Incentive-elicited striatal activation in adolescent children of alcoholics

• Published in: Addiction (Abingdon, England) Vol. 103; no. 8; pp. 1308 - 1319
• Main Authors: Bjork, James M., Knutson, Brian, Hommer, Daniel W.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2008; Blackwell
• Subjects: Addiction; Addictive behaviors; Adolescence; Adolescent; Adolescents; Adult and adolescent clinical studies; alcohol; Alcoholics; Alcoholism; Alcoholism - psychology; Alcoholism and acute alcohol poisoning; Analysis of Variance; at-risk children; Behavior, Addictive - psychology; Biological and medical sciences; Brain Mapping; Caudate Nucleus - physiology; Cerebral Cortex - physiopathology; Child; Child of Impaired Parents - psychology; Children; Children of alcoholics; Clinical psychology; Cues; Experimental psychology; Female; General aspects; Humans; impulsivity; Incentives; Longitudinal Studies; Magnetic Resonance Imaging; Male; Medical sciences; Motivation; Neural Pathways - physiopathology; Neurology; NMR; Nuclear magnetic resonance; nucleus accumbens; Nucleus Accumbens - physiology; Parents; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; reward; Risk factors; Risk-Taking; sensation-seeking; Social problems; striatum; Teenagers; Toxicology; U.S.A; ventral; Adolescence; sensation- seeking; Central nervous system; Activation; Encephalon; Sensation seeking; Alcoholic beverage; incentives; striatum; at-risk children; Child; Human; Incentive; alcohol; Drug addiction; Impulsivity; Ethanol; Alcoholism; Basal ganglion; Corpus striatum; Nucleus accumbens; Addiction; ventral; Adolescent; Risk factor; Reward; Psychiatry

ABSTRACT Aims  Deficient recruitment of motivational circuitry by non‐drug rewards has been postulated as a pre‐morbid risk factor for substance dependence (SD). We tested whether parental alcoholism, which confers risk of SD, is correlated with altered recruitment of ventral striatum (VS) by non‐dr...