Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV‐8‐negative multicentric Castleman disease

• Published in: American journal of hematology Vol. 91; no. 2; pp. 220 - 226
• Main Authors: Iwaki, Noriko, Fajgenbaum, David C., Nabel, Christopher S., Gion, Yuka, Kondo, Eisei, Kawano, Mitsuhiro, Masunari, Taro, Yoshida, Isao, Moro, Hiroshi, Nikkuni, Koji, Takai, Kazue, Matsue, Kosei, Kurosawa, Mitsutoshi, Hagihara, Masao, Saito, Akio, Okamoto, Masataka, Yokota, Kenji, Hiraiwa, Shinichiro, Nakamura, Naoya, Nakao, Shinji, Yoshino, Tadashi, Sato, Yasuharu
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.02.2016
• Subjects: Adult; Aged; Castleman Disease - pathology; Female; Hematology; Herpesvirus 8, Human - physiology; Humans; Lymph Nodes - pathology; Male; Middle Aged; Plasma Cells - pathology; Platelet Count; Syndrome; Thrombocytopenia - etiology; Thrombocytopenia - pathology; Young Adult

Multicentric Castleman disease (MCD) describes a heterogeneous group of disorders involving systemic inflammation, characteristic lymph node histopathology, and multi‐organ dysfunction because of pathologic hypercytokinemia. Whereas Human Herpes Virus‐8 (HHV‐8) drives the hypercytokinemia in a cohor...