Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase‐1

• Published in: British journal of pharmacology Vol. 125; no. 7; pp. 1437 - 1444
• Main Authors: Sammut, Ivan A., Foresti, Roberta, Clark, James E., Exon, David J., Vesely, Martin J. J., Sarathchandra, Padmini, Green, Colin J., Motterlini, Roberto
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.1998; Nature Publishing
• Subjects: Animals; Aorta, Thoracic; aortic contractility; Biological and medical sciences; Blood vessels and receptors; carbon monoxide; Carbon Monoxide - metabolism; Carbon Monoxide - physiology; cyclic GMP; Cyclic GMP - metabolism; Drug Interactions; Enzyme Induction - drug effects; Enzyme Inhibitors - pharmacology; Fundamental and applied biological sciences. Psychology; Gene Expression - drug effects; Haeme oxygenase‐1; Heme Oxygenase (Decyclizing) - antagonists & inhibitors; Heme Oxygenase (Decyclizing) - biosynthesis; Heme Oxygenase (Decyclizing) - genetics; Heme Oxygenase-1; Male; Muscle Tonus; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - physiology; Nitric Oxide Donors - pharmacology; Nitric Oxide Synthase - antagonists & inhibitors; NO donors; Penicillamine - analogs & derivatives; Penicillamine - pharmacology; Phenylephrine - pharmacology; Rats; Rats, Inbred Lew; tin protoporphyrin IX; Vascular Resistance - drug effects; Vascular Resistance - physiology; Vasoconstriction - drug effects; Vertebrates: cardiovascular system; Rat; Enzyme; Isozyme; Rodentia; Heme oxygenase (decyclizing); Smooth muscle; Gene expression; Muscle contraction; In vitro; Vertebrata; Mammalia; Blood vessel; Nitric oxide; Aorta; Circulatory system; Oxidoreductases; Carbon monoxide

1 The contribution of haeme oxygenase‐derived carbon monoxide (CO) to the regulation of vascular tone in thoracic aorta was investigated following induction of the inducible isoform of haeme oxygenase (HO‐1). 2 Isometric smooth muscle contractions were recorded in isolated rat aortic ring preparatio...