09.053 – volume: 9 start-page: 279 issue: 4 year: 2011 ident: 2020071621284221600_B93 article-title: Unravelling the effects of the environment and host genotype on the gut microbiome publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro2540 – volume: 464 start-page: 59 issue: 7285 year: 2010 ident: 2020071621284221600_B77 article-title: A human gut microbial gene catalogue established by metagenomic sequencing publication-title: Nature doi: 10.1038/nature08821 – volume-title: Curr Protoc Microbiol ident: 2020071621284221600_B114 article-title: Using QIIME to analyze 16S rRNA gene sequences from microbial communities doi: 10.1002/9780471729259.mc01e05s27 – volume: 531 start-page: 465 year: 2013 ident: 2020071621284221600_B116 article-title: Microbial community analysis using MEGAN publication-title: Methods Enzymol doi: 10.1016/B978-0-12-407863-5.00021-6 – volume: 6 start-page: 253 issue: 4 year: 2016 ident: 2020071621284221600_B7 article-title: Dissecting the interplay between intestinal microbiota and host immunity in health and disease: lessons learned from fermfree and gnotobiotic animal models publication-title: Eur J Microbiol Immunol (Bp) doi: 10.1556/1886.2016.00036 – volume: 27 start-page: 309 issue: 2 year: 1998 ident: 2020071621284221600_B30 article-title: The aging gut: nutritional issues publication-title: Gastroenterol Clin North Am doi: 10.1016/S0889-8553(05)70005-4 – volume: 18 start-page: 47 year: 2012 ident: 2020071621284221600_B89 article-title: Metagenomics of human microbiome: beyond 16s rDNA publication-title: Clin Microbiol Infect doi: 10.1111/j.1469-0691.2012.03865.x – volume: 500 start-page: 541 issue: 7464 year: 2013 ident: 2020071621284221600_B99 article-title: Richness of human gut microbiome correlates with metabolic markers publication-title: Nature doi: 10.1038/nature12506 – volume: 78 start-page: 717 issue: 3 year: 2012 ident: 2020071621284221600_B110 article-title: DECIPHER, a search-based approach to chimera identification for 16S rRNA sequences publication-title: Appl Environ Microbiol doi: 10.1128/AEM.06516-11 – volume: 56 start-page: 1761 issue: 7 year: 2007 ident: 2020071621284221600_B59 article-title: Metabolic endotoxemia initiates obesity and insulin resistance publication-title: Diabetes doi: 10.2337/db06-1491 – volume: 67 start-page: 275 issue: 4 year: 2015 ident: 2020071621284221600_B3 article-title: Keeping bugs in check: the mucus layer as a critical component in maintaining intestinal homeostasis publication-title: IUBMB Life doi: 10.1002/iub.1374 – volume: 6 start-page: e25792 issue: 10 year: 2011 ident: 2020071621284221600_B84 article-title: Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes publication-title: PLoS One doi: 10.1371/journal.pone.0025792 – volume: 35 start-page: S6 year: 2002 ident: 2020071621284221600_B106 article-title: Gastrointestinal microflora studies in late-onset autism publication-title: Clin Infect Dis doi: 10.1086/341914 – volume: 7 start-page: 56 issue: 2 year: 2004 ident: 2020071621284221600_B38 article-title: Probiotics and medical nutrition therapy publication-title: Nutr Clin Care – volume: 77 start-page: 18 issue: 1 year: 2017 ident: 2020071621284221600_B54 article-title: Energy-dense diet triggers changes in gut microbiota, reorganization of gut‑brain vagal communication and increases body fat accumulation publication-title: Acta Neurobiol Exp (Warsz) doi: 10.21307/ane-2017-033 – volume: 6 start-page: 6528 year: 2015 ident: 2020071621284221600_B22 article-title: Gut microbiome development along the colorectal adenoma-carcinoma sequence publication-title: Nat Commun doi: 10.1038/ncomms7528 – volume: 41 start-page: D387 issue: Database issue year: 2013 ident: 2020071621284221600_B88 article-title: TIGRFAMs and genome properties in 2013 publication-title: Nucleic Acids Res – volume: 31 start-page: 1638 issue: 9 year: 2016 ident: 2020071621284221600_B26 article-title: Links between the microbiome and bone publication-title: J Bone Miner Res doi: 10.1002/jbmr.2887 – volume: 44 start-page: 360 issue: 6 year: 2005 ident: 2020071621284221600_B35 article-title: Diet composition and age determine the effects of inulin-type fructans on intestinal calcium absorption in rat publication-title: Eur J Nutr doi: 10.1007/s00394-004-0535-6 – volume: 39 start-page: 1313 issue: 6 year: 2006 ident: 2020071621284221600_B67 article-title: Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells publication-title: Bone doi: 10.1016/j.bone.2006.06.009 – volume: 3 start-page: 78ps12 issue: 78 year: 2011 ident: 2020071621284221600_B100 article-title: Community health care: therapeutic opportunities in the human microbiome publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3001626 – volume: 26 start-page: 26164 year: 2015 ident: 2020071621284221600_B5 article-title: Contribution of diet to the composition of the human gut microbiota publication-title: Microb Ecol Health Dis – volume: 27 start-page: 1357 issue: 6 year: 2012 ident: 2020071621284221600_B31 article-title: The gut microbiota regulates bone mass in mice publication-title: J Bone Miner Res doi: 10.1002/jbmr.1588 – volume: 229 start-page: 1822 issue: 11 year: 2014 ident: 2020071621284221600_B39 article-title: Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model publication-title: J Cell Physiol doi: 10.1002/jcp.24636 – volume: 112 start-page: 399 year: 2017 ident: 2020071621284221600_B17 article-title: Kynurenine pathway metabolism and the microbiota-gut-brain axis publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2016.07.002 – volume: 15 start-page: 387 issue: 6 year: 2008 ident: 2020071621284221600_B119 article-title: MetaGeneAnnotator: detecting species-specific patterns of ribosomal binding site for precise gene prediction in anonymous prokaryotic and phage genomes publication-title: DNA Res doi: 10.1093/dnares/dsn027 – volume: 146 start-page: 1437 issue: 6 year: 2014 ident: 2020071621284221600_B81 article-title: Meta’omic analytic techniques for studying the intestinal microbiome publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.01.049 – volume: 32 start-page: 5 issue: 1 year: 2014 ident: 2020071621284221600_B82 article-title: Use of whole genome shotgun metagenomics: a practical guide for the microbiome-minded physician scientist publication-title: Semin Reprod Med doi: 10.1055/s-0033-1361817 – volume: 37 start-page: 1 year: 2016 ident: 2020071621284221600_B34 article-title: Prebiotics: why definitions matter publication-title: Curr Opin Biotechnol doi: 10.1016/j.copbio.2015.09.001 – volume: 158 start-page: 705 issue: 4 year: 2014 ident: 2020071621284221600_B44 article-title: Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences publication-title: Cell doi: 10.1016/j.cell.2014.05.052 – volume: 21 start-page: 895 issue: 8 year: 2015 ident: 2020071621284221600_B25 article-title: The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment publication-title: Nat Med doi: 10.1038/nm.3914 – volume: 9 start-page: 560 issue: 9 year: 2013 ident: 2020071621284221600_B49 article-title: Gut bacteria in health and disease publication-title: Gastroenterol Hepatol (N Y) – volume: 308 start-page: G840 issue: 10 year: 2015 ident: 2020071621284221600_B58 article-title: Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00029.2015 – volume: 32 start-page: 66 year: 2016 ident: 2020071621284221600_B23 article-title: Short chain fatty acids and gut microbiota differ between patients with Parkinson’s disease and age-matched controls publication-title: Parkinsonism Relat Disord doi: 10.1016/j.parkreldis.2016.08.019 – volume: 40 start-page: D284 issue: Database issue year: 2012 ident: 2020071621284221600_B86 article-title: eggNOG v3.0: orthologous groups covering 1133 organisms at 41 different taxonomic ranges publication-title: Nucleic Acids Res doi: 10.1093/nar/gkr1060 – volume: 489 start-page: 250 issue: 7415 year: 2012 ident: 2020071621284221600_B80 article-title: Genomic approaches to studying the human microbiota publication-title: Nature doi: 10.1038/nature11553 – volume: 49 start-page: 194 issue: 2 year: 2011 ident: 2020071621284221600_B75 article-title: Estrogen and peptide YY are associated with bone mineral density in premenopausal exercising women publication-title: Bone doi: 10.1016/j.bone.2011.04.011 – volume: 489 start-page: 242 issue: 7415 year: 2012 ident: 2020071621284221600_B15 article-title: Functional interactions between the gut microbiota and host metabolism publication-title: Nature doi: 10.1038/nature11552 – volume: 59 start-page: 65 issue: 1 year: 2016 ident: 2020071621284221600_B83 article-title: Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population publication-title: J Clin Biochem Nutr doi: 10.3164/jcbn.15-152 – volume: 57 start-page: 1569 issue: 8 year: 2014 ident: 2020071621284221600_B20 article-title: Aberrant gut microbiota composition at the onset of type 1 diabetes in young children publication-title: Diabetologia doi: 10.1007/s00125-014-3274-0 – volume: 26 start-page: 2631 issue: 20 year: 2010 ident: 2020071621284221600_B120 article-title: METAREP: JCVI metagenomics reports--an open source tool for high-performance comparative metagenomics publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq455 – volume: 24 start-page: 920 issue: 6 year: 2005 ident: 2020071621284221600_B29 article-title: Small bowel bacterial overgrowth may not affect bone mineral density in older people publication-title: Clin Nutr doi: 10.1016/j.clnu.2005.05.022 – volume: 59 start-page: 236 issue: 2 year: 1995 ident: 2020071621284221600_B37 article-title: Effect of galactooligosaccharides on calcium absorption and preventing bone loss in ovariectomized rats publication-title: Biosci Biotechnol Biochem doi: 10.1271/bbb.59.236 – volume: 490 start-page: 55 issue: 7418 year: 2012 ident: 2020071621284221600_B21 article-title: A metagenome-wide association study of gut microbiota in type 2 diabetes publication-title: Nature doi: 10.1038/nature11450 – volume: 109 start-page: 1779 issue: 10 year: 2013 ident: 2020071621284221600_B47 article-title: The prebiotic effect of Anoectochilus formosanus and its consequences on bone health publication-title: Br J Nutr doi: 10.1017/S0007114512003777 – ident: 2020071621284221600_B52 doi: 10.1080/10408398.2016.1211616 – volume: 15 start-page: 5936 issue: 47 year: 2009 ident: 2020071621284221600_B19 article-title: Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification publication-title: World J Gastroenterol doi: 10.3748/wjg.15.5936 – ident: 2020071621284221600_B55 doi: 10.1007/s00394-017-1445-8 – volume: 43 start-page: 61 issue: 2 year: 2004 ident: 2020071621284221600_B42 article-title: The effect of Lactobacillus helveticus fermented milk on acute changes in calcium metabolism in postmenopausal women publication-title: Eur J Nutr doi: 10.1007/s00394-004-0441-y – volume: 75 start-page: 7537 issue: 23 year: 2009 ident: 2020071621284221600_B113 article-title: Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities publication-title: Appl Environ Microbiol doi: 10.1128/AEM.01541-09 – volume: 27 start-page: 1489 issue: 11 year: 2011 ident: 2020071621284221600_B118 article-title: A robust and accurate binning algorithm for metagenomic sequences with arbitrary species abundance ratio publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr186 – volume: 16 start-page: 191 year: 2015 ident: 2020071621284221600_B4 article-title: Host genetic variation impacts microbiome composition across human body sites publication-title: Genome Biol doi: 10.1186/s13059-015-0759-1 – volume: 26 start-page: 91 issue: 1 year: 2016 ident: 2020071621284221600_B64 article-title: Changes in bone metabolism in morbidly obese patients after bariatric surgery: a meta-analysis publication-title: Obes Surg doi: 10.1007/s11695-015-1724-5 – volume: 15 start-page: 3463 issue: 20 year: 2015 ident: 2020071621284221600_B90 article-title: Metaproteomics reveals functional shifts in microbial and human proteins during a preterm infant gut colonization case publication-title: Proteomics doi: 10.1002/pmic.201400563 – volume: 147 start-page: 3 year: 2016 ident: 2020071621284221600_B97 article-title: Foodomics as part of the host-microbiota-exposome interplay publication-title: J Proteomics doi: 10.1016/j.jprot.2016.04.033 – volume: 25 start-page: 423 issue: 2 year: 2014 ident: 2020071621284221600_B65 article-title: Bone and mineral metabolism in patients undergoing Roux-en-Y gastric bypass publication-title: Osteoporosis Int doi: 10.1007/s00198-013-2480-9 – volume: 2013 start-page: 486186 year: 2013 ident: 2020071621284221600_B51 article-title: Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses publication-title: J Nutr Metab doi: 10.1155/2013/486186 – volume: 170 start-page: 3688 issue: 7 year: 2003 ident: 2020071621284221600_B61 article-title: Lipopolysaccharide promotes the survival of osteoclasts via Toll-like receptor 4, but cytokine production of osteoclasts in response to lipopolysaccharide is different from that of macrophages publication-title: J Immunol doi: 10.4049/jimmunol.170.7.3688 – volume: 28 start-page: 3150 issue: 23 year: 2012 ident: 2020071621284221600_B112 article-title: CD-HIT: accelerated for clustering the next-generation sequencing data publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts565 – volume: 7 start-page: 1144 year: 2016 ident: 2020071621284221600_B91 article-title: Gut microbiota profiling: metabolomics based approach to unravel compounds affecting human health publication-title: Front Microbiol doi: 10.3389/fmicb.2016.01144 – volume: 351 start-page: 854 issue: 6275 year: 2016 ident: 2020071621284221600_B32 article-title: Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition publication-title: Science doi: 10.1126/science.aad8588 – volume: 16 start-page: 308 issue: 3 year: 2010 ident: 2020071621284221600_B68 article-title: Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis publication-title: Nat Med doi: 10.1038/nm.2098 – volume: 7 start-page: e38581 issue: 6 year: 2012 ident: 2020071621284221600_B117 article-title: The PhyloPythiaS web server for taxonomic assignment of metagenome sequences publication-title: PLoS One doi: 10.1371/journal.pone.0038581 – volume: 23 start-page: 577 issue: 5 year: 2016 ident: 2020071621284221600_B43 article-title: Milk derived bioactive peptides and their impact on human health: a review publication-title: Saudi J Biol Sci doi: 10.1016/j.sjbs.2015.06.005 – volume: 10 start-page: 253 year: 2012 ident: 2020071621284221600_B73 article-title: Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study publication-title: J Transl Med doi: 10.1186/1479-5876-10-253 – volume: 4 start-page: 19 year: 2011 ident: 2020071621284221600_B107 article-title: DADA: Degree-Aware Algorithms for Network-Based Disease Gene Prioritization publication-title: BioData Min doi: 10.1186/1756-0381-4-19 – volume: 50 start-page: 1415 issue: 53 year: 2003 ident: 2020071621284221600_B28 article-title: Bone mineral density in patients with small intestinal bacterial overgrowth publication-title: Hepatogastroenterology – volume: 4 start-page: e002699 issue: 11 year: 2015 ident: 2020071621284221600_B24 article-title: Dysbiosis of gut microbiota with reduced trimethylamine-N-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack publication-title: J Am Heart Assoc doi: 10.1161/JAHA.115.002699 – volume: 157 start-page: 121 issue: 1 year: 2014 ident: 2020071621284221600_B16 article-title: Role of the microbiota in immunity and inflammation publication-title: Cell doi: 10.1016/j.cell.2014.03.011 – volume: 6 start-page: 7486 year: 2015 ident: 2020071621284221600_B45 article-title: Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment publication-title: Nat Commun doi: 10.1038/ncomms8486 – volume: 7 start-page: 668 issue: 9 year: 2010 ident: 2020071621284221600_B108 article-title: Rapidly denoising pyrosequencing amplicon reads by exploiting rank-abundance distributions publication-title: Nat Methods doi: 10.1038/nmeth0910-668b – volume: 8 start-page: e01703-16. issue: 1 year: 2017 ident: 2020071621284221600_B56 article-title: Effects of the dietary protein and carbohydrate ratio on gut microbiomes in dogs of different body conditions publication-title: MBio doi: 10.1128/mBio.01703-16 – volume: 64 start-page: 636 issue: 6 year: 2010 ident: 2020071621284221600_B102 article-title: Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial publication-title: Eur J Clin Nutr doi: 10.1038/ejcn.2010.19 – volume: 21 start-page: 494 issue: 3 year: 2011 ident: 2020071621284221600_B109 article-title: Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons publication-title: Genome Res doi: 10.1101/gr.112730.110 – volume: 27 start-page: i94 issue: 13 year: 2011 ident: 2020071621284221600_B115 article-title: Meta-IDBA: a de Novo assembler for metagenomic data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr216 – volume: 46 start-page: 549 issue: 3 year: 1981 ident: 2020071621284221600_B48 article-title: The absorption and secretion of calcium in the gastrointestinal tract of germ-free and conventional chicks publication-title: Br J Nutr doi: 10.1079/BJN19810064 – volume: 11 start-page: 497 issue: 8 year: 2014 ident: 2020071621284221600_B12 article-title: A role for the gut microbiota in IBS publication-title: Nat Rev Gastroenterol Hepatol doi: 10.1038/nrgastro.2014.40 – volume: 20 start-page: 2432 issue: 10 year: 2006 ident: 2020071621284221600_B69 article-title: Histone deacetylase 1-mediated histone modification regulates osteoblast differentiation publication-title: Mol Endocrinol doi: 10.1210/me.2006-0061 – volume: 35 start-page: 518 issue: 11 year: 2014 ident: 2020071621284221600_B96 article-title: Epigenomic regulation of host-microbiota interactions publication-title: Trends Immunol doi: 10.1016/j.it.2014.09.007 – volume: 4 start-page: 41 year: 2003 ident: 2020071621284221600_B85 article-title: The COG database: an updated version includes eukaryotes publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-4-41 – volume: 43 start-page: 527 issue: 3 year: 2015 ident: 2020071621284221600_B33 article-title: BALB/c and C57BL/6 mice differ in polyreactive IgA abundance, which impacts the generation of antigen-specific IgA and microbiota diversity publication-title: Immunity doi: 10.1016/j.immuni.2015.08.011 – volume: 9 start-page: e92368 issue: 3 year: 2014 ident: 2020071621284221600_B41 article-title: Probiotics protect mice from ovariectomy-induced cortical bone loss publication-title: PLoS One doi: 10.1371/journal.pone.0092368 – volume: 16 start-page: 509 issue: 5 year: 2013 ident: 2020071621284221600_B13 article-title: The role of gut microbiota in nutritional status publication-title: Curr Opin Clin Nutr Metab Care doi: 10.1097/MCO.0b013e3283638eb3 – volume: 46 start-page: 1077 issue: 5 year: 2001 ident: 2020071621284221600_B27 article-title: Small intestine bacterial overgrowth and metabolic bone disease publication-title: Dig Dis Sci doi: 10.1023/A:1010722314493 – volume: 42 start-page: D222 issue: Database issue year: 2014 ident: 2020071621284221600_B87 article-title: Pfam: the protein families database publication-title: Nucleic Acids Res doi: 10.1093/nar/gkt1223 – volume: 2015 start-page: 843089 year: 2015 ident: 2020071621284221600_B57 article-title: Serum levels of lipopolysaccharide and 1,3-β-D-glucan refer to the severity in patients with Crohn's disease publication-title: Mediators Inflamm doi: 10.1155/2015/843089 – volume: 357 start-page: 1076 issue: 9262 year: 2001 ident: 2020071621284221600_B104 article-title: Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(00)04259-8 – volume: 1372 start-page: 9 issue: 1 year: 2016 ident: 2020071621284221600_B92 article-title: The human gut microbiome and its dysfunctions through the meta-omics prism publication-title: Ann N Y Acad Sci doi: 10.1111/nyas.13033 – volume: 540 start-page: 19 issue: 1-2 year: 2013 ident: 2020071621284221600_B53 article-title: Ursodeoxycholic and deoxycholic acids: a good and a bad bile acid for intestinal calcium absorption publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2013.09.018 – volume: 113 start-page: 358 issue: 3 year: 2007 ident: 2020071621284221600_B105 article-title: Characterization of Lactobacillus plantarum PH04, a potential probiotic bacterium with cholesterol-lowering effects publication-title: Int J Food Microbiol doi: 10.1016/j.ijfoodmicro.2006.08.015 – volume: 2013 start-page: 181849 year: 2013 ident: 2020071621284221600_B62 article-title: Immunological reaction in TNF-α-mediated osteoclast formation and bone resorption in vitro and in vivo publication-title: Clin Dev Immunol doi: 10.1155/2013/181849 – volume: 81 start-page: 78 issue: 1 year: 2016 ident: 2020071621284221600_B76 article-title: Glucagon-like peptide-1(GLP-1) receptor agonists: potential to reduce fracture risk in diabetic patients? publication-title: Br J Clin Pharmacol doi: 10.1111/bcp.12777 – volume: 86 start-page: 479 issue: 4 year: 2001 ident: 2020071621284221600_B36 article-title: Effects of two fermentable carbohydrates (inulin and resistant starch) and their combination on calcium and magnesium balance in rats publication-title: Br J Nutr doi: 10.1079/BJN2001430 – volume: 11 start-page: 227 issue: 4 year: 2013 ident: 2020071621284221600_B1 article-title: The gut microbiota--masters of host development and physiology publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro2974 – volume: 18 start-page: 29 issue: 9 year: 2016 ident: 2020071621284221600_B8 article-title: The traveling microbiome publication-title: Curr Infect Dis Rep doi: 10.1007/s11908-016-0536-7 – volume: 444 start-page: 1027 issue: 7122 year: 2006 ident: 2020071621284221600_B14 article-title: An obesity-associated gut microbiome with increased capacity for energy harvest publication-title: Nature doi: 10.1038/nature05414 – volume: 32 start-page: 503 issue: 2 year: 2013 ident: 2020071621284221600_B60 article-title: Lipopolysaccharide (LPS) promotes osteoclast differentiation and activation by enhancing the MAPK pathway and COX-2 expression in RAW264.7 cells publication-title: Int J Mol Med doi: 10.3892/ijmm.2013.1406 – volume: 32 start-page: 822 issue: 8 year: 2014 ident: 2020071621284221600_B10 article-title: Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes publication-title: Nat Biotechnol doi: 10.1038/nbt.2939 – reference: 23197656 - Nucleic Acids Res. 2013 Jan;41(Database issue):D387-95 – reference: 12173102 - Clin Infect Dis. 2002 Sep 1;35(Suppl 1):S6-S16 – reference: 26945826 - Ann N Y Acad Sci. 2016 May;1372(1):9-19 – reference: 25982806 - Obes Surg. 2016 Jan;26(1):91-7 – reference: 27591074 - Parkinsonism Relat Disord. 2016 Nov;32:66-72 – reference: 2563083 - Lancet. 1989 Jan 21;1(8630):164 – reference: 24361610 - Biochim Biophys Acta. 2014 Mar;1840(3):1209-13 – reference: 27980855 - Eur J Microbiol Immunol (Bp). 2016 Dec 01;6(4):253-271 – reference: 9650019 - Gastroenterol Clin North Am. 1998 Jun;27(2):309-24 – reference: 21685107 - Bioinformatics. 2011 Jul 1;27(13):i94-101 – reference: 15481739 - Nutr Clin Care. 2004 Apr-Jun;7(2):56-68 – reference: 26912894 - Science. 2016 Feb 19;351(6275):854-7 – reference: 25417156 - Cell. 2014 Nov 6;159(4):789-99 – reference: 24008401 - Osteoporos Int. 2014 Feb;25(2):423-39 – reference: 27317164 - J Bone Miner Res. 2016 Sep;31(9):1638-46 – reference: 24679531 - Cell. 2014 Mar 27;157(1):121-41 – reference: 22043294 - PLoS One. 2011;6(10):e25792 – reference: 23985870 - Nature. 2013 Aug 29;500(7464):541-6 – reference: 26597155 - J Am Heart Assoc. 2015 Nov 23;4(11):null – reference: 25914114 - IUBMB Life. 2015 Apr;67(4):275-85 – reference: 22914093 - Nature. 2012 Aug 30;488(7413):621-6 – reference: 28119466 - MBio. 2017 Jan 24;8(1):null – reference: 24848255 - Sci Transl Med. 2014 May 21;6(237):237ra65 – reference: 23023125 - Nature. 2012 Oct 4;490(7418):55-60 – reference: 28360349 - Circ Res. 2017 Mar 31;120(7):1183-1196 – reference: 12511413 - Blood. 2003 May 1;101(9):3451-9 – reference: 24930037 - Diabetologia. 2014 Aug;57(8):1569-77 – reference: 21549231 - Bone. 2011 Aug;49(2):194-201 – reference: 22096231 - Nucleic Acids Res. 2012 Jan;40(Database issue):D284-9 – reference: 23740407 - Int J Mol Med. 2013 Aug;32(2):503-10 – reference: 20014457 - World J Gastroenterol. 2009 Dec 21;15(47):5936-45 – reference: 24677054 - J Cell Physiol. 2014 Nov;229(11):1822-30 – reference: 11591235 - Br J Nutr. 2001 Oct;86(4):479-85 – reference: 7766023 - Biosci Biotechnol Biochem. 1995 Feb;59(2):236-9 – reference: 20203603 - Nature. 2010 Mar 4;464(7285):59-65 – reference: 18940874 - DNA Res. 2008 Dec;15(6):387-96 – reference: 23184592 - Curr Protoc Microbiol. 2012 Nov;Chapter 1:Unit 1E.5. – reference: 22699611 - Nature. 2012 May 09;486(7402):222-7 – reference: 21490274 - Sci Transl Med. 2011 Apr 13;3(78):78ps12 – reference: 22647049 - Clin Microbiol Infect. 2012 Jul;18 Suppl 4:47-9 – reference: 26077811 - Proteomics. 2015 Oct;15(20):3463-73 – reference: 27499582 - J Clin Biochem Nutr. 2016 Jul;59(1):65-70 – reference: 23318837 - Appl Microbiol Biotechnol. 2013 Feb;97(4):1489-500 – reference: 18406397 - Arch Oral Biol. 2008 Oct;53(10):903-9 – reference: 22745671 - PLoS One. 2012;7(6):e38581 – reference: 26123276 - Nat Commun. 2015 Jun 30;6:7486 – reference: 12969510 - BMC Bioinformatics. 2003 Sep 11;4:41 – reference: 22950799 - Br J Nutr. 2013 May 28;109(10):1779-88 – reference: 24729765 - Gastroenterol Hepatol (N Y). 2013 Sep;9(9):560-9 – reference: 24751910 - Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):497-505 – reference: 27842515 - BMC Microbiol. 2016 Nov 14;16(1):274 – reference: 26106258 - Mediators Inflamm. 2015;2015:843089 – reference: 17140690 - Int J Food Microbiol. 2007 Feb 15;113(3):358-61 – reference: 19043404 - Nature. 2009 Jan 22;457(7228):480-4 – reference: 16298023 - Clin Nutr. 2005 Dec;24(6):920-4 – reference: 24390915 - Semin Reprod Med. 2014 Jan;32(1):5-13 – reference: 23509616 - J Nutr Metab. 2013;2013:486186 – reference: 15490199 - Eur J Nutr. 2005 Sep;44(6):360-4 – reference: 17456850 - Diabetes. 2007 Jul;56(7):1761-72 – reference: 27392632 - Neuropharmacology. 2017 Jan;112(Pt B):399-412 – reference: 24637895 - PLoS One. 2014 Mar 17;9(3):e92368 – reference: 25443494 - Trends Immunol. 2014 Nov;35(11):518-25 – reference: 27447891 - Curr Infect Dis Rep. 2016 Sep;18(9):29 – reference: 24892638 - Mol Endocrinol. 2014 Aug;28(8):1221-38 – reference: 24997787 - Nat Biotechnol. 2014 Aug;32(8):822-8 – reference: 23435359 - Nat Rev Microbiol. 2013 Apr;11(4):227-38 – reference: 23563425 - Nat Biotechnol. 2013 Apr;31(4):309-15 – reference: 23762085 - Clin Dev Immunol. 2013;2013:181849 – reference: 28379213 - Acta Neurobiol Exp (Wars). 2017;77(1):18-30 – reference: 27099876 - Br J Clin Pharmacol. 2016 Jan;81(1):78-88 – reference: 26214836 - Nat Med. 2015 Aug;21(8):895-905 – reference: 26909656 - Epigenetics. 2016 Mar 3;11(3):205-15 – reference: 20216555 - Eur J Clin Nutr. 2010 Jun;64(6):636-43 – reference: 28628112 - Nat Med. 2017 Jul;23 (7):859-868 – reference: 26431716 - Curr Opin Biotechnol. 2016 Feb;37:1-7 – reference: 22972297 - Nature. 2012 Sep 13;489(7415):242-9 – reference: 20709691 - Bioinformatics. 2010 Oct 1;26(19):2460-1 – reference: 26374288 - Genome Biol. 2015 Sep 15;16:191 – reference: 17183312 - Nature. 2006 Dec 21;444(7122):1027-31 – reference: 24982662 - Front Plant Sci. 2014 Jun 16;5:209 – reference: 7317349 - Br J Nutr. 1981 Nov;46(3):549-58 – reference: 26362264 - Immunity. 2015 Sep 15;43(3):527-40 – reference: 27111232 - J Clin Invest. 2016 Jun 1;126(6):2049-63 – reference: 27723756 - Nat Genet. 2016 Nov;48(11):1396-1406 – reference: 22972298 - Nature. 2012 Sep 13;489(7415):250-6 – reference: 20798169 - Bioinformatics. 2010 Oct 15;26(20):2631-2 – reference: 11297958 - Lancet. 2001 Apr 7;357(9262):1076-9 – reference: 23060610 - Bioinformatics. 2012 Dec 1;28(23):3150-2 – reference: 24486053 - Gastroenterology. 2014 May;146(6):1437-1448.e1 – reference: 24060133 - Methods Enzymol. 2013;531:465-85 – reference: 16884969 - Bone. 2006 Dec;39(6):1313-21 – reference: 19801464 - Appl Environ Microbiol. 2009 Dec;75(23):7537-41 – reference: 22510044 - J Med Food. 2012 Jul;15(7):664-70 – reference: 25758642 - Nat Commun. 2015 Mar 11;6:6528 – reference: 12646634 - J Immunol. 2003 Apr 1;170(7):3688-95 – reference: 22101057 - Appl Environ Microbiol. 2012 Feb;78(3):717-25 – reference: 27579006 - Saudi J Biol Sci. 2016 Sep;23(5):577-83 – reference: 27130534 - J Proteomics. 2016 Sep 16;147:3-20 – reference: 23852088 - Curr Opin Clin Nutr Metab Care. 2013 Sep;16(5):509-16 – reference: 24997786 - Nat Biotechnol. 2014 Aug;32(8):834-41 – reference: 14571751 - Hepatogastroenterology. 2003 Sep-Oct;50(53):1415-8 – reference: 27437760 - Crit Rev Food Sci Nutr. 2017 Dec 12;57(18):3959-3970 – reference: 25126780 - Cell. 2014 Aug 14;158(4):705-721 – reference: 27507964 - Front Microbiol. 2016 Jul 26;7:1144 – reference: 23259758 - J Transl Med. 2012 Dec 21;10:253 – reference: 11341652 - Dig Dis Sci. 2001 May;46(5):1077-82 – reference: 24288371 - Nucleic Acids Res. 2014 Jan;42(Database issue):D222-30 – reference: 20805793 - Nat Methods. 2010 Sep;7(9):668-9 – reference: 21493653 - Bioinformatics. 2011 Jun 1;27(11):1489-95 – reference: 22407806 - J Bone Miner Res. 2012 Jun;27(6):1357-67 – reference: 21407244 - Nat Rev Microbiol. 2011 Apr;9(4):279-90 – reference: 15083312 - Eur J Nutr. 2004 Apr;43(2):61-8 – reference: 24096173 - Arch Biochem Biophys. 2013 Dec;540(1-2):19-25 – reference: 16728531 - Mol Endocrinol. 2006 Oct;20(10):2432-43 – reference: 28393285 - Eur J Nutr. 2017 Apr 9;:null – reference: 20139991 - Nat Med. 2010 Mar;16(3):308-12 – reference: 21699738 - BioData Min. 2011 Jun 24;4:19 – reference: 25656825 - Microb Ecol Health Dis. 2015 Feb 04;26:26164 – reference: 21212162 - Genome Res. 2011 Mar;21(3):494-504 – reference: 25747351 - Am J Physiol Gastrointest Liver Physiol. 2015 May 15;308(10):G840-51 |
| SSID | ssj0014453 |
| Score | 2.5585752 |
| SecondaryResourceType | review_article |
| Snippet | ContextIt has been well established that the human gut microbiome plays a critical role in the regulation of important biological processes and the mechanisms... It has been well established that the human gut microbiome plays a critical role in the regulation of important biological processes and the mechanisms... Abstract It has been well established that the human gut microbiome plays a critical role in the regulation of important biological processes and the... We summarized potential mechanisms of gut microbiota on regulation of bone mass, outlined some useful tools for metagenomics, and presented examples of... |
| SourceID | pubmedcentral proquest pubmed crossref wolterskluwer oup |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 3635 |
| SubjectTerms | Animal models Animal research Animals Animals, Laboratory Anti-Bacterial Agents - pharmacology Bone and Bones - drug effects Bone and Bones - metabolism Bone mass Bone Resorption - microbiology Bone turnover Digestive system Excretion Exploration Gastrointestinal Microbiome - physiology Gastrointestinal tract Germ-Free Life Health Humans Intestinal microflora Intestine Metabolism Metagenomics Microbiomes Microbiota Mucosal immunity Osteoporosis Prebiotics Probiotics - pharmacology Reviews Studies |
| Title | Association Between Gut Microbiota and Bone Health: Potential Mechanisms and Prospective |
| URI | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00004678-201710000-00004 https://www.ncbi.nlm.nih.gov/pubmed/28973392 https://www.proquest.com/docview/1967045177 https://www.proquest.com/docview/3164379378 https://www.proquest.com/docview/1947098566 https://pubmed.ncbi.nlm.nih.gov/PMC5630250 |
| Volume | 102 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fa9RAEB60BRFE6u_YWiKID-Jictm9TXyRnrQW4cohFfIWsptdelWT2uTw3-_MZi9e8Orr7ZDkJrO735eZ-RbgjVYqmVTCMFsqzrhBzpqphDMVIwVSNhZKUUZ3fjY9_c6_5iL3H9xaX1a5XhPdQl01mr6Rf8BIkaSFIuWnq9-MTo2i7Ko_QuMu7JJ0GZEvmQ-EC7mCV6GkMgQ5yb3GJnWtXJJ8IS7QFJTJaE8a9bltwM1_qyYf_Gkoo93-cAXtG9vSyR489HgyPOoD4BHcMfVjuDf3GfMnkG_4P5z1RVnhl1UXzpe9BFNXhmVdhbOmNmHfk_QxXDQdFRHhdeeGOoOX7a_WWS2um3Vr5lM4Pzk-_3zK_GkKTIsJT5jmaSTSCvlgopSYcmsnsTJIWNKymiodaR7hRmVTYYU1RmTWxlZmJSdBnARxyTPYqfFRXkCYVpRs1SVyK6SHosqESaW2KrEENyITwPu1OwvtlcbpwIufBTEO9H5xqQvyfuG8H8Dbwfyql9i4zfA1vpvbbJi3OVi_ucLPxrb4Gztbh5OYspeI01K8wzCM04xyJ2VtmhVdgssoSxH8BvC8j4PhQZCzygRxZgByFCGDAUl4j0fq5YWT8iZ1NgShAbBRLBV9E2zhGBzCCUZ_0GVimPspgHdb7be65OX_XbIP952tK1A8gJ3uemVeIdDq1KGbTYewOzs-W3y7AdKiIxc |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIgESQrwJFAgScEBY5OV1goQQBcqWdqseFik3K05ssQWS0mRV8aP4j8w4DzZiy63X9aw3O56x58vMfAZ4misVBgXXzGQqYpFGzJqoMGLKRwikjM-Voozu7GAy_RJ9Tnm6Ab_7Xhgqq-z3RLtRF1VO78hfoaUI4kIR4u3xT0a3RlF2tb9CozWLPf3rFCFb_Wb3A67vsyDY-Th_P2XdrQIs50EUsjyKPR4XiItCpfgkMibwlcbAPc6Kicq9PPJwwzYxN9xozRNjfCOSLCJimBDPZ5z2AlzEc9ejCkKRDvgOoUlHeklVDyJIO0pPapI5IrZEPA_IB8LREThqq1uJbv8t0rx6WlECvf5m6-dXTsGd63CtC1_dd6293YANXd6ES7MuQX8L0pXldrfbGjD307JxZ4uW8anJ3Kws3O2q1G7bAvXaPawaqlnCeWeaGpEX9Y_aSh2eVH0n6G2Yn4ea78BmiY9yD9y4oNxuniGUQzTKi4TrWORGhYaiG0878LJXp8w7YnO6X-O7JICD2pdHuSTtS6t9B54P4scto8dZgk9wbc6SYZ3MVr9ysnP-Wv411bXDoU_JUgwLY_yFYRi9mlI1WamrJU0RCS-JMdZ24G5rB8ODIEQWIYa1DoiRhQwCxBg-HikXXy1zOJHBYczrABvZkmx7bqUFjBi9MPqDNvHD7EcOvFgrv1Yl9_-vksdweTqf7cv93YO9B3DFfs_WRm7BZnOy1A8xxmvUI-tZLshz9uQ_8lNcmg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+Between+Gut+Microbiota+and+Bone+Health%3A+Potential+Mechanisms+and+Prospective&rft.jtitle=The+journal+of+clinical+endocrinology+and+metabolism&rft.au=Chen%2C+Yuan-Cheng&rft.au=Greenbaum%2C+Jonathan&rft.au=Shen%2C+Hui&rft.au=Deng%2C+Hong-Wen&rft.date=2017-10-01&rft.pub=Copyright+Oxford+University+Press&rft.issn=0021-972X&rft.volume=102&rft.issue=10&rft.spage=3635&rft.epage=3646&rft_id=info:doi/10.1210%2Fjc.2017-00513&rft.externalDocID=00004678-201710000-00004 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-972X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-972X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-972X&client=summon |