Biophysical contrast sources for magnetic susceptibility and R2 mapping: A combined 7 Tesla, mass spectrometry and electron paramagnetic resonance study

• Published in: NeuroImage (Orlando, Fla.) Vol. 302; p. 120892
• Main Authors: Otsuka, Fábio Seiji, Otaduy, Maria Concepción Garcia, Rodriguez, Roberta Diehl, Langkammer, Christian, Barbosa, Jeam Haroldo Oliveira, Salmon, Carlos Ernesto Garrido
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.11.2024; Elsevier Limited; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Algorithms; atomic absorption spectrometry; Basal ganglia; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain mapping; death; electron paramagnetic resonance spectroscopy; Electron spin resonance; Electron Spin Resonance Spectroscopy - methods; Female; Ferritin; Ferritins - analysis; Ferritins - metabolism; Gray Matter - diagnostic imaging; Gray Matter - metabolism; hippocampus; Humans; Iron; Iron - analysis; Iron - metabolism; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic susceptibility; Male; Mass spectrometry; Mass Spectrometry - methods; Mass spectroscopy; Middle Aged; Neurological diseases; paramagnetism; postmortem changes; Quantitative susceptibility mapping; Red nucleus; Scientific imaging; Software; Substantia grisea; Substantia nigra; R2; Quantitative susceptibility mapping; Iron; Ferritin; Magnetic susceptibility; R

•R2* and QSM show variable regional contrast patterns. With similar contrast in iron-rich structures.•Iron and its molecular form as ferritin were shown to be the main contributors for the overall R2* and QSM contrast.•Analysis individualized by ROI showed different contributions of iron and ferriti...