Epoxy-Keto Derivative of Linoleic Acid Stimulates Aldosterone Secretion

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 43; no. 2, Part 2; pp. 358 - 363
• Main Authors: Goodfriend, Theodore L., Ball, Dennis L., Egan, Brent M., Campbell, William B., Nithipatikom, Kasem
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.02.2004; Hagerstown, MD Lippincott
• Subjects: Adult; African Continental Ancestry Group; Aldosterone - biosynthesis; Aldosterone - blood; Aldosterone - secretion; Animals; Biological and medical sciences; Blood vessels and receptors; Cells, Cultured; Endocrine kidney. Renin-angiotensin-aldosterone system; Fundamental and applied biological sciences. Psychology; Humans; Linoleic Acid - chemistry; Middle Aged; Obesity - blood; Obesity - ethnology; Oleic Acids - blood; Oleic Acids - chemistry; Oleic Acids - pharmacology; Rats; Vertebrates: cardiovascular system; Vertebrates: endocrinology; Zona Glomerulosa - cytology; Zona Glomerulosa - drug effects; Zona Glomerulosa - metabolism; Hypertension; Obesity; Oxidative stress; Adrenal glands; fatty acids; Steroid hormone; Mineralocorticoid; Nutrition disorder; Cardiovascular disease; Aldosterone; Linoleic acid; Adrenal hormone; adrenal gland; Nutritional status

ABSTRACT—Plasma levels of aldosterone are not always predictable from the activity of renin and the concentration of potassium. Among the unexplained are elevated levels of aldosterone in some obese humans. Obesity is characterized by increased plasma fatty acids and oxidative stress. We postulated...