Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase‐1 - Sammut, Ivan A.; Foresti, Roberta; Clark, James E.; Exon, David J.; Vesely, Martin J. J.; Sarathchandra, Padmini; Green, Colin J.; Motterlini, Roberto (British journal of pharmacology, 1998)
Keywords: Animals; Aorta, Thoracic; aortic contractility; Biological and medical sciences; Blood vessels and receptors; carbon monoxide; Carbon Monoxide - metabolism; Carbon Monoxide - physiology; cyclic GMP; Cyclic GMP - metabolism; Drug Interactions; Enzyme Induction - drug effects; Enzyme Inhibitors - pharmacology; Fundamental and applied biological sciences. Psychology; Gene Expression - drug effects; Haeme oxygenase‐1; Heme Oxygenase (Decyclizing) - antagonists & inhibitors; Heme Oxygenase (Decyclizing) - biosynthesis; Heme Oxygenase (Decyclizing) - genetics; Heme Oxygenase-1; Male; Muscle Tonus; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - physiology; Nitric Oxide Donors - pharmacology; Nitric Oxide Synthase - antagonists & inhibitors; NO donors; Penicillamine - analogs & derivatives; Penicillamine - pharmacology; Phenylephrine - pharmacology; Rats; Rats, Inbred Lew; tin protoporphyrin IX; Vascular Resistance - drug effects; Vascular Resistance - physiology; Vasoconstriction - drug effects; Vertebrates: cardiovascular system; Rat; Enzyme; Isozyme; Rodentia; Heme oxygenase (decyclizing); Smooth muscle; Gene expression; Muscle contraction; In vitro; Vertebrata; Mammalia; Blood vessel; Nitric oxide; Aorta; Circulatory system; Oxidoreductases; Carbon monoxide