The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells - Orecchioni, Stefania; Reggiani, Francesca; Talarico, Giovanna; Mancuso, Patrizia; Calleri, Angelica; Gregato, Giuliana; Labanca, Valentina; Noonan, Douglas M.; Dallaglio, Katiuscia; Albini, Adriana; Bertolini, Francesco (International journal of cancer, 2015)
Keywords: AMP-Activated Protein Kinases - metabolism; Angiogenesis; Animals; Apoptosis - drug effects; Breast cancer; Breast Neoplasms - blood supply; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cancer; Cell Line, Tumor; Electron Transport Complex I - antagonists & inhibitors; Female; Humans; Medical research; Metastasis; metformin; Metformin - pharmacology; Mice; Neoplasm Metastasis; Neovascularization, Pathologic - prevention & control; phenformin; Phenformin - pharmacology; Phosphorylation; TOR Serine-Threonine Kinases - metabolism; Tumor Microenvironment; phenformin; breast cancer; metformin; angiogenesis